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M. avium 104 MAV_0542 (hflB)

annotation: ATP-dependent metallopeptidase HflB
coordinates: 526345 - 528744
length: 799

MNRKNVIRTITAIAVVVLLGWSFFYFSDDTRGYKPVDTSVAMAQINGDNVKSAQIDDREQQLRLTLKKGN
GDTDNSDKVITKYPSGYAVDLFNALSAKNAKVSTVVNQGSILGELLVYVLPLLLLVGLFVMFSRMQGGAR
MGFGFGKSRAKQLSKDMPKTTFADVAGVDEAVEELYEIKDFLQNPGRYQALGAKIPKGVLLYGPPGTGKT
LLARAVAGEAGVPFFTISGSDFVEMFVGVGASRVRDLFDQAKQNNPCIIFVDEIDAVGRQRGAGLGGGHD
EREQTLNQLLVEMDGFDPRAGVILIAATNRPDILDPALLRPGRFDRQIPVSNPDLAGRRAVLAVHSKGKP
IAPDADLDGLAKRTVGMTGADLANVINEAALLTARENGTVITSAALEEAVDRVIGGPRRKGRIISEQEKK
ITAYHEGGHTLAAWAMPDIEPIYKVTILARGRTGGHAVAVPEEDKGLRTRSEMIAQLVFAMGGRAAEELV
FREPTTGAVSDIEQATKIARAMVTEFGMSSKLGAVKYGSEHGDPFLGRTMGTQADYSHEVARDIDDEIRK
LIEAAHTEAWEILTEYRDILDTLAGQLLEKETLHRAELESIFAGVEKRPRLTMFDDFGGRIPSDKPPIKT
PGELAIERGEPWPPPAPEPAFKAAIAKASEAAAAARLEADRNANGGNGSHANQGGNRQGPTQPDYGAPAG
WRAPGWPPQQSQQPNYWHPPAQPPYWQQPAHGYPGQQPYPGQQPYPGQPGGPAQSGPPQARPPYPPYPPY
PPPGQPAPEGGSPDRQDDDVSRSNPPAHG
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. avium 104MAV_0542hflB-100% (799)ATP-dependent metallopeptidase HflB
M. avium 104MAV_4716-1e-4539.62% (260) cell division protein 48
M. avium 104MAV_2400-1e-2936.45% (203) ATPase, AAA family protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3640cftsH0.085.41% (802) membrane-bound protease FTSH (cell division protein)
M. gilvum PYR-GCKMflv_1416-0.081.38% (784) ATP-dependent metalloprotease FtsH
M. tuberculosis H37RvRv3610cftsH0.085.41% (802) membrane-bound protease FTSH (cell division protein)
M. leprae Br4923MLBr_00222ftsH0.086.28% (809) putative integral membrane peptidase
M. abscessus ATCC 19977MAB_0533-0.078.24% (786) cell division protein FtsH-like protein
M. marinum MMMAR_5113ftsH0.082.48% (799) membrane-bound protease FtsH
M. smegmatis MC2 155MSMEG_6105-0.081.66% (807) cell division protein
M. thermoresistible (build 8)TH_0991ftsH0.079.28% (806) MEMBRANE-BOUND PROTEASE FTSH (CELL DIVISION PROTEIN)
M. ulcerans Agy99MUL_4192ftsH0.082.85% (799) membrane-bound protease FtsH
M. vanbaalenii PYR-1Mvan_5372-0.080.93% (813) ATP-dependent metalloprotease FtsH

