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VTKKLRVIQWTTGKVGKLSLRGVLDDPRLELVGVYAFSEEKAGSDAGALCGRPDTGVLATTDIDALLALK ADTVIYTPFMADIDQVVRLLESGLDVISTNLFLNVGGIQGETKQRLAAACQRGGSSLYITGVNPGWINTM VTAMTAVCRHVEMVSVSESADVSVYESPETWQSQGFSLSEAPPAVIETAKMWLSTFRDSVQRMAVALGFE LDDMEFFIEHATASERVHLGWWVIEKDTIAAMRAGWNGKVNGKTVVQSNVAWYMTTLLNEGWQFDDDHYH VVIKGEPGVDTRIRFLPPDSWGNHEWDTMTAMPAVSAAVDVAAAPAGILTLKDVGLPCAPAGLWLEG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1399 | - | - | 100% (347) | homoserine dehydrogenase |
| M. avium 104 | MAV_0371 | dapB | 2e-65 | 38.48% (343) | dihydrodipicolinate reductase |
| M. avium 104 | MAV_1757 | dapB | 4e-56 | 37.17% (339) | dihydrodipicolinate reductase N-terminus domain-containing |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1088 | - | 4e-37 | 32.47% (348) | hypothetical protein Mb1088 |
| M. gilvum PYR-GCK | Mflv_3226 | - | 1e-157 | 76.90% (342) | homoserine dehydrogenase, NAD-binding |
| M. tuberculosis H37Rv | Rv1059 | - | 5e-37 | 32.47% (348) | hypothetical protein Rv1059 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0727 | - | 2e-45 | 32.76% (348) | putative dihydrodipicolinate reductase |
| M. marinum M | MMAR_5250 | - | 1e-69 | 39.07% (343) | hypothetical protein MMAR_5250 |
| M. smegmatis MC2 155 | MSMEG_0560 | dapB | 2e-69 | 40.06% (342) | dihydrodipicolinate reductase N-terminus domain-containing |
| M. thermoresistible (build 8) | TH_4249 | - | 4e-65 | 36.95% (341) | PUTATIVE dihydrodipicolinate reductase |
| M. ulcerans Agy99 | MUL_3685 | - | 5e-54 | 36.69% (338) | hypothetical protein MUL_3685 |
| M. vanbaalenii PYR-1 | Mvan_5538 | - | 2e-69 | 39.03% (351) | dihydrodipicolinate reductase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_1399|M.avium_104 --MTKKLRVIQWTTGKVGKLSLRGVLDDPRLELVGVYAFSEEKAGSDAGA
Mflv_3226|M.gilvum_PYR-GCK ---MKKLRVIQWTTGKVGRLSMRGILDDPRLELVGVYAYSAEKAGADAGP
MAB_0727|M.abscessus_ATCC_1997 ---MSVIRVFQVATGNVGTEMIRRIASHPDLELAGLHCYSPEKVGRDAGE
MMAR_5250|M.marinum_M MPNS--YRVVQWTTGNVGKSSLQAIATHPALELVGCYAWSQEKAGRDAGE
MSMEG_0560|M.smegmatis_MC2_155 MPDTTGYRVVQWTTGNVGKSSVAAIAKNPTLELVGCYAWSGDKVGKDVGE
TH_4249|M.thermoresistible__bu VPNTP-YRVVQWTTGNVGKSSVQALAANPLYELVGVYAWSPDKVGRDAGE
