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DVRLTSEQQQLRDAAAEVAGDFGPGSVADLDDQARRTRLEKAVDATGFRTLRSDGASAVEVAIVAEEFGR GLVDVPFLGPVLADDLQRRLGRDVGAAPNTAPESVDLTGSLAGVVESPPELADLSDDESGRWYALALAAT TADIIGAARGTHALATEYAKVREQYGSAIGSYQAVAHMLAESLALIEGSISVARHAAWAVDELPVREAVE AARIAKIYSARAAMTVCETSIQVHGGIGNTWECLAHIYLRRVLAATETWPAKLEELTIGLS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4255 | - | - | 100% (272) | acyl-CoA dehydrogenase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_5311 | - | 1e-19 | 39.31% (173) | acyl-CoA dehydrogenase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_0393 | - | 1e-19 | 36.31% (179) | acyl-CoA dehydrogenase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3604c | fadE34 | 2e-17 | 30.90% (288) | acyl-CoA dehydrogenase FADE34 |
| M. gilvum PYR-GCK | Mflv_2393 | - | 1e-128 | 84.93% (272) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv3573c | fadE34 | 2e-17 | 30.90% (288) | acyl-CoA dehydrogenase FADE34 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 6e-07 | 30.00% (110) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4336 | - | 3e-19 | 34.78% (184) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_4792 | - | 1e-93 | 57.48% (301) | acyl-CoA dehydrogenase |
| M. avium 104 | MAV_0864 | - | 3e-99 | 60.47% (301) | acyl-CoA dehydrogenase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_4875 | - | 1e-105 | 71.32% (272) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_0130 | - | 2e-89 | 72.89% (225) | putative acyl-CoA dehydrogenase |
| M. ulcerans Agy99 | MUL_0361 | - | 2e-82 | 56.62% (272) | acyl-CoA dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3604c|M.bovis_AF2122/97 ----------MVATVTDEQSAARELVRGWARTAASGAAATAAVRDMEYGF
Rv3573c|M.tuberculosis_H37Rv ----------MVATVTDEQSAARELVRGWARTAASGAAATAAVRDMEYGF
MAB_4336|M.abscessus_ATCC_1997 ----------MPIAINSEHVALADSAHAFVERVVP--------TELLHET
Mvan_4255|M.vanbaalenii_PYR-1 ----------MDVRLTSEQQQLRDAAAEVAGDFGPGSVADLDDQARRTRL
Mflv_2393|M.gilvum_PYR-GCK ----------MDVRLTSEQRQLRDAAAEVAEELGPGSVADLDDSARRARL
MSMEG_4875|M.smegmatis_MC2_155 ----------MDVRLTAEQQQLREAAAKLADDLGPGSVHELEDRGRIARL
TH_0130|M.thermoresistible__bu --------------------------------------------------
MMAR_4792|M.marinum_M ----------MDVRLTAEQRQLCDSAAKMADDLGPASVQDLADEARIAKL
MUL_0361|M.ulcerans_Agy99 --------------MTRRRKWPTISVRHLCKDL--------ADEARIAKL
MAV_0864|M.avium_104 ----------MDVRLTAEQQQMRDAAAKLADDLGPATVQDLDDQGRISRL
MLBr_00737|M.leprae_Br4923 MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRARFPEE
Mb3604c|M.bovis_AF2122/97 EEGNADAWRPVFAGLAGLGLFGVAVPEDCGGAGGSIEDLCAMVDEAARAL
Rv3573c|M.tuberculosis_H37Rv EEGNADAWRPVFAGLAGLGLFGVAVPEDCGGAGGSIEDLCAMVDEAARAL
MAB_4336|M.abscessus_ATCC_1997 LETPLPWPPPFWKSAADQGLTSVHLAESVGGQGFGALELAIVVAEFGRGA
Mvan_4255|M.vanbaalenii_PYR-1 EK-----------------AVDATGFRTLRSDGASAVEVAIVAEEFGRGL
Mflv_2393|M.gilvum_PYR-GCK EK-----------------AVDATGFRTLRSDGASAVEVAIVAEEFGRGL
