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VHIGAGNFHRAHQAVYFDDLACSGISDQWGVSAISLRSHDVKDLLSAQDGLYTVVQRGHDHQTARVVGSI GSVHYAPNDGAAVRAALTDPRTRIVSLTITPNGYFLDPVTREFDADHPDVRADLVASGCYGTAWGYLTEA LEQRRRAGIAPFTVLCCDNIPDNTQAARTALVSFAALKNPGLARWIDRHVAFPSTMVDRITPQTSDSERE FVERTFGVADNWPVLTEPHSQWIIEDSFSDGRPPLDEVGVQFVTDVSDHKLIKTRLLNGTHIALACLATL AGYRRTDEAMKDPIIFDYVERLMRDEVQPLLPPVPGMNTPDYRDTLLTRLGNPRMSDQLSRLARRGSTKI ASFLLPSLHEAIAQDRPHTLLMLALAGWARYLRGYDLNGRKIRIDDPEADLLTKLANMAGNNPDPLLRHE ILADLRLVPGFSERLGEMVASIDEHGVIATLRQSLQDDSRELVAR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1054 | - | - | 100% (466) | D-mannonate oxidoreductase |
| M. avium 104 | MAV_1052 | - | 9e-91 | 39.52% (458) | mannitol 2-dehydrogenase |
| M. avium 104 | MAV_4838 | - | 1e-86 | 39.74% (463) | mannitol 2-dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_0571 | - | 3e-78 | 36.29% (463) | mannitol dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5576 | - | 7e-94 | 39.91% (456) | D-mannonate oxidoreductase |
| M. thermoresistible (build 8) | TH_0045 | - | 2e-92 | 39.01% (464) | D-mannonate oxidoreductase |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0571|M.marinum_M ----------MKLTAANASALDIPVPNYDRSQISIGIAHFGVGGFHRAHQ
TH_0045|M.thermoresistible__bu ----------MKLNAANLSALSIPTPGYDRGQVRVGIVHFGVGGFHRAHQ
MSMEG_5576|M.smegmatis_MC2_155 MRGVTYTTPPTKLSSSTLEQLTIPHPSYDRAKVQIGIVHFGVGGFHRAHQ
MAV_1054|M.avium_104 ------------------------------------MVHIGAGNFHRAHQ
:.*:*.*.******
MMAR_0571|M.marinum_M AMYLDRLLNAGLARDWGICGIGVLPGDERMRDALRSQDHLYTLILEHPDG
TH_0045|M.thermoresistible__bu AMYLDRLLNDGLAGEWGICGVGVLPNDRRMQEALSRQDHLYTLMLAHPDG
MSMEG_5576|M.smegmatis_MC2_155 AMYVDKLLEMGLASEWGICGVGLLANDRRMAEVMEAQDGLYTLLLEHPDG
MAV_1054|M.avium_104 AVYFDDLACSGISDQWGVSAISLRSHD--VKDLLSAQDGLYTVVQRGHD-
*:*.* * *:: :**:..:.: . * : : : ** ***:: *
MMAR_0571|M.marinum_M TREPRVIGSIVDYRYAPDEPESVIELLADPAIRIISLTITEGGY------
TH_0045|M.thermoresistible__bu TREPRVIGSIVDFRYAPDDPEGVIELLADPAVRIISLTITEGGYNLRDSD
MSMEG_5576|M.smegmatis_MC2_155 HREARVIGSIVDYRYAPDDQEGVIELLAAPTTKIISMTITEGGYYID---
MAV_1054|M.avium_104 HQTARVVGSIGSVHYAPNDGAAVRAALTDPRTRIVSLTITPNGYFLDPVT
: .**:*** . :***:: .* *: * :*:*:*** .**
MMAR_0571|M.marinum_M ----------------TAPRSAAFELVTEALNRRRQRGHGSPAIVSCDNI
TH_0045|M.thermoresistible__bu AGFDIDNPAVQRDLTGDGPPATVFGLVAAGLARRRERGLPSPTIVSCDNI
MSMEG_5576|M.smegmatis_MC2_155 ----------------SAPEINVFGLVTEALVRRRDRGIGSPTIVSCDNI
MAV_1054|M.avium_104 REFDADHPDVRADLVASGCYGTAWGYLTEALEQRRRAGIAPFTVLCCDNI
. .: :: .* :** * . :::.****
MMAR_0571|M.marinum_M VENGKVAERAFTSYADMSNPALAQWMRENTRFPNSMVDRITPVTTPELIE
TH_0045|M.thermoresistible__bu VENGDVARRVFTSYAELADPGLAQWMREHTRFPNSMVDRITPVTTPEVID
MSMEG_5576|M.smegmatis_MC2_155 EGNGDVARKAFTTYAERVHPGLGEWMSANTRFPNSMVDRITPVTTPEVIS
MAV_1054|M.avium_104 PDNTQAARTALVSFAALKNPGLARWIDRHVAFPSTMVDRITPQTSDSERE
* ..*. .:.::* .*.*..*: :. **.:******* *: . .
