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PNPFEVDGRGPSGNQLLTLAVVTLVAIVALTGAMLLKSAGRLNDYVRVVADLTNVGDGLPQKSDVKYHGV LVGEVDDVTPATGSEPNFVYINLKPEYAKTIPSSATARVVPSNVFAVSSVQLVDRGPGAPIRDGAHIAED HELPTVLFQTTVSKLRDLLNATGRGRDDNSVGILAAVGAATDSRRAKLLAGGAQLNRLINELNAIVATDT GPSTVSALLNATEGLKQSAPDLLDSLHQAVRPMQTLAEKREQLTALVHAGLTTVGTNKQAFDNHTDQLIG ITTGLTPPIGVFAKNADKFVPIFRNINKLSRNWFEHMWMADRDVPNMPIAVTLAPSYTYTRADCPRYGDV KGPSCFTAPEQVVRPDLPETLLPQNYKPPADLAPPAGTVIGPNGNLVAVGPPRVVPPGGPNLIDPNPPLP PWQPYPMPRVPGTSDPDDLEPPPPPATPPIPPAPVAPGGINGAGRPAVAPASYGGNVGPVGSRGERDQLR VIAGGSATPATQLLLGPVARGSAVSFVKEGPS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4516c | - | - | 100% (523) | putative Mce family protein |
| M. abscessus ATCC 19977 | MAB_1010c | - | 0.0 | 76.46% (497) | putative MCE family protein |
| M. abscessus ATCC 19977 | MAB_4568c | - | 0.0 | 62.31% (520) | putative Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3524c | mce4F | 5e-11 | 25.05% (543) | MCE-family protein MCE4F |
| M. gilvum PYR-GCK | Mflv_0010 | - | 1e-178 | 59.19% (544) | hypothetical protein Mflv_0010 |
| M. tuberculosis H37Rv | Rv3494c | mce4F | 5e-11 | 25.05% (543) | MCE-family protein MCE4F |
| M. leprae Br4923 | MLBr_02395 | Ag36 | 8e-06 | 34.44% (90) | proline rich antigenic protein |
| M. marinum M | MMAR_3864 | mce5A | 1e-179 | 60.76% (525) | Mce protein, Mce5A |
| M. avium 104 | MAV_0102 | - | 0.0 | 65.96% (520) | mce related protein |
| M. smegmatis MC2 155 | MSMEG_1143 | - | 1e-173 | 59.81% (530) | mce related protein |
| M. thermoresistible (build 8) | TH_2386 | - | 1e-164 | 60.38% (477) | mce related protein |
| M. ulcerans Agy99 | MUL_3796 | mce5A | 1e-177 | 60.38% (525) | Mce protein, Mce5A |
| M. vanbaalenii PYR-1 | Mvan_0959 | - | 0.0 | 62.43% (527) | hypothetical protein Mvan_0959 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3524c|M.bovis_AF2122/97 --------MIDRLAKIQLSIFAVITVITLSVMAIFYLRLPATFGIGTYGV
Rv3494c|M.tuberculosis_H37Rv --------MIDRLAKIQLSIFAVITVITLSVMAIFYLRLPATFGIGTYGV
MMAR_3864|M.marinum_M MPNSIESDGRGPSDRQLIGIGLVVVLLAAVLTIALLVKSTGRLNDYVRVT
MUL_3796|M.ulcerans_Agy99 MPNSIESDGCGPSDRQLIGIGLVVVLLAAVLTIALLVKSTGRLNDYVRVT
MAV_0102|M.avium_104 MANSLDFDGRGPTDHQLLALGATVLLIAGLITGGLLLKSTGRLNDYIRVV
Mflv_0010|M.gilvum_PYR-GCK MANSFEFDGRGPSDRQLLVCGVAVLAIVSIVTAVLLVKSTGRLDPRVRVV
Mvan_0959|M.vanbaalenii_PYR-1 MANSLEMDGRGPTDRQLLACGVALLVIALVVSGALLVKSTGRMDAHVRVV
MSMEG_1143|M.smegmatis_MC2_155 MGNSIELDGRGPSERQLLACGLAVLVVAGLISTVLLVKATGRLDPYVRVV
TH_2386|M.thermoresistible__bu MANSFDLDGRGPTDRQLLAGGVVVIVVLSVISTYLLVKATGRLDPFVRVV
MAB_4516c|M.abscessus_ATCC_199 MPNPFEVDGRGPSGNQLLTLAVVTLVAIVALTGAMLLKSAGRLNDYVRVV
MLBr_02395|M.leprae_Br4923 -----------------------------------MTDQPPPSGSNPTPA
. . .
