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SATARVKETVGIERMLSAAESELNHLRKYTTIWYVARLRGDLDIAALSAAGAVMQGNHPYLAARVDPVGR LFRVTTEQVRDTVVSVRYERLRDVAALPVLSLDDGTYAILVYPGDSGSAVAVGVDHSIADARLSYSYFHE LWELYTEIVTSGTIPRPRRQPIPMAPEAALAKRGLHRAALPEKPWFGPTSWAGRQQDNSTSPQMVLGWKQ RFDPELSASLRASARRRDTTLNTLVTGVIALAERALFRIGDDEPVNLGFESLVDYRRHLTPPAELGEIAN GIMIARSQVPVRANDDPLRVGAAVAAQINDDIASGFLVQSVNHIGGTALTGNWGPFIRITNPGVLPLPPL PAGLTLEDFDAQLTTPRTPSSGPPAPQASRYEVYSIGAEFTVVCKFAAGALTGEQAEALRAGIVAGVEAL AEP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_3092c | - | - | 100% (424) | acyltransferase PapA5 |
| M. abscessus ATCC 19977 | MAB_4931 | - | 9e-15 | 28.38% (296) | acyltransferase PapA5 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2964 | papA5 | 3e-16 | 24.59% (366) | acyltransferase PapA5 |
| M. gilvum PYR-GCK | Mflv_3386 | - | 2e-13 | 23.23% (353) | acyltransferase PapA5 |
| M. tuberculosis H37Rv | Rv2939 | papA5 | 3e-16 | 24.59% (366) | acyltransferase PapA5 |
| M. leprae Br4923 | MLBr_02349 | - | 2e-15 | 24.52% (367) | acyltransferase PapA5 |
| M. marinum M | MMAR_1768 | papA5 | 2e-21 | 26.17% (363) | polyketide synthase associated protein PapA5 |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | - | - | - | - | - |
| M. thermoresistible (build 8) | TH_2581 | - | 6e-05 | 26.25% (320) | PUTATIVE amino acid adenylation domain |
| M. ulcerans Agy99 | MUL_2011 | papA5 | 9e-22 | 26.45% (363) | acyltransferase PapA5 |
| M. vanbaalenii PYR-1 | Mvan_3119 | - | 4e-13 | 23.91% (343) | acyltransferase PapA5 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1768|M.marinum_M --------------MFPGAVIRKLAFSEEIYARYQAFTS---------FT
MUL_2011|M.ulcerans_Agy99 --------------MFPGAVIRKLAFSEEIYARYQAFTS---------FT
Mb2964|M.bovis_AF2122/97 --------------MFPGSVIRKLSHSEEVFAQYEVFTS---------MT
Rv2939|M.tuberculosis_H37Rv --------------MFPGSVIRKLSHSEEVFAQYEVFTS---------MT
MLBr_02349|M.leprae_Br4923 --------------MFAGSVIRKLSHSEEVFARYEVFTS---------MT
Mflv_3386|M.gilvum_PYR-GCK --------------MFPSSGIRKLARSEEMFAETQNFVG---------LA
Mvan_3119|M.vanbaalenii_PYR-1 --------------MFPSSGIRKLARSEEMFAETHNFIG---------LA
MAB_3092c|M.abscessus_ATCC_199 --------------MSATARVKETVGIERMLSAAESELNHLRKYTTIWYV
TH_2581|M.thermoresistible__bu VTRTDADRAVTIEDVMALTPLQRGLYSMTVLSESEYADGDP---YVIAMA
: . : ::. : : . . .
