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VAAASSSNPVDAGSPGWLTPIAELLTAADAELATAYPETRDEPQPIHTVYVSAALADVELPGQWGASALA LTARHEPSLAALDTQGVLPRVKERLAADPIQDLRLDFEDGYGWRGDSTEDADARKAGRTLRALSIAANPP AILGIRIKGLTSLHLRRSVRTLELVLDGASGVPRGFVTTIPKFRTVTQVEAALRLFDELERVHGLPSGSL RFELQIESPQAVLGADGAVTLAKAIHLAQGRLTALHYGTYDYSAACGIAAEQQSLEHPVADHAKAVMLAA AAQTGVWVCDGSTQVNPEGSPEQQAAALTRHHRLVTRALERGYWQGWDMHPGHLVTRWLATYGFHRRALA VAGPRILAYLQRQGGGVVDEPATAQALATGILRGLDCGAYTDSALPPGCDRAVLNQLVQRTHS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2939 | - | - | 100% (413) | hypothetical protein MAB_2939 |
| M. abscessus ATCC 19977 | MAB_1369 | - | 6e-08 | 21.89% (265) | citrate lyase beta chain |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_3173 | - | 6e-94 | 47.10% (397) | hypothetical protein Mflv_3173 |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_1209 | - | 1e-135 | 61.37% (409) | hypothetical protein MMAR_1209 |
| M. avium 104 | MAV_2730 | - | 3e-05 | 28.98% (176) | citrate lyase beta chain (Citrase beta chain) |
| M. smegmatis MC2 155 | MSMEG_5726 | - | 1e-130 | 61.62% (396) | hypothetical protein MSMEG_5726 |
| M. thermoresistible (build 8) | TH_3034 | - | 7e-08 | 25.62% (242) | PUTATIVE Citrate (pro-3S)-lyase |
| M. ulcerans Agy99 | MUL_2683 | - | 1e-136 | 61.61% (409) | hypothetical protein MUL_2683 |
| M. vanbaalenii PYR-1 | Mvan_4487 | - | 2e-08 | 22.10% (267) | citrate (pro-3S)-lyase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1209|M.marinum_M --------------MAAATENPKSGSRPVDSPA---LAHIDAVLAQVDQE
MUL_2683|M.ulcerans_Agy99 MAVSRVRGICDDGRVAAATENPKSGSRPVDSPA---LAHIDAVLAQVDQE
MSMEG_5726|M.smegmatis_MC2_155 --------------MPAPTHR-------VAADV---HARIDALLTQVDAD
MAB_2939|M.abscessus_ATCC_1997 --------------MAAASSS-----NPVDAGSPGWLTPIAELLTAADAE
Mflv_3173|M.gilvum_PYR-GCK -----------------MTRR-------LDDVV---LADIDRRLAAADAH
TH_3034|M.thermoresistible__bu --------------------------------------------------
Mvan_4487|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2730|M.avium_104 --------------------------------------------------
MMAR_1209|M.marinum_M LAARYPGDGPGVQPVHTVYVSAAEATSQTPSQWGGAAAALLQRH--VDLL
MUL_2683|M.ulcerans_Agy99 LAARYPGDGPGVQPVHTVYVSAAEATSQTPSQWGAAAAALLQRH--VDLL
MSMEG_5726|M.smegmatis_MC2_155 LAARFPGDRDAVQPVHTVYIGAADADEHTPRQWGEAALELLERH--ADLL
MAB_2939|M.abscessus_ATCC_1997 LATAYPETRDEPQPIHTVYVSAALADVELPGQWGASALALTARH--EPSL
Mflv_3173|M.gilvum_PYR-GCK LAARYPGDDGRRQPVHTVYIPGNRYSATTPAEWGSTALTAAKDAGGLDAV
TH_3034|M.thermoresistible__bu ----------------------------VP---GSSAKMIAKAK------
Mvan_4487|M.vanbaalenii_PYR-1 ---------------MENRYRPRRTCLSVP---GSSAKMIQKAK------
MAV_2730|M.avium_104 ---------------MAPTLRPRRSALYLP---GNKPRALEKGK------
* * .
