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MQHRIKQRTHWAVTHGIGRAYLKVLARRGEPVAQLGIDVGQAPDIYRIIDKIRERGRLSRAGDGWITADA QIVRTIFRDNRFVTFKPEHRSASPIIQRLAAWSDPQLLNPAEPPSILITDPPDHGRLRRLVAAPFTPRAI EGLRDRIQEVTNGHLDVLQQRQSPDLIADFTAKIPIAVIGEMIAVPPPDYSRLYTAMNRAIQLIATTAPS WSEYQDGTAALREIDEYLEKHVARLRREGTESELATALLDSDLSHFELKMFFAVFLGAGFVTTTHLMGKA IVTLLRHPEQLALLQADPSLWPNAVEELMRYDTSNQWSARVATETVEIEGHTIEAGQSALLLLGGANRDP AAFENPDVFDITRPNARENITLGTGIHVCLGQVLARAELHTALQTLFERFPRLSLAGEPEYLNGMGIHGL RLLPVTLG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4457 | - | - | 100% (428) | putative cytochrome P450 |
| M. abscessus ATCC 19977 | MAB_4456 | - | e-103 | 47.02% (436) | putative cytochrome P450 |
| M. abscessus ATCC 19977 | MAB_0276 | - | 7e-40 | 32.88% (371) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1912c | cyp140 | 7e-67 | 35.25% (434) | cytochrome p450 140 CYP140 |
| M. gilvum PYR-GCK | Mflv_0288 | - | 3e-66 | 36.09% (435) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv1880c | cyp140 | 7e-67 | 35.25% (434) | cytochrome p450 140 CYP140 |
| M. leprae Br4923 | MLBr_02088 | - | 1e-43 | 32.84% (338) | putative cytochrome p450 |
| M. marinum M | MMAR_2768 | cyp140A5 | 5e-70 | 37.04% (432) | cytochrome P450 140A5 Cyp140A5 |
| M. avium 104 | MAV_2156 | - | 4e-95 | 42.96% (426) | P450 heme-thiolate protein |
| M. smegmatis MC2 155 | MSMEG_0681 | - | 9e-66 | 35.59% (413) | P450 heme-thiolate protein |
| M. thermoresistible (build 8) | TH_2999 | - | 1e-64 | 35.56% (419) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_2979 | cyp140A5 | 7e-70 | 37.33% (434) | cytochrome P450 140A5 Cyp140A5 |
| M. vanbaalenii PYR-1 | Mvan_5525 | - | 3e-89 | 44.15% (419) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_2156|M.avium_104 -MRVR--LGARWMAMHGLPRAYFAVQARR-----GDPLARLLRSGTTGED
Mvan_5525|M.vanbaalenii_PYR-1 -MRSRPAVWLRWATVHGVPRAFLTVRARR-----GEPLARLILG---RGD
MAB_4457|M.abscessus_ATCC_1997 -MQHRIKQRTHWAVTHGIGRAYLKVLARR-----GEPVAQLGIDVGQAPD
Mflv_0288|M.gilvum_PYR-GCK MAVHPLRQRIRWLALHGVIRGLSKLAARRS----GDPQARLIADPEARND
