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NLIQEGEAMPQHRRLTYGDHPSQYVDILEPDEPAAALVHVIHGGFWREALSAELTAPIARDLCTDGFLVA NIEYRRVGGGGGWPETFEDVKAAIAAVRQAEPDLVRSLAVGHSAGGHLSLLALAAGLADFAVALAPVSDV DRALRENLGGGAAAEFLGVAGSSPREVRTASPIGNLGHRRQHVLIHGLRDVNVPVEHSQHYVSAARASGT PVDYFEFANLDHFDLIDPSSSAWRVAKQWIRYQLI*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_3447c | - | - | 100% (246) | putative lipase/esterase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0226 | lipC | 5e-15 | 32.24% (245) | esterase LipC |
| M. gilvum PYR-GCK | Mflv_0440 | - | 9e-10 | 29.02% (255) | alpha/beta hydrolase domain-containing protein |
| M. tuberculosis H37Rv | Rv0220 | lipC | 5e-15 | 32.24% (245) | esterase LipC |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_0463 | lipC | 7e-14 | 32.02% (253) | esterase LipC |
| M. avium 104 | MAV_4953 | - | 2e-13 | 32.52% (246) | alpha/beta hydrolase fold |
| M. smegmatis MC2 155 | MSMEG_5171 | - | 4e-22 | 35.81% (229) | hypothetical protein MSMEG_5171 |
| M. thermoresistible (build 8) | TH_2755 | - | 5e-12 | 29.57% (257) | PUTATIVE Alpha/beta hydrolase fold-3 domain protein |
| M. ulcerans Agy99 | MUL_1112 | lipC | 5e-14 | 32.02% (253) | esterase LipC |
| M. vanbaalenii PYR-1 | Mvan_0231 | - | 7e-10 | 27.20% (239) | alpha/beta hydrolase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0226|M.bovis_AF2122/97 ---MNQRRAAGSTGVAYIRWLLRARPADYMLALSVAGGSLPVVGKHLKPL
Rv0220|M.tuberculosis_H37Rv ---MNQRRAAGSTGVAYIRWLLRARPADYMLALSVAGGSLPVVGKHLKPL
MMAR_0463|M.marinum_M MAATGPTTMSMTSMMSRVKWMLRARPADYLLAMSVAGASLPVVGKHLEPL
MUL_1112|M.ulcerans_Agy99 --------------MSRVKWMLRARPADYLLAMSVAGASLPVVGKHLEPL
MAV_4953|M.avium_104 ---------MAPGMTPYLKWLLRARPADYALAVSLAGASLPVVGRHLEPL
Mflv_0440|M.gilvum_PYR-GCK MTERPDTRYPGPTLTTRLEWLLNAGPSDYMLALSVASASLPVIGKHLEPL
TH_2755|M.thermoresistible__bu ---MTVRPDGGSSAWLCARRLLRAGPADHLLALSAASGSLPIVGRHLEPL
Mvan_0231|M.vanbaalenii_PYR-1 MPKRRPLLRAVAELLNAANGLRPLARDGYLTIPVFAFGWPTSEVSPLYMA
MAB_3447c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_5171|M.smegmatis_MC2_155 -----------------------------------------MATIDGNTL
Mb0226|M.bovis_AF2122/97 GGVTAIGVWGARHASDFLSATAKDLLTP---GINEVRRRDRASTQEVSVA
Rv0220|M.tuberculosis_H37Rv GGVTAIGVWGARHASDFLSATAKDLLTP---GINEVRRRDRASTQEVSVA
MMAR_0463|M.marinum_M GCVTAMGVWGARHTPEFFAARAKDLFTP---GINVTRQRDRDSTNEVSAA
