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EPRPYFQPRPVPAWGAPLPPPAHAPMAPPQRGWHPPPITPFPGYQAPQPLPAYRVPPGRPVYPPPVGYGP RPRARGRSHTGLIIGGASFVLVAILMLGTVVVWSVHQDSGGRHPVRVTSTWQYSPTSTWISPKVTPPQPP PGPQPVYALGDNPLFRDREAGFTNAPCSTSTWPFDIPHAEAFYRDLLGCLDPEWKRLLDGLRLPWSSPGL VVAGSYVDSPCGGEDFSGGETAAFYCSANNTIYMSTVSMSPNRYGNHDGFYLAVYAHEYGHHVQELSGIS SEEWNQRVAAGVDSPVGLELSRRSELQAQCFSGMFLGSRRGGTITQHELDLAWNDQYRGDGQRSKRDHGS NEHSAAWWRHGSLKNRLWECNTWLSDSSEVS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2775c | - | - | 100% (382) | hypothetical protein MAB_2775c |
| M. abscessus ATCC 19977 | MAB_2867 | - | 4e-09 | 27.57% (214) | hypothetical protein MAB_2867 |
| M. abscessus ATCC 19977 | MAB_1370c | - | 7e-06 | 35.04% (117) | hypothetical protein MAB_1370c |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2605 | - | 4e-10 | 31.54% (130) | hypothetical protein Mb2605 |
| M. gilvum PYR-GCK | Mflv_2044 | - | 2e-10 | 47.83% (69) | integral membrane protein-like protein |
| M. tuberculosis H37Rv | Rv2575 | - | 4e-10 | 31.54% (130) | hypothetical protein Rv2575 |
| M. leprae Br4923 | MLBr_00222 | ftsH | 4e-07 | 43.75% (64) | putative integral membrane peptidase |
| M. marinum M | MMAR_2166 | - | 5e-09 | 47.62% (63) | proline and glycine rich transmembrane protein |
| M. avium 104 | MAV_3451 | - | 3e-08 | 24.06% (212) | metallopeptidase, zinc binding |
| M. smegmatis MC2 155 | MSMEG_3000 | - | 1e-07 | 28.57% (133) | metallopeptidase, zinc binding |
| M. thermoresistible (build 8) | TH_0541 | - | 8e-09 | 30.00% (130) | POSSIBLE CONSERVED MEMBRANE GLYCINE RICH PROTEIN |
| M. ulcerans Agy99 | MUL_4272 | - | 5e-09 | 52.24% (67) | hypothetical protein MUL_4272 |
| M. vanbaalenii PYR-1 | Mvan_2608 | - | 2e-09 | 27.81% (187) | protein of unknown function, zinc metallopeptidase putative |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_3000|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2608|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2605|M.bovis_AF2122/97 --------------------------------------------------
Rv2575|M.tuberculosis_H37Rv --------------------------------------------------
MAV_3451|M.avium_104 --------------------------------------------------
TH_0541|M.thermoresistible__bu --------------------------------------------------
Mflv_2044|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_2166|M.marinum_M --------------------------------------------------
MUL_4272|M.ulcerans_Agy99 --------------------------------------------------
MAB_2775c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00222|M.leprae_Br4923 MLLMNRKNVIRMVTAIAVVVLLGWSFFYFSDDTRGYKFVDTSVAMSQING
MSMEG_3000|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2608|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2605|M.bovis_AF2122/97 --------------------------------------------------
Rv2575|M.tuberculosis_H37Rv --------------------------------------------------
MAV_3451|M.avium_104 --------------------------------------------------
TH_0541|M.thermoresistible__bu --------------------------------------------------