MSMEG_0681|M.smegmatis_MC2_155 ---------------------MATLGLRR-----GDPQARLIADPVVRAD
TH_2999|M.thermoresistible__bu ------------LSLHGVIRALTAYGARR-----GDPQARLIADPAVRAD
Mb1912c|M.bovis_AF2122/97 -----MKDKLHWLAMHGVIRGIAAIGIRR-----GDLQARLIADPAVATD
Rv1880c|M.tuberculosis_H37Rv -----MKDKLHWLAMHGVIRGIAAIGIRR-----GDLQARLIADPAVATD
MMAR_2768|M.marinum_M -----MKDKLHWFAMHGVIRGMANIGLRR-----GELEARLIADPAVAAN
MUL_2979|M.ulcerans_Agy99 -----MKDKLHWFAMHGVIRGMANIGLRR-----GELEARLIADPAVAAN
MLBr_02088|M.leprae_Br4923 -MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRAD
. .: . :
MAV_2156|M.avium_104 RYALMEQIRARGPLMRAPFVWASVDHAVCRQVLRDKRFGVTSPTEMELPR
Mvan_5525|M.vanbaalenii_PYR-1 RLALIEEIRAAGPLMRTPVVWATADYDVCRTVLRDNDFGVADPSETGLPD
MAB_4457|M.abscessus_ATCC_1997 IYRIIDKIRERGRLSRAGDGWITADAQIVRTIFRDNRFVTFKPEHRSASP
Mflv_0288|M.gilvum_PYR-GCK PAAFADEVRTGDPVVRCRAVLLTVDHQAANEILRSDDFRVSSLG-AGLPA
MSMEG_0681|M.smegmatis_MC2_155 PTTFADQMRKQGPVIRGRVVLLTFDHAVAFDLLRSDDFQVSQLG-ANLPK
TH_2999|M.thermoresistible__bu PAAFADELRGRGPLIRGRAALLTFDHGVANELLRSDDFRVSELG-GNLPA
Mb1912c|M.bovis_AF2122/97 PVPFYDEVRSHGALVRNRANYLTVDHRLAHDLLRSDDFRVVSFG-ENLPP
Rv1880c|M.tuberculosis_H37Rv PVPFYDEVRSHGALVRNRANYLTVDHRLAHDLLRSDDFRVVSFG-ENLPP
MMAR_2768|M.marinum_M PGPFHDELRRHGRMVRTRVNYLTVDYQLAHDVLRSDDFHTISFG-ENLPG
MUL_2979|M.ulcerans_Agy99 PGPFHDELRRHGRMVRTRVNYLTVDYQLAHDVLRSDDFHTISFG-ENLPG
MLBr_02088|M.leprae_Br4923 PFPVYRALIDYGPMQLP-----GMPLTVFSSFSDCDEALRHPLSASDRLK
. : . : . .
MAV_2156|M.avium_104 PVRALIARTDPGVANPVAPPAMVIVDPPDHTRYRQLVAQSFTPRAIEALN
Mvan_5525|M.vanbaalenii_PYR-1 ALLGLIRRVDPGLPNPVEPPAMLMTDPPQHTEYRKLVSRSFTPRSIAALD
MAB_4457|M.abscessus_ATCC_1997 IIQRLAAWSDPQLLNPAEPPSILITDPPDHGRLRRLVAAPFTPRAIEGLR
Mflv_0288|M.gilvum_PYR-GCK PLRWVNRKTHPGLLHPIEPPSLLSIEPPDHTRCRKLVSSVFTTRAVNALR
MSMEG_0681|M.smegmatis_MC2_155 PLRWIADKTNPGLLHPIEPPSLLSIEPPDHTRMRKLVSSVFTTRAVATLR
TH_2999|M.thermoresistible__bu PLRWVAAKADTGHLHPIQPPSLLSIEPPDHTRLRKLVSSVFTTRAVATLK
Mb1912c|M.bovis_AF2122/97 PLRWLERRTRGDQLHPLREPSLLAVEPPDHTRYRKTVSAVFTSRAVSALR