CLUSTAL 2.0.9 multiple sequence alignment


Mb3640c|M.bovis_AF2122/97           ---MNRKNVTRTITAIAVVVLLGWSFFYFSDDTRGYKPVDTSVAITQING
Rv3610c|M.tuberculosis_H37Rv        ---MNRKNVTRTITAIAVVVLLGWSFFYFSDDTRGYKPVDTSVAITQING
MLBr_00222|M.leprae_Br4923          MLLMNRKNVIRMVTAIAVVVLLGWSFFYFSDDTRGYKFVDTSVAMSQING
MAV_0542|M.avium_104                ---MNRKNVIRTITAIAVVVLLGWSFFYFSDDTRGYKPVDTSVAMAQING
MMAR_5113|M.marinum_M               ---MNRKNVIRTVTVVAVVVVLGWSFFYFSDDTRGYKPVDTSVAMSQINA
MUL_4192|M.ulcerans_Agy99           ---MNRKNVIRTVTAVAVVVVLGWSFFYFSDDTRGYKPVDTSVAMSQINA
Mflv_1416|M.gilvum_PYR-GCK          ---MNRKNVIRTLTVIAVVLLLGWSFFYFSDDTRGYKPVDTTIAIAQING
Mvan_5372|M.vanbaalenii_PYR-1       ---MNRKNVIRTLTVIAVVLLLGWSFFYFSDDTRGYKPVDTSVAMAQISG
MSMEG_6105|M.smegmatis_MC2_155      ---MNRKNVIRTLTVIGVVLLLGWSFFYFSDDTRGYKPVDTTVALAQIRG
TH_0991|M.thermoresistible__bu      ---MNRKTVIRTLTIVAVVLLLGWSFFYFGDDTREYKPVDTSVALAQIQA
MAB_0533|M.abscessus_ATCC_1997      ---MNRTNVFRTLGVIVVVLLLGWSFFYFSDDTRGYKPVDTTVAIKQIDT
                                       ***..* * :  : **::********.**** ** ***::*: **  

Mb3640c|M.bovis_AF2122/97           DNVKSAQIDDREQQLRLILKKGNNETDGSEKVITKYPTGYAVDLFNALSA
Rv3610c|M.tuberculosis_H37Rv        DNVKSAQIDDREQQLRLILKKGNNETDGSEKVITKYPTGYAVDLFNALSA
MLBr_00222|M.leprae_Br4923          HNVKSAQIDDREQQLRLTLKKGNNDTDGSDKVITKYPTGYAVDLFNALSA
MAV_0542|M.avium_104                DNVKSAQIDDREQQLRLTLKKGNGDTDNSDKVITKYPSGYAVDLFNALSA
MMAR_5113|M.marinum_M               DNVKSAQIDDREQQLRLVLKKSSSDTDGSDKVITKYPTGYAVDLFNALTA
MUL_4192|M.ulcerans_Agy99           DNAKSAQIDDREQQLRLVLKKSSSDTDGSDKVITKYPTGYAVDLFNALTA
Mflv_1416|M.gilvum_PYR-GCK          DNVNSAQIDDREQQLRLELKNGNGDTENSTQILTKYPTGYGATLFESLQD
Mvan_5372|M.vanbaalenii_PYR-1       DNVKSAQIDDREQQLRLELKNGNGDTENSDKIITKYPTGYGVPLFEALQA
MSMEG_6105|M.smegmatis_MC2_155      DNVNSAQIDDREQQVRLDLKSGNGDTENSDKIITKYPTGYGVTLFNALQD
TH_0991|M.thermoresistible__bu      DNVDSAQIDDREQQVRLDLKNANSDTGDSDKIIAKYPTGYAVPLFDALQD
MAB_0533|M.abscessus_ATCC_1997      DNVKSARIDDREQQLRLDLKAANGDTEGKDKVITKYPTGYGVPLLEKLNG
                                    .*..**:*******:** ** ...:* .. ::::***:**.. *:: *  

Mb3640c|M.bovis_AF2122/97           KNAKVSTVVNQGSILGELLVYVLPLLLLVGLFVMFSRMQGGAR-MGFGFG
Rv3610c|M.tuberculosis_H37Rv        KNAKVSTVVNQGSILGELLVYVLPLLLLVGLFVMFSRMQGGAR-MGFGFG
MLBr_00222|M.leprae_Br4923          KNTKVTTAVNEGSILGELLVYVLPLLLLVGLFVMFSRMQGGAR-MGFGFG
MAV_0542|M.avium_104                KNAKVSTVVNQGSILGELLVYVLPLLLLVGLFVMFSRMQGGAR-MGFGFG
MMAR_5113|M.marinum_M               KNAKVSTVVNQGSILGELLVYVLPLLLLVGLFVMFSRMQGGAR-MGFGFG
MUL_4192|M.ulcerans_Agy99           KNAKVSTVVNQGSILGELLVYVLPLLLLVGLFVMFSRMQGGAR-MGFGFG
Mflv_1416|M.gilvum_PYR-GCK          KNIKTNTVVNQSSIFGTLLIYMLPLLLLVALFVLFSRMQSGGR-MGFGFG
Mvan_5372|M.vanbaalenii_PYR-1       KNTKINTVVNQSSILGTLLIYMLPLLLLVGLFVMFSRMQTGGR-MGFGFG
MSMEG_6105|M.smegmatis_MC2_155      KGAKTNTVVNQGSVFGTLLIYMLPLLLLVALFVMFSRMQTGGR-MGFGFG
TH_0991|M.thermoresistible__bu      KNAKVNTVVNQGSVLGTLLIYMLPLLLLVALFVFFMRMQSGGR-MGFGFG
MAB_0533|M.abscessus_ATCC_1997      KGAAVNTTVNQGSILGSLLLYLLPVILLVVLFFAFSRMQSGGRGMGFGFG
                                    *.   .*.**:.*::* **:*:**::*** **. * *** *.* ******

