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TRRRKWPTISVRHLCKDLADEARIAKLDRQIEASGWRALCSDGASGVEVAIVAEEFGRGLADAPFLGPVL ADDLARQLNSDSGRATTGVGGRAIDARGHRRALVLSGTAVLSADLDVAGAGADLTRLDAGLLGQPVAVGE VSADAAQRWDALALVATTADLVGDARGAHTLACDYAKIREQYGKAIGSHQAIAHLLAENLALIEGSVSVL RHAAWAVDELEPAQAVQAARMAKVYCARASRTVCETAVQVHGGIGNTWDCLVHVYLRRALTSTELWPVSL QEVGRGLS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_0361 | - | - | 100% (289) | acyl-CoA dehydrogenase |
| M. ulcerans Agy99 | MUL_3411 | fadE22 | 3e-21 | 31.68% (303) | acyl-CoA dehydrogenase FadE22 |
| M. ulcerans Agy99 | MUL_1194 | fadE6 | 2e-20 | 31.19% (295) | acyl-CoA dehydrogenase FadE6 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3594 | fadE33 | 2e-19 | 30.71% (280) | acyl-CoA dehydrogenase FADE33 |
| M. gilvum PYR-GCK | Mflv_2393 | - | 2e-79 | 55.64% (275) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv3564 | fadE33 | 2e-19 | 30.71% (280) | acyl-CoA dehydrogenase FADE33 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 3e-08 | 32.43% (111) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4336 | - | 3e-22 | 30.51% (272) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_4792 | - | 1e-147 | 96.70% (273) | acyl-CoA dehydrogenase |
| M. avium 104 | MAV_0864 | - | 1e-108 | 70.70% (273) | acyl-CoA dehydrogenase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_4875 | - | 2e-89 | 62.55% (267) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_0130 | - | 1e-76 | 57.20% (250) | putative acyl-CoA dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4255 | - | 3e-82 | 56.62% (272) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3594|M.bovis_AF2122/97 ------------MTPPEERQMLRETVASLVAKHAGPAAVRAAMASDRGYD
Rv3564|M.tuberculosis_H37Rv ------------MTPPEERQMLRETVASLVAKHAGPAAVRAAMASDRGYD
MUL_0361|M.ulcerans_Agy99 --------------MTRRRKWPTISVR-HLCKDL--------ADEAR---
MMAR_4792|M.marinum_M ----------MDVRLTAEQRQLCDSAA-KMADDLGPASVQDLADEAR---
MAV_0864|M.avium_104 ----------MDVRLTAEQQQMRDAAA-KLADDLGPATVQDLDDQGR---
MSMEG_4875|M.smegmatis_MC2_155 ----------MDVRLTAEQQQLREAAA-KLADDLGPGSVHELEDRGR---
TH_0130|M.thermoresistible__bu --------------------------------------------------
Mflv_2393|M.gilvum_PYR-GCK ----------MDVRLTSEQRQLRDAAA-EVAEELGPGSVADLDDSAR---
Mvan_4255|M.vanbaalenii_PYR-1 ----------MDVRLTSEQQQLRDAAA-EVAGDFGPGSVADLDDQAR---
MAB_4336|M.abscessus_ATCC_1997 ----------MPIAINSEHVALADSAHAFVERVVPTELLHETLETPLPWP
MLBr_00737|M.leprae_Br4923 MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRARFP--
Mb3594|M.bovis_AF2122/97 ESLWRLLCEQVGAAALVIPEELGGAGGELADAAIVVQELGRALVPSPLLG