Mvan_5538|M.vanbaalenii_PYR-1 MPNTASYRVVQWTTGNVGKSSVAAIAGNPTLELVGCYAWSDDKVGRDAGE
MUL_3685|M.ulcerans_Agy99 MSTARPLRVIQWTTGNIGRRSLHAIIGRPDLELVGVYAHGPDKVGVDAAE
Mb1088|M.bovis_AF2122/97 --MTMSLRVIQWATGSVGVAAIKGVLQHPELELVGCWVHSAAKSGKDVGE
Rv1059|M.tuberculosis_H37Rv --MTMSLRVIQWATGSVGVAAIKGVLQHPELELVGCWVHSAAKSGKDVGE
**.* :**.:* : : * **.* . * * *..
MAV_1399|M.avium_104 LCG-RPDTGVLATTDIDALLALKADTVIYTPFMADIDQVVRLLESGLDVI
Mflv_3226|M.gilvum_PYR-GCK LCG-RPETGVRATTDIDALIALNADTVLYTPFMADLDHAVRLLESGLDVI
MAB_0727|M.abscessus_ATCC_1997 LVG-LEPNGVIATGTVEEIVAAKPDVLTFHGVFPDEDLYVKVLEAGIDIV
MMAR_5250|M.marinum_M LCG-MAPLGITASNDVEALLALKPDCVVYNPMWIDVDELVRILSAGVNVV
MSMEG_0560|M.smegmatis_MC2_155 LCG-IEPLGVSATDDVDALLALKPDVVVYNPMWIDVDELVRILESGVNVV
TH_4249|M.thermoresistible__bu LAG-IEPLGVKATNDVDELLALKPDVVVYNPMWIDVDELVRILSAGINVV
Mvan_5538|M.vanbaalenii_PYR-1 LAG-IEPVGVTATNNVDALLALKPDVVVYNPMWIDVDELVRILEAGVNVV
MUL_3685|M.ulcerans_Agy99 LAGWPDPTGVRATSDIGALLALGADACCYNPLWPNIDELVGLLESGVNVC
Mb1088|M.bovis_AF2122/97 IIG-SPPLGVIATNSIDDVLALDADAVIYAPLLPSVDEVAALLRSGKNVV
Rv1059|M.tuberculosis_H37Rv IIG-SPPLGVIATNSIDDVLALDADAVIYAPLLPSVDEVAALLRSGKNVV
: * *: *: : ::* .* : . . * . :* :* ::
MAV_1399|M.avium_104 STNLFLN--------VGGIQGETKQRLAAACQRGGSSLYITGVNPG-WIN
Mflv_3226|M.gilvum_PYR-GCK STNLFLN--------VGGIQGETRDKLAAACEQGNSSLYITGVNPG-WIN
MAB_0727|M.abscessus_ATCC_1997 TTADWITGHHRDQNHPHPSGRPTTEVLQQACERGGSTFYGTGMNPG-LTQ
MMAR_5250|M.marinum_M TTAAFITG---------HNLGAGRDRILAACRHGGSTIFGSGVSPG-FAE
MSMEG_0560|M.smegmatis_MC2_155 STASFITG---------HNQGTGRDRIAEACTRGGSSMFGSGISPG-YVN
TH_4249|M.thermoresistible__bu SSASFITG---------HNLRDGRDRIEEACRQGGSTMFGSGISPG-FAE
Mvan_5538|M.vanbaalenii_PYR-1 ASASFITG---------RNLGDGRDKLADACQRGGSTLFGSGVSPG-FAE
MUL_3685|M.ulcerans_Agy99 TSAAWITGG--------KQTPRDRERILAACERGGATIFGSDAHPG-MTN
Mb1088|M.bovis_AF2122/97 TPLGWFYP-----------SEKEAAPLEVAAQAGNATLHGAGIGPGAVTE
Rv1059|M.tuberculosis_H37Rv TPLGWFYP-----------SEKEAAPLEVAAQAGNATLHGAGIGPGAVTE