Mb3640c|M.bovis_AF2122/97           KSRAKQLSKDMPKTTFADVAGVDEAVEELYEIKDFLQNPSRYQALGAKIP
Rv3610c|M.tuberculosis_H37Rv        KSRAKQLSKDMPKTTFADVAGVDEAVEELYEIKDFLQNPSRYQALGAKIP
MLBr_00222|M.leprae_Br4923          KSRAKQLSKDMPKTTFADVAGVDEAVEELYEIKDFLQNPCRYQTLGAKIP
MAV_0542|M.avium_104                KSRAKQLSKDMPKTTFADVAGVDEAVEELYEIKDFLQNPGRYQALGAKIP
MMAR_5113|M.marinum_M               KSRAKQLSKDMPKTTFADVAGVDEAVEELYEIKDFLQNPSRYQALGAKIP
MUL_4192|M.ulcerans_Agy99           KSRAKQLSKDMPKTTFADVAGVDEAVEELYEIKDFLQNPSRYQALGAKIP
Mflv_1416|M.gilvum_PYR-GCK          KSKAKMLSKDMPRTTFADVAGVDEAVEELYEIKDFLQNPSRYQALGAKIP
Mvan_5372|M.vanbaalenii_PYR-1       KSKAKMLGKDMPKTTFADVAGVDEAVEELYEIKDFLQNPSRYQALGAKIP
MSMEG_6105|M.smegmatis_MC2_155      KSRAKQLSKDMPKTTFADVAGVDEAVEELYEIKDFLQNPSRYQALGAKIP
TH_0991|M.thermoresistible__bu      KSKAKQLSKDMPKTTFADVAGVDEAVEELYEIKDFLQNPSRYQALGAKIP
MAB_0533|M.abscessus_ATCC_1997      KSRAKQLSKDMPKTTFADVAGVDEAVEELYEIKDFLQNPSRYQALGAKIP
                                    **:** *.****:************************** ***:******

Mb3640c|M.bovis_AF2122/97           KGVLLYGPPGTGKTLLARAVAGEAGVPFFTISGSDFVEMFVGVGASRVRD
Rv3610c|M.tuberculosis_H37Rv        KGVLLYGPPGTGKTLLARAVAGEAGVPFFTISGSDFVEMFVGVGASRVRD
MLBr_00222|M.leprae_Br4923          KGVLLYGPPGTGKTLLARAVAGEAGVPFFTISGSDFVEMFVGVGASRVRD
MAV_0542|M.avium_104                KGVLLYGPPGTGKTLLARAVAGEAGVPFFTISGSDFVEMFVGVGASRVRD
MMAR_5113|M.marinum_M               KGVLLYGPPGTGKTLLARAVAGEAGVPFFTISGSDFVEMFVGVGASRVRD
MUL_4192|M.ulcerans_Agy99           KGVLLYGPPGTGKTLLARAVAGEAGVPFFTISGSDFVEMFVGVGASRVRD
Mflv_1416|M.gilvum_PYR-GCK          KGVLLYGPPGTGKTLLARAVAGEAGVPFFTISGSDFVEMFVGVGASRVRD
Mvan_5372|M.vanbaalenii_PYR-1       KGVLLYGPPGTGKTLLARAVAGEAGVPFFTISGSDFVEMFVGVGASRVRD
MSMEG_6105|M.smegmatis_MC2_155      KGVLLYGPPGTGKTLLARAVAGEAGVPFFTISGSDFVEMFVGVGASRVRD
TH_0991|M.thermoresistible__bu      KGVLLYGPPGTGKTLLARAVAGEAGVPFFTISGSDFVEMFVGVGASRVRD
MAB_0533|M.abscessus_ATCC_1997      RGVLLYGPPGTGKTLLARAVAGEAGVPFFTISGSDFVEMFVGVGASRVRD
                                    :*************************************************

