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MNVLAAAMRDAMTRSPHDLVVLDKDSDTWRSCPWPEVHGMAESIAVRLLQRDRLGAVGLVGEPTVELIAA IQGAWLAGVAVSLLPRPRRGADPSEWAHSTLQRFGGIGVDTVLSHGGVLRTLAAADSAVSVCDLAQAART PTSTGLEYQDDSGVAILQGTAGSTGNPRTAVLSPAAVLSNMRGLIERLRLDGASDRACSWLPLYHDMGLA FLLTSVLSGMPLWQAPTGAFSAAPLRWAEWLSDSQATFTAGPNFGYSMIGRYAGRVRDVDLGALRIAING GEPVDCEGFQRFAMAMAPFGFRASAATPAYGMAEATCAVTMPSCGEGLQIDERTESGVPQRYALLGRPIA GMQLRIAATDEPSGEGVGEVEIHGSSMMTGYLGDTTGRSDGDWFPTGDIGYLVDGALVICGRSKEVITVA GRNIFPTEIEQVAAQVDGVRHGGVVAVGSKSGAAQSRLLIAAEFVGADRDVTRSAVIKRVISVCGVTPAD VVLMPPGSLPRTSSGKLRRLEVRRQLLG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0030 | - | - | 100% (518) | acyl-CoA synthetase |
| M. avium 104 | MAV_2874 | - | e-170 | 60.08% (521) | acyl-CoA synthetase |
| M. avium 104 | MAV_1150 | - | 1e-67 | 33.33% (507) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1380 | fadD33 | 1e-171 | 59.23% (520) | long-chain-fatty-acid-- |
| M. gilvum PYR-GCK | Mflv_4411 | - | 1e-160 | 55.92% (524) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv1345 | fadD33 | 1e-171 | 59.23% (520) | long-chain-fatty-acid-- |
| M. leprae Br4923 | MLBr_00243 | - | 3e-67 | 34.12% (510) | long-chain-fatty-acid--CoA ligase |
| M. abscessus ATCC 19977 | MAB_1692 | - | 3e-72 | 34.77% (512) | acyl-CoA synthetase |
| M. marinum M | MMAR_0174 | pks16_1 | 4e-74 | 33.79% (515) | polyketide synthase Pks16_1 |
| M. smegmatis MC2 155 | MSMEG_2131 | - | 1e-160 | 57.25% (524) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_3540 | - | 1e-162 | 57.92% (530) | PUTATIVE acyl-CoA synthase |
| M. ulcerans Agy99 | MUL_4922 | pks16_1 | 8e-74 | 33.59% (515) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_1945 | - | 1e-161 | 57.55% (523) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_2131|M.smegmatis_MC2_155 ----------MNVLSAALTEAMTTSSADLVVFE------PETRTWHRHPW
TH_3540|M.thermoresistible__bu ----------VTVLAQALADALTTAGADLVVLD------QETRSWSRHPW
Mb1380|M.bovis_AF2122/97 ----------MSELAAVLTRSMQASAGDLMVLD------RETSLWCRHPW
Rv1345|M.tuberculosis_H37Rv ----------MSELAAVLTRSMQASAGDLMVLD------RETSLWCRHPW
Mflv_4411|M.gilvum_PYR-GCK ----------MSVLATALSEAMTASTRDLVLLD------RASGQWVRHPW
Mvan_1945|M.vanbaalenii_PYR-1 ----------MSVLATAVSHAMTASLRELVLLD------RASGQWSRHPW