Rv1880c|M.tuberculosis_H37Rv PLRWLERRTRGDQLHPLREPSLLAVEPPDHTRYRKTVSAVFTSRAVSALR
MMAR_2768|M.marinum_M PLRWLERRTRDEQLHPLRPPSLLAVEPPDHTRYRKTVSAVFTSRAVAALR
MUL_2979|M.ulcerans_Agy99 PLRWLERRTRDEQLHPLRPPSLLAVEPPDHTRYRKTVSAVFTSRAVAALR
MLBr_02088|M.leprae_Br4923 ATLAQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALE
.* .::: :**:* . *: *: *:.: : *
MAV_2156|M.avium_104 TRVAQVTMELIERIAAT---PQPDLIADFATRLPVAIIAEILGMPPDSYP
Mvan_5525|M.vanbaalenii_PYR-1 TRIGELTAELLDDLGRR---REVDLIADYAAQLPAAVISRMLGVPDEDRA
MAB_4457|M.abscessus_ATCC_1997 DRIQEVTNGHLDVLQQR---QSPDLIADFTAKIPIAVIGEMIAVPPPDYS
Mflv_0288|M.gilvum_PYR-GCK DRVQLTADQLLDDLERE--SGVVDIVERYCSQLPVAVISDILGVPEQDRK
MSMEG_0681|M.smegmatis_MC2_155 ERVEQTAHELLDGLEAE--SGVVDIVERYCAQLPVAVIGDILGVPEPDRP
TH_2999|M.thermoresistible__bu ERLQQTAFDLLDGLDEVGASDVVDVIDRYCSQLPIAVISDILGVPDEDRD
Mb1912c|M.bovis_AF2122/97 DLVEQTAINLLDRFAEQ--PGIVDVVGRYCSQLPIVVISEILGVPEHDRP
Rv1880c|M.tuberculosis_H37Rv DLVEQTAINLLDRFAEQ--PGIVDVVGRYCSQLPIVVISEILGVPEHDRP
MMAR_2768|M.marinum_M DRVEQTANSLLDQLAQR--PGVVDVVGQYCSQLPIMVISEILGVPEQDRG
MUL_2979|M.ulcerans_Agy99 DRVEQTANSLLDQLAQR--PGVVDVVGQYCSQLPIMVISEILGVPEQDRG
MLBr_02088|M.leprae_Br4923 GDIAALVDSLLDKGAAAG---QFDVIADLAFPLAVAVICRLLGVPYEDAP
: . :: *:: :. :* ::.:* .
MAV_2156|M.avium_104 RMLAWGRSGSPLLDLGID-WKTYRDAIAGLRGVDEYLLAHFHQL----RA
Mvan_5525|M.vanbaalenii_PYR-1 RILGWGETGAALLDIGIG-WRPFRAAIDGLVDVDTHLGAHFRRL----HQ
MAB_4457|M.abscessus_ATCC_1997 RLYTAMNRAIQLIATTAPSWSEYQDGTAALREIDEYLEKHVARL----RR
Mflv_0288|M.gilvum_PYR-GCK HILHFGELGAPSLDIGLS-WRQFQQVEEGLVGFNAWLGDHLEAL----RR
MSMEG_0681|M.smegmatis_MC2_155 NILRYGELGAPSLDIGLS-WSQYQQVNEGIIGFETWLNRHLRTL----RR
TH_2999|M.thermoresistible__bu RILHFGELGAPSLDIGLS-WRQYRQVREGIVGFNTWLTAHLQRL----RR
Mb1912c|M.bovis_AF2122/97 RVLEFGELAAPSLDIGIP-WRQYLRVQQGIRGFDCWLEGHLQQL----RH
Rv1880c|M.tuberculosis_H37Rv RVLEFGELAAPSLDIGIP-WRQYLRVQQGIRGFDCWLEGHLQQL----RH
MMAR_2768|M.marinum_M RVLEYGELAAPSLDIGVP-YRQYRRIQQGITGFNSWLTAHLEQL----RR
MUL_2979|M.ulcerans_Agy99 RVLEYGELAAPSLDIGVT-YRQYRRIQQGITGFNSWLTAHLEQL----RR
