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MDVRLTAEQQQMRDAAAKLADDLGPATVQDLDDQGRISRLDKQIEMSGWRSLRSDGASGVEVAIVAEEFG RRLVDTPFLGPVLADDLLRHVGADAAATTVAVDDRAVDARGARRAVSLSGGAVLAVDVQPAPDNVDLTRA DATTVGAPETLGEVGSDVAGQWRALALVTTTADLVGVARGAHALACDYAKIREQYGNPIGSYQAIAHLLA ESLALIEGSISVARHAAWAVDALAPAEAIRAAQIAKVYCARAARTVCETAIQVHGGIGNTWECAAHVYLR RALTSTELWPVALKEIDLGLS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0864 | - | - | 100% (301) | acyl-CoA dehydrogenase domain-containing protein |
| M. avium 104 | MAV_1631 | - | 2e-26 | 32.26% (341) | putative acyl-CoA dehydrogenase |
| M. avium 104 | MAV_1267 | - | 2e-23 | 31.99% (347) | acyl-CoA dehydrogenase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0277c | fadE6 | 4e-22 | 29.45% (343) | acyl-CoA dehydrogenase FADE6 |
| M. gilvum PYR-GCK | Mflv_2393 | - | 4e-96 | 59.80% (301) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv0271c | fadE6 | 5e-22 | 29.45% (343) | acyl-CoA dehydrogenase FADE6 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 6e-08 | 28.57% (147) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4336 | - | 2e-23 | 33.69% (279) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_4792 | - | 1e-122 | 71.43% (301) | acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4875 | - | 1e-103 | 64.47% (304) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_0130 | - | 9e-81 | 61.60% (250) | putative acyl-CoA dehydrogenase |
| M. ulcerans Agy99 | MUL_0361 | - | 1e-108 | 70.70% (273) | acyl-CoA dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4255 | - | 4e-99 | 60.47% (301) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0277c|M.bovis_AF2122/97 ----------MSIAITPEHYELADSVRSLVARVAPSEVLHAALESPVENP
Rv0271c|M.tuberculosis_H37Rv ----------MSIAITPEHYELADSVRSLVARVAPSEVLHAALESPVENP
MAB_4336|M.abscessus_ATCC_1997 ----------MPIAINSEHVALADSAHAFVERVVPTELLHETLETPLPWP
MMAR_4792|M.marinum_M ----------MDVRLTAEQRQLCDSAAKMADDLGPASVQDLADEARIAKL
MUL_0361|M.ulcerans_Agy99 --------------MTRRRKWPTISVRHLCKDL--------ADEARIAKL
MAV_0864|M.avium_104 ----------MDVRLTAEQQQMRDAAAKLADDLGPATVQDLDDQGRISRL
MSMEG_4875|M.smegmatis_MC2_155 ----------MDVRLTAEQQQLREAAAKLADDLGPGSVHELEDRGRIARL
TH_0130|M.thermoresistible__bu --------------------------------------------------
Mflv_2393|M.gilvum_PYR-GCK ----------MDVRLTSEQRQLRDAAAEVAEELGPGSVADLDDSARRARL
Mvan_4255|M.vanbaalenii_PYR-1 ----------MDVRLTSEQQQLRDAAAEVAGDFGPGSVADLDDQARRTRL
MLBr_00737|M.leprae_Br4923 MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRARFP--
Mb0277c|M.bovis_AF2122/97 PPYWQAAAEQGLQGVHLAESVGGQGFGILELAVVLAEFGYGAVPGPFVPS
Rv0271c|M.tuberculosis_H37Rv PPYWQAAAEQGLQGVHLAESVGGQGFGILELAVVLAEFGYGAVPGPFVPS
MAB_4336|M.abscessus_ATCC_1997 PPFWKSAADQGLTSVHLAESVGGQGFGALELAIVVAEFGRGAVPGPFVPS
MMAR_4792|M.marinum_M DRQIEAAGWTALR---------SDGASGVEVAIVAEEFGRGLADAPFLGP
MUL_0361|M.ulcerans_Agy99 DRQIEASGWRALC---------SDGASGVEVAIVAEEFGRGLADAPFLGP
MAV_0864|M.avium_104 DKQIEMSGWRSLR---------SDGASGVEVAIVAEEFGRRLVDTPFLGP
MSMEG_4875|M.smegmatis_MC2_155 ENTVAATEWRTLR---------SDGASGVEVAIVAEEFARGLVDVPFLGP
TH_0130|M.thermoresistible__bu ----------VLR---------SDGASGVEVAIVAEEFARGLVDVPFIGP
Mflv_2393|M.gilvum_PYR-GCK EKAVDATGFRTLR---------SDGASAVEVAIVAEEFGRGLVDVPYLGP
Mvan_4255|M.vanbaalenii_PYR-1 EKAVDATGFRTLR---------SDGASAVEVAIVAEEFGRGLVDVPFLGP
MLBr_00737|M.leprae_Br4923 EEALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASASLIPA
: .:* . : .:* *.. . . : .