Mb3640c|M.bovis_AF2122/97           LFEQAKQNSPCIIFVDEIDAVGRQRGAGLGGGHDEREQTLNQLLVEMDGF
Rv3610c|M.tuberculosis_H37Rv        LFEQAKQNSPCIIFVDEIDAVGRQRGAGLGGGHDEREQTLNQLLVEMDGF
MLBr_00222|M.leprae_Br4923          LFDQAKQNSPCIIFVDEIDAVGRQRGTGLGGGHDEREQTLNQLLVEMDGF
MAV_0542|M.avium_104                LFDQAKQNNPCIIFVDEIDAVGRQRGAGLGGGHDEREQTLNQLLVEMDGF
MMAR_5113|M.marinum_M               LFEQAKQNSPCIIFVDEIDAVGRQRGAGLGGGHDEREQTLNQLLVEMDGF
MUL_4192|M.ulcerans_Agy99           LFEQAKQNSPCIIFVDEIDAVGRQRGAGLGGGHDEREQTLNQLLVEMDGF
Mflv_1416|M.gilvum_PYR-GCK          LFEQAKQNSPCIIFVDEIDAVGRQRGAGLGGGHDEREQTLNQLLVEMDGF
Mvan_5372|M.vanbaalenii_PYR-1       LFEQAKQNSPCIIFVDEIDAVGRQRGAGLGGGHDEREQTLNQLLVEMDGF
MSMEG_6105|M.smegmatis_MC2_155      LFEQAKQNSPCIIFVDEIDAVGRQRGAGLGGGHDEREQTLNQLLVEMDGF
TH_0991|M.thermoresistible__bu      LFEQAKQNSPCIIFVDEIDAVGRQRGAGLGGGHDEREQTLNQLLVEMDGF
MAB_0533|M.abscessus_ATCC_1997      LFEQAKQNSPCIIFVDEIDAVGRQRGAGLGGGHDEREQTLNQLLVEMDGF
                                    **:*****.*****************:***********************

Mb3640c|M.bovis_AF2122/97           GDRAGVILIAATNRPDILDPALLRPGRFDRQIPVSNPDLAGRRAVLRVHS
Rv3610c|M.tuberculosis_H37Rv        GDRAGVILIAATNRPDILDPALLRPGRFDRQIPVSNPDLAGRRAVLRVHS
MLBr_00222|M.leprae_Br4923          GDRAGVILIAATNRPDILDPALLRPGRFDRQIPVSNPDLAGRRAVLRVHS
MAV_0542|M.avium_104                DPRAGVILIAATNRPDILDPALLRPGRFDRQIPVSNPDLAGRRAVLAVHS
MMAR_5113|M.marinum_M               GDRAGVILIAATNRPDILDPALLRPGRFDRQIPVTNPDLAGRRAVLRVHS
MUL_4192|M.ulcerans_Agy99           GDRAGVILIAATNRPDILDPALLRPGRFDRQIPVTNPDLAGRRAVLRVHS
Mflv_1416|M.gilvum_PYR-GCK          GDRQGVILIAATNRPDILDPALLRPGRFDRQIPVSSPDLAGRRAVLKVHS
Mvan_5372|M.vanbaalenii_PYR-1       GDRQGVILIAATNRPDILDPALLRPGRFDRQIPVSNPDLAGRRAVLRVHS
MSMEG_6105|M.smegmatis_MC2_155      GDRQGVILIAATNRPDILDPALLRPGRFDRQIPVSNPDLAGRRAVLKVHS
TH_0991|M.thermoresistible__bu      GDRQGVILIAATNRPDILDPALLRPGRFDRQIPVTNPDLAGRKAVLRVHA
MAB_0533|M.abscessus_ATCC_1997      GDRQGVILIAATNRPDILDPALLRPGRFDRQIPVSSPDLAGRKAVLKVHS
                                    . * ******************************:.******:*** **:

Mb3640c|M.bovis_AF2122/97           KGKPMAADADLDGLAKRTVGMTGADLANVINEAALLTARENGTVITGPAL
Rv3610c|M.tuberculosis_H37Rv        KGKPMAADADLDGLAKRTVGMTGADLANVINEAALLTARENGTVITGPAL
MLBr_00222|M.leprae_Br4923          KGKPIADDADLDGLAKRTVGMTGADLANVVNEAALLTARENGLVITGPAL
MAV_0542|M.avium_104                KGKPIAPDADLDGLAKRTVGMTGADLANVINEAALLTARENGTVITSAAL
MMAR_5113|M.marinum_M               KGKPIADGADLDGLAKRTVGMTGADLANVINEAALLTARENGTVITGPAL
MUL_4192|M.ulcerans_Agy99           KGKPIADGADLDGLAKRTVGMTGADLANVINEAALLTARENGTVITGPAL
Mflv_1416|M.gilvum_PYR-GCK          QGKPIAEDADLEGLAKRTVGMSGADLANVINEAALLTARENGTIITGPAL
Mvan_5372|M.vanbaalenii_PYR-1       QGKPIADDADLDGLAKRTVGMSGADLANVINEAALLTARENGTIITGPAL
MSMEG_6105|M.smegmatis_MC2_155      QGKPIAPDADLDGLAKRTVGMSGADLANVINEAALLTARENGTVITGPAL
TH_0991|M.thermoresistible__bu      QGKPLAPDVDLDGLAKRTVGMSGADLANVINEAALLTARENGTMITGPAL
MAB_0533|M.abscessus_ATCC_1997      AGKPFGPDVDFDGLAKRTVGMSGADLANVINEAALLTARENGTVITAAAL
                                     ***:. ..*::*********:*******:************ :**..**

Mb3640c|M.bovis_AF2122/97           EEAVDRVIGGPRRKGRIISEQEKKITAYHEGGHTLAAWAMPDIEPIYKVT
Rv3610c|M.tuberculosis_H37Rv        EEAVDRVIGGPRRKGRIISEQEKKITAYHEGGHTLAAWAMPDIEPIYKVT
MLBr_00222|M.leprae_Br4923          EEAVDRVIGGPRRKGRIISEQEKKITAYHEGGHTLAAWAMPDIEPIYKVT
MAV_0542|M.avium_104                EEAVDRVIGGPRRKGRIISEQEKKITAYHEGGHTLAAWAMPDIEPIYKVT
MMAR_5113|M.marinum_M               EEAVDRVIGGPRRKGRIISEHEKKITAYHEGGHTLAAWAMPDIDPVYKVT
MUL_4192|M.ulcerans_Agy99           EEAVDRVIGGPRRKGRIISEHEKKITAYHEGGHTLAAWAMPDIDPVYKVT
Mflv_1416|M.gilvum_PYR-GCK          EEAVDRVVGGPRRKSRIISEHEKKITAYHEGGHTLAAWAMPDIEPIYKVT
Mvan_5372|M.vanbaalenii_PYR-1       EEAVDRVVGGPRRKSRIISEHEKKITAYHEGGHTLAAWAMPDIDPIYKVT
MSMEG_6105|M.smegmatis_MC2_155      EEAVDRVVGGPRRKSRIISEHEKKITAYHEGGHTLAAWAMPDIEPIYKVT
TH_0991|M.thermoresistible__bu      EEAVDRVVGGPRRKSRLISELEKKITAYHEGGHTLAAWAMPDIEPIYKVT
MAB_0533|M.abscessus_ATCC_1997      EESVDRVVGGPRRKGRIISEHEKKITAYHEAGHTLAAWAMPDIERVYKVT
                                    **:****:******.*:*** *********.************: :****

