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MELQKQSPDDDDVVITGIGLVAGTVTDPEELFWQLADGASFIRQHQEHRDAELPASVSGHVDEETVRKLA RALPEQAARVGAAGVLGWHAAVQAWKRSGLPNLAGSDRVGVFAACNKLAFAPDTLADLSRLYDRQAGTFD LDAYLDHLEAVSDLPDDLLQFLPDTMTASLAEYFGLGGPLVTHAEACAAGGVAIGSGYRHIRSGELDVAL VGGAERLTTYSIVTAFAALGALAPTGDKPSAEISRPFDKGRNGFVIADGAAFLVLERRSHAEARGAQALA RVAGYMGTAEAVRITSSERDGATYAECMRAAIADAGLSPSDIHHVNAHGTGTQANDECEAAALHLVFGAG AASIPLTSTKSSLGHGFAASGAIEAVLSAMSLREQIIPPTLNFSEPDDVTKGLDVVTKARHHEFDTVLSN SFGFGGMNCTLILAKEA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2028 | - | - | 100% (437) | 3-oxoacyl-(Acyl-carrier-protein) synthase II KasB |
| M. abscessus ATCC 19977 | MAB_2030 | - | 1e-54 | 33.26% (436) | 3-oxoacyl-(Acyl-carrier-protein) synthase II KasA |
| M. abscessus ATCC 19977 | MAB_1877c | - | 3e-54 | 32.94% (428) | 3-oxoacyl-(acyl carrier protein) synthase II |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2270 | kasB | 7e-51 | 31.69% (426) | 3-oxoacyl-(acyl carrier protein) synthase II |
| M. gilvum PYR-GCK | Mflv_2776 | - | 2e-54 | 33.72% (433) | 3-oxoacyl-(acyl carrier protein) synthase II |
| M. tuberculosis H37Rv | Rv2246 | kasB | 7e-51 | 31.69% (426) | 3-oxoacyl-(acyl carrier protein) synthase II |
| M. leprae Br4923 | MLBr_01656 | kasB | 1e-48 | 31.37% (424) | 3-oxoacyl-(acyl carrier protein) synthase II |
| M. marinum M | MMAR_3339 | kasB | 9e-51 | 31.09% (431) | 3-oxoacyl- |
| M. avium 104 | MAV_2191 | - | 1e-52 | 31.38% (427) | 3-oxoacyl-(acyl carrier protein) synthase II |
| M. smegmatis MC2 155 | MSMEG_4328 | - | 1e-49 | 31.48% (432) | 3-oxoacyl-(acyl carrier protein) synthase II |
| M. thermoresistible (build 8) | TH_3425 | - | 2e-52 | 40.36% (275) | PUTATIVE beta-ketoacyl synthase |
| M. ulcerans Agy99 | MUL_1303 | kasB | 6e-51 | 31.09% (431) | 3-oxoacyl-(acyl carrier protein) synthase II |
| M. vanbaalenii PYR-1 | Mvan_3757 | - | 5e-53 | 33.95% (433) | 3-oxoacyl-(acyl carrier protein) synthase II |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3339|M.marinum_M ---------------------MTELVTGKAFPHVVVTGIAMTTALATDAE