Mflv_2044|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_2166|M.marinum_M --------------------------------------------------
MUL_4272|M.ulcerans_Agy99 --------------------------------------------------
MAB_2775c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00222|M.leprae_Br4923 HNVKSAQIDDREQQLRLTLKKGNNDTDGSDKVITKYPTGYAVDLFNALSA
MSMEG_3000|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2608|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2605|M.bovis_AF2122/97 --------------------------------------------------
Rv2575|M.tuberculosis_H37Rv --------------------------------------------------
MAV_3451|M.avium_104 --------------------------------------------------
TH_0541|M.thermoresistible__bu --------------------------------------------------
Mflv_2044|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_2166|M.marinum_M --------------------------------------------------
MUL_4272|M.ulcerans_Agy99 --------------------------------------------------
MAB_2775c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00222|M.leprae_Br4923 KNTKVTTAVNEGSILGELLVYVLPLLLLVGLFVMFSRMQGGARMGFGFGK
MSMEG_3000|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2608|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2605|M.bovis_AF2122/97 --------------------------------------------------
Rv2575|M.tuberculosis_H37Rv --------------------------------------------------
MAV_3451|M.avium_104 --------------------------------------------------
TH_0541|M.thermoresistible__bu --------------------------------------------------
Mflv_2044|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_2166|M.marinum_M --------------------------------------------------
MUL_4272|M.ulcerans_Agy99 --------------------------------------------------
MAB_2775c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00222|M.leprae_Br4923 SRAKQLSKDMPKTTFADVAGVDEAVEELYEIKDFLQNPCRYQTLGAKIPK
MSMEG_3000|M.smegmatis_MC2_155 -------------------------------MTFNEGMQIDTSTTSTSGG
Mvan_2608|M.vanbaalenii_PYR-1 -------------------------------MTFNEGMRIDTSTTSTSSG
Mb2605|M.bovis_AF2122/97 -------------------------------MTFNEGVQIDTSTTSTSGS
Rv2575|M.tuberculosis_H37Rv -------------------------------MTFNEGVQIDTSTTSTSGS
MAV_3451|M.avium_104 -------------------------------MTFNEGMQIDTSTASSSG-
TH_0541|M.thermoresistible__bu -------------------------------------MRIDTSTTSTGGG
Mflv_2044|M.gilvum_PYR-GCK ----------------------------MTENPPPGGYPPPPQGGYPPPP
MMAR_2166|M.marinum_M ----------------------------MSQPPENPGNQADPQGGDQSTP
MUL_4272|M.ulcerans_Agy99 -----------------------------MSTLPPPGYPVEPNSGAPGYE
MAB_2775c|M.abscessus_ATCC_199 ----------------------------MEPRPYFQPRPVPAWGAPLPPP
MLBr_00222|M.leprae_Br4923 GVLLYGPPGTGKTLLARAVAGEAGVPFFTISGSDFVEMFVGVGASRVRDL
MSMEG_3000|M.smegmatis_MC2_155 G-----------------RRGPGRGMAIGG-----------------GLG
Mvan_2608|M.vanbaalenii_PYR-1 G-----------------GRGPGRGIAVGG-----------------GLG
Mb2605|M.bovis_AF2122/97 --------------------GGGRRLAIGG-----------------GLG
Rv2575|M.tuberculosis_H37Rv --------------------GGGRRLAIGG-----------------GLG
MAV_3451|M.avium_104 --------------------GGGMGMAVGG-----------------GGL