Mb0277c|M.bovis_AF2122/97 A---------------IASALIAAHDPQAKVLAELATGAAIAAYALDSGL
Rv0271c|M.tuberculosis_H37Rv A---------------IASALIAAHDPQAKVLAELATGAAIAAYALDSGL
MAB_4336|M.abscessus_ATCC_1997 V---------------IASALISAHDPDHPLLSDLASGASIATFSSTSSF
MMAR_4792|M.marinum_M V---------------LADDLARQLNSDSGRVTTGVGGRAIDARGHRRAL
MUL_0361|M.ulcerans_Agy99 V---------------LADDLARQLNSDSGRATTGVGGRAIDARGHRRAL
MAV_0864|M.avium_104 V---------------LADDLLRHVGADAAATTVAVDDRAVDARGARRAV
MSMEG_4875|M.smegmatis_MC2_155 I---------------LADDLAQRLGRAV---------------------
TH_0130|M.thermoresistible__bu V---------------LNDEVRRIVGREP---------------------
Mflv_2393|M.gilvum_PYR-GCK V---------------LVDDLHRRVGRD----------------------
Mvan_4255|M.vanbaalenii_PYR-1 V---------------LADDLQRRLGRD----------------------
MLBr_00737|M.leprae_Br4923 VNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMRT
: . :
Mb0277c|M.bovis_AF2122/97 TATRHGDVLVIR--------------GEVRAVPAAAQASVLVLPVAIESR
Rv0271c|M.tuberculosis_H37Rv TATRHGDVLVIR--------------GEVRAVPAAAQASVLVLPVAIESR
MAB_4336|M.abscessus_ATCC_1997 TATPAGDGLSVD--------------GQARSVLSATSATYVVAPVAIDSD
MMAR_4792|M.marinum_M VLSGT----------------------------AVLSADLDVAGAGADLT
MUL_0361|M.ulcerans_Agy99 VLSGT----------------------------AVLSADLDVAGAGADLT
MAV_0864|M.avium_104 SLSGG----------------------------AVLAVDVQPAPDNVDLT
MSMEG_4875|M.smegmatis_MC2_155 ---------------------------------AVPDAAAGTAG--VDLT
TH_0130|M.thermoresistible__bu ---------------------------------AAPVAGPESIGVDVDLT
Mflv_2393|M.gilvum_PYR-GCK -----------------------------------PVAG--ADPQTVDLT
Mvan_4255|M.vanbaalenii_PYR-1 -----------------------------------VGAAPNTAPESVDLT
MLBr_00737|M.leprae_Br4923 RAKADGDDWILNGFKCWITNGGKSTWYTVMAVTDPDKGANGISAFIVHKD
.