MUL_1112|M.ulcerans_Agy99 GCVTAMGVWGARHTPEFVAARAKDLFTP---GINVTRQRDRDSTNEVSAA
MAV_4953|M.avium_104 AGLTAMGMWGARHAPEVISAATRDMFAP---GGGDARRRDRESTQQVSLA
Mflv_0440|M.gilvum_PYR-GCK GALTAAGVWGARHAPDFVGALAKSLVAPNDVGKKEKQQQERDSTNAITQA
TH_2755|M.thermoresistible__bu GSAAAMSLWGFRHLPDFVGATVKSWLAP---GSAELRRRQREMTNEVSRQ
Mvan_0231|M.vanbaalenii_PYR-1 GSMLDAIRRGVRGDFRGARGRIALLLTAAAWALLYLIHRRNVAAQPYFED
MAB_3447c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_5171|M.smegmatis_MC2_155 EGISATTPWTLHHR---------------------ASGAKRSNVVRFLAP
Mb0226|M.bovis_AF2122/97 ALRGIVSPD--------------DLAVEWPAPERTPPVCGALRHRRYVHR
Rv0220|M.tuberculosis_H37Rv ALRGIVSPD--------------DLAVEWPAPERTPPVCGALRHRRYVHR
MMAR_0463|M.marinum_M ALRGIVSTA--------------DLDVEWPAPQRTPPVCEAFRHRRYLHR
MUL_1112|M.ulcerans_Agy99 ALRGIVSTA--------------DLDVEWPAPQRTPPVCEAFRHRRYLHR
MAV_4953|M.avium_104 ALRGLVSAA--------------ELESQWPVAQRTPPIWDGVRRHRHLYR
Mflv_0440|M.gilvum_PYR-GCK ALRGLVSQK--------------DLEIEWPAAERTPPVWKMREHRRHVHR
TH_2755|M.thermoresistible__bu ALRGLLPADPAAPGASEVSSGSAGSALDWPAPDRVPPLWRMLQHRRHLYR
Mvan_0231|M.vanbaalenii_PYR-1 PLREALGEN-----------YQRIAEAAKSSRRRRVGVFPPDLVRRRYVE
MAB_3447c|M.abscessus_ATCC_199 --MNLIQEG-----------------EAMPQHRR----------------
MSMEG_5171|M.smegmatis_MC2_155 LLAAIVTSAG---------------CGALPTEVTETPAAAEVEVLPEVTV
: .
Mb0226|M.bovis_AF2122/97 RRVLYGDDP-AQLLDVWRRKDMPTKP-APVLIFVPGGAWVHGSRAIQGYA
Rv0220|M.tuberculosis_H37Rv RRVLYGDDP-AQLLDVWRRKDMPTKP-APVLIFVPGGAWVHGSRAIQGYA
MMAR_0463|M.marinum_M GGVHYGNSP-AQVLDVWRRDDLPTEP-APVLIFVPGGAWIHGSRAIQGYA
MUL_1112|M.ulcerans_Agy99 GGVHYGNSP-AQVLDVWRRDDLPTEP-APVLIFVPGGAWIHGSRAIQGYA
MAV_4953|M.avium_104 RAVHYGHHP-AQVLDVWRRKDLPAQP-APVLIFVPGGAWVHGKSMGQGSA
Mflv_0440|M.gilvum_PYR-GCK TSVRYGPRP-TQLLDVWRRDDVPAD--APVMIFVPGGAWVHGGRMLQGYA
TH_2755|M.thermoresistible__bu GAVRYGDHT-ENVLDVWRRKDLPAQP-APVLIFVPGGAWVHGSRMLQGYA
Mvan_0231|M.vanbaalenii_PYR-1 SVVQYGPLR-VNRADIWRRADLPRDGKAPVLLQVPGGAWAIGMRRPQAYP
MAB_3447c|M.abscessus_ATCC_199 --LTYGDHP-SQYVDILE----PDEPAAALVHVIHGGFWREALSAELTAP
MSMEG_5171|M.smegmatis_MC2_155 QRFEYAADSEQNWADLYLPAGPQQVDSIPLVVLIHGGAWQSKLGADVFDG
. *. : *: .:: : ** *
Mb0226|M.bovis_AF2122/97 VLSRLAAQGWVCLSIDYR-VAPHHRWPRHILDVKTAIAWARANVDKF-GG
Rv0220|M.tuberculosis_H37Rv VLSRLAAQGWVCLSIDYR-VAPHHRWPRHILDVKTAIAWARANVDKF-GG
