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RKIRVAVIGAGPAGIYAADILTKEYEHAQVDVFDRLPAPYGLVRYGVAPDHPRIKEIIKALRRVLSRDEI RFIGNVHYGTDIKLSELRRFYDAVIFSTGARADRGLDIPGIDLPESYGAADFVSWYDGHPDVPRDWPLTA TSVAVLGAGNVALDIARMLAKPADEQLSTEIPANVYQGLALNQATDVHVFARRGPAQIKFSPMEFRELSH SPSVDVIVHPEGFEIDEGSQQAINSSKATKLVVDTMMKYLGQEPTGAPHRIHIHLCQSPAAVLGIDRVEG LRTERTELIGDGTVRGTGEFTDWPVQAVYRAVGYLSSHLADLPFDHHAGVIPHDAGRVLDIDGIPIESTY VTGWVKRGPVGLIGHTKSDAAETITSLLADLPGIQPAEISDPDAIFAHLRGSGIDYTTWEEWERLDAHEV ALGQEQSRERIKVVPREEMISAGRQAS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4171c | - | - | 100% (448) | NADPH-ferredoxin reductase FprA |
| M. abscessus ATCC 19977 | MAB_3482 | - | 9e-77 | 36.73% (452) | NADPH-ferredoxin reductase FprA |
| M. abscessus ATCC 19977 | MAB_0930 | - | 8e-63 | 35.10% (453) | putative ferredoxin/ferredoxin--NADP reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3133 | fprA | 3e-75 | 36.93% (463) | NADPH:adrenodoxin oxidoreductase FprA |
| M. gilvum PYR-GCK | Mflv_4452 | - | 3e-74 | 37.74% (461) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. tuberculosis H37Rv | Rv3106 | fprA | 1e-74 | 36.72% (463) | NADPH:adrenodoxin oxidoreductase FPRA (NADPH-ferredoxin |
| M. leprae Br4923 | MLBr_00666 | fprA | 4e-71 | 34.73% (452) | putative NADPH-ferredoxin reductase |
| M. marinum M | MMAR_1526 | fprA_1 | 3e-76 | 37.01% (462) | NADPH:adrenodoxin oxidoreductase FprA_1 |
| M. avium 104 | MAV_4007 | - | 8e-81 | 39.42% (449) | NADPH-ferredoxin reductase fpra |
| M. smegmatis MC2 155 | MSMEG_5681 | - | 2e-58 | 33.79% (438) | ferredoxin/ferredoxin--NADP reductase |
| M. thermoresistible (build 8) | TH_2151 | fprA | 5e-78 | 37.91% (459) | NADPH:ADRENODOXIN OXIDOREDUCTASE FPRA (NADPH-FERREDOXIN |
| M. ulcerans Agy99 | MUL_2413 | fprA_1 | 3e-76 | 36.80% (462) | NADPH:adrenodoxin oxidoreductase FprA_1 |
| M. vanbaalenii PYR-1 | Mvan_1910 | - | 1e-77 | 39.02% (469) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3133|M.bovis_AF2122/97 --------------------------------------------------
Rv3106|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00666|M.leprae_Br4923 --------------------------------------------------
MAV_4007|M.avium_104 --------------------------------------------------
MMAR_1526|M.marinum_M --------------------------------------------------
MUL_2413|M.ulcerans_Agy99 --------------------------------------------------
Mflv_4452|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1910|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2151|M.thermoresistible__bu --------------------------------------------------
MSMEG_5681|M.smegmatis_MC2_155 MPHVITQSCCSDGSCVYACPVNCIHPSPDEPGFATAEMLYIDPDACVDCG