Mb3640c|M.bovis_AF2122/97           ILARGRTGGHAVAVPEEDKGLRTRSEMIAQLVFAMGGRAAEELVFREPTT
Rv3610c|M.tuberculosis_H37Rv        ILARGRTGGHAVAVPEEDKGLRTRSEMIAQLVFAMGGRAAEELVFREPTT
MLBr_00222|M.leprae_Br4923          ILARGRTGGHAVAVPEEDKGLRTRSEMIAQLVFAMGGRAAEELVFREPTT
MAV_0542|M.avium_104                ILARGRTGGHAVAVPEEDKGLRTRSEMIAQLVFAMGGRAAEELVFREPTT
MMAR_5113|M.marinum_M               ILARGRTGGHAVAVPEEDKGLRTRSEMIAQLVFAMGGRAAEELVFREPTT
MUL_4192|M.ulcerans_Agy99           ILARGRTGGHAVAVPEEDKGLRTRSEMIAQLVFAMGGRAAEELVFREPTT
Mflv_1416|M.gilvum_PYR-GCK          ILARGRTGGHAMAVPEDDKGLMTRSEMIARLVFAMGGRAAEELVFREPTT
Mvan_5372|M.vanbaalenii_PYR-1       ILARGRTGGHAMSVPEDDKGLMTRSEMIARLVFAMGGRAAEELVFREPTT
MSMEG_6105|M.smegmatis_MC2_155      ILARGRTGGHAVAVPEDDKGLMTRSEMIARLVFAMGGRAAEELVFREPTT
TH_0991|M.thermoresistible__bu      ILARGRTGGHAVAVPEDDKGLMTRSEMIARLVFAMGGRAAEELVFREPTT
MAB_0533|M.abscessus_ATCC_1997      ILARGRTGGHAIAVPEDDKGLATRSEMIAQLVFAMGGRAAEELVFREPTT
                                    ***********::***:**** *******:********************

Mb3640c|M.bovis_AF2122/97           GAVSDIEQATKIARSMVTEFGMSSKLGAVKYGSEHGDPFLGRTMGTQPDY
Rv3610c|M.tuberculosis_H37Rv        GAVSDIEQATKIARSMVTEFGMSSKLGAVKYGSEHGDPFLGRTMGTQPDY
MLBr_00222|M.leprae_Br4923          GAVSDIEKATKIARSMVTEFGMSSKLGAVRYGSEHGDPFLGRTMGTQADY
MAV_0542|M.avium_104                GAVSDIEQATKIARAMVTEFGMSSKLGAVKYGSEHGDPFLGRTMGTQADY
MMAR_5113|M.marinum_M               GAVSDIEQATKVARAMVTEYGMSARLGAVKYGTEHGDPFLGRSMGTQSDY
MUL_4192|M.ulcerans_Agy99           GAVSDIEQATKVARAMVTEYGMSARLGAVKYGTEHGDPFLGRSMGTQSDY
Mflv_1416|M.gilvum_PYR-GCK          GASSDIDQATKIARAMVTEYGMSSKLGAVRYGSEHGDPFLGRTMGNQADY
Mvan_5372|M.vanbaalenii_PYR-1       GAVSDIEQATKIARAMVTEYGMSSKLGAVRYGTEHGDPFLGRTMGTQADY
MSMEG_6105|M.smegmatis_MC2_155      GAVSDIEQATKIARAMVTEYGMSSKLGAVRYGTEHGDPFLGRTMGTQADY
TH_0991|M.thermoresistible__bu      GAVSDIEQATKIARAMVTEYGMSSKLGAVRYGTEHGDPFLGRTMGTHADY
MAB_0533|M.abscessus_ATCC_1997      GAVSDIEQATKKARAMVTEFGMSAKLGAVRYGTEHGDPFLGRTMGTQADY
                                    ** ***::*** **:****:***::****:**:*********:**.:.**

Mb3640c|M.bovis_AF2122/97           SHEVAREIDEEVRKLIEAAHTEAWEILTEYRDVLDTLAGELLEKETLHRP
Rv3610c|M.tuberculosis_H37Rv        SHEVAREIDEEVRKLIEAAHTEAWEILTEYRDVLDTLAGELLEKETLHRP
MLBr_00222|M.leprae_Br4923          SHEVARDIDDEVRKLIEAAHTEAWEILTEYRDVLDTLAGELLEKETLHRP
MAV_0542|M.avium_104                SHEVARDIDDEIRKLIEAAHTEAWEILTEYRDILDTLAGQLLEKETLHRA
MMAR_5113|M.marinum_M               SHEVAREIDEEVRKLIEAAHTEAWEILTEYRDVLDTLAGQLLEKETLHRP
MUL_4192|M.ulcerans_Agy99           SHEVAREIDEEVRKLIEAAHTEAWEILTEYRDVLDTLAGQLLEKETLHRP
Mflv_1416|M.gilvum_PYR-GCK          SHEVAQIIDDEIRKLIEAAHTEAWEILTEYRDVLDTLAGELLEKETLHRV
Mvan_5372|M.vanbaalenii_PYR-1       SHEVAQIIDDEVRKLIEAAHTEAWEILTEYRDVLDTLAGELLEKETLHRV
MSMEG_6105|M.smegmatis_MC2_155      SHEVAQIIDDEVRKLIEAAHTEAWEILTEYRDVLDILAGELLEKETLHRA
TH_0991|M.thermoresistible__bu      SHEVARDIDDEIRKLIEAAHTEAWEILTEYRDVLDVLAGELLEKETLHRR
MAB_0533|M.abscessus_ATCC_1997      SHEVAREIDEEVRNLIEAAHTEAWAILTEYRDVLDTLAGALLEKETVVRK
                                    *****: **:*:*:********** *******:** *** ******: * 