MMAR_0463|M.marinum_M LLSRLAEQGWVCLSIDYR-VAPHHRWPRHIHDVKAAIAWARANVDKF-GG
MUL_1112|M.ulcerans_Agy99 LLSRLAEQGWVCLSIDYR-VAPHHRWPRHIHDVKAAIAWARANVDKF-GG
MAV_4953|M.avium_104 LMSRLAEQGWVCLAIDYR-VAPHHRWPRHIVDVKTAIAWARANVDKF-GG
Mflv_0440|M.gilvum_PYR-GCK LMHHLAEMGWVCLSVEYR-VAPHNPWPAHINDVKTAIAWARANVDKF-GG
TH_2755|M.thermoresistible__bu LLSHLAEQGWVCLSIDYR-VAPQHPWPAHLTDVKTAIAWARANVDKF-GG
Mvan_0231|M.vanbaalenii_PYR-1 LLSHLADHGWICVSIDYR-VSPRNTWPDHIVDVKRALAWIKEHIAEY-GG
MAB_3447c|M.abscessus_ATCC_199 IARDLCTDGFLVANIEYRRVGGGGGWPETFEDVKAAIAAVRQAEPDL-VR
MSMEG_5171|M.smegmatis_MC2_155 LARELADHGMAVYNIEYRRVGSGGGWPTTFHDVATALDYVTEVDKRFPQL
: *. * ::** *. ** : ** *:
Mb0226|M.bovis_AF2122/97 DRNFIAVAGCSAGGHLSALAGLTANDPQYQAELPEGSDTSVDAVVGIYGR
Rv0220|M.tuberculosis_H37Rv DRNFIAVAGCSAGGHLSALAGLTANDPQYQAELPEGSDTSVDAVVGIYGR
MMAR_0463|M.marinum_M DRNFIAVAGCSAGGHLSALAGLTANDPDYQSELPEGSDTSVDAAVGIYGR
MUL_1112|M.ulcerans_Agy99 DRNFIAVAGCSAGGHLSALAGLTANDPDYQSELPEGSDTSVDAAVGIYGR
MAV_4953|M.avium_104 DRNFVAIAGCSAGGHLSALAGLTPDDPQYRGMLPEGADTSVDAVVGIYGR
Mflv_0440|M.gilvum_PYR-GCK NRDFVAIAGTSAGGHLAALAGLTANDPEMQGELPEGSDTSVDAVVGIYGR
TH_2755|M.thermoresistible__bu DRDFVAVAGCSAGGHLAALAGLTENDPDMQTELPEGSDTSVDAVVGVYGR
Mvan_0231|M.vanbaalenii_PYR-1 DPDFVAITGGSAGGHLSALAALTADDPQFQPGFED-ADTSVAAAVPIYGR
MAB_3447c|M.abscessus_ATCC_199 S----LAVGHSAGGHLSLLA-LAAGLADFAVALAPVSDVDRALRENLGG-
MSMEG_5171|M.smegmatis_MC2_155 TVDDELVVGHSAGAQLAVWAGTRHKLR--DDEVGSHPSFRPTRVVSLAGP
.* ***.:*: * . .. : *
Mb0226|M.bovis_AF2122/97 YDWEDRSTPERARFVDFLERVVVQRTIDRHPEVFRDASPIQRVTRNAPPF
Rv0220|M.tuberculosis_H37Rv YDWEDRSTPERARFVDFLERVVVQRTIDRHPEVFRDASPIQRVTRNAPPF
MMAR_0463|M.marinum_M YDWEDRSTAERARFVDFLERVVVKRSIKRHPQVFRDASPVARVHTNAPPF
MUL_1112|M.ulcerans_Agy99 YDWEDRSTAERARFVDFLERVVVKRSIKRHPQVFRDASPVARVHTNAPPF
MAV_4953|M.avium_104 YDWEDRSTPERVRFVDFLERVVVRKSIARHPEVFRDASPIARVHRNAPPF
Mflv_0440|M.gilvum_PYR-GCK YDWEDKSTVERVRFMDFLERVVVKRKFDKHPDVFRKASPMARIHSEAPPF
TH_2755|M.thermoresistible__bu YDWVDRSTAERVRFLDFLERVVVRKRLDRHPEVFHRASPMHRVHGDAPPF
Mvan_0231|M.vanbaalenii_PYR-1 YDWVSGRGSGRREFIAFLQEFVVKKPISGNRQLYVDASPRYRLRADAPPF
MAB_3447c|M.abscessus_ATCC_199 --------GAAAEFLGVAG---------SSPREVRTASPIGNLG-HRRQH
MSMEG_5171|M.smegmatis_MC2_155 LDMVYAAEHGDHHIVRVLGG-----RPTEVPDRYTSVDPIQNIDPEVP-V
.:: . ..* .: .