TH_0541|M.thermoresistible__bu --------------------GGGRRIAVGG-----------------GIG
Mflv_2044|M.gilvum_PYR-GCK PSEGGYPPPPPEGGYPPPPPAGGYQQPPPG-------------------G
MMAR_2166|M.marinum_M ----GYPPPP-NYGTPPPPPPPGYGAPPAGPP---------------GYG
MUL_4272|M.ulcerans_Agy99 AAG---------------YPPSGYADPPPAYG---------------PPP
MAB_2775c|M.abscessus_ATCC_199 AHAP--------------MAPPQRGWHPPPIT---------------PFP
MLBr_00222|M.leprae_Br4923 FDQAKQNSPCIIFVDEIDAVGRQRGTGLGGGHDEREQTLNQLLVEMDGFG
MSMEG_3000|M.smegmatis_MC2_155 GLLIVVLALFLG---------VDPG--------------------QVLPQ
Mvan_2608|M.vanbaalenii_PYR-1 GLLIVVVALFLG---------VDPS--------------------TVLPQ
Mb2605|M.bovis_AF2122/97 GLLVVVVAMLLG---------VDPG--------------------GVLSQ
Rv2575|M.tuberculosis_H37Rv GLLVVVVAMLLG---------VDPG--------------------GVLSQ
MAV_3451|M.avium_104 GLIILLGALFLG---------VDPG--------------------RVMPQ
TH_0541|M.thermoresistible__bu GLLVVVVALLLG---------VDPG--------------------TVTPQ
Mflv_2044|M.gilvum_PYR-GCK AYPPPPGPGGYP---------PPPGQ-------------------GGYPP
MMAR_2166|M.marinum_M APPPPPGYGTPP---------PPPGY-------------------GTPPP
MUL_4272|M.ulcerans_Agy99 AYGPPPGYGAPP---------PGYGPPP-----------------GYAPP
MAB_2775c|M.abscessus_ATCC_199 GYQAPQPLPAYR---------VPPGR-------------------PVYPP
MLBr_00222|M.leprae_Br4923 DRAGVILIAATNRPDILDPALLRPGRFDRQIPVSNPDLAGRRAVLRVHSK
. .
MSMEG_3000|M.smegmatis_MC2_155 QQQ----MDSEGAEAGGFDLSQCRTGADANEIVQCR-----------VVA
Mvan_2608|M.vanbaalenii_PYR-1 QPP----MDTQGVEAPGFDLSQCQTGKDANEIVQCR-----------VVA
Mb2605|M.bovis_AF2122/97 QP-----LDTRDHVAPGFDLSQCRTGADANRFVQCR-----------VVA
Rv2575|M.tuberculosis_H37Rv QP-----LDTRDHVAPGFDLSQCRTGADANRFVQCR-----------VVA
MAV_3451|M.avium_104 QQ-----TNTGGYSAPGFDLSQCKTGADANKYVQCR-----------VVA
TH_0541|M.thermoresistible__bu QQR----LDPGGAASEGFDLSQCRTGADANRLAECR-----------VVA
Mflv_2044|M.gilvum_PYR-GCK PPG-GYGMPPAGFGG-GY-----PPPGQGYPPVGGP----------PSLD
MMAR_2166|M.marinum_M PPPPGYGQAPGGYAPPGYNPPPPPPPGYGPPPAGYPAQPGFGGPAKPPFS
MUL_4272|M.ulcerans_Agy99 PPG--YGPPPGYGPPPGYGP---PPPGYGPPLVPGAVKPG--IIPLRPLT
MAB_2775c|M.abscessus_ATCC_199 PVGYGPRPRARGRSHTGLIIGGASFVLVAILMLGTVVVWS-------VHQ
MLBr_00222|M.leprae_Br4923 GKPIADDADLDGLAKRTVGMTGADLANVVNEAALLTAREN------GLVI
MSMEG_3000|M.smegmatis_MC2_155 TGNSVDGVWQQLLQGYQRPQ--------VRLFTGQVNTG-CGTATSDVGP
Mvan_2608|M.vanbaalenii_PYR-1 TGNSLDGVWEQLMPGYTRPQ--------IELFTSGVETEGCGFASSDVGP
Mb2605|M.bovis_AF2122/97 TGNSVDAVWKPLLPGYTRPH--------MRLFSGQVGTG-CGPASSEVGP
Rv2575|M.tuberculosis_H37Rv TGNSVDAVWKPLLPGYTRPH--------MRLFSGQVGTG-CGPASSEVGP
MAV_3451|M.avium_104 TGNSVDAVWHQLMPRYTRPH--------VRLFTGRVNTG-CGPATTAVGP
TH_0541|M.thermoresistible__bu TGNSLDAVWAQLLPGYQRPR--------IMLFTDAVNTG-CGAATSDVGP
Mflv_2044|M.gilvum_PYR-GCK IGAAFSWSFNKFSKNAVPLI--------VPTLVYALVIGVLGAVIFGLAS
MMAR_2166|M.marinum_M VGEAISWAWNRFTQNAMALV--------VPIVIYGLILSAVGGVMVGLFF
MUL_4272|M.ulcerans_Agy99 LSDIFNGAVGYIRANPKATLGLTA----IVVVVMQVITLLAAIGPLEAAS
MAB_2775c|M.abscessus_ATCC_199 DSGGRHPVRVTSTWQYSPTSTWIS----PKVTPPQPPPGPQPVYALGDNP
MLBr_00222|M.leprae_Br4923 TGPALEEAVDRVIGGPRRKGRIISEQEKKITAYHEGGHTLAAWAMPDIEP
.