:. :: : *. *.:::. :. ** :
MAV_1399|M.avium_104 TMVTAMTAVCRHVEMVSVSESADVSVYESPETWQ-SQGFSLSEAPPAVIE
Mflv_3226|M.gilvum_PYR-GCK TMVTAMTAVCRDVQKVSIVESADVSVYESAETWQ-ALGMGQPEVTPEVAG
MAB_0727|M.abscessus_ATCC_1997 ILGVIHSCDVAEIENVTVIESVDVSCHHSVDSWE-MVGYGLPVGDPSIPA
MMAR_5250|M.marinum_M LLAIVSAMVCNRIDKVTVNEAADTTFYDSPATER-PVGFGQPIDHPQLQA
MSMEG_0560|M.smegmatis_MC2_155 QLSVVAAGICDRVDKITVNEAADTTFYDSPATEK-PVGFGQPIDHPDLQA
TH_4249|M.thermoresistible__bu LLAIIGTQMCDRVDKVTICEQSDTTFYDSPATEK-PVGFGTPIDDPNLPQ
Mvan_5538|M.vanbaalenii_PYR-1 LLAIVAGTACDRIDKITIAESADTTLYDSPDTER-PVGFGTAIDDPNLQP
MUL_3685|M.ulcerans_Agy99 MVGMVLSGSCERVDEIRITESVDCSTYESAATQT-AMGFSQHPDTPGLAE
Mb1088|M.bovis_AF2122/97 LFPLLLSVMSTGVTFVRSEEFSDLRSYGAPDVLRYVMGFGGTPDSALTGP
Rv1059|M.tuberculosis_H37Rv LFPLLLSVMSTGVTFVRSEEFSDLRSYGAPDVLRYVMGFGGTPDSALTGP
. : : * * : : * . .
MAV_1399|M.avium_104 TAKMWLSTFRDSVQRMAVALGFELD-DMEFFIEHATASERVHLGWWVIEK
Mflv_3226|M.gilvum_PYR-GCK LAEFGFTTFAESVQRMALALGFDLD-EMEFVVEHQTASERVDLGWFCMEK
MAB_0727|M.abscessus_ATCC_1997 LLEKGTRVFADGVYLMADCFGLELD-DVTFSYELGACTEDIDLGWYRLPK
MMAR_5250|M.marinum_M MTAQGTAIFGEAVRLVADALGVELD-EVRCVAEHAQTTADLDLGSWTIAA
MSMEG_0560|M.smegmatis_MC2_155 MTAQGTGVFGEAVRMIADALGIELD-EVRCDAEYAQTTEDLDLGSWTIPA
TH_4249|M.thermoresistible__bu MASQGTAIFAEAVQLIADSLGVELD-EIVCEAEYAQTTEDLDLGSWKIGA
Mvan_5538|M.vanbaalenii_PYR-1 MAANGTAVFAEAVQLVADALAIELD-EIKCVSEYAQTTEDLVMASWTIPA
MUL_3685|M.ulcerans_Agy99 SVRVESEVFAESAAMMADAIGATLD-KMTFDVTFTAATADTDLGFMKIPA
Mb1088|M.bovis_AF2122/97 MQKILDGGFLQSVRLCVDRLGFAADPQIRTSQEVAVATAPIDSPIGVIEP
Rv1059|M.tuberculosis_H37Rv MQKILDGGFLQSVRLCVDRLGFAADPQIRTSQEVAVATAPIDSPIGVIEP
* :.. . :. * .: : :
MAV_1399|M.avium_104 DTIAAMRAGWNGKVNGKTVVQSNVAWYMT-TLLNEGWQFDDD--HYHVVI
Mflv_3226|M.gilvum_PYR-GCK DTIAAIRGGWNAKVKGKTVIESRVAWYLT-DKLNGGWVFDDD--HYHVVI
MAB_0727|M.abscessus_ATCC_1997 GSLGANYLKYQGIVGGVPKVEVHVEWQMT-PKTEPHWNVKG---CYITKI
MMAR_5250|M.marinum_M GCVAGVHASWQGVAGGRTIVELNVRWRKG-QTLEPDWQIDQD--GWVIQV