Mb3524c|M.bovis_AF2122/97 SADFVAGGGLYKNANVTYRGVAVGRVESVG----LNPNGVTAHMRLNSGT
Rv3494c|M.tuberculosis_H37Rv SADFVAGGGLYKNANVTYRGVAVGRVESVG----LNPNGVTAHMRLNSGT
MMAR_3864|M.marinum_M ADLRNVGDGLPKRSDVKYHGVLVGMVDGVAPAANGRPNYVHINLKPEYAA
MUL_3796|M.ulcerans_Agy99 ADLRNVGDGLPKRSDVKYHGVLVGMVDGVAPAANGRPNYVHINLKPEYAA
MAV_0102|M.avium_104 AELTNVGDGLPARSDVKYHGLLVGAVDNVIPAAYGKPNYVHINLKPEYAQ
Mflv_0010|M.gilvum_PYR-GCK AAMVNVGDGLPQRSDVKYHGVLVGAVDDVTPAENGEPNFVHIDLKPEYAK
Mvan_0959|M.vanbaalenii_PYR-1 AALVNVGDGLPQRSDVKYHGVLVGAVDDVTPAQYGDPNFVHIDLKPEYAA
MSMEG_1143|M.smegmatis_MC2_155 AALINVGDGLPQRSDVKYHGVLVGMVEDVTPAAHGEPNYVHINLNPEYAS
TH_2386|M.thermoresistible__bu ADLVNVGDGLPQRSDVKYHGVLVGHVDSVTPAAHGHPNYVHINLDRHHAR
MAB_4516c|M.abscessus_ATCC_199 ADLTNVGDGLPQKSDVKYHGVLVGEVDDVTPATGSEPNFVYINLKPEYAK
MLBr_02395|M.leprae_Br4923 PPPPGSSGGY-------------------------EPSFAPSELGSAYPP
. ..* *. . .:
Mb3524c|M.bovis_AF2122/97 AIPSNVTATVRSVSAIGEQYIDLVPP--ENPSSTKLRNGFRIQRQNTRIG
Rv3494c|M.tuberculosis_H37Rv AIPSNVTATVRSVSAIGEQYIDLVPP--ENPSSTKLRNGFRIQRQNTRIG
MMAR_3864|M.marinum_M SIPAAVTARVVPSSVFAVSSVQLIDAPAPRGRQPAIRAGTHIPEDSRLPT
MUL_3796|M.ulcerans_Agy99 SIPAAVTARVVPSSVFAVSSVQLIDAPAPRGRQPAIRAGTHIPEDSRLPT
MAV_0102|M.avium_104 DIPSAVTARVVPSNVFAVSSVQLVDG-APG---PSIRNGARIPEDLQLST
Mflv_0010|M.gilvum_PYR-GCK SIPANVTARVVPSNVFAVSSVQLVG---SGGP--PIQPGAEIPEDTELPT
Mvan_0959|M.vanbaalenii_PYR-1 SIPAGVTARVVPSNVFAVSSVQLVDR--SGGP--PIQSGARIPEDTELPT
MSMEG_1143|M.smegmatis_MC2_155 SIPSTVTARVVPSNVFAVSSVQLVDR--DGGAGPAISAGAQIPEDTELPT
TH_2386|M.thermoresistible__bu SIPATVTARVVPSNVFAVSSVQLVDR--DGGPGTPIQAGAHIPEDTELPT
MAB_4516c|M.abscessus_ATCC_199 TIPSSATARVVPSNVFAVSSVQLVDR----GPGAPIRDGAHIAEDHELPT
MLBr_02395|M.leprae_Br4923 PTAPPVGGSYPPPPPPGGSYPPPPPP-----------GGSYPPPPPSTGA
.. . . . . . *
Mb3524c|M.bovis_AF2122/97 QDVADLLRQAETLLGSLGDTRLRELLHEAFIATNGAGPELARLIESARLL
Rv3494c|M.tuberculosis_H37Rv QDVADLLRQAETLLGSLGDTRLRELLHEAFIATNGAGPELARLIESARLL
