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VQYVTRTTGLERLDLPYMALPNSSLAGVDLSTEFLGRRLAAPVLIGAMTGGAKLAATINRNLAAAAQELG IGMMLGSQRVMLVEPDSADTFAVREVAPDILLIGNIGLAQLGNIAPAAQLNSLVRRVGADALAVHTNPLQ EAVQPGGDTDFTGQVYRLAELTHAVEFPVLLKEVGHGISGAAARRLGGCRLAAIDVAGAGGTSWARVEQF VRFGAITSPELAEWGIPTAEALVEVHAELPHMPLIGSGGIRTGMDAAKAIALGASVVSVALPLLAPAVQS PQAVVAWLQQFLDELRIAMHCADVSTIADLRRISLRPRSSPR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_3242 | - | - | 100% (322) | isopentenyl pyrophosphate isomerase |
| M. abscessus ATCC 19977 | MAB_2126 | - | 5e-05 | 33.73% (83) | putative L-lactate 2-monooxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_4187 | - | 1e-106 | 62.50% (312) | isopentenyl pyrophosphate isomerase |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_4812 | idi2 | 1e-107 | 63.98% (322) | isopentenyl pyrophosphate isomerase type 2 Idi2 |
| M. avium 104 | MAV_3894 | fni | 1e-105 | 61.80% (322) | isopentenyl pyrophosphate isomerase |
| M. smegmatis MC2 155 | MSMEG_2337 | fni | 7e-87 | 61.57% (268) | isopentenyl pyrophosphate isomerase |
| M. thermoresistible (build 8) | TH_0845 | - | 7e-08 | 35.42% (96) | lactate 2-monooxygenase |
| M. ulcerans Agy99 | MUL_0380 | idi2 | 1e-106 | 63.35% (322) | isopentenyl pyrophosphate isomerase |
| M. vanbaalenii PYR-1 | Mvan_2176 | - | 1e-107 | 64.42% (312) | isopentenyl pyrophosphate isomerase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4187|M.gilvum_PYR-GCK -----------------MTPDPASALQHRKRRHIDVCLTDPVDYQTLTTG
Mvan_2176|M.vanbaalenii_PYR-1 -----------------MTSDPGSALQHRKRRHIDVCLTEAVDYQSLTTG
MMAR_4812|M.marinum_M -----------------MTNDPA-EISSRKRRHIDVCLNDEVNYVGVTTG
MUL_0380|M.ulcerans_Agy99 -----------------MTNDPA-EISSRKRRHIDVCLNDEVNYVGVTTG
MAV_3894|M.avium_104 -----------------MD-----AMTHRKRRHIDVCLSDPVEFDGVTTG
MSMEG_2337|M.smegmatis_MC2_155 -----------------MRVTGDRDAVARKRRHIDVCLNEAVDHQSVSTG
MAB_3242|M.abscessus_ATCC_1997 -----------------------------------------MQYVTRTTG
TH_0845|M.thermoresistible__bu MAFGDYQLEIYLQGLSGVVPSLPMAFAELEARARAAMSPSVWSYVAGGAG
