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VPSQRRILVVDDEPTICASISARLRAEGYAVDTEDNGLDAVRHCRENPPDLMVLDVMLPGLDGLEVCRQV QAHAPIPVLMLTARGTETDMLVGLGVGADDYLPKPFSMRVLVARVAALLRRTHRIAPPSTDVRIGQVRID VSERRVYHRDDEVHLTRTEFDLLAYLADNPRVAISRDRLLDQVWGWSAGLPSGRRTVDSHIKALRRKLGQ ELIRTVHGIGYALEAPR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_1720 | - | - | 100% (227) | putative two-component system response regulator |
| M. abscessus ATCC 19977 | MAB_3339 | - | 1e-44 | 43.78% (233) | putative sensory transduction protein |
| M. abscessus ATCC 19977 | MAB_1076 | - | 1e-43 | 42.41% (224) | two component response transcriptional regulatory protein MprA |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3274c | mtrA | 4e-43 | 40.79% (228) | two component sensory transduction transcriptional |
| M. gilvum PYR-GCK | Mflv_3887 | - | 2e-44 | 43.40% (235) | two component transcriptional regulator |
| M. tuberculosis H37Rv | Rv3246c | mtrA | 4e-43 | 40.79% (228) | two component sensory transduction transcriptional |
| M. leprae Br4923 | MLBr_00773 | mtrA | 5e-43 | 40.79% (228) | putative two-component response regulator |
| M. marinum M | MMAR_4455 | trcR | 3e-43 | 41.96% (224) | two-component transcriptional regulator TrcR |
| M. avium 104 | MAV_4209 | - | 5e-43 | 40.79% (228) | DNA-binding response regulator MtrA |
| M. smegmatis MC2 155 | MSMEG_1874 | mtrA | 1e-44 | 41.67% (228) | DNA-binding response regulator MtrA |
| M. thermoresistible (build 8) | TH_4129 | - | 1e-44 | 41.23% (228) | PUTATIVE DNA-binding response regulator MtrA |
| M. ulcerans Agy99 | MUL_4624 | trcR | 2e-43 | 41.96% (224) | two component transcriptional regulator TrcR |
| M. vanbaalenii PYR-1 | Mvan_3674 | - | 6e-48 | 45.69% (232) | two component transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3274c|M.bovis_AF2122/97 --------------------------MDTMRQRILVVDDDASLAEMLTIV
Rv3246c|M.tuberculosis_H37Rv --------------------------MDTMRQRILVVDDDASLAEMLTIV
MAV_4209|M.avium_104 --------------------------MDSMRQRILVVDDDASLAEMLTIV
MLBr_00773|M.leprae_Br4923 --------------------------MDIMRQRILVVDDDASLAEMLTIV
MSMEG_1874|M.smegmatis_MC2_155 --------------------------MDTMRQRILVVDDDPSLAEMLTIV
TH_4129|M.thermoresistible__bu -------------------LSRFGDNMDTMRQRILVVDDDPSLAEMLTIV