MSMEG_4875|M.smegmatis_MC2_155 EN-----------------TVAATEWRTLRSDGASGVEVAIVAEEFARGL
TH_0130|M.thermoresistible__bu ---------------------------VLRSDGASGVEVAIVAEEFARGL
MMAR_4792|M.marinum_M DR-----------------QIEAAGWTALRSDGASGVEVAIVAEEFGRGL
MUL_0361|M.ulcerans_Agy99 DR-----------------QIEASGWRALCSDGASGVEVAIVAEEFGRGL
MAV_0864|M.avium_104 DK-----------------QIEMSGWRSLRSDGASGVEVAIVAEEFGRRL
MLBr_00737|M.leprae_Br4923 ALAALN----------ASGFNAIHVPEEYGGQGADSVAACIVIEEVARVD
. * . . : * .*
Mb3604c|M.bovis_AF2122/97 VPGPVATTA----VATLVVS----DPKLRSALASGERFAGVAIDGGVQVD
Rv3573c|M.tuberculosis_H37Rv VPGPVATTA----VATLVVS----DPKLRSALASGERFAGVAIDGGVQVD
MAB_4336|M.abscessus_ATCC_1997 VPGPFVPSV----IASALISAHDPDHPLLSDLASGASIATFSSTSSFTAT
Mvan_4255|M.vanbaalenii_PYR-1 VDVPFLGPV----LADDLQR------------------------------
Mflv_2393|M.gilvum_PYR-GCK VDVPYLGPV----LVDDLHR------------------------------
MSMEG_4875|M.smegmatis_MC2_155 VDVPFLGPI----LADDLAQ------------------------------
TH_0130|M.thermoresistible__bu VDVPFIGPV----LNDEVRR------------------------------
MMAR_4792|M.marinum_M ADAPFLGPV----LADDLAR------------------------------
MUL_0361|M.ulcerans_Agy99 ADAPFLGPV----LADDLAR------------------------------
MAV_0864|M.avium_104 VDTPFLGPV----LADDLLR------------------------------
MLBr_00737|M.leprae_Br4923 ASASLIPAVNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAG
. . . :
Mb3604c|M.bovis_AF2122/97 PKTS--TASGTVGRVLGGAPGGVVLLP--ADGNWLLVDTACDEVVVEPLR
Rv3573c|M.tuberculosis_H37Rv PKTS--TASGTVGRVLGGAPGGVVLLP--ADGNWLLVDTACDEVVVEPLR
MAB_4336|M.abscessus_ATCC_1997 PAGDGLSVDGQARSVLSATSATYVVAPVAIDSDRRWVVLSADDVTLDSQQ
Mvan_4255|M.vanbaalenii_PYR-1 ------RLGRD-----------------------------VGAAPNTAPE
Mflv_2393|M.gilvum_PYR-GCK ------RVGRD-----------------------------PVAG--ADPQ
MSMEG_4875|M.smegmatis_MC2_155 ------RLGRAV--------------------------AVPDAAAGTAG-
TH_0130|M.thermoresistible__bu ------IVGREP--------------------------AAPVAGPESIGV
MMAR_4792|M.marinum_M ------QLNSDSGRVTTGVGGRAIDARGHRRALVLSGTAVLSADLDVAGA
MUL_0361|M.ulcerans_Agy99 ------QLNSDSGRATTGVGGRAIDARGHRRALVLSGTAVLSADLDVAGA
MAV_0864|M.avium_104 ------HVGADAAATTVAVDDRAVDARGARRAVSLSGGAVLAVDVQPAPD
MLBr_00737|M.leprae_Br4923 SDAASMRTRAKADGDDWILNGFKCWITNGGKSTWYTVMAVTDPDKGANGI
Mb3604c|M.bovis_AF2122/97 ATDFSL--------------------PLARMVLTSAPVTVLEVSG----E
Rv3573c|M.tuberculosis_H37Rv ATDFSL--------------------PLARMVLTSAPVTVLEVSG----E
MAB_4336|M.abscessus_ATCC_1997 SVDPLR--------------------PVAHVTATAVQVPADRVLSNLTDA
Mvan_4255|M.vanbaalenii_PYR-1 SVDLTG--------------------SLAGVVESPPELADLSDDES---G
Mflv_2393|M.gilvum_PYR-GCK TVDLTN--------------------SLAGVVESPSELSDLSDEDA---G
MSMEG_4875|M.smegmatis_MC2_155 -VDLTN--------------------SAAGVLQSPAELSELRAGDA---A
TH_0130|M.thermoresistible__bu DVDLTG--------------------SKAGVIEAPAELAEAAAEDR---Q
MMAR_4792|M.marinum_M GADLTR--------------------LDAGLLGQPVAIGEVSADAA---Q