Mb0226|M.bovis_AF2122/97 LVIHGSRDCVIPVEQARSFVERLR-AVSRSQVGYLELPGAGHGFDLLDGA
Rv0220|M.tuberculosis_H37Rv LVIHGSRDCVIPVEQARSFVERLR-AVSRSQVGYLELPGAGHGFDLLDGA
MMAR_0463|M.marinum_M LVIHGSRDGVIPVAQARSFVERLR-AVSRSLVAYVELPGAGHGFDLLDGA
MUL_1112|M.ulcerans_Agy99 LVIHGSRDGVIPVAQARSFVERLR-AVSRSLVAYVELPGAGHGFDLLDGA
MAV_4953|M.avium_104 LVIHGSKDSVIPVEQARSFVERLR-AVSHSTVGYLELPGAGHGYDLIDGE
Mflv_0440|M.gilvum_PYR-GCK LVIHGTGDSVIPVAQAQSFVERLR-NVSRSVVGYVELPGAGHGFDMTDGA
TH_2755|M.thermoresistible__bu LLVHGSADTVIPVRQARDFADRLR-SVSRSAVSYLELPGAGHGFDLLDGA
Mvan_0231|M.vanbaalenii_PYR-1 FILHGRDDSIIPVPEGRAFAEALR-NVSTSPVVYAEIPHAQHAFDFYYGS
MAB_3447c|M.abscessus_ATCC_199 VLIHGLRDVNVPVEHSQHYVSAAR-ASG-TPVDYFEFANLDH-FDLIDPS
MSMEG_5171|M.smegmatis_MC2_155 LALHGTRDTVVSPENSRRYVAAVKQQGGRAAVKMLTGENHTSIVSLRSPS
. :** * :. ..: :. : . : * .:
Mb0226|M.bovis_AF2122/97 -RTGPTAHAIALFLNQVHRSRAQF-AKEVI
Rv0220|M.tuberculosis_H37Rv -RTGPTAHAIALFLNQVHRSRAQF-AKEVI
MMAR_0463|M.marinum_M -RTGSATHAISLFLNQIHRTRAQL-SKEVI
MUL_1112|M.ulcerans_Agy99 -RTGSATHAISLFLNQIHRTRAQL-SKEVI
MAV_4953|M.avium_104 -RAGAAAHVCSLFLDQVHRSKTRIGAKEVI
Mflv_0440|M.gilvum_PYR-GCK -RTGAAATAIGLFLNHIHRNRSLVGAKEVI
TH_2755|M.thermoresistible__bu -RTGSAATAVGLFLDHVQRNRSRVRGRAVG
Mvan_0231|M.vanbaalenii_PYR-1 PRAHYTAQAVEEFLSWVQGERMLARKAG--
MAB_3447c|M.abscessus_ATCC_199 ------SSAWRVAKQWIRYQLI--------
MSMEG_5171|M.smegmatis_MC2_155 -----HDEVLRAITTTSQTDLDDLLTE---
. :