MAB_4171c|M.abscessus_ATCC_199 --------------------------------------------------
Mb3133|M.bovis_AF2122/97 --------------------------------------------------
Rv3106|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00666|M.leprae_Br4923 --------------------------------------------------
MAV_4007|M.avium_104 --------------------------------------------------
MMAR_1526|M.marinum_M -------------------------------------------------M
MUL_2413|M.ulcerans_Agy99 ------------------------MHRATATLSAHVPPARSRARTEGRTM
Mflv_4452|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1910|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2151|M.thermoresistible__bu --------------------------------------------------
MSMEG_5681|M.smegmatis_MC2_155 ACVSACPVGAIAPDTRLEPRQLPFVEINAAFYPKREGKLPPTSKLAPVIE
MAB_4171c|M.abscessus_ATCC_199 --------------------------------------------------
Mb3133|M.bovis_AF2122/97 ---MRP---YYIAIVGSGPSAFFAAASLLKAADTTEDLDMAVDMLEMLPT
Rv3106|M.tuberculosis_H37Rv ---MRP---YYIAIVGSGPSAFFAAASLLKAADTTEDLDMAVDMLEMLPT
MLBr_00666|M.leprae_Br4923 ---MRPHHIHHIAIVGSGPSGFFAAASVLKAADASDEINVAVDMLEMLPT
MAV_4007|M.avium_104 ---MRP---YHVAIVGSGPSGFFAAASLLKAADGSEHPDIAVDMLEMLPT
MMAR_1526|M.marinum_M PQNQRP---YHVAVVGSGPSGFFAAASLLKAADSSDEIEVAVDILEMLPT
MUL_2413|M.ulcerans_Agy99 PQNQRP---YHVAVVGSGPSGFFAAASLLKAADSSDEIEVAVDILEMLPT
Mflv_4452|M.gilvum_PYR-GCK MPPLRP---YYVAIVGSGPSGYFAAASLLKSGGADGNRDVCVDMLEMLPT
Mvan_1910|M.vanbaalenii_PYR-1 MPVMRP---YYVAIVGSGPSGFFAAASLLKFGDSPENRDVRVDMLEMLPT
TH_2151|M.thermoresistible__bu ---------LQVAIVGSGPSGFFAAASLLKSADSAEGRDVRVDMLEMLPT
MSMEG_5681|M.smegmatis_MC2_155 APKITRDGPLTVAIVGSGPAAMYAADELLTQRG------VRVNVFEKLPT
MAB_4171c|M.abscessus_ATCC_199 ---MRK---IRVAVIGAGPAGIYAADILTKEYEH-----AQVDVFDRLPA
:*::*:**:. :** : . *:::: **:
Mb3133|M.bovis_AF2122/97 PWGLVRSGVAPDHPKIKSISKQFEKTAEDPRFRFFGNVVVGEHVQPGELS
Rv3106|M.tuberculosis_H37Rv PWGLVRSGVAPDHPKIKSISKQFEKTAEDPRFRFFGNVVVGEHVQPGELS
MLBr_00666|M.leprae_Br4923 PWGLVRSGVAPDHPKIKSISKQFEKTAEDPRFRFFGNVIVGKHIEPAELA
MAV_4007|M.avium_104 PWGLVRSGVAPDHPKIKSISKQFEKTAADPRFRFFGNVSVGEHVQASELA
MMAR_1526|M.marinum_M PWGLVRSGVAPDHPKIKSISKQFEKTAEDPRIRFFGNVVVGEHVTTAELT
MUL_2413|M.ulcerans_Agy99 PWGLVRSGVAPDHPKIKSISKQFEKTAEDPRVRFFGNVVVGEHVTTAELT
Mflv_4452|M.gilvum_PYR-GCK PWGLVRSGVAPDHPKIKSISAQFDKTSADPRFRFFGNVVIGEHVHPDELA
Mvan_1910|M.vanbaalenii_PYR-1 PWGLVRSGVAPDHPKIKSISAQFEKTSLDPRFRFFGNVDVGEHVHPSELA
TH_2151|M.thermoresistible__bu PWGLVRSGVAPDHPKIKSISAQFEKVAADPRFRFFGNITVGDHVRPDELA
MSMEG_5681|M.smegmatis_MC2_155 PYGLVRAGVAPDHQSTKRVTELFDRMAAQRGFTFYLNVEVGKHLTHADLL
MAB_4171c|M.abscessus_ATCC_199 PYGLVRYGVAPDHPRIKEIIKALRRVLSRDEIRFIGNVHYGTDIKLSELR
*:**** ****** * : : : . * *: * .: :*