MUL_0361|M.ulcerans_Agy99 GADLTR--------------------LDAGLLGQPVAVGEVSADAA---Q
MAV_0864|M.avium_104 NVDLTR--------------------ADATTVGAPETLGEVGSDVA---G
MLBr_00737|M.leprae_Br4923 SAFIVHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTG
. : :
Mb3604c|M.bovis_AF2122/97 RVEDLAATVLA-----AEAAGVARWTLDTAVAYAKVREQFGKPIGSFQAV
Rv3573c|M.tuberculosis_H37Rv RVEDLAATVLA-----AEAAGVARWTLDTAVAYAKVREQFGKPIGSFQAV
MAB_4336|M.abscessus_ATCC_1997 RATSIISTIVS-----AEAVGVARWATDTASEYAKVREQFGRPIGQFQGI
Mvan_4255|M.vanbaalenii_PYR-1 RWYALALAATT-----ADIIGAARGTHALATEYAKVREQYGSAIGSYQAV
Mflv_2393|M.gilvum_PYR-GCK RWYALALAATA-----ADMVGAARGTQRLATEYAKVREQYGSAIGSYQAV
MSMEG_4875|M.smegmatis_MC2_155 RWHALALAATS-----ADLVGAARGAHALAVDYAKVREQYGSTIGSYQAV
TH_0130|M.thermoresistible__bu RWYALALAVTS-----ADILGAARGAHALAVDYAKVREQYGAPIGSYQAV
MMAR_4792|M.marinum_M RWYALALVATS-----ADLVGDARGAHALACDYAKIREQYGKAIGSHQAI
MUL_0361|M.ulcerans_Agy99 RWDALALVATT-----ADLVGDARGAHTLACDYAKIREQYGKAIGSHQAI
MAV_0864|M.avium_104 QWRALALVTTT-----ADLVGVARGAHALACDYAKIREQYGNPIGSYQAI
MLBr_00737|M.leprae_Br4923 FKTALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSI
: : *: * *: : * *:* *:*:* .*. .*.:
Mb3604c|M.bovis_AF2122/97 KHLCAQMLCRAEQADVAAADAARAAADSDGT--QLSIAAAVAASIGIDAA
Rv3573c|M.tuberculosis_H37Rv KHLCAQMLCRAEQADVAAADAARAAADSDGT--QLSIAAAVAASIGIDAA
MAB_4336|M.abscessus_ATCC_1997 KHKCATMAAVTERATAAVWDAARALDDADENPGVVEFAASVAATLAPAAA
Mvan_4255|M.vanbaalenii_PYR-1 AHMLAESLALIEGSISVARHAAWAVDELPVR--EAVEAARIAKIYSARAA
Mflv_2393|M.gilvum_PYR-GCK AHLLAESEALIEGSISVSRHAAWAVDELPAR--EAIEAARVAKIYCARAA
MSMEG_4875|M.smegmatis_MC2_155 AHLLAEGLALIEGSISVLRHAAWGVDELEPD--EAVRAGRIAKVYCARAA
TH_0130|M.thermoresistible__bu AHMLAEGLALIEGSISVLRHAAWAVDELPAD--EAVRAGRYAKIYCARAA
MMAR_4792|M.marinum_M AHLLAENLALIEGSVSVLRHAAWAVDELEPA--QAVQAARMAKVYCARAS
MUL_0361|M.ulcerans_Agy99 AHLLAENLALIEGSVSVLRHAAWAVDELEPA--QAVQAARMAKVYCARAS
MAV_0864|M.avium_104 AHLLAESLALIEGSISVARHAAWAVDALAPA--EAIRAAQIAKVYCARAA
MLBr_00737|M.leprae_Br4923 QFMLADMAMKVEAARLIVYAAAARAERGEPD---LGFISAASKCFASDIA
. * * : ** . : :
Mb3604c|M.bovis_AF2122/97 KANAKDCIQVLGGIGCTWEHDAHLYLRRAHGIGGFLGGSGRWLRRVTALT
Rv3573c|M.tuberculosis_H37Rv KANAKDCIQVLGGIGCTWEHDAHLYLRRAHGIGGFLGGSGRWLRRVTALT
MAB_4336|M.abscessus_ATCC_1997 QQCAQDCIQVHGGIGYTWEHDAHIYYRRALGLTAALGRSGGAPATVVRTA
Mvan_4255|M.vanbaalenii_PYR-1 MTVCETSIQVHGGIGNTWECLAHIYLRRVL--------------------
Mflv_2393|M.gilvum_PYR-GCK MTVCETSIQVHGGIGNTWECLAHIYLRRVL--------------------
MSMEG_4875|M.smegmatis_MC2_155 RTVCETAIQVHGGIGNTWECLAHVYLRRAL--------------------
TH_0130|M.thermoresistible__bu RTVCETAIQVHGGIGNTWECLAHVFLRRVL--------------------
MMAR_4792|M.marinum_M RTVCETAVQVHGGIGNTWDCLVHVYLRRAL--------------------
MUL_0361|M.ulcerans_Agy99 RTVCETAVQVHGGIGNTWDCLVHVYLRRAL--------------------
MAV_0864|M.avium_104 RTVCETAIQVHGGIGNTWECAAHVYLRRAL--------------------
MLBr_00737|M.leprae_Br4923 MEVTTDAVQLFGGAGYTSDFPVERFMRDAK--------------------
.:*: ** * * : .. : * .