Mb0277c|M.bovis_AF2122/97 DEWVVLRNDQLEIEAVKSLDPLRPIAHVRANAVDVSDDALLSNLTMTTAH
Rv0271c|M.tuberculosis_H37Rv DEWVVLRNDQLEIEAVKSLDPLRPIAHVRANAVDVSDDALLSNLTMTTAH
MAB_4336|M.abscessus_ATCC_1997 RRWVVLSADDVTLDSQQSVDPLRPVAHVTATAVQVPADRVLSNLTDARAT
MMAR_4792|M.marinum_M RLDAGLLGQPVAIGEVSADAAQR-------------------------WY
MUL_0361|M.ulcerans_Agy99 RLDAGLLGQPVAVGEVSADAAQR-------------------------WD
MAV_0864|M.avium_104 RADATTVGAPETLGEVGSDVAGQ-------------------------WR
MSMEG_4875|M.smegmatis_MC2_155 NSAAGVLQSPAELSELRAGDAAR-------------------------WH
TH_0130|M.thermoresistible__bu GSKAGVIEAPAELAEAAAEDRQR-------------------------WY
Mflv_2393|M.gilvum_PYR-GCK NSLAGVVESPSELSDLSDEDAGR-------------------------WY
Mvan_4255|M.vanbaalenii_PYR-1 GSLAGVVESPPELADLSDDESGR-------------------------WY
MLBr_00737|M.leprae_Br4923 DEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTGFKTALATL
:
Mb0277c|M.bovis_AF2122/97 ALMSTLLSAEAVGVARWATDTASAYAKIREQFGRPIGQFQAIKHKCAEMI
Rv0271c|M.tuberculosis_H37Rv ALMSTLLSAEAVGVARWATDTASAYAKIREQFGRPIGQFQAIKHKCAEMI
MAB_4336|M.abscessus_ATCC_1997 SIISTIVSAEAVGVARWATDTASEYAKVREQFGRPIGQFQGIKHKCATMA
MMAR_4792|M.marinum_M ALALVATSADLVGDARGAHALACDYAKIREQYGKAIGSHQAIAHLLAENL
MUL_0361|M.ulcerans_Agy99 ALALVATTADLVGDARGAHTLACDYAKIREQYGKAIGSHQAIAHLLAENL
MAV_0864|M.avium_104 ALALVTTTADLVGVARGAHALACDYAKIREQYGNPIGSYQAIAHLLAESL
MSMEG_4875|M.smegmatis_MC2_155 ALALAATSADLVGAARGAHALAVDYAKVREQYGSTIGSYQAVAHLLAEGL
TH_0130|M.thermoresistible__bu ALALAVTSADILGAARGAHALAVDYAKVREQYGAPIGSYQAVAHMLAEGL
Mflv_2393|M.gilvum_PYR-GCK ALALAATAADMVGAARGTQRLATEYAKVREQYGSAIGSYQAVAHLLAESE
Mvan_4255|M.vanbaalenii_PYR-1 ALALAATTADIIGAARGTHALATEYAKVREQYGSAIGSYQAVAHMLAESL
MLBr_00737|M.leprae_Br4923 DHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFMLADMA
*: :* *: : * *:* *:*:* .*. .*.: . *
Mb0277c|M.bovis_AF2122/97 ADTERATAAVWDAARALDDAGESSSDVEFAAAVAATLAPATAQRCTQDCI
Rv0271c|M.tuberculosis_H37Rv ADTERATAAVWDAARALDDAGESSSDVEFAAAVAATLAPATAQRCTQDCI
MAB_4336|M.abscessus_ATCC_1997 AVTERATAAVWDAARALDDADENPGVVEFAASVAATLAPAAAQQCAQDCI
MMAR_4792|M.marinum_M ALIEGSVSVLRHAAWAVDELE--PAQAVQAARMAKVYCARASRTVCETAV
MUL_0361|M.ulcerans_Agy99 ALIEGSVSVLRHAAWAVDELE--PAQAVQAARMAKVYCARASRTVCETAV
MAV_0864|M.avium_104 ALIEGSISVARHAAWAVDALA--PAEAIRAAQIAKVYCARAARTVCETAI
MSMEG_4875|M.smegmatis_MC2_155 ALIEGSISVLRHAAWGVDELE--PDEAVRAGRIAKVYCARAARTVCETAI
TH_0130|M.thermoresistible__bu ALIEGSISVLRHAAWAVDELP--ADEAVRAGRYAKIYCARAARTVCETAI
Mflv_2393|M.gilvum_PYR-GCK ALIEGSISVSRHAAWAVDELP--AREAIEAARVAKIYCARAAMTVCETSI
Mvan_4255|M.vanbaalenii_PYR-1 ALIEGSISVARHAAWAVDELP--VREAVEAARIAKIYSARAAMTVCETSI
MLBr_00737|M.leprae_Br4923 MKVEAARLIVYAAAARAERGE---PDLGFISAASKCFASDIAMEVTTDAV
* : ** : . : .. : .:
Mb0277c|M.bovis_AF2122/97 QVHGGIGFTWEHDTNVYYRRALMLAACFGRGSEYPQRVVDTATTAGMRPV
Rv0271c|M.tuberculosis_H37Rv QVHGGIGFTWEHDTNVYYRRALMLAACFGRGSEYPQRVVDTATTAGMRPV
MAB_4336|M.abscessus_ATCC_1997 QVHGGIGYTWEHDAHIYYRRALGLTAALGRSGGAPATVVRTAVEHGLRKV
MMAR_4792|M.marinum_M QVHGGIGNTWDCLVHVYLRRALTSTELWP---------------------
MUL_0361|M.ulcerans_Agy99 QVHGGIGNTWDCLVHVYLRRALTSTELWP---------------------
MAV_0864|M.avium_104 QVHGGIGNTWECAAHVYLRRALTSTELWP---------------------
MSMEG_4875|M.smegmatis_MC2_155 QVHGGIGNTWECLAHVYLRRALTSTELWP---------------------
TH_0130|M.thermoresistible__bu QVHGGIGNTWECLAHVFLRRVLTSTDLWP---------------------
Mflv_2393|M.gilvum_PYR-GCK QVHGGIGNTWECLAHIYLRRVLAATEAWP---------------------
Mvan_4255|M.vanbaalenii_PYR-1 QVHGGIGNTWECLAHIYLRRVLAATETWP---------------------
MLBr_00737|M.leprae_Br4923 QLFGGAGYTSDFPVERFMRDAKITQIYEG---------------------
*:.** * * : .. : * .