Mb3640c|M.bovis_AF2122/97           ELESIFADVEKRPRLTMFDDFGGRIPSDKPPIKTPGELAIERGEPWPQPV
Rv3610c|M.tuberculosis_H37Rv        ELESIFADVEKRPRLTMFDDFGGRIPSDKPPIKTPGELAIERGEPWPQPV
MLBr_00222|M.leprae_Br4923          ELEGIFASVEKRPRLTMFDDFGGRIPSDKPPIKTPGELAIERGEPWPQPV
MAV_0542|M.avium_104                ELESIFAGVEKRPRLTMFDDFGGRIPSDKPPIKTPGELAIERGEPWPPPA
MMAR_5113|M.marinum_M               ELESIFSDVEKRPRLTMFDDFGGRIPSDKPPIKTPGELAIERGEPWPQPM
MUL_4192|M.ulcerans_Agy99           ELESIFSDVEKRPRLTMFDDFGGRIPSDKPPIKTPGELAIERGEPWPQPM
Mflv_1416|M.gilvum_PYR-GCK          ELEAIFGDVKKRPRLTMFDDFGGRVPSDKPPIKTPGELAIERGEPWPKPV
Mvan_5372|M.vanbaalenii_PYR-1       ELEAIFGDVKKRPRLTMFDDFGGRVPSDKPPIKTPGELAIERGEPWPKPL
MSMEG_6105|M.smegmatis_MC2_155      ELEAIFGDVKKRPRLTMFDDFGGRVPSDKPPIKTPGELAMERGEPWPPPV
TH_0991|M.thermoresistible__bu      ELEVILADVKKRPRLTMFDDFGGRTPSDKPPIKTPGELAMERGEPWPKPE
MAB_0533|M.abscessus_ATCC_1997      ELEEIFSGVQRRPRLTMFDDFGGRIPSDKPPIKTPGELAIERGEPWPPPV
                                    *** *:..*::************* **************:******* * 

Mb3640c|M.bovis_AF2122/97           PEPAFKAAIAQATQAAEAARSDAGQTGHGANGSPAGTHRSGDRQ---YGS
Rv3610c|M.tuberculosis_H37Rv        PEPAFKAAIAQATQAAEAARSDAGQTGHGANGSPAGTHRSGDRQ---YGS
MLBr_00222|M.leprae_Br4923          PEPAFKAAIARASQAAEASHQAAQSDTDGPPGQGANGSHAGDRQR-QHGP
MAV_0542|M.avium_104                PEPAFKAAIAKASEAAAAARLEADRNANGGNGSHAN--QGGNRQ----GP
MMAR_5113|M.marinum_M               PEPAFKQAIAQATQAAQAA--QAAQSASEGTGRGPNGSRGADAN----PG
MUL_4192|M.ulcerans_Agy99           PEPAFKQAIAQAT--------QAAQSASEGTGRGPNGSRGADAN----PG
Mflv_1416|M.gilvum_PYR-GCK          PEPAFKTAIAQASRAAAEAAPKNGGNGANGAH-APG--------------
Mvan_5372|M.vanbaalenii_PYR-1       PEPAFKTAIAQASRAAAEQAQKNGGNGSQASNGVPGG------------P
MSMEG_6105|M.smegmatis_MC2_155      PEPAFKAAIAAANREAEKRNGTNGAP-SNGAP-APAG------------P
TH_0991|M.thermoresistible__bu      PEPAFKVAIAEATRAAEAASGQNGQNGHNGTPGPTGPNGTPSAPAQQPAP
MAB_0533|M.abscessus_ATCC_1997      PEPAFKKAIAEQAAAAAPANGVPPAPAGPHGHLPNGQGG-------QPVP
                                    ****** ***                                        