Rv3564|M.tuberculosis_H37Rv ESLWRLLCEQVGAAALVIPEELGGAGGELADAAIVVQELGRALVPSPLLG
MUL_0361|M.ulcerans_Agy99 ---IAKLDRQIEASGWRALCSDGASG---VEVAIVAEEFGRGLADAPFLG
MMAR_4792|M.marinum_M ---IAKLDRQIEAAGWTALRSDGASG---VEVAIVAEEFGRGLADAPFLG
MAV_0864|M.avium_104 ---ISRLDKQIEMSGWRSLRSDGASG---VEVAIVAEEFGRRLVDTPFLG
MSMEG_4875|M.smegmatis_MC2_155 ---IARLENTVAATEWRTLRSDGASG---VEVAIVAEEFARGLVDVPFLG
TH_0130|M.thermoresistible__bu -----------------VLRSDGASG---VEVAIVAEEFARGLVDVPFIG
Mflv_2393|M.gilvum_PYR-GCK ---RARLEKAVDATGFRTLRSDGASA---VEVAIVAEEFGRGLVDVPYLG
Mvan_4255|M.vanbaalenii_PYR-1 ---RTRLEKAVDATGFRTLRSDGASA---VEVAIVAEEFGRGLVDVPFLG
MAB_4336|M.abscessus_ATCC_1997 PP-FWKSAADQGLTSVHLAESVGGQGFGALELAIVVAEFGRGAVPGPFVP
MLBr_00737|M.leprae_Br4923 -EEALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASASLIP
. *. . .** *..* . . :
Mb3594|M.bovis_AF2122/97 TT---------------LAELALLAAAKPDAQALTELAQGSA--------
Rv3564|M.tuberculosis_H37Rv TT---------------LAELALLAAAKPDAQALTELAQGSA--------
MUL_0361|M.ulcerans_Agy99 PV---------------LADDLARQLNSDSGRATTGVGG-----------
MMAR_4792|M.marinum_M PV---------------LADDLARQLNSDSGRVTTGVGG-----------
MAV_0864|M.avium_104 PV---------------LADDLLRHVGADAAATTVAVDD-----------
MSMEG_4875|M.smegmatis_MC2_155 PI---------------LADDLAQRLGRAV--------------------
TH_0130|M.thermoresistible__bu PV---------------LNDEVRRIVGREP--------------------
Mflv_2393|M.gilvum_PYR-GCK PV---------------LVDDLHRRVGRD---------------------
Mvan_4255|M.vanbaalenii_PYR-1 PV---------------LADDLQRRLGRD---------------------
MAB_4336|M.abscessus_ATCC_1997 SV---------------IASALISAHDPDHPLLSDLASGASI--------
MLBr_00737|M.leprae_Br4923 AVNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMR
. : .
Mb3594|M.bovis_AF2122/97 ------IGALVLDPDYVVNGDIADIVVAATSGQLTRWTRFSAQPVATMDP
Rv3564|M.tuberculosis_H37Rv ------IGALVLDPDYVVNGDIADIVVAATSGQLTRWTRFSAQPVATMDP
MUL_0361|M.ulcerans_Agy99 -------RAIDARGHRRALVLSGTAVLSADLDVAGAGADLTRLDAGLLGQ
MMAR_4792|M.marinum_M -------RAIDARGHRRALVLSGTAVLSADLDVAGAGADLTRLDAGLLGQ
MAV_0864|M.avium_104 -------RAVDARGARRAVSLSGGAVLAVDVQPAPDNVDLTRADATTVGA
MSMEG_4875|M.smegmatis_MC2_155 ------------------------AVPDAAAGTAG--VDLTNSAAGVLQS
TH_0130|M.thermoresistible__bu ------------------------AAPVAGPESIGVDVDLTGSKAGVIEA
Mflv_2393|M.gilvum_PYR-GCK --------------------------PVAG--ADPQTVDLTNSLAGVVES
Mvan_4255|M.vanbaalenii_PYR-1 --------------------------VGAAPNTAPESVDLTGSLAGVVES
MAB_4336|M.abscessus_ATCC_1997 ------ATFSSTSSFTATPAGDGLSVDGQARSVLSATSATYVVAPVAIDS
MLBr_00737|M.leprae_Br4923 TRAKADGDDWILNGFKCWITNGGKSTWYTVMAVTDPDKGANGISAFIVHK
:
Mb3594|M.bovis_AF2122/97 TRRLARLQSEETEPLC-----------------------------PDPGI