MMAR_3864|M.marinum_M VLFQTTLSKLRDLLAAAGRGREDNSLGILAAIAAATDHRRASLLSGG---
MUL_3796|M.ulcerans_Agy99 VLFQTTVSKLRDLLAAAGRGREDNSLGILAAIAAATDHRRASLLSGG---
MAV_0102|M.avium_104 VIFQTTISKLRDILAATGRGREDHSVGILAAVAAATNNRRGPLLTAG---
Mflv_0010|M.gilvum_PYR-GCK VLFQTTISKLRDILAATGRGREDDTVGILAAVHAATEDRRTELLTSG---
Mvan_0959|M.vanbaalenii_PYR-1 VLFQTTISKLRDILAATGRGREDDTVGILAAVNAATEDRRTELLTSG---
MSMEG_1143|M.smegmatis_MC2_155 VLFQTTISKLRDILAATGRGREDRTVGVLAAVNAATEGRRTELLTSG---
TH_2386|M.thermoresistible__bu VLFQTTISKLRDILAATGRGREDRTVGILAAVNAATENRRTELLSAG---
MAB_4516c|M.abscessus_ATCC_199 VLFQTTVSKLRDLLNATGRGRDDNSVGILAAVGAATDSRRAKLLAGG---
MLBr_02395|M.leprae_Br4923 YAPPPPGPAIRSLPKEAYTFWVTRVLAYVIDNIPAT--------------
. : : .:
Mb3524c|M.bovis_AF2122/97 VDEANANYPQVSQLIDQAGPFLQAQIRAGGDIKSLADGLARFTWQLRAAD
Rv3494c|M.tuberculosis_H37Rv VDEANANYPQVSQLIDQAGPFLQAQIRAGGDIKSLADGLARFTWQLRAAD
MMAR_3864|M.marinum_M --------AQLNRLLDQLNSIVATDS-EPSTVAALID----ATRGLQASA
MUL_3796|M.ulcerans_Agy99 --------AQLNRLLDQLNSIVATDS-EPSTVAALID----ATRGLQASA
MAV_0102|M.avium_104 --------AQLTRVLDELNAIVATDP-GPSTVSALLD----ATRGLQSTA
Mflv_0010|M.gilvum_PYR-GCK --------AQLNRMVDELDRIVATEP-GPTTVSALVD----ATRGLQQTA
Mvan_0959|M.vanbaalenii_PYR-1 --------AQLNSLVDELDRIVATDP-GPTTVSALVD----ATRGLQQTA
MSMEG_1143|M.smegmatis_MC2_155 --------AQLNRLIDEVDSIVATDPSAPTTVSTLIE----ATRGLQQTA
TH_2386|M.thermoresistible__bu --------AQLDLLIDEIDSIVATDP-GPTTVSALIG----ATRGLQQTA
MAB_4516c|M.abscessus_ATCC_199 --------AQLNRLINELNAIVATDT-GPSTVSALLN----ATEGLKQSA
MLBr_02395|M.leprae_Br4923 -------------VLLGIGMLIQTLTKQEACVTDITQYN---VNQYCATQ
:: . :: : : : . :
Mb3524c|M.bovis_AF2122/97 PRLRDTLAGAPDAIDEANTAFSGIRPSFPALAASLANLGRVGVIYHKSIE
Rv3494c|M.tuberculosis_H37Rv PRLRDTLADAPDAIDEANTAFSGIRPSFPALAASLANLGRVGVIYHKSIE
MMAR_3864|M.marinum_M PELVEALHQAVEPMKTFAETRAQLA---ALLAGADHTIGTAQQSLGNHID
MUL_3796|M.ulcerans_Agy99 PELVEALHQAVEPMKTFAETRAQLA---ALLAGADHTIGTAQQSLGNHID