Mflv_3887|M.gilvum_PYR-GCK --------------MSTMDHPQGSPSEHSRGYRALVVDDEVPLAEVVASY
Mvan_3674|M.vanbaalenii_PYR-1 -----------------MEKPAATP---SAGYRALVVDDEVPLAEVVASY
MAB_1720|M.abscessus_ATCC_1997 ---------------------------MPSQRRILVVDDEPTICASISAR
MMAR_4455|M.marinum_M ---MTGSTRTQRPRQAILGQLPRIHRADGSPIRVLLVDDEPALTNLVKMA
MUL_4624|M.ulcerans_Agy99 MKAMTGSTRTQRPRQAILGQLPRIHRADGSPIRVLLVDDEPALTNLVKMA
* *:***: .: :
Mb3274c|M.bovis_AF2122/97 LRGEGFDTAVIGDGTQALTAVRELRPDLVLLDLMLPGMNGIDVCRVLR-A
Rv3246c|M.tuberculosis_H37Rv LRGEGFDTAVIGDGTQALTAVRELRPDLVLLDLMLPGMNGIDVCRVLR-A
MAV_4209|M.avium_104 LRGEGFDTAVIGDGTQALTAVRELRPDLVLLDLMLPGMNGIDVCRVLR-A
MLBr_00773|M.leprae_Br4923 LRGEGFDTAVIGDGTQALTAVRELRPDLVLLDLMLPGMNGIDVCRVLR-A
MSMEG_1874|M.smegmatis_MC2_155 LRGEGFDTAVIGDGSQALTAVRELRPDLVLLDLMLPGMNGIDVCRVLR-A
TH_4129|M.thermoresistible__bu LRGEGFDTAVIGDGSQALTAVRELRPDLVLLDLMLPGMNGIDVCRVLR-A
Mflv_3887|M.gilvum_PYR-GCK LQREQFDAVVADNGVDAIALARDFDPDVVILDLGLPGIDGLEVCRSLR-T
Mvan_3674|M.vanbaalenii_PYR-1 LRREQFDVSLAHSGADALAQAREIDPDVVILDLALPGIDGVEVCRQLR-T
MAB_1720|M.abscessus_ATCC_1997 LRAEGYAVDTEDNGLDAVRHCRENPPDLMVLDVMLPGLDGLEVCRQVQ-A
MMAR_4455|M.marinum_M LHYEGWDVEIAHNGREAISKFDKISPDVLVLDIMLPDVDGLQILQRVRDS
MUL_4624|M.ulcerans_Agy99 LHYEGWDVEIAHNGREAISKFDKISPDVLVLDIMLPDVDGLQILQRVRDS
*: * : . .* :*: . **:::**: **.::*::: : :: :
Mb3274c|M.bovis_AF2122/97 DSGVPIVMLTAKTDTVDVVLGLESGADDYIMKPFKPKELVARVRARLRR-
Rv3246c|M.tuberculosis_H37Rv DSGVPIVMLTAKTDTVDVVLGLESGADDYIMKPFKPKELVARVRARLRR-
MAV_4209|M.avium_104 DSGVPIVMLTAKTDTVDVVLGLESGADDYIMKPFKPKELVARVRARLRR-
MLBr_00773|M.leprae_Br4923 DSGVPIVMLTAKTDTVDVVLGLESGADDYIMKPFKPKELVARVRARLRR-
MSMEG_1874|M.smegmatis_MC2_155 DSGVPIVMLTAKTDTVDVVLGLESGADDYVMKPFKPKELVARVRARLRR-
TH_4129|M.thermoresistible__bu DSGVPIVMLTAKSDTVDVVLGLESGADDYVVKPFKPKELVARVRARLRR-
Mflv_3887|M.gilvum_PYR-GCK FSDAYVVMLTARDTELDTVLGLTVGADDYVTKPFSPRELVARIRAMLRRP
Mvan_3674|M.vanbaalenii_PYR-1 FSDAYVVMLTARDTEMDTIVGLSVGADDYVTKPFSPRELVARIRAMLRRP
MAB_1720|M.abscessus_ATCC_1997 HAPIPVLMLTARGTETDMLVGLGVGADDYLPKPFSMRVLVARVAALLRR-
MMAR_4455|M.marinum_M DAYTPTLFLTARDSVMDRVTGLTAGADDYMTKPFSLEELVARLRGLLRR-
MUL_4624|M.ulcerans_Agy99 DAYTPTLFLTARDSVMDRVTGLTAGADDYMTKPFSLEELVARLRGLLRR-
: ::***: * : ** *****: ***. . ****: . ***
Mb3274c|M.bovis_AF2122/97 ----------NDDEPAEMLSIADVEIDVPAHKVTRNGEQISLTPLEFDLL