Rv3564|M.tuberculosis_H37Rv TRRLARLQSEETEPLC-----------------------------PDPGI
MUL_0361|M.ulcerans_Agy99 PVAVGEVSADAAQ-----------------------------------RW
MMAR_4792|M.marinum_M PVAIGEVSADAAQ-----------------------------------RW
MAV_0864|M.avium_104 PETLGEVGSDVAG-----------------------------------QW
MSMEG_4875|M.smegmatis_MC2_155 PAELSELRAGDAA-----------------------------------RW
TH_0130|M.thermoresistible__bu PAELAEAAAEDRQ-----------------------------------RW
Mflv_2393|M.gilvum_PYR-GCK PSELSDLSDEDAG-----------------------------------RW
Mvan_4255|M.vanbaalenii_PYR-1 PPELADLSDDESG-----------------------------------RW
MAB_4336|M.abscessus_ATCC_1997 DRRWVVLSADDVTLDSQQSVDPLRPVAHVTATAVQVPADRVLSNLTDARA
MLBr_00737|M.leprae_Br4923 DDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTGFKTALAT
Mb3594|M.bovis_AF2122/97 ADTAAILLAAEQIGAAERCLQLTVEYAKSRVQFGRPIGSFQALKHRMADL
Rv3564|M.tuberculosis_H37Rv ADTAAILLAAEQIGAAERCLQLTVEYAKSRVQFGRPIGSFQALKHRMADL
MUL_0361|M.ulcerans_Agy99 DALALVATTADLVGDARGAHTLACDYAKIREQYGKAIGSHQAIAHLLAEN
MMAR_4792|M.marinum_M YALALVATSADLVGDARGAHALACDYAKIREQYGKAIGSHQAIAHLLAEN
MAV_0864|M.avium_104 RALALVTTTADLVGVARGAHALACDYAKIREQYGNPIGSYQAIAHLLAES
MSMEG_4875|M.smegmatis_MC2_155 HALALAATSADLVGAARGAHALAVDYAKVREQYGSTIGSYQAVAHLLAEG
TH_0130|M.thermoresistible__bu YALALAVTSADILGAARGAHALAVDYAKVREQYGAPIGSYQAVAHMLAEG
Mflv_2393|M.gilvum_PYR-GCK YALALAATAADMVGAARGTQRLATEYAKVREQYGSAIGSYQAVAHLLAES
Mvan_4255|M.vanbaalenii_PYR-1 YALALAATTADIIGAARGTHALATEYAKVREQYGSAIGSYQAVAHMLAES
MAB_4336|M.abscessus_ATCC_1997 TSIISTIVSAEAVGVARWATDTASEYAKVREQFGRPIGQFQGIKHKCATM
MLBr_00737|M.leprae_Br4923 LDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFMLADM
*: :* *. : *:* * *:* .*. .*.: . *
Mb3594|M.bovis_AF2122/97 YVTIAAARAVVADACHAPTPTN---------AATARLAASEALSTAAAEG
Rv3564|M.tuberculosis_H37Rv YVTIAAARAVVADACHAPTPTN---------AATARLAASEALSTAAAEG
MUL_0361|M.ulcerans_Agy99 LALIEGSVSVLRHAAWAVDELEPAQ--AVQAARMAKVYCARASRTVCETA
MMAR_4792|M.marinum_M LALIEGSVSVLRHAAWAVDELEPAQ--AVQAARMAKVYCARASRTVCETA
MAV_0864|M.avium_104 LALIEGSISVARHAAWAVDALAPAE--AIRAAQIAKVYCARAARTVCETA
MSMEG_4875|M.smegmatis_MC2_155 LALIEGSISVLRHAAWGVDELEPDE--AVRAGRIAKVYCARAARTVCETA
TH_0130|M.thermoresistible__bu LALIEGSISVLRHAAWAVDELPADE--AVRAGRYAKIYCARAARTVCETA
Mflv_2393|M.gilvum_PYR-GCK EALIEGSISVSRHAAWAVDELPARE--AIEAARVAKIYCARAAMTVCETS
Mvan_4255|M.vanbaalenii_PYR-1 LALIEGSISVARHAAWAVDELPVRE--AVEAARIAKIYSARAAMTVCETS
MAB_4336|M.abscessus_ATCC_1997 AAVTERATAAVWDAARALDDADENPGVVEFAASVAATLAPAAAQQCAQDC
MLBr_00737|M.leprae_Br4923 AMKVEAARLIVYAAAARAERGEPDLG---FISAASKCFASDIAMEVTTDA
: *. . : ..