Mb3604c|M.bovis_AF2122/97 QAGVRRRLGVDLA-EVAGLRPEIAAAVAEVAALPEEKRQVALADTGLLAP
Rv3573c|M.tuberculosis_H37Rv QAGVRRRLGVDLA-EVAGLRPEIAAAVAEVAALPEEKRQVALADTGLLAP
MAB_4336|M.abscessus_ATCC_1997 VEHGLRKVDIDLAPETEALRAEIRAEVAALKEIPSGKRNTAIAEGGWVLP
Mvan_4255|M.vanbaalenii_PYR-1 ---------------------------AATETWPAKLEELT---IGLS--
Mflv_2393|M.gilvum_PYR-GCK ---------------------------AATEAWPVTLEELT---IGLS--
MSMEG_4875|M.smegmatis_MC2_155 ---------------------------TSTELWPVGLEDLEVSDLGFS--
TH_0130|M.thermoresistible__bu ---------------------------TSTDLWPVKLEDID---LGFS--
MMAR_4792|M.marinum_M ---------------------------TSTELWPVSLQEVG---RGLS--
MUL_0361|M.ulcerans_Agy99 ---------------------------TSTELWPVSLQEVG---RGLS--
MAV_0864|M.avium_104 ---------------------------TSTELWPVALKEID---LGLS--
MLBr_00737|M.leprae_Br4923 --------------------------ITQIYEGTNQIQRVVMSRALLR--
: . .
Mb3604c|M.bovis_AF2122/97 HWPAPYGRGASPAEQLLIDQELAAAKVERPDLVIGWWAAPTILEHGTPEQ
Rv3573c|M.tuberculosis_H37Rv HWPAPYGRGASPAEQLLIDQELAAAKVERPDLVIGWWAAPTILEHGTPEQ
MAB_4336|M.abscessus_ATCC_1997 YLPTPWGRAASPVEQVIISQEFLTGKVRRPQLGIATWLVPSIVAYGTEEQ
Mvan_4255|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2393|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4875|M.smegmatis_MC2_155 --------------------------------------------------
TH_0130|M.thermoresistible__bu --------------------------------------------------
MMAR_4792|M.marinum_M --------------------------------------------------
MUL_0361|M.ulcerans_Agy99 --------------------------------------------------
MAV_0864|M.avium_104 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3604c|M.bovis_AF2122/97 IERFVPATMRGEFLWCQLFSEPGAGSDLASLRTKAVRADGGWLLTGQKVW
Rv3573c|M.tuberculosis_H37Rv IERFVPATMRGEFLWCQLFSEPGAGSDLASLRTKAVRADGGWLLTGQKVW
MAB_4336|M.abscessus_ATCC_1997 KQRFLPPTFRGEMMWCQLFSEPGAGSDLAGLSTKAVKVEGGWRLTGQKIW
Mvan_4255|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2393|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4875|M.smegmatis_MC2_155 --------------------------------------------------
TH_0130|M.thermoresistible__bu --------------------------------------------------
MMAR_4792|M.marinum_M --------------------------------------------------
MUL_0361|M.ulcerans_Agy99 --------------------------------------------------
MAV_0864|M.avium_104 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3604c|M.bovis_AF2122/97 TSAAHKARWGVCLARTDPDAPKHKGITYFLVDMTTPGIEIRPLREITGDS
Rv3573c|M.tuberculosis_H37Rv TSAAHKARWGVCLARTDPDAPKHKGITYFLVDMTTPGIEIRPLREITGDS
MAB_4336|M.abscessus_ATCC_1997 TSVAQFADWGACLARTDPSAPKHNGITYFLVDMKSEGVTVRPLREMTGGA
Mvan_4255|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2393|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4875|M.smegmatis_MC2_155 --------------------------------------------------
TH_0130|M.thermoresistible__bu --------------------------------------------------
MMAR_4792|M.marinum_M --------------------------------------------------