MMAR_1209|M.marinum_M SELGD---------DAALGLVQRRLAAGPIEDLRLDFEDGYGIRGDDVED
MUL_2683|M.ulcerans_Agy99 SELGD---------DAALGLVQRRLAAGPIEDLRLDFEDGYGIRGDDVED
MSMEG_5726|M.smegmatis_MC2_155 TELSDG------EGDTALALTRKRLADAPIADLRLDFEDGYGRRSDDVED
MAB_2939|M.abscessus_ATCC_1997 AALDT---------QGVLPRVKERLAADPIQDLRLDFEDGYGWRGDSTED
Mflv_3173|M.gilvum_PYR-GCK AALVGPNNETDCEPETLATLVEHKLTTEPIEDLRIDFEDGYGTVDDATED
TH_3034|M.thermoresistible__bu --------------------------TLPADQVFLDLEDAVAP------D
Mvan_4487|M.vanbaalenii_PYR-1 --------------------------TLPADEVFLDLEDAVAP------G
MAV_2730|M.avium_104 --------------------------SLPADVLIFDLEDAVGP------D
* : :*:**. . .
MMAR_1209|M.marinum_M DDAVRAGQTLRSLGLPVC-----GVRIKGLTSSEWRRALRTLELVLDG--
MUL_2683|M.ulcerans_Agy99 DDAVRAGQTLRSLGLPVC-----GVRIKGLTSSEWRRALRTLELVLDG--
MSMEG_5726|M.smegmatis_MC2_155 ADALRAGETLRALGLQSS-----GVRIKGLTMAERTRAVRTLELVLD---
MAB_2939|M.abscessus_ATCC_1997 ADARKAGRTLRALSIAANPPAILGIRIKGLTSLHLRRSVRTLELVLDG--
Mflv_3173|M.gilvum_PYR-GCK ADVAQAIATLRSALDAGTSTPFVGTRFKGLEAATRARGLRTLDMFVSGLV
TH_3034|M.thermoresistible__bu AKAEARTRVAAALAEDG-----WGDQMRGVRVNDWSTPWTHSDVIEVV--
Mvan_4487|M.vanbaalenii_PYR-1 AKEQARGQVAAALAEPG-----WAGQLRGVRVNDWTTPWTHSDIIEVV--
MAV_2730|M.avium_104 AKAESRAAVCEAISSPD-----YRPREIVVRINGLDTEWHDDDLAAVA--
. . : : : ::
MMAR_1209|M.marinum_M -AGGVPDGFVFTVPKLRAGDQVGAAVQLCEALETAHGLPTGALKFELQIE
MUL_2683|M.ulcerans_Agy99 -AGGVPDGFVFTVPKLRAGDQVGAAVQLCEALETAHGLPTGALKFELQIE
MSMEG_5726|M.smegmatis_MC2_155 --GGIPDGFVFTVPKLRAAEQVTAAVWVCEALESAHGLPERTLQFELQIE
MAB_2939|M.abscessus_ATCC_1997 -ASGVPRGFVTTIPKFRTVTQVEAALRLFDELERVHGLPSGSLRFELQIE
Mflv_3173|M.gilvum_PYR-GCK ASGGLPEGLTLTLPKVTSVDQVEAMVAVASALEDANGLSAGRIRFEVQVE
TH_3034|M.thermoresistible__bu -SAAGAHLDIIVLPKVTDVSHIHALDLLLSQLEVQHGLPVGRIGIEAQIE
Mvan_4487|M.vanbaalenii_PYR-1 -ARAGASLDIVVLPKVTDASHVHALDLLLSQLEATHGLPLGRIGIEAQIE
MAV_2730|M.avium_104 ----GSAADGVLVPKVETAQQVQALDRALDTLG-----ASASLQLWVMME
. :**. :: * . * . : : :*
MMAR_1209|M.marinum_M SPQAVIGPDGAATLARAIHMSQRRCTGLHYGTYDYSAACGIAPQHQALDH
MUL_2683|M.ulcerans_Agy99 SPQAVIGPDGAATLARAIHMSQRRCTGLHYGTYDYSAACGIAPQHQALDH
MSMEG_5726|M.smegmatis_MC2_155 SPQAVLGPDGTATVAAAIHRADGRCTGLHYGTYDYSAACGIAPQHQSLDH
MAB_2939|M.abscessus_ATCC_1997 SPQAVLGADGAVTLAKAIHLAQGRLTALHYGTYDYSAACGIAAEQQSLEH
Mflv_3173|M.gilvum_PYR-GCK TPQAILGADGRAPVAQFIHAGQGRVSSLHYGTYDYSASLGIAAAYQSMEH
TH_3034|M.thermoresistible__bu NAQGLTNIDAIAAAP--------RVQALVLGPADLMASLNMRTLVVGEQP