MMAR_1768|M.marinum_M AHVRGPVDIDAMSEAFDALLQAHPVFAAHLEEGPDGNHHIVANDLLHSGL
MUL_2011|M.ulcerans_Agy99 AHVRGPVDIDAMSEAFDALLQAHPVFAAHLEEGPDGNHHIVANDLLHSGL
Mb2964|M.bovis_AF2122/97 IQLRGVIDVDALSDAFDALLETHPVLASHLEQSSDGGWNLVADDLLHSGI
Rv2939|M.tuberculosis_H37Rv IQLRGVIDVDALSDAFDALLETHPVLASHLEQSSDGGWNLVADDLLHSGI
MLBr_02349|M.leprae_Br4923 IQLRGVLDIDALSEAFDALVQAHPVLASHLETSSDGGWNLVADDLLHPGI
Mflv_3386|M.gilvum_PYR-GCK AHVRGTVDETALADAFDALLQAHPVLNGHLEQLPDGKWEIVLDDLMHEGL
Mvan_3119|M.vanbaalenii_PYR-1 AHVKGSMDADALSDAFDLLLQAHPVLGGHLEQLPDGKWEIVLDDLMHPGI
MAB_3092c|M.abscessus_ATCC_199 ARLRGDLDIAALSAAGAVMQGNHPYLAARVD--PVGRLFRVTTEQVRDTV
TH_2581|M.thermoresistible__bu ADVTGSLDVPLLERCAAAMLDRHPNLRVSFVHGDLPHPVQIVPSRVTLPW
: * :* : . : ** : . : . :
MMAR_1768|M.marinum_M VVIDG----------RRAENPHVQLDQRDSLFRLQLTLGESENLVTAYVH
MUL_2011|M.ulcerans_Agy99 VVIDG----------RRAENPHVQLDQRDSLFRLQLTLGESENLVTAYVH
Mb2964|M.bovis_AF2122/97 CVIDG----TAATNGSPSGNAELRLDQSVSLLHLQLILREGGAELTLYLH
Rv2939|M.tuberculosis_H37Rv CVIDG----TAATNGSPSGNAELRLDQSVSLLHLQLILREGGAELTLYLH
MLBr_02349|M.leprae_Br4923 CVVDAN---NGAQSGCGGIQSETRLDQSVSLLNLRLTPREGGGELVLYIH
Mflv_3386|M.gilvum_PYR-GCK EVVEC---------HGDQEPPPLLFDQTAALTHLRLTRRDDETHLTLYIH
Mvan_3119|M.vanbaalenii_PYR-1 EVVEL---------TGDEPAPPLIFDQTVSLVHLRLTIRDGQAQPTLYIH
MAB_3092c|M.abscessus_ATCC_199 VSVRY--------ERLRDVAALPVLSLDDGTYAILVYPGDSGSAVAVGVD
TH_2581|M.thermoresistible__bu RHVRVRSAAEAAELEQRERRRPFDLERGPVIRFLLIEVPGPRWRLVIVAH
: :. : : . .
MMAR_1768|M.marinum_M HSLADAHHLGSLLDELLSRYTDVVTTGDPGPITPEPAPQPAEDLLKRRGI
MUL_2011|M.ulcerans_Agy99 HSLADAHHLGSLLDELLSRYTDVVTTGDPGPITPEPAPQPAEDLLKRRGI
Mb2964|M.bovis_AF2122/97 HCMADGHHGAVLVDELFSRYTDAVTTGDPGPITPQPTPLSMEAVLAQRGI
Rv2939|M.tuberculosis_H37Rv HCMADGHHGAVLVDELFSRYTDAVTTGDPGPITPQPTPLSMEAVLAQRGI
MLBr_02349|M.leprae_Br4923 HSMADGHHGAVLVDELFSRYTDVVTTGDPGPIIPQATPLSMEAVLQQRGV
Mflv_3386|M.gilvum_PYR-GCK HSLADGHHQFSLVEELFSTYTDLVTTGTARQAPVAPAPAALETILSDRGV
Mvan_3119|M.vanbaalenii_PYR-1 HSLADGHHQFSLVEELFSTYTDLVTTGTTKPVEVHPAPEPLEVILANRGV
MAB_3092c|M.abscessus_ATCC_199 HSIADARLSYSYFHELWELYTEIVTSGTIPRPRRQPIPMAPEAALAKRGL
TH_2581|M.thermoresistible__bu HIVIDGWSLPLFVSELLTLYR---AGGEPQALGTPPRPYRDYIGWLAN--
* : *. . ** * : * . * .