MAV_0030|M.avium_104 ----------MNVLAAAMRDAMTRSPHDLVVLD------KDSDTWRSCPW
MMAR_0174|M.marinum_M --------------MRRLCDSQGATQHGLTTAPVGADGRSHLDQLTNTPW
MUL_4922|M.ulcerans_Agy99 ----------MNTIMRRLCDSQGATQHGLTTAPVGADGRSHLDQLTNTPW
MAB_1692|M.abscessus_ATCC_1997 MSRLREDRPGSNPVIDRLLAGAGITGRGLTSAPIGPDGASQLDELSTTAW
MLBr_00243|M.leprae_Br4923 ----------MSKFTEKMFRNARESSKGIVTG--------EPHNPVRHTW
: : : .*
MSMEG_2131|M.smegmatis_MC2_155 GQVHLRAQNVAERIG---QDGSSAVGIVGEPTVEGVAAILGALLAGSAVS
TH_3540|M.thermoresistible__bu PEVYVRAENVADRVL---ADEATAVGLVGEPTVELISAIIGALLAGAAVS
Mb1380|M.bovis_AF2122/97 PEVHGLAESVAAWLLD--HDRPAAVGLVGEPTVELVAAIQGAWLAGAAVS
Rv1345|M.tuberculosis_H37Rv PEVHGLAESVAAWLLD--HDRPAAVGLVGEPTVELVAAIQGAWLAGAAVS
Mflv_4411|M.gilvum_PYR-GCK QELHTRAENIAEHIL---NDRDGAVGLVGEPTAELVSAIQGTWLAGRALA
Mvan_1945|M.vanbaalenii_PYR-1 QEVHARAENIAERVL---DGPDGAVGLVGEPTVEFVAAIQGAWLAGRAVS
MAV_0030|M.avium_104 PEVHGMAESIAVRLLQ--RDRLGAVGLVGEPTVELIAAIQGAWLAGVAVS
MMAR_0174|M.marinum_M SDIHHLGRRAAGALQRDGVTPGDVVAVLAGAPGEIAPLVQGAWMCGAAVT
MUL_4922|M.ulcerans_Agy99 SDIHHLGRRAAGALQRDGVTPGDVVAVLAGAPGEIAPLVQGAWMCGAAVT
MAB_1692|M.abscessus_ATCC_1997 ADVHRTGLRIAGALQAAGVRPGDAVAVLAGAPGEIAPLVQGIWFSGASVT
MLBr_00243|M.leprae_Br4923 GQVHERASRIAGGLAGVGVGHGDAVGVLVGVPVEIAPTAQGLWMRGASLT
::: . * : .*.:: . * . * : * :::
MSMEG_2131|M.smegmatis_MC2_155 ILPGLVRGADPDQWADSTLNRFANIGVTTVFSHGSYLEQLR-TRDSS--L
TH_3540|M.thermoresistible__bu VLPGPVRGADPRQWAQGTLKRFTGIGVRTVFSHGAQLELLRGVDDASGAP
Mb1380|M.bovis_AF2122/97 ILPGPVRGANDQRWADATLTRFLGIGVRTVLSQGSYLARLRSVDTAG--V
Rv1345|M.tuberculosis_H37Rv ILPGPVRGANDQRWADATLTRFLGIGVRTVLSQGSYLARLRSVDTAG--V
Mflv_4411|M.gilvum_PYR-GCK ILPGPIRGADEREWAAATAQRFAGIGVGQILTYGEHLELLR-PNVFG--I
Mvan_1945|M.vanbaalenii_PYR-1 ILPGPVRGADDRQWAMSTVERFAGIGVSQALSYGNHLELLG-ANGSR--L
MAV_0030|M.avium_104 LLPRPRRGADPSEWAHSTLQRFGGIGVDTVLSHGGVLRTLAAADSAV---
MMAR_0174|M.marinum_M MLHQPTHRSDLQAWAADTKKTLSMVGASTVVVGSPFQSAAQEFAKVG--L
MUL_4922|M.ulcerans_Agy99 MLHQPTHRSDLQAWAADTKKTLSMVGASTAVVGSPFQSAAQEFAKVG--L
MAB_1692|M.abscessus_ATCC_1997 MLHQPTHRSDMRLWVEDTGRALAAVGSSTVVVGDPFMAAASQFGAVA--A
MLBr_00243|M.leprae_Br4923 MLHQPTPRTDLAVWEEDTTTVIDMIEAKAVIISDPFMAVAPILEARG--V
:* :: * * : : . .