Mb3133|M.bovis_AF2122/97 ERYDAVIYAVGAQSDRMLNIPGEDLPGSIAAVDFVGWYNAHPHFEQISPD
Rv3106|M.tuberculosis_H37Rv ERYDAVIYAVGAQSDRMLNIPGEDLPGSIAAVDFVGWYNAHPHFEQVSPD
MLBr_00666|M.leprae_Br4923 ERYDAVIYAVGAQSDRALNIPGEDLPGSIAAVDFVGWYNAHPNFHERSPD
MAV_4007|M.avium_104 ERYDAVIYAVGAQSDRALNIPGEDLPGSIAAVDFVGWYNAHPNFEEATPD
MMAR_1526|M.marinum_M ERYDAVIYAIGAQSDKPLNIPGENLPGSVAAVDFVGWYNAHPNFEHSTPD
MUL_2413|M.ulcerans_Agy99 ERYDAVIYAIGAQSDKPLNIPGENLPGSMAAVDFVGWYNAHPNFEHSTPD
Mflv_4452|M.gilvum_PYR-GCK ERYDAVIYAIGAQSDRALGIPGEDLPGSVPAVDFVGWYNAHPHFVDMAPD
Mvan_1910|M.vanbaalenii_PYR-1 ERYDAVIYAIGAQADRELGIPGEDLPGSLAAVDFVGWYNAHPYFEGMAPD
TH_2151|M.thermoresistible__bu ERYDAVIYAIGTQADRALNIPGEELPGSVAAVDFVGWYNAHPHFENIDPD
MSMEG_5681|M.smegmatis_MC2_155 GHHHAVVYAVGAPNDRRLDIEGMDLPGTATATEVVAWINGHPDHTDLPVR
MAB_4171c|M.abscessus_ATCC_199 RFYDAVIFSTGARADRGLDIPGIDLPESYGAADFVSWYDGHPDVPRDWP-
:.**::: *: *: *.* * :** : *.:.*.* :.**
Mb3133|M.bovis_AF2122/97 LSGARAVVIGNGNVALDVARILLTDPDVLARTDIADHALESLRPRGIQEV
Rv3106|M.tuberculosis_H37Rv LSGARAVVIGNGNVALDVARILLTDPDVLARTDIADHALESLRPRGIQEV
MLBr_00666|M.leprae_Br4923 LSGSRAVVIGNGNVALDVTRILITDPDVLAFTDIADHALESLRPRGIEEV
MAV_4007|M.avium_104 LSGSRAVVVGNGNVALDVARILVTDPDVLGLTDIADHALESLRPCGVDEV
MMAR_1526|M.marinum_M LSGRRAVVIGNGNVAIDVARILVTDPEVLALTDIADHALESLRPRGVEEV
MUL_2413|M.ulcerans_Agy99 LSGRRAVVIGNGNVAIDVARILVTDPEVLALTDIADHALGSLRPRGVEEV
Mflv_4452|M.gilvum_PYR-GCK VSGGRAVVVGNGNVAIDVARILVSDPDVLAETDIADHALESLHARGVEEV
Mvan_1910|M.vanbaalenii_PYR-1 LSGGRAVVVGNGNVAIDVARILVSDPDVLAETDIADHALRSLHARGVEEV
TH_2151|M.thermoresistible__bu LSGGRAVVIGNGNVALDVARILVTDPEALAKTDIADHALEALRSRGIEEV
MSMEG_5681|M.smegmatis_MC2_155 LDHERVVIVGNGNVALDVARVLTSDPDALARTDISDHALAALRSSAVQEV
MAB_4171c|M.abscessus_ATCC_199 LTATSVAVLGAGNVALDIARMLAKPADEQLSTEIPANVYQGLALNQATDV
: ..::* ****:*::*:* . .: *:*. :. .* :*
Mb3133|M.bovis_AF2122/97 VIVGRRGPLQAAFTTLELRELADLDG---VDVVIDPAELDG-ITDEDAAA
Rv3106|M.tuberculosis_H37Rv VIVGRRGPLQAAFTTLELRELADLDG---VDVVIDPAELDG-ITDEDAAA
MLBr_00666|M.leprae_Br4923 VIVGRRGPLQTAFTTLELRELADIEG---VDVLVDPAQLEG-ISDENAAA
MAV_4007|M.avium_104 VVIGRRGPLQTAFTTLELRELGELDN---VDVIVDPAQLEG-VTDEDVAA
MMAR_1526|M.marinum_M VIIGRRGPLQAAFTTLELRELGELEG---VDVVVDPAQLEG-ISDADAEA
MUL_2413|M.ulcerans_Agy99 VIIGRRGPLQAAFTTLELRELGELEG---VDVVVDPAQLEG-ISDADAEA
Mflv_4452|M.gilvum_PYR-GCK LIIGRRGPLQAPFTTLELRELGDLEALGDVDVIVDPGDFAD-ITDEDLEA
Mvan_1910|M.vanbaalenii_PYR-1 MIIGRRGPLQAPFTTLELRELGDLEALGDVDIVIDPADFAD-ITDDDLEA
TH_2151|M.thermoresistible__bu VIVGRRGPLQATFTTLELRELGALEGLADVDVVVDPADFAD-ITDEDLEA
MSMEG_5681|M.smegmatis_MC2_155 VIAARRGPAASAFT---LPELIGLTS--TCDVVLDSADHDL-VLRDLAQE
MAB_4171c|M.abscessus_ATCC_199 HVFARRGPAQIKFSPMEFRELSHSPS---VDVIVHPEGFEIDEGSQQAIN
: .**** *: : ** *:::..