MSMEG_3000|M.smegmatis_MC2_155 FYCPVDKTAYFDTDF--------------FDVLKTQFGSSGGPLAQEYVV
Mvan_2608|M.vanbaalenii_PYR-1 FYCPVDKTAYFDTGF--------------FDVLKTQFGSSGGPLAEEYVV
Mb2605|M.bovis_AF2122/97 FYCPVDKTAYFDTDF--------------FQVLVTQFGSSGGPFAEEYVV
Rv2575|M.tuberculosis_H37Rv FYCPVDKTAYFDTDF--------------FQVLVTQFGSSGGPFAEEYVV
MAV_3451|M.avium_104 FYCPVDQTAYFDTDF--------------FQELVDRFGSSGGPFAQEYVV
TH_0541|M.thermoresistible__bu FYCPADQTAYFDTGF--------------FDVLRDQFGSSGGPLAQEYVV
Mflv_2044|M.gilvum_PYR-GCK LFP-ADYTSYSGADG------------AGMSLDMGPAATIILFLGLIMLF
MMAR_2166|M.marinum_M AFSDRTSTTYTDAYGNTS---------ETVNMTMSPLASIVMFIGYLAVF
MUL_4272|M.ulcerans_Agy99 RFDTHPSELSWGVVGAWTGS-------AAAGLLVSWLGGMLLSGILTVVV
MAB_2775c|M.abscessus_ATCC_199 LFRDREAGFTNAPCSTSTWP-------FDIPHAEAFYRDLLGCLDPEWKR
MLBr_00222|M.leprae_Br4923 IYKVTILARGRTGGHAVAVPEEDKGLRTRSEMIAQLVFAMGGRAAEELVF
:
MSMEG_3000|M.smegmatis_MC2_155 AHEFGHHVQNLLGVLGRAQ-RDPEG-------ATGAG-------------
Mvan_2608|M.vanbaalenii_PYR-1 AHEFGHHIQNLEGVLGRAQ-QDPTG-------PTGGG-------------
Mb2605|M.bovis_AF2122/97 AHEYGHHVQNLLGVLGRAQ-QGAQG-------AAGSG-------------
Rv2575|M.tuberculosis_H37Rv AHEYGHHVQNLLGVLGRAQ-QGAQG-------AAGSG-------------
MAV_3451|M.avium_104 AHEYGHHVQNLQGVLGRSQ-QGAQG-------AGGNG-------------
TH_0541|M.thermoresistible__bu AHEFGHHVQNLQGTLGRAHGPAAQG-------PQGAG-------------
Mflv_2044|M.gilvum_PYR-GCK VVGGAISAAYMAGVLDIANGQQVEFGSFFKPRNIGAV-------------
MMAR_2166|M.marinum_M AVVLFMHAGITTGCLDIADGKPVTIGSFFKPRNLGMV-------------
MUL_4272|M.ulcerans_Agy99 GRAVFGSPITISEAWARVRGRILALIGLALLEGAGLV-------------
MAB_2775c|M.abscessus_ATCC_199 LLDGLRLPWSSPGLVVAGSYVDSPCGG----EDFSGG-------------
MLBr_00222|M.leprae_Br4923 REPTTGAVSDIEKATKIARSMVTEFGMSSKLGAVRYGSEHGDPFLGRTMG
MSMEG_3000|M.smegmatis_MC2_155 ---------------VRTELQADCYAGVWAHYASITRQESTG--------
Mvan_2608|M.vanbaalenii_PYR-1 ---------------VRTELQADCYAGIWAHYASITKQEGTD--------
Mb2605|M.bovis_AF2122/97 ---------------VRTELQADCYAGVWAYYASTVKQESTG--------
Rv2575|M.tuberculosis_H37Rv ---------------VRTELQADCYAGVWAYYASTVKQESTG--------
MAV_3451|M.avium_104 ---------------VRTELQADCYAGIWAHYASTVKQESTG--------