MAV_0102|M.avium_104 PDLVDVLHDAVRPMQTLVEKREQFR---SLVTGSYHTFSVNRQAFDNHTD
Mflv_0010|M.gilvum_PYR-GCK PELVDALHQAVQPMQTLVEQSAQLT---SLVNGGIRTSETTRTAFDNHAD
Mvan_0959|M.vanbaalenii_PYR-1 PELVDALHQAVEPMQTLVEQSAQLT---TFINGGINTVGTTHTALNNHTD
MSMEG_1143|M.smegmatis_MC2_155 PELVDALHTAVRPMQTLVEQRSQLD---SLISAGMNTLDTTRTALNNHTD
TH_2386|M.thermoresistible__bu PELLDALHQAVQPMQTLVQQRAQLD---ALIGGALHTSATTHTALTNHTD
MAB_4516c|M.abscessus_ATCC_199 PDLLDSLHQAVRPMQTLAEKREQLT---ALVHAGLTTVGTNKQAFDNHTD
MLBr_02395|M.leprae_Br4923 PTGIGMLAFWFAWLMATAYLVWNYG----------YRQGATGSSIGKTVM
* * : :
Mb3524c|M.bovis_AF2122/97 QLLVVFPALFAAIITSAGGVPQDEGAKLDFKIDLHDPPPCMTGFLPPPLV
Rv3494c|M.tuberculosis_H37Rv QLLVVFPALFAAIITSAGGVPQDEGAKLDFKIDLHDPPPCMTGFLPPPLV
MMAR_3864|M.marinum_M QLIQITTDFTPVLGVLAQ--QSDNFLPAVIKLDNLATKFMDEVWMPENNT
MUL_3796|M.ulcerans_Agy99 QLIQITTDFTPVLGVLAQ--QSDNFLPAVIKLDNLATKFMDEVWMPENNT
MAV_0102|M.avium_104 QLIEMTQNLTPVLGVFAM--NSDKFVPIFTRLNRLSDKFFQEVWDPELDT
Mflv_0010|M.gilvum_PYR-GCK RLVRITTELTPVVGSLAD--TSRHWVPAFVKLNELSRKFFDEVWIHEHDI
Mvan_0959|M.vanbaalenii_PYR-1 RMVRITTELTPVIGNLAQ--TSHHWVPAFVKLNGLSRKFFDEVWMHDRDV
MSMEG_1143|M.smegmatis_MC2_155 RLVKITSELTPVVGNLAD--TSHHWLPAFVKLNNLSDKFFDEVWRPERNV
TH_2386|M.thermoresistible__bu RMVTITTEMTPVIGNLAD--TSHHWLPAFIKMNGLSDKFFEEVWRPERDI
MAB_4516c|M.abscessus_ATCC_199 QLIGITTGLTPPIGVFAK--NADKFVPIFRNINKLSRNWFEHMWMADRDV
MLBr_02395|M.leprae_Br4923 KFKVISEATGQPIGFGMS---VVRQLAHFVDAVICCIGFLFPLWDSKRQT
:: : : . :
Mb3524c|M.bovis_AF2122/97 RSPADESVREIPRDMYCKTAQNDPSTVRGARNYPCQEFPGKRAPTVQLCR
Rv3494c|M.tuberculosis_H37Rv RSPADESVREIPRDMYCKTAQNDPSTVRGARNYPCQEFPGKRAPTVQLCR
MMAR_3864|M.marinum_M GN-MRVNLSFTPSHSYTRADCPRYGELKGPSCFTAPLVPVR--PDLPEVL
MUL_3796|M.ulcerans_Agy99 GN-MRVNLSFTPSHSYTRADCPRYGELKGPSCFTAPLVPVR--PDLPDVL
MAV_0102|M.avium_104 GN-MRVNLALTPTYTYTRADCPRYGQLQGPSCFTAPTIAVR--PDLPEVL
Mflv_0010|M.gilvum_PYR-GCK GN-MRINLSFTPTYSYTRADCPQYAGLKGPSCYTAPLVPTR--AALPDVL