MSMEG_2131|M.smegmatis_MC2_155 VIHDDAEVAHAQRSTTLELG-APLGEFAVLQGTAGSTGTPRTAQLRPDAV
TH_3540|M.thermoresistible__bu AIHDVSTVAHDRRSTTLLPP-SEPNGIAILQGTAGSTGTPRTAALPAEAV
Mb1380|M.bovis_AF2122/97 TIGDLSTAAHTNRSATPVAS-EGP---AVLQGTAGSTGAPRTAILSPGAV
Rv1345|M.tuberculosis_H37Rv TIGDLSTAAHTNRSATPVAS-EGP---AVLQGTAGSTGAPRTAILSPGAV
Mflv_4411|M.gilvum_PYR-GCK TVHDLAVVGHAQRSTTLVSAPAAPGTPAVLQGTAGSTGTPRTALLSQDAV
Mvan_1945|M.vanbaalenii_PYR-1 QVHDVTAVGHTRRSTTLSPQAAPAGAPAVLQGTAGSTGTPRTALLSPEAV
MAV_0030|M.avium_104 SVCDLAQAARTPTSTGLEYQ--DDSGVAILQGTAGSTGNPRTAVLSPAAV
MMAR_0174|M.marinum_M RGLELSELLTADEGRIVVAE---EDSPAFLQLTSGSTGHPKAVSITYRNI
MUL_4922|M.ulcerans_Agy99 RGLELSELLTADEGRIVVAE---EDSPAFLQLTSGSTGHPKAVSITYRNI
MAB_1692|M.abscessus_ATCC_1997 QVLEMSALLDGPPGEIVQSD---QDAIAFLQLTSGSTGTPKAVSISYRNI
MLBr_00243|M.leprae_Br4923 KVVTVEQLLAADPVDPIETD---EDDLALMQLTSGSTGSPKAVQITHRNV
*.:* *:**** *::. : :
MSMEG_2131|M.smegmatis_MC2_155 LANLRGLAERVG-LAGSDIGCSWLPLYHDMGLT-FLLSAAVGGTETWQAP
TH_3540|M.thermoresistible__bu LANLRGLTTRTS-VTTDDVGCSWLPLYHDMGLS-FLLSGALVGAELWQAP
Mb1380|M.bovis_AF2122/97 LSNLRGLNQRVGTDAATDVGCSWLPLYHDMGLA-FVLSAALAGAPLWLAP
Rv1345|M.tuberculosis_H37Rv LSNLRGLNQRVGTDAATDVGCSWLPLYHDMGLA-FVLSAALAGAPLWLAP
Mflv_4411|M.gilvum_PYR-GCK KHNVAGMLRHTDVDPGRDRGLTWLPLYHDMGLT-FLLTGFMSGSEMWLAP
Mvan_1945|M.vanbaalenii_PYR-1 LNNVSALWQHTSTDPDRDVGMTWLPLYHDMGLT-FLLTGFLTGAEMWLAP
MAV_0030|M.avium_104 LSNMRGLIERLRLDGASDRACSWLPLYHDMGLA-FLLTSVLSGMPLWQAP
MMAR_0174|M.marinum_M EANGRALMAAASADVASDVVVSWLPLFHDMGMMGLLIIPMYEGMDAVHIT
MUL_4922|M.ulcerans_Agy99 EANGRALMAAASADVASDVVVSWLPLFHDMGMMGLLIIPMYEGMDAVHIT
MAB_1692|M.abscessus_ATCC_1997 EANLRAMVSASGADPETDVVVSWLPLFHDMGMMGFLIVPMCRAMSTVSVT
MLBr_00243|M.leprae_Br4923 YSNVEAMFIGVRYNVEKDVMISWLPCFHDMGMIGFLTVPMYFGAELVKVT
* .: * :*** :****: :: . .