Mb3133|M.bovis_AF2122/97 VGKVCKQNIKVLRGYADREPRPGHRRMVFRFLTSPIEIKGKRKVERIVLG
Rv3106|M.tuberculosis_H37Rv VGKVCKQNIKVLRGYADREPRPGHRRMVFRFLTSPIEIKGKRKVERIVLG
MLBr_00666|M.leprae_Br4923 AGKTTRQNIKVLRDYTVRTPKPGHRRIVFRFLTSPIEIKGKGKVERIVLG
MAV_4007|M.avium_104 AGKTAKQNISVLRDYAKRSPRPGHRRIVLRFMTSPIEIKGDGRVESIVLG
MMAR_1526|M.marinum_M AGKGIKQNIKVLRGYTERAPRPGHRRIVFKFMTSPVEIRGTDRVEQIVLG
MUL_2413|M.ulcerans_Agy99 AGKGVKQNIKVLRGYTERAPRPGHRRIVFKFMTSPVEIKGTDRVEQIVLG
Mflv_4452|M.gilvum_PYR-GCK AGKTVRNNIKVLRGYAETTPKGAKRRIVFRFRTSPIEIRGDGKVESIVLG
Mvan_1910|M.vanbaalenii_PYR-1 AGKTVRNNIKVLRGYADKAPKGARRRIVFRFRTSPIEIKGGDRVQSIVLG
TH_2151|M.thermoresistible__bu AGKTVKQNVKVLRGYAEQGVRGAPRRIVFRFRTSPIEIRGDGRVQSIVLG
MSMEG_5681|M.smegmatis_MC2_155 TDPLTRNKLEILAKLGDASAPITRPRIRFAYQLTPRRVLGENQVTAVEFG
MAB_4171c|M.abscessus_ATCC_199 SSKATKLVVDTMMKYLGQEPTGAPHRIHIHLCQSPAAVLGIDRVEGLRTE
. : :. : *: : :* : * :* :
Mb3133|M.bovis_AF2122/97 RNELVSDGSGRVAAKDTGEREELPAQLVVRSVGYRGVPTPGLPFDDQSGT
Rv3106|M.tuberculosis_H37Rv RNELVSDGSGRVAAKDTGEREELPAQLVVRSVGYRGVPTPGLPFDDQSGT
MLBr_00666|M.leprae_Br4923 QNELVTDDNGRVAAKDTGVREELPAQLIVRSIGYRGVPTPGLPFDDSSVT
MAV_4007|M.avium_104 RNELVTDETGRVLARDTGEREELPVQLVVRSVGYRGVPTPGLPFDEKTAT
MMAR_1526|M.marinum_M HNELVTDEDGWVSAKDTGEREELPVQLVVRSVGYRGVPTPGLPFDQKRGI
MUL_2413|M.ulcerans_Agy99 HNELVTDEDGWVSAKDTGEREEVPVQLVVRSVGYRGVPTPGLPFDQKCGI
Mflv_4452|M.gilvum_PYR-GCK RNELIRGDDGRISAKDTGERDEVAAQLVVRAVGYRGLPTPGLPFDDRAGT
Mvan_1910|M.vanbaalenii_PYR-1 RNELTKGADGRVSAADTGEREEVPAQLVVRAVGYRGLPTPGLPFDERAGT
TH_2151|M.thermoresistible__bu RNELVSDATGRIVAKDTGAREELPAQLVVRAIGYRGLPTPGLPFDERSGT
MSMEG_5681|M.smegmatis_MC2_155 -------------VTGTDEVRTLDAGLLLTSIGYRGKAIADLPFDEDASV
MAB_4171c|M.abscessus_ATCC_199 RTELIGDG----TVRGTGEFTDWPVQAVYRAVGYLSSHLADLPFDHHAGV
. .*. . : ::** . ..****.