TH_0541|M.thermoresistible__bu ---------------VRTELQADCYAGVWAHYAAITEQEDTG--------
Mflv_2044|M.gilvum_PYR-GCK ---------------VIASLIVGIATSIGYVLCIVPGLIVSI--------
MMAR_2166|M.marinum_M ---------------ILTGLLVIVLTAIGSVLCIVPGLIFGF--------
MUL_4272|M.ulcerans_Agy99 ---------------ALAGLVVVILVGVAAAANGATAALLGFPLVLLVGL
MAB_2775c|M.abscessus_ATCC_199 ---------------ETAAFYCSANNTIYMSTVSMSPNRYGN--------
MLBr_00222|M.leprae_Br4923 TQADYSHEVARDIDDEVRKLIEAAHTEAWEILTEYRDVLDTLAGELLEKE
:
MSMEG_3000|M.smegmatis_MC2_155 -------VPFLEPLSDKD----IADALSAAASVGDDRIQQSATGRVNPEA
Mvan_2608|M.vanbaalenii_PYR-1 -------VPFLEPLSDKD----IADALSAASAVGDDRIQEAATGRVSPES
Mb2605|M.bovis_AF2122/97 -------VPYLEPLSDKD----IQDALAAAAAVGDDRIQQQTTGRTNPET
Rv2575|M.tuberculosis_H37Rv -------VPYLEPLSDKD----IQDALAAAAAVGDDRIQQQTTGRTNPET
MAV_3451|M.avium_104 -------VPYLEPLSDKD----IADALSAAASVGDDRIQKQATGRVNPES
TH_0541|M.thermoresistible__bu -------VPFLEPLSDQD----IADALSAAAAVGDDRIQQAATGRVSPES
Mflv_2044|M.gilvum_PYR-GCK -------FALFTTVFIVDRNLSAIDGIKASIAVAKANFLQVFLTWLIFNV
MMAR_2166|M.marinum_M -------LAQFAIIAAVDRSLSPIDSIKSSFATVRAELGNTALSWLVQYA
MUL_4272|M.ulcerans_Agy99 LVAYLYTVLMFAPVLIVLERLPLVDAITRSFALVTGGFWRVLGIRLLTAI
MAB_2775c|M.abscessus_ATCC_199 ------HDGFYLAVYAHEYGHHVQELSGISSEEWNQRVAAGVDSPVGLEL
MLBr_00222|M.leprae_Br4923 TLHRPELEGIFASVEKRPRLTMFDDFGGRIPSDKPPIKTPGELAIERGEP
: :
MSMEG_3000|M.smegmatis_MC2_155 WT------------------------HGSSAQRQKWFTEG----------
Mvan_2608|M.vanbaalenii_PYR-1 WT------------------------HGSSTQRQKWFTTG----------
Mb2605|M.bovis_AF2122/97 WT------------------------HGSAAQRQKWFTVG----------
Rv2575|M.tuberculosis_H37Rv WT------------------------HGSAAQRQKWFTVG----------
MAV_3451|M.avium_104 WT------------------------HGSSEQRQKWFTIG----------
TH_0541|M.thermoresistible__bu WT------------------------HGSSAQRQKWFTVG----------
Mflv_2044|M.gilvum_PYR-GCK LI------------------------SVGSFVCYIGLIVT----------
MMAR_2166|M.marinum_M VV------------------------LAGELLCFVGMLVG----------
MUL_4272|M.ulcerans_Agy99 VVGLVGGAISAPFGIVGQILLGATASEGSTGMFLVGMTLSSIGSAISQII
MAB_2775c|M.abscessus_ATCC_199 SR-----------------------RSELQAQCFSGMFLGSRRGGTITQH