MMAR_1768|M.marinum_M KQSALTGFERFLPLLFAYDLPP--IAEEMRKFEAPEPVPVTRCRLTSQET
MUL_2011|M.ulcerans_Agy99 KQSALTGFERFLPLLFAYDLPP--IAEEMRKFEAPEPVPVTRCRLTSQET
Mb2964|M.bovis_AF2122/97 RKQGLSGAERFMSVMYAYEIPATETPAVLAHPGLPQAVPVTRLWLSKQQT
Rv2939|M.tuberculosis_H37Rv RKQGLSGAERFMSVMYAYEIPATETPAVLAHPGLPQAVPVTRLWLSKQQT
MLBr_02349|M.leprae_Br4923 KKHALSGAERFMSVMYAYDLPATGTPAVLAEPGLPQAVPVTRLWLTKQET
Mflv_3386|M.gilvum_PYR-GCK EKKLRSGLERLLAAMFAYDVPPSRRAPAENNPVLPQRVPMEFCKLSEAET
Mvan_3119|M.vanbaalenii_PYR-1 EKRTRSGLERLLAAMFVYDLPPSRRAPSDVNPVLPQLVPMAYCTLSEQDT
MAB_3092c|M.abscessus_ATCC_199 HRAALPEKPWFG--------PTSWAGRQQDNSTSPQMVLGWKQRFDPELS
TH_2581|M.thermoresistible__bu -RDQDAGRALWSEHLAGLDGPTLLTPALSDAEPAPGLPSRTEVRLPADAT
: . *. * : :
MMAR_1768|M.marinum_M ADLVSFSRDNGLSFNAVLAA--AILLAE-----------------WRLRE
MUL_2011|M.ulcerans_Agy99 ADLVSFSRDNGLSFNAVLAA--AILLAE-----------------WRLRE
Mb2964|M.bovis_AF2122/97 SDLMAFGREHRLSLNAVVAA--AILLTE-----------------WQLRN
Rv2939|M.tuberculosis_H37Rv SDLMAFGREHRLSLNAVVAA--AILLTE-----------------WQLRN
MLBr_02349|M.leprae_Br4923 SDLAAFGREHRLSINAVVAA--AILMTE-----------------WRLRE
Mflv_3386|M.gilvum_PYR-GCK ENIIGFCRANKLGLNSLLSA--SILMAE-----------------WQLRE
Mvan_3119|M.vanbaalenii_PYR-1 EKIIAFCRANKLGLNSLLSA--AVLMAE-----------------WNVRR
MAB_3092c|M.abscessus_ATCC_199 ASLRASARRRDTTLNTLVTG--VIALAERA--------------LFRIGD
TH_2581|M.thermoresistible__bu RRLVADARTRGVTLNTLVQMGWAALLSVFTDRRDVTFGMTVSGRPDELAG
: . * . :*::: :: .:
MMAR_1768|M.marinum_M TPHVPIPYCYAVDLRFLLSPPVGATESTNPVG--LATYLAEIGPDTDITE
MUL_2011|M.ulcerans_Agy99 TPHVPIPYCYAVDLRFLLSPPVGATESTNPVG--LATYLAEIGPDTDITE
Mb2964|M.bovis_AF2122/97 TPHVPIPYVYPVDLRFVLAPPVAPTEATNLLG--AASYLAEIGPNTDIVD
Rv2939|M.tuberculosis_H37Rv TPHVPIPYVYPVDLRFVLAPPVAPTEATNLLG--AASYLAEIGPNTDIVD
MLBr_02349|M.leprae_Br4923 TPHVPIPYVYPVDLRYVLAPPVAPTESTNLLG--AAGYLAEIGQDTDIVD
Mflv_3386|M.gilvum_PYR-GCK TPNIPVPYVYPVDLRYLLSPPVSATECTNPVG--IATYLAEISPDTDVVD
Mvan_3119|M.vanbaalenii_PYR-1 TPNIPVPYVYPVDLRYLLSPPVSATESTNPVG--IATYLAEIEKGTDIAE
MAB_3092c|M.abscessus_ATCC_199 DEPVNLGFESLVDYRRHLTPPAELGEIANGIM--IARSQVPVRANDDPLR
TH_2581|M.thermoresistible__bu VESMVGLFINTVPLRVRLDPAGTVGAQCRALQRTAARLRDHSYLTHTELR
: : * * * *. . : *
MMAR_1768|M.marinum_M LAADIVATFRADLSDGMIHQSALRSG-RILEGTPPGLPPFVLCTNVSTLP
MUL_2011|M.ulcerans_Agy99 LAADIVATFRADLSDGMIHQSALRSG-RILEGTPPGLPPFILCTNVSTLP
Mb2964|M.bovis_AF2122/97 LASDIVATLRADLANGVIQQSGLHFG-TAFEGTPPGLPPLVFCTDATSFP
Rv2939|M.tuberculosis_H37Rv LASDIVATLRADLANGVIQQSGLHFG-TAFEGTPPGLPPLVFCTDATSFP
MLBr_02349|M.leprae_Br4923 LATDIVATLRADLANGVVQQSGLHFG-TAFEGTPPGLPPLVFCTDATAFP
Mflv_3386|M.gilvum_PYR-GCK LARDINDTFKADIADGVIQQSFLHFS-PQYVGNPPGLPDVVMFTDNGIVP
Mvan_3119|M.vanbaalenii_PYR-1 LARDINDTYKKDIAEGVIQQSFLHFS-PQYVGNPPGLPDVVMFTDNGIVP
MAB_3092c|M.abscessus_ATCC_199 VGAAVAAQINDDIASGFLVQSVNHIGGTALTGN---WGPFIRITNPGVLP
TH_2581|M.thermoresistible__bu TLGGVGDLFDSLLVYENFPPGGLVGEHRFEANGATFVPAALESLSHFPVT
: : . . . : . ..