MUL_1303|M.ulcerans_Agy99 ---------------------MTELVTGKAFPHVVVTGIAMTTALATDAE
Mb2270|M.bovis_AF2122/97 MGVPPLAGASRTDMEGTFARPMTELVTGKAFPYVVVTGIAMTTALATDAE
Rv2246|M.tuberculosis_H37Rv MGVPPLAGASRTDMEGTFARPMTELVTGKAFPYVVVTGIAMTTALATDAE
MLBr_01656|M.leprae_Br4923 -------------MIARLMTTSPELVTGKAFPNVVVTGIAMTTALATDAE
MAV_2191|M.avium_104 MRAATARKVAGQVREGIFARPMTELVTGKTLPNVVVTGIAMTTALATDAE
MSMEG_4328|M.smegmatis_MC2_155 ---------------------MAALSTGNGLPNVVVTGVAMTTALATDAE
Mflv_2776|M.gilvum_PYR-GCK ---------------------MASPTTGNGLPDVVVTGIAMTTALATDAE
Mvan_3757|M.vanbaalenii_PYR-1 ---------------------MASPTTGNGLPDVVVTGIAMTTSLATDAE
TH_3425|M.thermoresistible__bu ----------------------------------VVTAVTATTSIAPDVE
MAB_2028|M.abscessus_ATCC_1997 ---------------------MELQKQSPDDDDVVITGIGLVAGTVTDPE
*:*.: .:. ..* *
MMAR_3339|M.marinum_M TTWKLLLDSQSGIRTLDDPFVEEFNLPVRIGGHLLEEFDHQLTRVE---L
MUL_1303|M.ulcerans_Agy99 TTWKLLLDSQSGIRTLDDPFVEEFNLPVRIGGHLLEEFDHQLTRVE---L
Mb2270|M.bovis_AF2122/97 TTWKLLLDRQSGIRTLDDPFVEEFDLPVRIGGHLLEEFDHQLTRIE---L
Rv2246|M.tuberculosis_H37Rv TTWKLLLDRQSGIRTLDDPFVEEFDLPVRIGGHLLEEFDHQLTRIE---L
MLBr_01656|M.leprae_Br4923 TTWKLLLDNQSGIRMLDDPFIEEFNLPVRIGGHLLEEFDHQLTRVE---L
MAV_2191|M.avium_104 TTWKLLLDSQSGIRTLDDPFVEEFDLPVRIGGHLLEEFDSQLTRVE---L
MSMEG_4328|M.smegmatis_MC2_155 STWKKLLDGQSGIRTLTDPFVEEYNLPVRIGGHLLEEFDSELTRVE---L
Mflv_2776|M.gilvum_PYR-GCK QTWTSLLDGRSGIRKLDDPFVEQFDLPVRIGGHLLEEFDAQLTKVE---N
Mvan_3757|M.vanbaalenii_PYR-1 ATWKSLLDGHSGIRKLQDPFVEEFDLPVQIGGHLLEEFDSQLTKVE---N
TH_3425|M.thermoresistible__bu GTWKGLLAGESGIHVLEDDFIEKWDLPVRIGGHLKEAVDDHMTRID---I
MAB_2028|M.abscessus_ATCC_1997 ELFWQLADGASFIR--QHQEHRDAELPASVSGHVDEETVRKLARALPEQA
: * * *: . .. :**. :.**: * .:::
MMAR_3339|M.marinum_M RRTAYLQRMSTVIGRRVWENAGSPEVDTNRLAVSIGTG--LGSAEELVFG
MUL_1303|M.ulcerans_Agy99 RRTAYLQRMSTVIGRRVWENAGSPEVDTNRLAVSIGTG--LGSAEELVFG
Mb2270|M.bovis_AF2122/97 RRMGYLQRMSTVLSRRLWENAGSPEVDTNRLMVSIGTG--LGSAEELVFS
Rv2246|M.tuberculosis_H37Rv RRMGYLQRMSTVLSRRLWENAGSPEVDTNRLMVSIGTG--LGSAEELVFS
MLBr_01656|M.leprae_Br4923 RRMGYLQRMSTVLSRRLWENAGSPEVDTNRLMVSIGTG--LGSAEELVFS
MAV_2191|M.avium_104 RRTGYLQRMSTILGRRVWENAGSPEVDSNRLMVSIGTG--LGSSEEMVFS