MSMEG_2131|M.smegmatis_MC2_155 TTAFASAPFSWVHWLTESRATLTAAPNMAYGLIGKYSRR---LTDVDLSA
TH_3540|M.thermoresistible__bu TTAFAASPFSWLHWLTASRATMTAAPNMAYGLIGKYSRR---VTDVDLGR
Mb1380|M.bovis_AF2122/97 TTAFTASPFRWLSWLSDSGATMTAAPNFAYNLIGKYARR---VSEVDLGA
Rv1345|M.tuberculosis_H37Rv TTAFTASPFRWLSWLSDSGATMTAAPNFAYNLIGKYARR---VSEVDLGA
Mflv_4411|M.gilvum_PYR-GCK TASFAASPFRWLAWLSESRAGLTAAPNFAYSVIGKYARR---VPDVDLSN
Mvan_1945|M.vanbaalenii_PYR-1 TAAFAASPFRWLTWLSDSRASLTAAPNFAYSVIGRYARR---VSDVDLGR
MAV_0030|M.avium_104 TGAFSAAPLRWAEWLSDSQATFTAGPNFGYSMIGRYAGR---VRDVDLGA
MMAR_0174|M.marinum_M PADFLNDPLLWAELITKHRGSITAAPNFAYSLLARRLRR-AQDHAFDLSS
MUL_4922|M.ulcerans_Agy99 PADFLNDPLLWAELITKHRGSITAAPNFAYSLLARRLRR-AQDHAFDLSS
MAB_1692|M.abscessus_ATCC_1997 PMDFLGDPLLWAKLISTYRGSMTAGPNFAYSLLARRLRK-APDGAYDLSS
MLBr_00243|M.leprae_Br4923 PIDFLRDTLLWAKLIDKYKGTVICGPNFAYSLFTKRLRKQAKPGQFDLST
. * .: * : . . ..**:.*.:: : : **.
MSMEG_2131|M.smegmatis_MC2_155 MRFALNGGEPVDIDGTARFGTELSRFGFDPGALSPSYGLAESSCAVTVPV
TH_3540|M.thermoresistible__bu LRFALNGGEPVDCDATTRFATEMARFGFDAAALCPSYGLAESTCAVTVPI
Mb1380|M.bovis_AF2122/97 LRVTLNGGEPVDCDGLTRFAEAMAPFGFDAGAVLPSYGLAESTCAVTVPV
Rv1345|M.tuberculosis_H37Rv LRVTLNGGEPVDCDGLTRFAEAMAPFGFDAGAVLPSYGLAESTCAVTVPV
Mflv_4411|M.gilvum_PYR-GCK LRFALNGGEPVDCDGFELFLRELSRFGLDPGVAAPSYGLAESTCAVTSPR
Mvan_1945|M.vanbaalenii_PYR-1 LRFAINGGEPVDCEGFQLFLDELARFGLDPRAAAPSYGLAESTCAVTTPE
MAV_0030|M.avium_104 LRIAINGGEPVDCEGFQRFAMAMAPFGFRASAATPAYGMAEATCAVTMPS
MMAR_0174|M.marinum_M LRFALNGAEGIDVATLERLATEGARFGLRRDAIVPAYGMAEATLAISVVR
MUL_4922|M.ulcerans_Agy99 LRFALNGAEGIDVATLERLATEGARFGLRRDAIVPAYGMAEATLAISVVR
MAB_1692|M.abscessus_ATCC_1997 LQFALSGAEAIDVATLERFVAEGARFGMRADAVVPAYGMAEATLAVSFVR
MLBr_00243|M.leprae_Br4923 LRIAMSGAEPVDPADVEDLIDAGRPFGFRPEAILPAYGMAETTLAVSFSP
::.::.*.* :* : **: . *:**:**:: *::
MSMEG_2131|M.smegmatis_MC2_155 PGVGLKVDEITVTTEAGSSTQKLAV---------LGHAIAGMEVRLQPG-
TH_3540|M.thermoresistible__bu PGAGLQIDEVEVVTEAGTATRRHAV---------LGEAIPGMQVRIAPRP