Mvan_4487|M.vanbaalenii_PYR-1 DAKGLTNVDAIASAP--------RVQALVLGPADLMASLNMRTLEVGEQP
MAV_2730|M.avium_104 TPRAFLRAEEVASAS-------DRLAGLVVGTNDLVNELHGR--------
.:.. : .. . * .* *. *
MMAR_1209|M.marinum_M PVADHAKAVMLAAAAQTGVRVSDGSTNVVPEGTEEQVVQAFRSHYRLVTR
MUL_2683|M.ulcerans_Agy99 PVADHAKAVMLAAAAQTGVRVSDGSTNVVPEGTEEQVVQAFRSHYRLVTR
MSMEG_5726|M.smegmatis_MC2_155 PIADHAKAVMQTAAAQTGVWVADGSTQVSPVGTDEQVAQAIRRHHRLVTR
MAB_2939|M.abscessus_ATCC_1997 PVADHAKAVMLAAAAQTGVWVCDGSTQVNPEGSPEQQAAALTRHHRLVTR
Mflv_3173|M.gilvum_PYR-GCK PAADHAKNVMQLAVAGTGVHMSDGSTNIVPAGDPDDVAAAWTLHARLVRR
TH_3034|M.thermoresistible__bu EGYDVGDAYHHVLMR---ILIAARTHGIAAIDGPFLQIRDVEAFRRVAAR
Mvan_4487|M.vanbaalenii_PYR-1 EGYTEGDAYHHVLMR---ILVAARANGIAAIDGPYLKVRDVASFRRVAGR
MAV_2730|M.avium_104 ----HVAGRGPVVPALGLALLGARAAGKVVLDGVFNDITDDAGFRAEAAQ
: : . . . :
MMAR_1209|M.marinum_M SLERGYYQGWDMHPGHLVTRWLATFTFFRAALGVAAPRLQAYLERAGGGV
MUL_2683|M.ulcerans_Agy99 SLERGYYQGWDMHPGHLVTRWLATFTFFRAALGVAAPRLQAYLERAGGGV
MSMEG_5726|M.smegmatis_MC2_155 SLERGLYQGWDMHPGHLVTRWLATFAFFRAAMAAAAPRLQNYLDRRGGAI
MAB_2939|M.abscessus_ATCC_1997 ALERGYWQGWDMHPGHLVTRWLATYGFHRRALAVAGPRILAYLQRQGGGV
Mflv_3173|M.gilvum_PYR-GCK HLERGIYQGWDMHPAQLVTRYLATYAFYRGAFSPAAARLRNYVHQLDSTV
TH_3034|M.thermoresistible__bu SAALGYDGKWVLHPDQIAAG-NEVFSPRQEDYNHAELILEAYEWYTS---
Mvan_4487|M.vanbaalenii_PYR-1 SAALGYDGKWVLHPDQIEAG-NEIFSPRQQAYDHAELILEAYEWHTS---
MAV_2730|M.avium_104 GREMGFDGKTLIHPSQIAPA-NEVFGPSQHELADARKVVSAYQ-------
* :** :: . : : * : *
MMAR_1209|M.marinum_M IDEPATAEALAAVVLRGLDCGAFSADQVRDAAPGATESVLRALKMRIPQE
MUL_2683|M.ulcerans_Agy99 IDEPATAEALAAVVLRGLDCGAFSADQVRDAAPGATESVLRALKMRIPQE
MSMEG_5726|M.smegmatis_MC2_155 VDEPATAEALATVVLRGLDCGAFEAADVLALAPGATVEVLHDLKNRI---
MAB_2939|M.abscessus_ATCC_1997 VDEPATAQALATGILRGLDCGAYTDS---ALPPGCDRAVLNQLVQRTHS-
Mflv_3173|M.gilvum_PYR-GCK MDEPATARALAGVIHRGSVCGALTVDEIETALDLPLSTVRDIALGRPTRS
TH_3034|M.thermoresistible__bu --QAGGARGAAMLGDEMIDEASRKMALVIAAKGRAAGMTRTGGRFQPPS-
Mvan_4487|M.vanbaalenii_PYR-1 --QAGGARGAVMLGDEMIDEASRKMALVIAGKGRAAGMQRTGEGFRPPS-
MAV_2730|M.avium_104 -QAQAAGTSVITVDGRMIESLHVRDAQRILALADLISERDAAS-------
. . . .
MMAR_1209|M.marinum_M YNPS
MUL_2683|M.ulcerans_Agy99 YNPS
MSMEG_5726|M.smegmatis_MC2_155 ----
MAB_2939|M.abscessus_ATCC_1997 ----
Mflv_3173|M.gilvum_PYR-GCK TQ--
TH_3034|M.thermoresistible__bu ----
Mvan_4487|M.vanbaalenii_PYR-1 ----
MAV_2730|M.avium_104 ----