MLBr_02088|M.leprae_Br4923 EFGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRG
.. : * :. * :
MAV_2156|M.avium_104 DPHSDNPFGRMAADG------SLTDRELTANAALIVGAGFETTVNLIGNG
Mvan_5525|M.vanbaalenii_PYR-1 NGADGTPFSSLALDG------SLSGRELISNAALLVGAGVETTVNLIGNG
MAB_4457|M.abscessus_ATCC_1997 E-GTESELATALLDS------DLSHFELKMFFAVFLGAGFVTTTHLMGKA
Mflv_0288|M.gilvum_PYR-GCK NPGDDLMSELILASAAADEAGRLSERELQATAGLVLAAGFETTVNLLGNG
MSMEG_0681|M.smegmatis_MC2_155 DPGDDLLSQIITASESGATGEPLTDRELKALAGLVLAAGFETTVNLLGNG
TH_2999|M.thermoresistible__bu DPGEDLLSQLIQAADAETT-----ERELEALAGLVLAAGFETTVNLLGNG
Mb1912c|M.bovis_AF2122/97 APGDDLMSQLIQIAESGDNETQLDETELRAIAGLVLVAGFETTVNLLGNG
Rv1880c|M.tuberculosis_H37Rv APGDDLMSQLIQIAESGDNETQLDETELRAIAGLVLVAGFETTVNLLGNG
MMAR_2768|M.marinum_M NPGDDLMSQLIRVAESGDAGTYLDESELRAVAGLVLVAGFETTVNLLGNG
MUL_2979|M.ulcerans_Agy99 NPGDDLMSQLIRVAESGDAGTYLDKSELRAIAGLVLVAGFETTVNLLGNG
MLBr_02088|M.leprae_Br4923 TPGEDLISRLIELDESGD---QLTEEEIIATCGLLLVAGHETTVNLIANA
*: .:.: ** **.:*:.:.
MAV_2156|M.avium_104 IVLLLRHPEQLALLHDNPDLWPSAVEEILRIASPVQMTARTPACDVDIAG
Mvan_5525|M.vanbaalenii_PYR-1 IAALLDHPDQLALLRDDPGLWPSAVEEILRYDSPVQMTARTAHRDTEIAG
MAB_4457|M.abscessus_ATCC_1997 IVTLLRHPEQLALLQADPSLWPNAVEELMRYDTSNQWSARVATETVEIEG
Mflv_0288|M.gilvum_PYR-GCK IRMLLDTPQHLETLAARPDLWPNTVEEILRLDSPVQMSARFARRDVEVAG
MSMEG_0681|M.smegmatis_MC2_155 IRMLLDHREHLETLAARPDVWPNAVEEILRLDSPVQMTARAAVRDVDVAG
TH_2999|M.thermoresistible__bu IRMLLDTPGHLDTLAARPELWPNAVEEILRLDPPVQMTARVARVDTDIAG
Mb1912c|M.bovis_AF2122/97 IRMLLDTPEHLATLRQHPELWPNTVEEILRLDSPVQLTARVACRDVEVAG
Rv1880c|M.tuberculosis_H37Rv IRMLLDTPEHLATLRQHPELWPNTVEEILRLDSPVQLTARVACRDVEVAG
MMAR_2768|M.marinum_M IRMLLDAPEQLETLRQRPELWPNAVEEILRLDSPVQLTARVARTDVEIAS
MUL_2979|M.ulcerans_Agy99 IRMLLDAPEQLETLRQRPELWPNAVEEILRLDSPVQLTARVARTDVEIAS
MLBr_02088|M.leprae_Br4923 VLAMLRNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKDMTIGQ
: :* : * * * .*** :* .. : .* . :
MAV_2156|M.avium_104 AHIGAGEMVGLFLGGANRDPKVFSDPTTFDVTRPNAREHLAFASGIHACL
Mvan_5525|M.vanbaalenii_PYR-1 VGIRKGAVIVMLLGGANRDPKVFDRPQTFDITRANARDHLAFASGIHVCL