Mb3133|M.bovis_AF2122/97 IPNVGGRINGSPN------EYVVGWIKRGPTGVIGTNKKDAQDTVDTLIK
Rv3106|M.tuberculosis_H37Rv IPNVGGRINGSPN------EYVVGWIKRGPTGVIGTNKKDAQDTVDTLIK
MLBr_00666|M.leprae_Br4923 IPNTNGRVNGSRN------EYVVGWIKRGPTGVIGTNKKDSQDTVDTLME
MAV_4007|M.avium_104 IPNTGGRVEGSRN------EYVVGWIKRGPTGVIGTNKKDSQDTVDTLLA
MMAR_1526|M.marinum_M IPNTAGRVQGSSN------EYVVGWIKRGPTGVIGTNKKDSQDTVDTLMA
MUL_2413|M.ulcerans_Agy99 IPNTAGRVQGSSN------EYVVGWIKRGPTGVIGTNKKDSQDTVDTLMA
Mflv_4452|M.gilvum_PYR-GCK IPHVDGKVEGRRN------DYVVGWIKRGPTGVIGSNKKDSADTVATLLN
Mvan_1910|M.vanbaalenii_PYR-1 IPHTDGRVAGSRN------EYVVGWIKRGPTGVIGSNKKDSADTVDTLLA
TH_2151|M.thermoresistible__bu IPHTDGRIEGSRN------EYVVGWIKRGPSGVIGSNKKDSQDTVDTLLA
MSMEG_5681|M.smegmatis_MC2_155 VPNDGGRVIDPATGAPVPGAYVAGWIKRGPTGFIGTNKSCAAQTVHHLVD
MAB_4171c|M.abscessus_ATCC_199 IPHDAGRVLDIDG-IPIESTYVTGWVKRGPVGLIGHTKSDAAETITSLLA
:*: *:: . **.**:**** *.** .*. : :*: *:
Mb3133|M.bovis_AF2122/97 DLGNAKEGAECKSFPEDHADQVADWLAARQPKLVTSAHWQVIDAFERAAG
Rv3106|M.tuberculosis_H37Rv NLGNAKEGAECKSFPEDHADQVADWLAARQPKLVTSAHWQVIDAFERAAG
MLBr_00666|M.leprae_Br4923 NLAGAND---TEKFGADHADRLAEWLAERQPKLVTSAHWQAIDRFERAAG
MAV_4007|M.avium_104 DLANAGPDG-LADFPDDHADRLADWLASRQPKLVTTAHWELIDAHERAAG
MMAR_1526|M.marinum_M DLTAAELN----TFPSGHTADLADWLSSRQPELVTAEHWKSIDHFERAAG
MUL_2413|M.ulcerans_Agy99 DLTAAELN----TFPSSHTADLADWLSSRQPELVTAEHWKSIDHFERAAG
Mflv_4452|M.gilvum_PYR-GCK DLSSAELA----DFGSDHPDKVQQWLQERQPKLITSEHWKLIDTHERTAG
Mvan_1910|M.vanbaalenii_PYR-1 DLAAAELT----EFDAGHLEDIERWLLERQPKLVTNEHWKLIDAHERSAG
TH_2151|M.thermoresistible__bu DLRDAELA----DFGPDHHDELAAWLSSRQPKLVTADHWNVIDEHERGAG
MSMEG_5681|M.smegmatis_MC2_155 DYNAGALTD-----PPRKPSALDKLVRARQPDVVDAAGWRAIDAAEIARG
MAB_4171c|M.abscessus_ATCC_199 DLPGIQPA------EISDPDAIFAHLRGSGIDYTTWEEWERLDAHEVALG
: . : : . *. :* * *
Mb3133|M.bovis_AF2122/97 EPHGRPRVKLASLAELLRIGLG----------------
Rv3106|M.tuberculosis_H37Rv EPHGRPRVKLASLAELLRIGLG----------------
MLBr_00666|M.leprae_Br4923 EPHGRPRVKLPNLAELLRIGHG----------------
MAV_4007|M.avium_104 EARGRPRVKLPSLAKLLRVSHG----------------
MMAR_1526|M.marinum_M EALGRPRVKLPNVTEMLRIGHA----------------
MUL_2413|M.ulcerans_Agy99 EALGRPRVKLPNVTEMLRIGHA----------------
Mflv_4452|M.gilvum_PYR-GCK EGSGRPRVKVTSVEDLLRIGHA----------------
Mvan_1910|M.vanbaalenii_PYR-1 AGSGRPRVKLSNVAEMLRVGGRG---------------
TH_2151|M.thermoresistible__bu QQCGRPRVKLASVAELLRVGHG----------------
MSMEG_5681|M.smegmatis_MC2_155 -GDDRPRDKFTTVPEMLAVAVTAPKPSVRQRLTAGLLG
MAB_4171c|M.abscessus_ATCC_199 QEQSRERIKVVPREEMISAGRQAS--------------
.* * *. .:: .