.. :*
Mflv_4187|M.gilvum_PYR-GCK FER-YQLPYNALTQT--------DLHSVDLGTEFMGSRLRAPVLIG--AM
Mvan_2176|M.vanbaalenii_PYR-1 FER-YRLPYNALTQT--------DLHSVDLSTEFLGSHLRAPVLIG--AM
MMAR_4812|M.marinum_M LER-YRLPFNALTQT--------SLADIDLSAEFFGAPLRAPVLIG--AM
MUL_0380|M.ulcerans_Agy99 LER-YRLPFNALTQT--------SLADIDLSAEFFGAPLRAPVLIG--AM
MAV_3894|M.avium_104 LDR-YRLPYHALTQT--------SLGDIDVSTSFFGANLRAPILIG--AM
MSMEG_2337|M.smegmatis_MC2_155 LER-YRLPYHALTQT--------NLTEIDLTTNFLGKPLRAPVLIG--AM
MAB_3242|M.abscessus_ATCC_1997 LER-LDLPYMALPNS--------SLAGVDLSTEFLGRRLAAPVLIG--AM
TH_0845|M.thermoresistible__bu DERTQRINVSAFDNWGLIPRMLVGATERDLSVNLFGLTLPSPIFMAPIGV
:* : *: : . *: ..::* * :*:::. .:
Mflv_4187|M.gilvum_PYR-GCK TGGAALSGIINRNLAEAAQQLGVGMMLG--SQRVMID-DAV---AAESFD
Mvan_2176|M.vanbaalenii_PYR-1 TGGAALSGIINRNLAAAAQQLGIGMMLG--SQRVMID-DEA---AAASFE
MMAR_4812|M.marinum_M TGGAELSATINRNLATAAQRLGIGMMLG--SQRIMLD-DARGQRAASSFA
MUL_0380|M.ulcerans_Agy99 TGGAELSAMINRNLATAAQRLGIGMMLG--SQRIMLD-DARGQRAASSFA
MAV_3894|M.avium_104 TGGAEMSKTINRNLAAAAQQLGIGMMLG--SQRIMLD-SALGERAADSFA
MSMEG_2337|M.smegmatis_MC2_155 TGGAELSGTINRNLAAAAQKLGVGMMLG--SQRIMLRSGEQAAHRSESFA
MAB_3242|M.abscessus_ATCC_1997 TGGAKLAATINRNLAAAAQELGIGMMLG--SQRVMLVEPDS----ADTFA
TH_0845|M.thermoresistible__bu LGICAQDHHGDLACARAAARTGVPLVVSTLTQDPLEDIAAEFGDTPGFFQ
* . : * ** . *: :::. :* : . *
Mflv_4187|M.gilvum_PYR-GCK VRGVAPDVLVIGNIGLAQLQ--PSMVPALAAALDRVGANGLAVHTNPLQE
Mvan_2176|M.vanbaalenii_PYR-1 VRGVAPDILLIGNIGLAQLR--SSMVPGLAAALDRVGANGLAVHTNPLQE
MMAR_4812|M.marinum_M VREVAPDVLLIGNIGLAQLT--KAAVPAVAAALRRVGANALAVHANSLQE
MUL_0380|M.ulcerans_Agy99 VREVAPDVLLIGNIGLAQLT--KAAVPAVAAALRRVGANALAVHANSLQE
MAV_3894|M.avium_104 VRDVAPDVLLFGNIGLSQLA--KTAVPHLVKALDRVGADALAVHTNPLQE
MSMEG_2337|M.smegmatis_MC2_155 VRDVAPDVLLVGNIGLSQLT--HDNAPLITDALRRVGADALAVHTNPLQE
MAB_3242|M.abscessus_ATCC_1997 VREVAPDILLIGNIGLAQLGN-IAPAAQLNSLVRRVGADALAVHTNPLQE
TH_0845|M.thermoresistible__bu LYTPNDRDLAASLVRRAEKAGYKGIIVTLDTWIPGWRPRDLSTSNFPQLR
: * . : :: : : . *:. . .