Mb3640c|M.bovis_AF2122/97           TQPDYGAPAGWHAPGWPPRSS--------HRPS---YSGEPAPTYPGQ--
Rv3610c|M.tuberculosis_H37Rv        TQPDYGAPAGWHAPGWPPRSS--------HRPS---YSGEPAPTYPGQ--
MLBr_00222|M.leprae_Br4923          TQPDYGAPPGWHAPGWPPQQPPDYWYPPEQQPSQSPYWPQPAPSYPGQAP
MAV_0542|M.avium_104                TQPDYGAPAGWRAPGWPPQQSQQP--NYWHPPAQPPYWQQPAHGYPGQQP
MMAR_5113|M.marinum_M               SHPDYGAPAGWRAPGWPPPSE----------------RPQPSGYSPDQ--
MUL_4192|M.ulcerans_Agy99           SHPDYGAPAGWRAPGWPPPSE----------------RPQPSGYSPDQ--
Mflv_1416|M.gilvum_PYR-GCK          --PDYGAPAGWHAPGWPPPPGGPQQQQPPQQ---QGYWYPGPPQQQGWQG
Mvan_5372|M.vanbaalenii_PYR-1       TQPDYGAPAGWHAPGWPPQAGGP---HPPQP---QGYWYP-PPPPSGWQG
MSMEG_6105|M.smegmatis_MC2_155      TQPDYGAPAGWHAPGWPPPQQSQQPGYQPQ----QGYWYP-PPHPSGWQ-
TH_0991|M.thermoresistible__bu      VVPDYGAPAGWHAPGWPPQPTPQQQPPPYQQP--HGQWYP-PQQQPGWQ-
MAB_0533|M.abscessus_ATCC_1997      PGVNYGAPAGWHAPGWPPPGQAPHP-------------------QPGYQ-
                                       :****.**:******                            .   

Mb3640c|M.bovis_AF2122/97           -----PYP--------------------------TGQADPGSDESSAEQD
Rv3610c|M.tuberculosis_H37Rv        -----PYP--------------------------TGQADPGSDESSAEQD
MLBr_00222|M.leprae_Br4923          P----PYPS----------------YPPCPSYPPPGQSAPDAGKPPAQLD
MAV_0542|M.avium_104                YPGQQPYPGQPGGPAQSGPPQARPPYPPYPPYPPPGQPAPEGG-SPDRQD
MMAR_5113|M.marinum_M               --------------------------------------PSDTDESSEQQD
MUL_4192|M.ulcerans_Agy99           --------------------------------------PSDTDESSEQQD
Mflv_1416|M.gilvum_PYR-GCK          NAPTPAYPG----------------YPPYQPYPQPGQHAPHGGAPAPNPT
Mvan_5372|M.vanbaalenii_PYR-1       APQAPAYPG----------------YPPYQPHSQPGQPAPHGGAAAASPK
MSMEG_6105|M.smegmatis_MC2_155      --QPQPYP--------------------YQPYPHPGQQGTS--PEHGRPS
TH_0991|M.thermoresistible__bu      -QQQQPYPSQ---------------YSPYQPYPQPSPPAPPGGAAPND--
MAB_0533|M.abscessus_ATCC_1997      -----PYPP--------------------QPYPYP----------VPTPH
                                                                                      

Mb3640c|M.bovis_AF2122/97           DEVSRTKP-AHG----------------------
Rv3610c|M.tuberculosis_H37Rv        DEVSRTKP-AHG----------------------
MLBr_00222|M.leprae_Br4923          EGVSPSNPPAHG----------------------
MAV_0542|M.avium_104                DDVSRSNPPAHG----------------------
MMAR_5113|M.marinum_M               RDVSRSNPPAHG----------------------
MUL_4192|M.ulcerans_Agy99           RDVSRSNPPAHG----------------------
Mflv_1416|M.gilvum_PYR-GCK          DDPGQDRGRENGHRDTERRDTDRGDTNRNGPANG
Mvan_5372|M.vanbaalenii_PYR-1       EDPGHEGGGENGRSAP--------------PSNG
MSMEG_6105|M.smegmatis_MC2_155      EQSGQDDGHTGDRSNP----------------HG
TH_0991|M.thermoresistible__bu      QESGQDPNRTNPPGQG------------------
MAB_0533|M.abscessus_ATCC_1997      QQPGPAPDEGSESKG-------------------
                                       .