Mb1380|M.bovis_AF2122/97 PGIGLLADRVID----GSGAHKHAV---------LGNPIPGMEVRISCG-
Rv1345|M.tuberculosis_H37Rv PGIGLLADRVID----GSGAHKHAV---------LGNPIPGMEVRISCG-
Mflv_4411|M.gilvum_PYR-GCK PGTGLLVDDITDP--DTGTPRRHAV---------LGEPIPGMELRIAPS-
Mvan_1945|M.vanbaalenii_PYR-1 PGTGLVVESITDP--ATDAVQRHAV---------LGRPIPGMDVRISES-
MAV_0030|M.avium_104 CGEGLQIDERTES----GVPQRYAL---------LGRPIAGMQLRIAAT-
MMAR_0174|M.marinum_M PGEGFRVCPPHPDLVAAQGEAAAPR-------VMLGPPVPGCDVRVVSE-
MUL_4922|M.ulcerans_Agy99 PGEGFRVCPPHPDLVAAQGEAAAPR-------VMLGPPVPGCDVRVVSE-
MAB_1692|M.abscessus_ATCC_1997 RGEGYRVCPPHPDLVAAQGTQASAR-------VPLGLPLPGCEVRVVTE-
MLBr_00243|M.leprae_Br4923 VGEGLLVDEVDADLLAALRRAVPATKGNIRRLVSLGPLLDGLEVRIVDE-
* * . ** : * ::*:
MSMEG_2131|M.smegmatis_MC2_155 DEDAGVVDREVGEVEIRGTSMMSGYR---GEAP-LDPGEWFPTGDLGYLT
TH_3540|M.thermoresistible__bu DQQVGITGREVGEVQIRGSSMMSGYL---GEPP-IDREAWFPTGDLGYFV
Mb1380|M.bovis_AF2122/97 DQAAGNASREIGEIEIRGASMMAGYL---GQQP-IDPDDWFATGDLGYLG
Rv1345|M.tuberculosis_H37Rv DQAAGNASREIGEIEIRGASMMAGYL---GQQP-IDPDDWFATGDLGYLG
Mflv_4411|M.gilvum_PYR-GCK EG-RRSGEREIGEVEIRGTSMMSGYL---GEEP-LAPGQWFPTGDLGYLT
Mvan_1945|M.vanbaalenii_PYR-1 EHSRKVGDHTIGELEIRGTSMMSGYL---GQDP-LEPGEWFRTGDLGYLT
MAV_0030|M.avium_104 DEPSGEG---VGEVEIHGSSMMTGYL---GDTTGRSDGDWFPTGDIGYLV
MMAR_0174|M.marinum_M -DRTVLAPSEIGELEIRGDNVTAGYRTEAGFEPAVDAGGWLATGDVGYLT
MUL_4922|M.ulcerans_Agy99 -DRTVLAPSEIGELEIRGDNVTAGYRTEAGFEPAVDAGGWLATGDVGYLA
MAB_1692|M.abscessus_ATCC_1997 -DRQVLAPESIGELEIRGDNVTAGYRTASGFESMLDAQGWLSTGDIGYLT
MLBr_00243|M.leprae_Br4923 -DGNVLPSRGVGVIELRGESLTPGYITMGGFISAQDEHGWYDTGDLGYQM
:* ::::* .: .** * . * ***:**
MSMEG_2131|M.smegmatis_MC2_155 DDG-LVICGRKKELITVAGRNIFPTEIERIAARVKGVREGAVVAVGTNER
TH_3540|M.thermoresistible__bu DGG-LVVCGRAKEMITVAGRNVFPTEIEQVAGQVPGVREGAVVAVGTNEN
Mb1380|M.bovis_AF2122/97 AGG-LVVCGRAKEVISIAGRNIFPTEVELVAAQVRGVREGAVVALGTGDR
Rv1345|M.tuberculosis_H37Rv AGG-LVVCGRAKEVISIAGRNIFPTEVELVAAQVRGVREGAVVALGTGDR
Mflv_4411|M.gilvum_PYR-GCK DAG-LVVCGRVKELITIAGRNIFPTEVERVAAEVRGVREGAVVAVGTDSG