Rv3246c|M.tuberculosis_H37Rv ----------NDDEPAEMLSIADVEIDVPAHKVTRNGEQISLTPLEFDLL
MAV_4209|M.avium_104 ----------NDDEPAEMLSIADVEIDVPAHKVTRNGEQISLTPLEFDLL
MLBr_00773|M.leprae_Br4923 ----------NDDEPAEMLSIADVDIDVPAHKVTRNGEHISLTPLEFDLL
MSMEG_1874|M.smegmatis_MC2_155 ----------NEDEPAEMLSIGDVEIDVPAHKVTRQGEQISLTPLEFDLL
TH_4129|M.thermoresistible__bu ----------NEDEPAEMLSIGDIDIDVPAHKVTRNGEQIQLTPLEFDLL
Mflv_3887|M.gilvum_PYR-GCK RLLQSPPTGADR-EVTPPRRFGALSIDVAAREVRIADDPILLTRTEFDIL
Mvan_3674|M.vanbaalenii_PYR-1 RTVATPISAATAADEPPPRAFGPLAIDVAGRQVFIDDEPVLLTRTEFDIL
MAB_1720|M.abscessus_ATCC_1997 --------THRIAPPSTDVRIGQVRIDVSERRVYHRDDEVHLTRTEFDLL
MMAR_4455|M.marinum_M -------SSHLAPPADESLKVGDLKLDAASREVTRGGTPISLSSTEFELL
MUL_4624|M.ulcerans_Agy99 -------SSHLAPPADESLKVGDLKLDAASREVTRGGTPISLSSTEFELL
.. : :*.. :.* . : *: **::*
Mb3274c|M.bovis_AF2122/97 VALARKPRQVFTRDVLLEQVWGY--RHPADTRLVNVHVQRLRAKVEKDPE
Rv3246c|M.tuberculosis_H37Rv VALARKPRQVFTRDVLLEQVWGY--RHPADTRLVNVHVQRLRAKVEKDPE
MAV_4209|M.avium_104 VALARKPRQVFTRDVLLEQVWGY--RHPADTRLVNVHVQRLRAKVEKDPE
MLBr_00773|M.leprae_Br4923 VALARKPRQVFTRDVLLEQVWGY--RHPADTRLVNVHVQRLRAKVEKDPE
MSMEG_1874|M.smegmatis_MC2_155 VALARKPRQVFTRDVLLEQVWGY--RHPADTRLVNVHVQRLRAKVEKDPE
TH_4129|M.thermoresistible__bu VALARKPRQVFTRDVLLEQVWGY--RHPADTRLVNVHVQRLRAKVEKDPE
Mflv_3887|M.gilvum_PYR-GCK QALSGRPGIVLSRRQLLEIIRDE--PWVGNDQLVDVHIGHLRRKLGDDAA
Mvan_3674|M.vanbaalenii_PYR-1 AALSSRPAVVFSRRQLLEAVWGD--SWGGNEHLVDVHIGHLRRKLADDPA
MAB_1720|M.abscessus_ATCC_1997 AYLADNPRVAISRDRLLDQVWGWSAGLPSGRRTVDSHIKALRRKLG----
MMAR_4455|M.marinum_M RFLMRNPRRALSRTEILDRVWNY--DFAGRTSIVDLYISYLRKKIDAD--
MUL_4624|M.ulcerans_Agy99 RFLMRNPRRALSRTEILDRVWNY--DFAGRTSIVDLYISYLRKKIDAD--
* .* .::* :*: : . . *: :: ** *:
Mb3274c|M.bovis_AF2122/97 NPTVVLTVRGVGYKAGPP-
Rv3246c|M.tuberculosis_H37Rv NPTVVLTVRGVGYKAGPP-
MAV_4209|M.avium_104 NPTVVLTVRGVGYKAGPP-
MLBr_00773|M.leprae_Br4923 NPTVVLTVRGVGYKAGPP-
MSMEG_1874|M.smegmatis_MC2_155 NPQVVLTVRGVGYKAGPP-
TH_4129|M.thermoresistible__bu NPQVVLTVRGVGYKAGPP-
Mflv_3887|M.gilvum_PYR-GCK RPRYIATVRGVGYRMGTGA
Mvan_3674|M.vanbaalenii_PYR-1 DPRYVITVRGVGYRMGSGQ
MAB_1720|M.abscessus_ATCC_1997 -QELIRTVHGIGYALEAPR
MMAR_4455|M.marinum_M REPMIHTVRGIGYMLRPAE
MUL_4624|M.ulcerans_Agy99 REPMIHTVRGIGYMLRPAE
: **:*:** .