Mb0277c|M.bovis_AF2122/97 DIDLDPSTEKLRAQIRAEVAALKAMPREPRTVAIAEGGWVLPYLPKPWGR
Rv0271c|M.tuberculosis_H37Rv DIDLDPSTEKLRAQIRAEVAALKAMPREPRTVAIAEGGWVLPYLPKPWGR
MAB_4336|M.abscessus_ATCC_1997 DIDLAPETEALRAEIRAEVAALKEIPSGKRNTAIAEGGWVLPYLPTPWGR
MMAR_4792|M.marinum_M -------------------VSLQEVG---RGLS-----------------
MUL_0361|M.ulcerans_Agy99 -------------------VSLQEVG---RGLS-----------------
MAV_0864|M.avium_104 -------------------VALKEID---LGLS-----------------
MSMEG_4875|M.smegmatis_MC2_155 -------------------VGLEDLEVSDLGFS-----------------
TH_0130|M.thermoresistible__bu -------------------VKLEDID---LGFS-----------------
Mflv_2393|M.gilvum_PYR-GCK -------------------VTLEELT---IGLS-----------------
Mvan_4255|M.vanbaalenii_PYR-1 -------------------AKLEELT---IGLS-----------------
MLBr_00737|M.leprae_Br4923 ------------------TNQIQRVVMSRALLR-----------------
:: :
Mb0277c|M.bovis_AF2122/97 AASPVEQIIIAQEFTAGRVKRPQIAIATWIVPSIVAFGTDNQKQRLLPPT
Rv0271c|M.tuberculosis_H37Rv AASPVEQIIIAQEFTAGRVKRPQIAIATWIVPSIVAFGTDNQKQRLLPPT
MAB_4336|M.abscessus_ATCC_1997 AASPVEQVIISQEFLTGKVRRPQLGIATWLVPSIVAYGTEEQKQRFLPPT
MMAR_4792|M.marinum_M --------------------------------------------------
MUL_0361|M.ulcerans_Agy99 --------------------------------------------------
MAV_0864|M.avium_104 --------------------------------------------------
MSMEG_4875|M.smegmatis_MC2_155 --------------------------------------------------
TH_0130|M.thermoresistible__bu --------------------------------------------------
Mflv_2393|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4255|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb0277c|M.bovis_AF2122/97 FRGDIFWCQLFSEPGAGSDLASLATKATRVDGGWRITGQKIWTTGAQYSQ
Rv0271c|M.tuberculosis_H37Rv FRGDIFWCQLFSEPGAGSDLASLATKATRVDGGWRITGQKIWTTGAQYSQ
MAB_4336|M.abscessus_ATCC_1997 FRGEMMWCQLFSEPGAGSDLAGLSTKAVKVEGGWRLTGQKIWTSVAQFAD
MMAR_4792|M.marinum_M --------------------------------------------------
MUL_0361|M.ulcerans_Agy99 --------------------------------------------------
MAV_0864|M.avium_104 --------------------------------------------------
MSMEG_4875|M.smegmatis_MC2_155 --------------------------------------------------
TH_0130|M.thermoresistible__bu --------------------------------------------------
Mflv_2393|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4255|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb0277c|M.bovis_AF2122/97 WGALLARTDPSAPKHNGITYFLLDMKSEGVQVKPLRELTGKEFFNTVYLD
Rv0271c|M.tuberculosis_H37Rv WGALLARTDPSAPKHNGITYFLLDMKSEGVQVKPLRELTGKEFFNTVYLD
MAB_4336|M.abscessus_ATCC_1997 WGACLARTDPSAPKHNGITYFLVDMKSEGVTVRPLREMTGGALFNEVFID
MMAR_4792|M.marinum_M --------------------------------------------------
MUL_0361|M.ulcerans_Agy99 --------------------------------------------------
MAV_0864|M.avium_104 --------------------------------------------------
MSMEG_4875|M.smegmatis_MC2_155 --------------------------------------------------