MSMEG_0560|M.smegmatis_MC2_155 GCVAGVYASWKGIVAGHTRVEINVRWRKG-QTLQPDWKIDQD--GWVIEV
TH_4249|M.thermoresistible__bu GCVAGVYASWQGRIGGRTLIDLNVRWKKG-QTLEPNWQLERE--GWKITV
Mvan_5538|M.vanbaalenii_PYR-1 GHVAGVYASWQGIANGKTVIDINVRWKKG-QTLDPDWQLDGD--GWKITI
MUL_3685|M.ulcerans_Agy99 GTVGSVYGYHRGWVGDRNVVSVGFNWTMG-NHVVPPKPLKH---GHVIQV
Mb1088|M.bovis_AF2122/97 GQVAGRRFHWEALVEDTVVVQIAVNWLMGSENLDPPWSFGPAGERYEIEV
Rv1059|M.tuberculosis_H37Rv GQVAGRRFHWEALVEDTVVVQIAVNWLMGSENLDPPWSFGPAGERYEIEV
. :.. .. . :. . * . :
MAV_1399|M.avium_104 KGEPGVDTRIRFLPPD------------SWGNHEWDTMTAMPAVSAAVDV
Mflv_3226|M.gilvum_PYR-GCK AGEPEVQTRIRFVPPE------------HWGNHEWDTMTAMPAVNAAHNV
MAB_0727|M.abscessus_ATCC_1997 QGDPCVYSKHMVIPKPGTD-----FTDPAAFASVGMTVTGLPALNAIRSV
MMAR_5250|M.marinum_M DGTPTVTTKVSFLPPP---YFQ--AETIADFMVLGHIMTAMPTINAIPAV
MSMEG_0560|M.smegmatis_MC2_155 AGRPTVTMKVGFLPPP---DFE--ATTLEEFMVLGHIMTATPPLNAIPAV
TH_4249|M.thermoresistible__bu DGRPTVNMEIGFLPPP---DFG--ATTMEEFMVLGHIMTAMPPIHMIPAV
Mvan_5538|M.vanbaalenii_PYR-1 DGRPTVNMQVGFLPPQ---DMIENAKTLEDFFVLGHIMTAMPPIHAIPAV
MUL_3685|M.ulcerans_Agy99 FGLPNMRTVLHCLPPK---DWT-----ESGFMGLGMIYTAMPVTNAVPAV
Mb1088|M.bovis_AF2122/97 RGSPDTCVTIKGWQPQT--------VAAGLKSNPGIVATAAHCVNAIPAT
Rv1059|M.tuberculosis_H37Rv RGSPDTCVTIKGWQPQT--------VAAGLKSNPGIVATAAHCVNAIPAT
* * *. .
MAV_1399|M.avium_104 AAAPAGILTLKDVGLPCAPAGLWLEG------------
Mflv_3226|M.gilvum_PYR-GCK AAAPAGILTLQDVGLPCAPAGPWESERRNAPIG-----
MAB_0727|M.abscessus_ATCC_1997 IDAPPGILTSADLPLRGFAGRFK---------------
MMAR_5250|M.marinum_M VAAAPGIVTYSDLALTLPRGMVPTDRNSDPKLGASRTP
MSMEG_0560|M.smegmatis_MC2_155 VAAPPGIVTYNDLPLILPRGVVPTP-------------
TH_4249|M.thermoresistible__bu VAAEPGIATYNDLPLPQARGVVRV--------------
Mvan_5538|M.vanbaalenii_PYR-1 VAAAPGIATYNDLPLPTPRGVVPTA-------------
MUL_3685|M.ulcerans_Agy99 VAAKPGIVTLADLPPITGRAAL----------------
Mb1088|M.bovis_AF2122/97 CAAPAGIQSFFDLPLITGRAAPGLAR------------
Rv1059|M.tuberculosis_H37Rv CAAPAGIQSFFDLPLITGRAAPGLAR------------
* .** : *: .