Mflv_4187|M.gilvum_PYR-GCK AMQHN---GDTDFSGSMSRLREVVDSLGYPVMLKEVGHGIGASAAAQLVD
Mvan_2176|M.vanbaalenii_PYR-1 AMQHD---GDTDFSGSIGRLCDVAGAIGYPVVLKEVGHGIGAAAAAELVG
MMAR_4812|M.marinum_M AMQHG---GDTDFSGSLGRLRDAADLLDYPVLLKEVGHGIGAAAVAQLLR
MUL_0380|M.ulcerans_Agy99 AMQHG---GDTDFSGSLGRLRDAADLLDYPVLLKEVGHGIGAAAVAQLLR
MAV_3894|M.avium_104 AMQHN---GDTDFSGSLSRLREAAAALDYPVLLKEVGHGIGGAAAAELVG
MSMEG_2337|M.smegmatis_MC2_155 AIQAN---GDTDFAGSRERLLEIGPSIGCPLLLKEVGHGIGAAAVAELTG
MAB_3242|M.abscessus_ATCC_1997 AVQPG---GDTDFTGQVYRLAELTHAVEFPVLLKEVGHGISGAAARRLGG
TH_0845|M.thermoresistible__bu GYSLANYTSDPVFSAGLQQPPEQNPQAVVTRWVQLFGNSLTWDDLPWLRS
. . .*. *:. : : . :: .*:.: *
Mflv_4187|M.gilvum_PYR-GCK ----CPVAAVDVAGAGGTSWARIEQFV-RYGEVRYPALAEWGIPTAQALT
Mvan_2176|M.vanbaalenii_PYR-1 ----CPIAAIDVAGAGGTSWARIEQFV-RYGDVRYPALAEWGVPTAQALT
MMAR_4812|M.marinum_M LPGGLPVSGIDVAGAGGTSWSRVEQLV-RYGELRYPELADWGIPTAEAIV
MUL_0380|M.ulcerans_Agy99 LPGGLPVSGIDVAGAGGTSWSRVEQLV-RYGELRYPELADWGIPTAEAIV
MAV_3894|M.avium_104 GEGQPPVAGIDVAGAGGTSWSRVEQFV-RYGELRYPDLADWGVPTARAIV
MSMEG_2337|M.smegmatis_MC2_155 GRDDVPVAAIDVAGAGGTSWSRVEQFV-RYGTVRYPDLADWGVPTARAII
MAB_3242|M.abscessus_ATCC_1997 ----CRLAAIDVAGAGGTSWARVEQFV-RFGAITSPELAEWGIPTAEALV
TH_0845|M.thermoresistible__bu -LTTLPLILKGICHPDDVRRAKDAGVDGIYCSNHGGRQANGGLPAIDCLP
: .:. .... :: . : *: *:*: .:
Mflv_4187|M.gilvum_PYR-GCK EVRGILPDVPLVASGGIRTGMDAAKALAMGAEVVAIARP-LLAPAVESVG
Mvan_2176|M.vanbaalenii_PYR-1 EVRQMLPDVPLVASGGIRTGMDAAKALAMGARVVAVARP-LLAPAVESVE
MMAR_4812|M.marinum_M EVRQALPAVPLVASGGIRTGMDAAKAIALGADVVAIARP-LLAPAIESAT
MUL_0380|M.ulcerans_Agy99 EVRQALPAVPLVASGGIRTGMDAAKSIALGADVVAIARP-LLAPAIESAT
MAV_3894|M.avium_104 EVRRLLPEIPLVASGGIRTGMDAAKAIALGADVVAVARP-LLPAAIESSA
MSMEG_2337|M.smegmatis_MC2_155 EVRQALPRIPLVASGGIRTGMDAAKGLFALDGVETIS---CFRAVIEGS-
MAB_3242|M.abscessus_ATCC_1997 EVHAELPHMPLIGSGGIRTGMDAAKAIALGASVVSVALP-LLAPAVQSPQ
TH_0845|M.thermoresistible__bu DVVAAADGMPVLFDSGIRSGADIVKALALGATAVGIGRPYPYGLALGGED
:* :*:: ..***:* * .*.: . :. .: .
Mflv_4187|M.gilvum_PYR-GCK AVVDWLQRFIDELLVCLHGSGAANLSALRERGVTELP----
Mvan_2176|M.vanbaalenii_PYR-1 AVVDWLQRFIDELLVCLHGCGAANLSALRGRGVTELP----
MMAR_4812|M.marinum_M AVQGWLQLFLDELRVCLHCCGARDLTSLRDIGVTAIR----
MUL_0380|M.ulcerans_Agy99 AVQDWLQLFLDELRVCLHCCGAPDLTSLRDIGVTAIR----
MAV_3894|M.avium_104 AVVDWLRPFIDELRVCLHGCGVADLAGLRAVELIRLA----
MSMEG_2337|M.smegmatis_MC2_155 ---GWLG-------VCRRRSGRARGRAECPGAVWTWRCCRS
MAB_3242|M.abscessus_ATCC_1997 AVVAWLQQFLDELRIAMHCADVSTIADLRRISLRPRSSPR-
TH_0845|M.thermoresistible__bu GVVHVLRSLLAEADLIMAVDGYPTLADLTPDALRRVT----
* : . :