MSMEG_4328|M.smegmatis_MC2_155 RRLSYLQKMATVLGRRVWANAGSPEVDARRLMVSMGTG--LGSTEELVFA
Mflv_2776|M.gilvum_PYR-GCK RRMSYIQKMATVLGRRVWENAGAPEVDTERLLVSIGTG--LGGAEALVFA
Mvan_3757|M.vanbaalenii_PYR-1 RRMSYVQKMATVLGRRVWENAGSPEVDTERLLVSIGTG--LGGAEALVFA
TH_3425|M.thermoresistible__bu RRMSYVQRMAKLLSGRVWDAAGNPEVDPDRFSVVIGTG--LGGGEKIVET
MAB_2028|M.abscessus_ATCC_1997 ARVGAAGVLGWHAAVQAWKRSGLPNLAGSDRVGVFAACNKLAFAPDTLAD
* . :. . : * :* *:: :.: *. :
MMAR_3339|M.marinum_M YDEMRVRGF--------------RAISPLAVQKYMPNGAAAAVGLERHAK
MUL_1303|M.ulcerans_Agy99 YDEMRVRGF--------------RAISPLAVQKYMPNGAAAAVGLERHAK
Mb2270|M.bovis_AF2122/97 YDDMRARGM--------------KAVSPLTVQKYMPNGAAAAVGLERHAK
Rv2246|M.tuberculosis_H37Rv YDDMRARGM--------------KAVSPLTVQKYMPNGAAAAVGLERHAK
MLBr_01656|M.leprae_Br4923 YDDMRARGM--------------KAVSPLAVQKYMPNGAAAAVGLEHHAK
MAV_2191|M.avium_104 YDDMRARGM--------------KAVSPLGVQKYMPNGAAAAVGLEHHAK
MSMEG_4328|M.smegmatis_MC2_155 YDGMRSKGL--------------RAVSPLVVQMYMPNGAAAAIGLERQAK
Mflv_2776|M.gilvum_PYR-GCK YDGLRERGL--------------RSVSPLSVQMYMPNGPSAVVGLERHAK
Mvan_3757|M.vanbaalenii_PYR-1 YDGLRERGL--------------RSVSPLSVQMYMPNGPSAVVGLERHAK
TH_3425|M.thermoresistible__bu YDAMNEGGP--------------RKVSPLAVQMIMPNGAAAVVGLQLGAR
MAB_2028|M.abscessus_ATCC_1997 LSRLYDRQAGTFDLDAYLDHLEAVSDLPDDLLQFLPDTMTASLAEYFGLG
. : * : :*: :* :.
MMAR_3339|M.marinum_M AGVMTPVSACASGSEAIARAWQQVVLGEADIAICGGVETRIEAVPIAGFA
MUL_1303|M.ulcerans_Agy99 AGVMTPVSACASGSEAIARAWQQVVLGEADIAICGGVETRIEAVPIAGFA
Mb2270|M.bovis_AF2122/97 AGVMTPVSACASGAEAIARAWQQIVLGEADAAICGGVETRIEAVPIAGFA
Rv2246|M.tuberculosis_H37Rv AGVMTPVSACASGAEAIARAWQQIVLGEADAAICGGVETRIEAVPIAGFA
MLBr_01656|M.leprae_Br4923 AGVMTPVSACASGSEAIAHAWQQIVLGEADSAICGGVETKIEAVPIAGFS
MAV_2191|M.avium_104 AGVITPVSACASGSEGIAQAWRNIVFGEADIAICGGVETKIEAVPIAAFA
MSMEG_4328|M.smegmatis_MC2_155 AGVCTSISACASGSEAIANAWRNIVLGEADIAICGGVETKIEAVPIAGFA
Mflv_2776|M.gilvum_PYR-GCK AGVVTPVSACASGSEGIAQAWRNIVMGEADIAICGGVEQRIEAVPIAAFA
Mvan_3757|M.vanbaalenii_PYR-1 AGVVTPVSACASGSEGIAQAWRNIVLGEADIAICGGVEQRIEAVPIAGFA
TH_3425|M.thermoresistible__bu AGVITPVSACASGSEAIAHGWRQIVMGDADIAVVGGVEGGIEALPIAAFS