Mb3594|M.bovis_AF2122/97 IQLHGGIAITWEHDMHLYFKRAHGSAQLLESP------------------
Rv3564|M.tuberculosis_H37Rv IQLHGGIAITWEHDMHLYFKRAHGSAQLLESP------------------
MUL_0361|M.ulcerans_Agy99 VQVHGGIGNTWDCLVHVYLRRALTSTELWPVS------------------
MMAR_4792|M.marinum_M VQVHGGIGNTWDCLVHVYLRRALTSTELWPVS------------------
MAV_0864|M.avium_104 IQVHGGIGNTWECAAHVYLRRALTSTELWPVA------------------
MSMEG_4875|M.smegmatis_MC2_155 IQVHGGIGNTWECLAHVYLRRALTSTELWPVG------------------
TH_0130|M.thermoresistible__bu IQVHGGIGNTWECLAHVFLRRVLTSTDLWPVK------------------
Mflv_2393|M.gilvum_PYR-GCK IQVHGGIGNTWECLAHIYLRRVLAATEAWPVT------------------
Mvan_4255|M.vanbaalenii_PYR-1 IQVHGGIGNTWECLAHIYLRRVLAATETWPAK------------------
MAB_4336|M.abscessus_ATCC_1997 IQVHGGIGYTWEHDAHIYYRRALGLTAALGRSGGAPATVVRTAVEHGLRK
MLBr_00737|M.leprae_Br4923 VQLFGGAGYTSDFPVERFMRDAKITQIYEGTN------------------
:*:.** . * : . : : .
Mb3594|M.bovis_AF2122/97 ------------REVLRRLESEVWESP-----------------------
Rv3564|M.tuberculosis_H37Rv ------------REVLRRLESEVWESP-----------------------
MUL_0361|M.ulcerans_Agy99 ------------LQEVG---RGLS--------------------------
MMAR_4792|M.marinum_M ------------LQEVG---RGLS--------------------------
MAV_0864|M.avium_104 ------------LKEID---LGLS--------------------------
MSMEG_4875|M.smegmatis_MC2_155 ------------LEDLEVSDLGFS--------------------------
TH_0130|M.thermoresistible__bu ------------LEDID---LGFS--------------------------
Mflv_2393|M.gilvum_PYR-GCK ------------LEELT---IGLS--------------------------
Mvan_4255|M.vanbaalenii_PYR-1 ------------LEELT---IGLS--------------------------
MAB_4336|M.abscessus_ATCC_1997 VDIDLAPETEALRAEIRAEVAALKEIPSGKRNTAIAEGGWVLPYLPTPWG
MLBr_00737|M.leprae_Br4923 -----------QIQRVVMSRALLR--------------------------
: .