MMAR_0571|M.marinum_M RLDSEFGVRDAWPVAAEPFAMWVLEDDFSHGRPPLEQAGVELVDDVAPYE
TH_0045|M.thermoresistible__bu TLATDFDVEDSWPVVAEPFCMWVLEDDFADGRPPWERAGVKLVDDVRPYE
MSMEG_5576|M.smegmatis_MC2_155 TVEREFGVADQWPVVAEPFTTWVLEDSFSDGRPPYEEVGVMVVDDVTPYE
MAV_1054|M.avium_104 FVERTFGVADNWPVLTEPHSQWIIEDSFSDGRPPLDEVGVQFVTDVSDHK
: *.* * *** :**. *::**.*:.**** :..** .* ** ::
MMAR_0571|M.marinum_M AMKLRLLNAGHQGLCYFAYLAGYRLVHEAAQDPLIADFLCRYFDEEAAPT
TH_0045|M.thermoresistible__bu AMKLRLLNAGHQSLCYFAYLSGYRLVHEAAQDPLFAEFLSRYMDSEAMPT
MSMEG_5576|M.smegmatis_MC2_155 LMKLRLLNASHQALCYFGYLAGYRLVHDAASDPLFADFLLAYMDSEATPT
MAV_1054|M.avium_104 LIKTRLLNGTHIALACLATLAGYRRTDEAMKDPIIFDYVERLMRDEVQPL
:* ****. * .*. :. *:*** ..:* .**:: ::: : .*. *
MMAR_0571|M.marinum_M LTAIGG--LTEFKNGLLPRFANAYVRDTVARLCAESSDRIPKWLLPVVRD
TH_0045|M.thermoresistible__bu LQPVPG--LHEFKDQLIPRFANAHVRDTIARLCAESSDRIPKWLLPVIRD
MSMEG_5576|M.smegmatis_MC2_155 LQPVPGIDLDEYKHTLIERFANPGVRDTIARLCYGSSDRIPKWLVPVIRE
MAV_1054|M.avium_104 LPPVPGMNTPDYRDTLLTRLGNPRMSDQLSRLARRGSTKIASFLLPSLHE
* .: * :::. *: *:.*. : * ::**. .* :*..:*:* :::
MMAR_0571|M.marinum_M NLRSTGPVRLSAAIVASWARYAEGIDEAGQPIEVVDRLADTLGPIARSQR
TH_0045|M.thermoresistible__bu NLASGGPVRLAAATVASWARYAEGVDEQGEPIDVVDRLADTLIPIARSQR
MSMEG_5576|M.smegmatis_MC2_155 NLKTGAPIRLSAAVVASWARYAEGVDEQGEPINVEDQLADTLVPIALSQR
MAV_1054|M.avium_104 AIAQDRPHTLLMLALAGWARYLRGYDLNGRKIRIDDPEADLLTKLANMAG
: * * :*.**** .* * *. * : * ** * :*
MMAR_0571|M.marinum_M HDARAFLANRAVFGDLIDQPRFVQPYLWALDSLHRVGARATLQALLDKDG
TH_0045|M.thermoresistible__bu DNPPAFIENRAIFGDLVDQPRFVEAYRWALESLHRVGARATLEALLRERS
MSMEG_5576|M.smegmatis_MC2_155 EHPTAFIENTEVFGDLASSQRFVDEYLWALDSLHRHGARATLESLRS---
MAV_1054|M.avium_104 NNPDPLLR-HEILADLRLVPGFSERLGEMVASIDEHGVIATLRQSLQDDS
... .:: ::.** * : : *:.. *. ***.
MMAR_0571|M.marinum_M S-----
TH_0045|M.thermoresistible__bu ------
MSMEG_5576|M.smegmatis_MC2_155 ------
MAV_1054|M.avium_104 RELVAR