MAB_2028|M.abscessus_ATCC_1997 GPLVTHAEACAAGGVAIGSGYRHIRSGELDVALVGGAERLTTYSIVTAFA
. : * .***:*. .*. .:::: *: * *: **.* ::.*:
MMAR_3339|M.marinum_M NMRIVMSTNNDDPAGACRPFDKDRDGFVFGEGGALMVIETEEHAKARGAN
MUL_1303|M.ulcerans_Agy99 NMRIVMSTNNDDPAGACRPFDKDRDGFVFGEGGALMVIETEEHAKARGAN
Mb2270|M.bovis_AF2122/97 QMRIVMSTNNDDPAGACRPFDRDRDGFVFGEGGALLLIETEEHAKARGAN
Rv2246|M.tuberculosis_H37Rv QMRIVMSTNNDDPAGACRPFDRDRDGFVFGEGGALLLIETEEHAKARGAN
MLBr_01656|M.leprae_Br4923 QMRIVMSTKNDNPAGACRPFDRDRDGFVFGEAGALMLIETEDSAKARSAN
MAV_2191|M.avium_104 QMRIVMSTKNDDPVGACRPFDRDRTGFVFGEAGALMVIETEEHAKARGAN
MSMEG_4328|M.smegmatis_MC2_155 QMRIVLSNSNDDPEGACKPFDKDRNGFVFGEAGALMVIETEEHAKARGAN
Mflv_2776|M.gilvum_PYR-GCK QMRIVMSTNNDDPAGACRPFDKDRDGFVFGEAGALLVIETEEHAKARGAT
Mvan_3757|M.vanbaalenii_PYR-1 QMRIVMSANNDDPAGACRPFDKDRDGFVFGEAGALMVIETEEHARARGAT
TH_3425|M.thermoresistible__bu MMR-AMSTRNDDPEGASRPFDKDRDGFVFGEAGALMVIETEEHAKARGAQ
MAB_2028|M.abscessus_ATCC_1997 ALGALAPTGDKPSAEISRPFDKGRNGFVIADGAAFLVLERRSHAEARGAQ
: . :. . .:***:.* ***:.:..*::::* .. *.**.*
MMAR_3339|M.marinum_M ILARIMGASITSDGFHMVAPDPNGERAGHAITRAVQLAGLQPSDIDHVNA
MUL_1303|M.ulcerans_Agy99 ILARIMGASITSDGFHMVAPDPNGERAGHAITRAVQLAGLQPSDIDHVNA
Mb2270|M.bovis_AF2122/97 ILARIMGASITSDGFHMVAPDPNGERAGHAITRAIQLAGLAPGDIDHVNA
Rv2246|M.tuberculosis_H37Rv ILARIMGASITSDGFHMVAPDPNGERAGHAITRAIQLAGLAPGDIDHVNA
MLBr_01656|M.leprae_Br4923 ILARIMGASITSDGFHMVAPDPNGERAGHAIARAVHLAGLSPSDIDHVNA
MAV_2191|M.avium_104 ILARIMGASITSDGYHMVAPDPNGERAGHAMSRAIQLAGLTPGDIDHVNA
MSMEG_4328|M.smegmatis_MC2_155 ILGRLMGASVTSDGYHIVAPDPNGEQAGYAMTRAIELAGLKPTDIDHVNA
Mflv_2776|M.gilvum_PYR-GCK PLARLMGASITSDGFHMVAPDPDGERAGYAMTRAIELAGLTPTDIDHVNA
Mvan_3757|M.vanbaalenii_PYR-1 PLARVMGASITSDGYHMVAPDPNGERAGYAITRAIELAGLKPTDIDHVNA
TH_3425|M.thermoresistible__bu PLARLLGAGITSDAFHMVAPASDGVRAGHAMKRAMETAGLSPKDIDHVNA
MAB_2028|M.abscessus_ATCC_1997 ALARVAGYMGTAEAVRITSSERDGATYAECMRAAIADAGLSPSDIHHVNA
*.*: * *::. ::.:. :* . .: *: *** * **.****
MMAR_3339|M.marinum_M HATGTQVGDVAEGRAINNALGSH--KPAVYAPKSALGHSVGAVGAVESIL
MUL_1303|M.ulcerans_Agy99 HATGTQVGDVAEGRAINNALGSH--KPAVYAPKSALGHSVGAVGAVESIL