MUL_0361|M.ulcerans_Agy99 --------------------------------------------------
MAV_0864|M.avium_104 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3604c|M.bovis_AF2122/97 LFNEVFLDNVFVPDEMVVGAVNDGWRLARTTLANERVAMATG-TALGNPM
Rv3573c|M.tuberculosis_H37Rv LFNEVFLDNVFVPDEMVVGAVNDGWRLARTTLANERVAMATG-TALGNPM
MAB_4336|M.abscessus_ATCC_1997 LFNEVFIDDVFVPDELVVGEVNRGWEVSRNTLTAERVSIGSSDLPFLASL
Mvan_4255|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2393|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4875|M.smegmatis_MC2_155 --------------------------------------------------
TH_0130|M.thermoresistible__bu --------------------------------------------------
MMAR_4792|M.marinum_M --------------------------------------------------
MUL_0361|M.ulcerans_Agy99 --------------------------------------------------
MAV_0864|M.avium_104 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3604c|M.bovis_AF2122/97 EELLKVLGDMELDVAQQDRLGRLILLAQAGALLDRRIAELAVGGQDPGAQ
Rv3573c|M.tuberculosis_H37Rv EELLKVLGDMELDVAQQDRLGRLILLAQAGALLDRRIAELAVGGQDPGAQ
MAB_4336|M.abscessus_ATCC_1997 DDLVAFVGTHDLGEVARDRAGQLIAEGHGVKLLNLRSTLLTLAGGDPMPS
Mvan_4255|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2393|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4875|M.smegmatis_MC2_155 --------------------------------------------------
TH_0130|M.thermoresistible__bu --------------------------------------------------
MMAR_4792|M.marinum_M --------------------------------------------------
MUL_0361|M.ulcerans_Agy99 --------------------------------------------------
MAV_0864|M.avium_104 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3604c|M.bovis_AF2122/97 SSVRKLIGVRYRQALAEYLMEVSDGGGLVEN------RAVYDFLNTRCLT
Rv3573c|M.tuberculosis_H37Rv SSVRKLIGVRYRQALAEYLMEVSDGGGLVEN------RAVYDFLNTRCLT
MAB_4336|M.abscessus_ATCC_1997 AAVSKLLGMRTGQGYAEFVVNHFGQDGAIGDSEQEQGRWADYLLASRATT
Mvan_4255|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2393|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4875|M.smegmatis_MC2_155 --------------------------------------------------
TH_0130|M.thermoresistible__bu --------------------------------------------------
MMAR_4792|M.marinum_M --------------------------------------------------
MUL_0361|M.ulcerans_Agy99 --------------------------------------------------
MAV_0864|M.avium_104 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3604c|M.bovis_AF2122/97 IAGGTEQILLTVAAERLLGLPR--
Rv3573c|M.tuberculosis_H37Rv IAGGTEQILLTVAAERLLGLPR--
MAB_4336|M.abscessus_ATCC_1997 IYGGTSEVQLNIIAERLLGLPRDP
Mvan_4255|M.vanbaalenii_PYR-1 ------------------------
Mflv_2393|M.gilvum_PYR-GCK ------------------------
MSMEG_4875|M.smegmatis_MC2_155 ------------------------
TH_0130|M.thermoresistible__bu ------------------------
MMAR_4792|M.marinum_M ------------------------
MUL_0361|M.ulcerans_Agy99 ------------------------
MAV_0864|M.avium_104 ------------------------
MLBr_00737|M.leprae_Br4923 ------------------------