MMAR_1768|M.marinum_M PIRTPEDVELVDFHSRIHCAMDVP----------------FGFYACSIAT
MUL_2011|M.ulcerans_Agy99 PIRTPEDVELVDFHSRIHCAMDVP----------------FGFYACSIAT
Mb2964|M.bovis_AF2122/97 TMRTPPGLEIEDIKGQFYCSISVP----------------LDLYSCAVYA
Rv2939|M.tuberculosis_H37Rv TMRTPPGLEIEDIKGQFYCSISVP----------------LDLYSCAVYA
MLBr_02349|M.leprae_Br4923 TMRTPPDLAIEDIQGRFYCSISVP----------------LDLYSCGVYE
Mflv_3386|M.gilvum_PYR-GCK PMRMPPDMELAASHGELYFAVGAG----------------IEIYTSKIFA
Mvan_3119|M.vanbaalenii_PYR-1 PLRTPPDMEVAASHGEFYFAVGAG----------------IEIYTSKIFN
MAB_3092c|M.abscessus_ATCC_199 LPPLPAGLTLEDFDAQLTTPRTPSSGPPA-----------PQASRYEVYS
TH_2581|M.thermoresistible__bu IAAHLAGDELTVLVETLQGALGPVCPEQLGRRLLTTVQRLITMWDRPLRE
. : : . :
MMAR_1768|M.marinum_M DRLSIELHGSIPAPQLLLDAIRDILCSVPSEYGLFME-------------
MUL_2011|M.ulcerans_Agy99 DRLSIELHGSIPAPQLLLDAIRDILCSVPSEYGLFME-------------
Mb2964|M.bovis_AF2122/97 GQLIIEHHGHIAEPGKSLEAIRSLLCTVPSEYGWIME-------------
Rv2939|M.tuberculosis_H37Rv GQLIIEHHGHIAEPGKSLEAIRSLLCTVPSEYGWIME-------------
MLBr_02349|M.leprae_Br4923 GQLIIEHHGHIEEPAKALEAIRSLLCTVPSEYGWIME-------------
Mflv_3386|M.gilvum_PYR-GCK GRLMIEYHSHGPAPEKSVQTIETLLRGIAARQAAARVS------------
Mvan_3119|M.vanbaalenii_PYR-1 GQLMIEYHSHGPDREKSVAAIEEQLRAVVARQSGVG--------------
MAB_3092c|M.abscessus_ATCC_199 IGAEFTVVCKFAAGALTGEQAEALRAGIVAGVEALAEP------------
TH_2581|M.thermoresistible__bu VSILLDEERHEQRTAVAAAASDRPDGAAVSTRGGVHGAISAAVRRTPDAV
: :
MMAR_1768|M.marinum_M ---------------------
MUL_2011|M.ulcerans_Agy99 ---------------------
Mb2964|M.bovis_AF2122/97 ---------------------
Rv2939|M.tuberculosis_H37Rv ---------------------
MLBr_02349|M.leprae_Br4923 ---------------------
Mflv_3386|M.gilvum_PYR-GCK ---------------------
Mvan_3119|M.vanbaalenii_PYR-1 ---------------------
MAB_3092c|M.abscessus_ATCC_199 ---------------------
TH_2581|M.thermoresistible__bu ALSWADGALTXXXXRAAVATR