Mvan_1945|M.vanbaalenii_PYR-1 DDG-LVVCGRVKELITVAGRNIFPSEVERVAAQVRGVREGAVVAVGTDGN
MAV_0030|M.avium_104 DGA-LVICGRSKEVITVAGRNIFPTEIEQVAAQVDGVRHGGVVAVGSKSG
MMAR_0174|M.marinum_M ENGQPVICGRKKDILIISGRNVHPEDIERSVVGIAGIRSGGVAAVRLATA
MUL_4922|M.ulcerans_Agy99 ENGQPVICGRKKDILIISGRNVHPEDIERSVVGIAGIRSGGVAAVRLATA
MAB_1692|M.abscessus_ATCC_1997 ADGQPVICGRKKDILIISGRNVHPEDIERSVAGISGVRSGGVAAVRLHTA
MLBr_00243|M.leprae_Br4923 ENGHIVVCGRVKDVIIMAGRNVYPTDIERAAGRVDGVRPGCAVAVRLDAG
. *:*** *::: ::***:.* ::* . : *:* * ..*:
MSMEG_2131|M.smegmatis_MC2_155 AVRPGLVIAAEFRGPDEAG----ARSEVVQRVASECGVVPADVVFLAPGS
TH_3540|M.thermoresistible__bu SVRPGLVIVAEYRGRDEAG----ARSQVVQRVASECGVVPTDVLLRPPGS
Mb1380|M.bovis_AF2122/97 STRPGLVVAAEFRGPDEAN----ARAELIQRVASECGIVPSDVVFVSPGS
Rv1345|M.tuberculosis_H37Rv STRPGLVVAAEFRGPDEAN----ARAELIQRVASECGIVPSDVVFVSPGS
Mflv_4411|M.gilvum_PYR-GCK SARQGLVIAAEFRGADESG----AKSEVVQRVASQCGVVPSEVVFLKPGS
Mvan_1945|M.vanbaalenii_PYR-1 SARQGLIVAAEFRGPDEAG----ARSEVVQRVASQCGVVPADVVFLAPGS
MAV_0030|M.avium_104 AAQSRLLIAAEFVGADRDV----TRSAVIKRVISVCGVTPADVVLMPPGS
MMAR_0174|M.marinum_M SASEGFVMVAESALHADDAESNRIRTEVADRVFVNLGVSPRAVHVVPAGW
MUL_4922|M.ulcerans_Agy99 SASEGFVMVAESALHADDAESNRIRTEVADRVFVNLGVSPRAVHVVPAGW
MAB_1692|M.abscessus_ATCC_1997 SAGEGFAMVAESALHADIAESERIRAEVADRVYRTLGVSPRDVHVVPAGW
MLBr_00243|M.leprae_Br4923 HSRETFAVAVESNAFEDTAEVRRIEHQVAHEVLKEVDVRPRNVVVLGPGT
: :..* . : ..* .: * * . .*
MSMEG_2131|M.smegmatis_MC2_155 LPRTSSGKLRRLEVKRQLEESKG---
TH_3540|M.thermoresistible__bu LPRTSSGKLRRLEVKRNLEGVGR---
Mb1380|M.bovis_AF2122/97 LPRTSSGKLRRLAVRRSLEMAD----
Rv1345|M.tuberculosis_H37Rv LPRTSSGKLRRLAVRRSLEMAD----
Mflv_4411|M.gilvum_PYR-GCK LPRTSSGKLRRLAVKNDLDGLRAPVS
Mvan_1945|M.vanbaalenii_PYR-1 LPRTSSGKLRRLEVKQNLEAARV---
MAV_0030|M.avium_104 LPRTSSGKLRRLEVRRQLLG------
MMAR_0174|M.marinum_M LPKTSSGKLRRRQTSERLRLFDDAL-
MUL_4922|M.ulcerans_Agy99 LPKTSSGKLRRRQTSERLRLFDDAL-
MAB_1692|M.abscessus_ATCC_1997 IPKTSSGKLRRRATSERLKRCEPAR-
MLBr_00243|M.leprae_Br4923 IPKTPSGKLRR-ASSVTLVT------
:*:*.****** *