Mb2270|M.bovis_AF2122/97 HATGTQVGDLAEGRAINNALGGN--RPAVYAPKSALGHSVGAVGAVESIL
Rv2246|M.tuberculosis_H37Rv HATGTQVGDLAEGRAINNALGGN--RPAVYAPKSALGHSVGAVGAVESIL
MLBr_01656|M.leprae_Br4923 HATGTQVGDLAEAKAINKALCNN--RPAVYAPKSALGHSVGAVGAVESIL
MAV_2191|M.avium_104 HATGTSVGDVAESKAINNALGPHGGNAAVYAPKAALGHSVGAVGAVESIL
MSMEG_4328|M.smegmatis_MC2_155 HATGTNVGDVAESKAINNAMGGH--KPAVYAPKGALGHSVGAVGAVESIL
Mflv_2776|M.gilvum_PYR-GCK HATGTSVGDVAEGRAINRALGGH--RPAVYAPKSALGHSVGAVGAVESIL
Mvan_3757|M.vanbaalenii_PYR-1 HATGTSVGDLAEGHAINLAMGGH--RPAVYAPKSALGHSVGAVGAVESIL
TH_3425|M.thermoresistible__bu HATGTPIGDTAEANAIRVAGVEH---APVYAPKSALGHSIGAVGALESVL
MAB_2028|M.abscessus_ATCC_1997 HGTGTQANDECEAAALHLVFGAGAASIPLTSTKSSLGHGFAASGAIEAVL
*.*** .* .*. *:. . .: :.*.:***...* **:*::*
MMAR_3339|M.marinum_M TVLALRDQVVPPTLNLVNLDPEIDLDVVAGKPRPGNYRYAVNNSFGFGGH
MUL_1303|M.ulcerans_Agy99 TVLALRDQVVPPTLNLVNLDPEIDLDVVAGKPRPGNYRYAVNNSFGFGGH
Mb2270|M.bovis_AF2122/97 TVLALRDQVIPPTLNLVNLDPEIDLDVVAGEPRPGNYRYAINNSFGFGGH
Rv2246|M.tuberculosis_H37Rv TVLALRDQVIPPTLNLVNLDPEIDLDVVAGEPRPGNYRYAINNSFGFGGH
MLBr_01656|M.leprae_Br4923 TVLALRDQVIPPTLNLVNLDPDIDLDVVAGKPRPGDYRYAVNNSFGFGGH
MAV_2191|M.avium_104 TVLALRDQVVPPTLNLENLDPEIDLDVVAGKPRPGNYQYAINNSFGFGGH
MSMEG_4328|M.smegmatis_MC2_155 TVLALRDGIIPPTRNLNNLDPEIDLDVVAGEPRQGDYKYAINNSFGFGGH
Mflv_2776|M.gilvum_PYR-GCK TVQALRDGVVPPTLNLKNQDPEIDLDVVAGSPRPGNYNYALNNSFGFGGH
Mvan_3757|M.vanbaalenii_PYR-1 TVQSLRDGIIPPTLNLKNLDPEIDLDVVAGGPRPGNYEYAINNSFGFGGH
TH_3425|M.thermoresistible__bu TVLTLRDGVIPPTLNYETPDPEIDLDIVAGEPRYGDYRYAINNSFGFGGH
MAB_2028|M.abscessus_ATCC_1997 SAMSLREQIIPPTLNFSEPDDVTKGLDVVTKARHHEFDTVLSNSFGFGGM
:. :**: ::*** * * . *. .* :: .:.*******
MMAR_3339|M.marinum_M NVAITFGRY-
MUL_1303|M.ulcerans_Agy99 NVAITFGRY-
Mb2270|M.bovis_AF2122/97 NVAIAFGRY-
Rv2246|M.tuberculosis_H37Rv NVAIAFGRY-
MLBr_01656|M.leprae_Br4923 NVAIAFGCY-
MAV_2191|M.avium_104 NVAIAFGRY-
MSMEG_4328|M.smegmatis_MC2_155 NVALAFGKY-
Mflv_2776|M.gilvum_PYR-GCK NVALAFGKY-
Mvan_3757|M.vanbaalenii_PYR-1 NVALAFGKY-
TH_3425|M.thermoresistible__bu NVALAFGRY-
MAB_2028|M.abscessus_ATCC_1997 NCTLILAKEA
* :: :.