MLBr_00222|M.leprae_Br4923 WPQPVPEP-----------AFKAAIARASQAAEASHQAAQSDTDGPPGQG
MSMEG_3000|M.smegmatis_MC2_155 ---YRTGDPNKCDTFATNDLG-----------------------------
Mvan_2608|M.vanbaalenii_PYR-1 ---YQTGDPARCDTFATNNLG-----------------------------
Mb2605|M.bovis_AF2122/97 ---YQTGDPNICDTFSAADLG-----------------------------
Rv2575|M.tuberculosis_H37Rv ---YQTGDPNICDTFSAADLG-----------------------------
MAV_3451|M.avium_104 ---YQTGDPKQCDTFSAPDLG-----------------------------
TH_0541|M.thermoresistible__bu ---YQTGDPQRCDTFATDDLG-----------------------------
Mflv_2044|M.gilvum_PYR-GCK ---VPLAVLYMVYAYRTLTGGYVAPATP----------------------
MMAR_2166|M.marinum_M ---VPVASLIQTYTWRKLSGGQVVELSQPGPPAGLPPGPPPGAPPGPQFG
MUL_4272|M.ulcerans_Agy99 TAPFTAGVVVLLYTDRRMRAEAFDLVLQTGAAGGPAAVESTDTLWLTRPL
MAB_2775c|M.abscessus_ATCC_199 ELDLAWNDQYRGDGQRSKRDHGSNEHSAAWWRHGSLKNRLWECNTWLSDS
MLBr_00222|M.leprae_Br4923 ANGSHAGDRQRQHGPTQPDYGAPPGWHAPGWPPQQPPDYWYPPEQQPSQS
MSMEG_3000|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2608|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2605|M.bovis_AF2122/97 --------------------------------------------------
Rv2575|M.tuberculosis_H37Rv --------------------------------------------------
MAV_3451|M.avium_104 --------------------------------------------------
TH_0541|M.thermoresistible__bu --------------------------------------------------
Mflv_2044|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_2166|M.marinum_M --------------------------------------------------
MUL_4272|M.ulcerans_Agy99 --------------------------------------------------
MAB_2775c|M.abscessus_ATCC_199 SEVS----------------------------------------------
MLBr_00222|M.leprae_Br4923 PYWPQPAPSYPGQAPPPYPSYPPCPSYPPPGQSAPDAGKPPAQLDEGVSP
MSMEG_3000|M.smegmatis_MC2_155 -------
Mvan_2608|M.vanbaalenii_PYR-1 -------
Mb2605|M.bovis_AF2122/97 -------
Rv2575|M.tuberculosis_H37Rv -------
MAV_3451|M.avium_104 -------
TH_0541|M.thermoresistible__bu -------
Mflv_2044|M.gilvum_PYR-GCK -------
MMAR_2166|M.marinum_M -------
MUL_4272|M.ulcerans_Agy99 -------
MAB_2775c|M.abscessus_ATCC_199 -------
MLBr_00222|M.leprae_Br4923 SNPPAHG