Mvan_0959|M.vanbaalenii_PYR-1 GN-MRVNLSFTPTYSYTRADCPQYGELKGPSCFTAPLVPTR--PELPDVL
MSMEG_1143|M.smegmatis_MC2_155 GN-MRMNLSFTPSYTYTRADCPQYGELKGPSCFTAPLVVTR--PALPDQM
TH_2386|M.thermoresistible__bu GN-MRMNLSLTPSYTYTRADCPRYGELKGPSCYTAPLVVTR--PSLPDVL
MAB_4516c|M.abscessus_ATCC_199 PN-MPIAVTLAPSYTYTRADCPRYGDVKGPSCFTAPEQVVR--PDLPETL
MLBr_02395|M.leprae_Br4923 LADKIMTTVCLPI-------------------------------------
*
Mb3524c|M.bovis_AF2122/97 DPRGYVPVGTNPWRGPPIPYGTEVTDGRNILPPNKFPYIPPGADP--DPG
Rv3494c|M.tuberculosis_H37Rv DPRGYVPVGTNPWRGPPIPYGTEVTDGRNILPPNKFPYIPPGADP--DPG
MMAR_3864|M.marinum_M LPQNYQPP-----KDLAPPPGTAVGPDGNLVALG-----PPLINP--SPN
MUL_3796|M.ulcerans_Agy99 LPQNYQPP-----KDLAPPPGTAVGPDGNLVALG-----PPLINP--SPN
MAV_0102|M.avium_104 LPQNYHPP-----TDLAPPPGTQIGPDGNLVATG-----PPLYNP--DPS
Mflv_0010|M.gilvum_PYR-GCK LPQNYQPP-----KDLQPPPGTEIGPSGNLIAVG-----PPLVNP--NPS
Mvan_0959|M.vanbaalenii_PYR-1 LPQNYQPP-----ADLKPPPGTEVGPNGNLVAVG-----PPLVNP--NPD
MSMEG_1143|M.smegmatis_MC2_155 LPRNYQPP-----KDLAPPPGTVVGENGNLVAVG-----PPLINP--NPS
TH_2386|M.thermoresistible__bu LPQNYQPP-----KDLAPPPGTIVGENGNLVAVG-----PPLVNP--NPN
MAB_4516c|M.abscessus_ATCC_199 LPQNYKPP-----ADLAPPAGTVIGPNGNLVAVG-----PPRVVPPGGPN
MLBr_02395|M.leprae_Br4923 --------------------------------------------------
Mb3524c|M.bovis_AF2122/97 VPIVGPPPPGQVAGPGPAPHQPAQPAPPPNDNGPPPPFTSWMPPGYPPEP
Rv3494c|M.tuberculosis_H37Rv VPIVGPPPPGQVAGPGPAPHQPAQPAPPPNDNGPPPPFTSWMPPGYPPEP
MMAR_3864|M.marinum_M LTDPNPPLPAW---LTPSPRVPGTGDPD-DAPPAPP-----------APP
MUL_3796|M.ulcerans_Agy99 LTDPNPPLPAW---LTPSPRVPGTGDPD-DAPPAPP-----------APP
MAV_0102|M.avium_104 LADPNPPLPWWPWQIGPAPRVPGTADPD-DAPPPPPPS----PPPSPAPP
Mflv_0010|M.gilvum_PYR-GCK LADPNPPLPPW---MPPSPPVPLTANPA-LVPPPQLPAPLSPPAPVAPKP
Mvan_0959|M.vanbaalenii_PYR-1 LRDPNPPLPPW---LSPSPPVPGTANPA-LVPVPQPPVPLSPPAPVAPKP
MSMEG_1143|M.smegmatis_MC2_155 LADPNPPLPPW---MAPAPPVPGTANSA-LPVTPPPGVNQSPLAPVAPKP
TH_2386|M.thermoresistible__bu LADPNPPLPPG---MFPAPPVPGTSNPD-LVPIPPPPVNLSPLAPVAPNP