TH_0130|M.thermoresistible__bu --------------------------------------------------
Mflv_2393|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4255|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb0277c|M.bovis_AF2122/97 DVFVPDELVLGEVNRGWEVSRNTLTAERVSIGGSDSTFLPTLGEFVDFVR
Rv0271c|M.tuberculosis_H37Rv DVFVPDELVLGEVNRGWEVSRNTLTAERVSIGGSDSTFLPTLGEFVDFVR
MAB_4336|M.abscessus_ATCC_1997 DVFVPDELVVGEVNRGWEVSRNTLTAERVSIGSSDLPFLASLDDLVAFVG
MMAR_4792|M.marinum_M --------------------------------------------------
MUL_0361|M.ulcerans_Agy99 --------------------------------------------------
MAV_0864|M.avium_104 --------------------------------------------------
MSMEG_4875|M.smegmatis_MC2_155 --------------------------------------------------
TH_0130|M.thermoresistible__bu --------------------------------------------------
Mflv_2393|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4255|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb0277c|M.bovis_AF2122/97 DYRFEGQFDQVARHRAGQLIAEGHATKLLNLRSTLLTLAGGDPMAPAAIS
Rv0271c|M.tuberculosis_H37Rv DYRFEGQFDQVARHRAGQLIAEGHATKLLNLRSTLLTLAGGDPMAPAAIS
MAB_4336|M.abscessus_ATCC_1997 THDLG----EVARDRAGQLIAEGHGVKLLNLRSTLLTLAGGDPMPSAAVS
MMAR_4792|M.marinum_M --------------------------------------------------
MUL_0361|M.ulcerans_Agy99 --------------------------------------------------
MAV_0864|M.avium_104 --------------------------------------------------
MSMEG_4875|M.smegmatis_MC2_155 --------------------------------------------------
TH_0130|M.thermoresistible__bu --------------------------------------------------
Mflv_2393|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4255|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb0277c|M.bovis_AF2122/97 KLLSMRTGQGYAEFAVSSFGTDAVIGDTERLPGKWGEYLLASRATTIYGG
Rv0271c|M.tuberculosis_H37Rv KLLSMRTGQGYAEFAVSSFGTDAVIGDTERLPGKWGEYLLASRATTIYGG
MAB_4336|M.abscessus_ATCC_1997 KLLGMRTGQGYAEFVVNHFGQDGAIGDSEQEQGRWADYLLASRATTIYGG
MMAR_4792|M.marinum_M --------------------------------------------------
MUL_0361|M.ulcerans_Agy99 --------------------------------------------------
MAV_0864|M.avium_104 --------------------------------------------------
MSMEG_4875|M.smegmatis_MC2_155 --------------------------------------------------
TH_0130|M.thermoresistible__bu --------------------------------------------------
Mflv_2393|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4255|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb0277c|M.bovis_AF2122/97 TSEVQLNIIAERLLGLPRDP
Rv0271c|M.tuberculosis_H37Rv TSEVQLNIIAERLLGLPRDP
MAB_4336|M.abscessus_ATCC_1997 TSEVQLNIIAERLLGLPRDP
MMAR_4792|M.marinum_M --------------------
MUL_0361|M.ulcerans_Agy99 --------------------
MAV_0864|M.avium_104 --------------------
MSMEG_4875|M.smegmatis_MC2_155 --------------------
TH_0130|M.thermoresistible__bu --------------------
Mflv_2393|M.gilvum_PYR-GCK --------------------
Mvan_4255|M.vanbaalenii_PYR-1 --------------------
MLBr_00737|M.leprae_Br4923 --------------------