Mb3594|M.bovis_AF2122/97 --------------------------------------------------
Rv3564|M.tuberculosis_H37Rv --------------------------------------------------
MUL_0361|M.ulcerans_Agy99 --------------------------------------------------
MMAR_4792|M.marinum_M --------------------------------------------------
MAV_0864|M.avium_104 --------------------------------------------------
MSMEG_4875|M.smegmatis_MC2_155 --------------------------------------------------
TH_0130|M.thermoresistible__bu --------------------------------------------------
Mflv_2393|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4255|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4336|M.abscessus_ATCC_1997 RAASPVEQVIISQEFLTGKVRRPQLGIATWLVPSIVAYGTEEQKQRFLPP
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3594|M.bovis_AF2122/97 --------------------------------------------------
Rv3564|M.tuberculosis_H37Rv --------------------------------------------------
MUL_0361|M.ulcerans_Agy99 --------------------------------------------------
MMAR_4792|M.marinum_M --------------------------------------------------
MAV_0864|M.avium_104 --------------------------------------------------
MSMEG_4875|M.smegmatis_MC2_155 --------------------------------------------------
TH_0130|M.thermoresistible__bu --------------------------------------------------
Mflv_2393|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4255|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4336|M.abscessus_ATCC_1997 TFRGEMMWCQLFSEPGAGSDLAGLSTKAVKVEGGWRLTGQKIWTSVAQFA
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3594|M.bovis_AF2122/97 --------------------------------------------------
Rv3564|M.tuberculosis_H37Rv --------------------------------------------------
MUL_0361|M.ulcerans_Agy99 --------------------------------------------------
MMAR_4792|M.marinum_M --------------------------------------------------
MAV_0864|M.avium_104 --------------------------------------------------
MSMEG_4875|M.smegmatis_MC2_155 --------------------------------------------------
TH_0130|M.thermoresistible__bu --------------------------------------------------
Mflv_2393|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4255|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4336|M.abscessus_ATCC_1997 DWGACLARTDPSAPKHNGITYFLVDMKSEGVTVRPLREMTGGALFNEVFI
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3594|M.bovis_AF2122/97 --------------------------------------------------
Rv3564|M.tuberculosis_H37Rv --------------------------------------------------
MUL_0361|M.ulcerans_Agy99 --------------------------------------------------
MMAR_4792|M.marinum_M --------------------------------------------------
MAV_0864|M.avium_104 --------------------------------------------------
MSMEG_4875|M.smegmatis_MC2_155 --------------------------------------------------
TH_0130|M.thermoresistible__bu --------------------------------------------------
Mflv_2393|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4255|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4336|M.abscessus_ATCC_1997 DDVFVPDELVVGEVNRGWEVSRNTLTAERVSIGSSDLPFLASLDDLVAFV
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3594|M.bovis_AF2122/97 --------------------------------------------------
Rv3564|M.tuberculosis_H37Rv --------------------------------------------------
MUL_0361|M.ulcerans_Agy99 --------------------------------------------------
MMAR_4792|M.marinum_M --------------------------------------------------
MAV_0864|M.avium_104 --------------------------------------------------
MSMEG_4875|M.smegmatis_MC2_155 --------------------------------------------------
TH_0130|M.thermoresistible__bu --------------------------------------------------
Mflv_2393|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4255|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4336|M.abscessus_ATCC_1997 GTHDLGEVARDRAGQLIAEGHGVKLLNLRSTLLTLAGGDPMPSAAVSKLL
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3594|M.bovis_AF2122/97 --------------------------------------------------
Rv3564|M.tuberculosis_H37Rv --------------------------------------------------
MUL_0361|M.ulcerans_Agy99 --------------------------------------------------
MMAR_4792|M.marinum_M --------------------------------------------------
MAV_0864|M.avium_104 --------------------------------------------------
MSMEG_4875|M.smegmatis_MC2_155 --------------------------------------------------
TH_0130|M.thermoresistible__bu --------------------------------------------------
Mflv_2393|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4255|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4336|M.abscessus_ATCC_1997 GMRTGQGYAEFVVNHFGQDGAIGDSEQEQGRWADYLLASRATTIYGGTSE
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3594|M.bovis_AF2122/97 -----------------
Rv3564|M.tuberculosis_H37Rv -----------------
MUL_0361|M.ulcerans_Agy99 -----------------
MMAR_4792|M.marinum_M -----------------
MAV_0864|M.avium_104 -----------------
MSMEG_4875|M.smegmatis_MC2_155 -----------------
TH_0130|M.thermoresistible__bu -----------------
Mflv_2393|M.gilvum_PYR-GCK -----------------
Mvan_4255|M.vanbaalenii_PYR-1 -----------------
MAB_4336|M.abscessus_ATCC_1997 VQLNIIAERLLGLPRDP
MLBr_00737|M.leprae_Br4923 -----------------