MAB_4516c|M.abscessus_ATCC_199 LIDPNPPLPPWQP--YPMPRVPGTSDPDDLEPPPPPATPPIPPAPVAPGG
MLBr_02395|M.leprae_Br4923 --------------------------------------------------
Mb3524c|M.bovis_AF2122/97 PQVPYPATIPPPPPPEGTGPPP-------------------GPAPGPQPQ
Rv3494c|M.tuberculosis_H37Rv PQVPYPATIPPPPPPEGTGPPP-------------------GPAPGPQPQ
MMAR_3864|M.marinum_M GAAAPS-----------------------------------AFGGNVGPV
MUL_3796|M.ulcerans_Agy99 GAAAPS-----------------------------------AFGGNVGPV
MAV_0102|M.avium_104 GPVAPA-----------------------------------AYGGNVGPV
Mflv_0010|M.gilvum_PYR-GCK GDPPPRPAAPAPAAPAPAPAAPAPAPAAPGPGSAEAPFAPASFGGNVGPV
Mvan_0959|M.vanbaalenii_PYR-1 GDPPPPPAAPPVSGPAPLPAEAAPA----------------GYGGNVGPV
MSMEG_1143|M.smegmatis_MC2_155 GSPPPPPPAPG-----PLPAEAAPA----------------SFGGNVGPV
TH_2386|M.thermoresistible__bu NKPRPPVPAPP-----PAP------------------------GG-----
MAB_4516c|M.abscessus_ATCC_199 INGAGRPAVAP-----------------------------ASYGGNVGPV
MLBr_02395|M.leprae_Br4923 --------------------------------------------------
Mb3524c|M.bovis_AF2122/97 ASGPAYTIYDQLSG-AFADPAGGTGIFAPGMTGASSAENWVDLMRDPRQL
Rv3494c|M.tuberculosis_H37Rv ASGPAYTIYDQLSG-AFADPAGGTGIFAPGMTGASSAENWVDLMRDPRQL
MMAR_3864|M.marinum_M GSRQERDALALITG--RPATVATELLLGPLARGTVVSLRNSGAGGEPR--
MUL_3796|M.ulcerans_Agy99 GSRQEGDALALITG--RPATVATELLLGPLARGTVVSLRNSGAGGEPR--
MAV_0102|M.avium_104 GSQRERDQLGLITGQGRPASVATQLLLGPVARGSAVSLQPRPAPGGPK--
Mflv_0010|M.gilvum_PYR-GCK GSQQEQRQLSLITG--RHATPATQLLLGPLARGTTVS-----IDGEP---
Mvan_0959|M.vanbaalenii_PYR-1 GSRHELDQLGYITG--QPATVATQLLLGPVARGTTVS-----EGVR----
MSMEG_1143|M.smegmatis_MC2_155 GSEQERVTLSVITG--QPASTATQLLLGPVARGTTVSLAEPTAGEEPR--
TH_2386|M.thermoresistible__bu -------------------------------------------GEEPR--
MAB_4516c|M.abscessus_ATCC_199 GSRGERDQLRVIAG--GSATPATQLLLGPVARGSAVS----FVKEGPS--
MLBr_02395|M.leprae_Br4923 --------------------------------------------------