MAB_4457|M.abscessus_ATCC_1997 HTIEAGQSALLLLGGANRDPAAFENPDVFDITRPNARENITLGTGIHVCL
Mflv_0288|M.gilvum_PYR-GCK TRIERGELVIVHLAGANRDPNVFDDPHRFDIERDNAGRHLSFSGGRHFCL
MSMEG_0681|M.smegmatis_MC2_155 TAVGRGELVVLHIAGANRDPKVFDDPHRFDIERDNAGRHLSFSGGRHFCL
TH_2999|M.thermoresistible__bu TAVRRGEMVIIHLAGANRDPKVFADPHRFDIERANAHRHLSFSGGRHFCL
Mb1912c|M.bovis_AF2122/97 VRIKRGEVVVIYLAAANRDPAVFPDPHRFDIERPNAGRHLAFSTGRHFCL
Rv1880c|M.tuberculosis_H37Rv VRIKRGEVVVIYLAAANRDPAVFPDPHRFDIERPNAGRHLAFSTGRHFCL
MMAR_2768|M.marinum_M WPINRGEMVVAYLAGANRDPAVFPNPHRFDVERANAGRHLAFSTGRHFCL
MUL_2979|M.ulcerans_Agy99 WPINRGEMVVAYLAGANRDPAVFPNPHRFDVERANAGRHLAFSTGRHFCL
MLBr_02088|M.leprae_Br4923 TTLTEGDTMVLLLAAANRDPAVYSRPDEFDPDRPSS-RHLAFAVGSHFCL
: * :..***** .: * ** * .: ::::. * * **
MAV_2156|M.avium_104 GAALARIEGATALRALFENFPDLRLTAAPQRRSLINLHGYTRLPAQLGGR
Mvan_5525|M.vanbaalenii_PYR-1 GAALARIEGATALRELFTRYPDLHLTAPAEPRDLVTLHGYRHLPVRLG-R
MAB_4457|M.abscessus_ATCC_1997 GQVLARAELHTALQTLFERFPRLSLAGEPEYLNGMGIHGLRLLPVTLG--
Mflv_0288|M.gilvum_PYR-GCK GAALARAEGEVGLRTFFQRYPDAQLAGSGSRRDTRVLRGWSTLPITLGKA
MSMEG_0681|M.smegmatis_MC2_155 GAALARAEGEVGLRAFFDRFPDARLAGDPVRRDTRVLRGWSTLPIALGKA
TH_2999|M.thermoresistible__bu GAALARAEGEVGLRTFFQRYPKARSAGGGDRRDTRVLRGWASLPITLGPA
Mb1912c|M.bovis_AF2122/97 GAALARAEGEVGLRTFFDRFPDVRAAGAGSRRDTRVLRGWSTLPVTLGPA
Rv1880c|M.tuberculosis_H37Rv GAALARAEGEVGLRTFFDRFPDVRAAGAGSRRDTRVLRGWSTLPVTLGPA
MMAR_2768|M.marinum_M GAALARAEGEVGLRTFFERFPDVRAAGAGSRRDTRVLRGWSTLPVTLGPA
MUL_2979|M.ulcerans_Agy99 GAALARAEGEVGLRTFFERFPDVRAAGAGSRRDTRVLRGWSTLPVTLGPA
MLBr_02088|M.leprae_Br4923 GAALARLEATVTLSAISARFPQVQLAGELVYKPNVAMRGMSALPVQV---
* .*** * . * : .:* :. ::* ** :
MAV_2156|M.avium_104 RTTSTTIPV
Mvan_5525|M.vanbaalenii_PYR-1 AATATRRAS
MAB_4457|M.abscessus_ATCC_1997 ---------
Mflv_0288|M.gilvum_PYR-GCK PAALGS---
MSMEG_0681|M.smegmatis_MC2_155 RAAVGS---
TH_2999|M.thermoresistible__bu RTTVGS---
Mb1912c|M.bovis_AF2122/97 RSMVSP---
Rv1880c|M.tuberculosis_H37Rv RSMVSP---
MMAR_2768|M.marinum_M RALAAS---
MUL_2979|M.ulcerans_Agy99 RALAAS---
MLBr_02088|M.leprae_Br4923 ---------