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MTGSAKRRAVIVAGARTPFVRAFGEFTRMDTIALADEAVRGLLDNTKVSSSEIEAIVWGGVILPAGAPNV AREIALDLKLGHGVEGHTVTRACASGLQAITTAAAAIERGEYDVMIAGGSDSTSNAGVNLPQKLIHAAAP LALGKPKPKDYLDAAWSLAPFTGLLPRRPKIEERTTGEVMGESADKMAKIHGITRQAQDEFAVRSHRRAA AAIASGRFDREVVPVAGVTRDGLVRENTSVEKLATLKPVFNRDGTVTAGNASPLTDGAAAVLLMSEEKAR ALGLRPLAAFRSWSYVSVDPADEVLIGPAISMPRALEKAGLDLDDVDYIDIHEAFAAQTLSVLEALGSKK WATDRLGRSEAVGTPDIDKVNVHGGSVSIGHPFGATGARMVTTMANELALSGKGTALLGICAAGGHGASA VLERVD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_1002 | - | - | 100% (426) | putative acetyl-CoA C-acyltransferase (thiolase) |
| M. abscessus ATCC 19977 | MAB_4442c | - | 4e-69 | 37.39% (436) | acetyl-CoA acetyltransferase |
| M. abscessus ATCC 19977 | MAB_1463 | - | 6e-57 | 33.41% (428) | acetyl-CoA acetyltransferase FadA |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0249 | fadA2 | 8e-69 | 38.39% (435) | acetyl-CoA acetyltransferase |
| M. gilvum PYR-GCK | Mflv_0411 | - | 7e-70 | 38.57% (433) | acetyl-CoA acetyltransferase |
| M. tuberculosis H37Rv | Rv0243 | fadA2 | 8e-69 | 38.39% (435) | acetyl-CoA acetyltransferase |
| M. leprae Br4923 | MLBr_02564 | fadA2 | 2e-67 | 36.59% (440) | acetyl-CoA acetyltransferase |
| M. marinum M | MMAR_0504 | fadA2 | 4e-68 | 38.89% (432) | acetyl-CoA acyltransferase FadA2 |
| M. avium 104 | MAV_4915 | - | 2e-68 | 39.11% (427) | acetyl-CoA acetyltransferase |
| M. smegmatis MC2 155 | MSMEG_0373 | - | 6e-73 | 38.95% (439) | acetyl-CoA acetyltransferase |
| M. thermoresistible (build 8) | TH_0255 | - | 3e-51 | 32.55% (424) | acetyl-CoA acetyltransferase |
| M. ulcerans Agy99 | MUL_1167 | fadA2 | 3e-68 | 38.89% (432) | acetyl-CoA acetyltransferase |
| M. vanbaalenii PYR-1 | Mvan_0260 | - | 1e-69 | 38.34% (433) | acetyl-CoA acetyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0249|M.bovis_AF2122/97 ---------MAPAA--------KNTSQTRRRVAVLGGNRIPFARSDGAYA
Rv0243|M.tuberculosis_H37Rv ---------MAPAA--------KNTSQTRRRVAVLGGNRIPFARSDGAYA
MMAR_0504|M.marinum_M ---------MAPAA--------EKNAQTKRRVAVLGGNRIPFARSDGAYA
MUL_1167|M.ulcerans_Agy99 ---------MAPAA--------EKNAQTKRRVAVLGGNRIPFARSDGAYA
MAV_4915|M.avium_104 -------------------------------MAVLGGNRIPFARSDGAYA
MLBr_02564|M.leprae_Br4923 MLGETRRLQVAPASSVASDKTIQRTTFAKQRVAVLGGNRIPFARSNGAYA
Mflv_0411|M.gilvum_PYR-GCK ----------------------MADSKTARRVAILGGNRIPFARSDGAYA
Mvan_0260|M.vanbaalenii_PYR-1 ---------MTLDTPSVSREADVADTNTTRRVAILGGNRIPFARADGAYA
MSMEG_0373|M.smegmatis_MC2_155 ----------------------MAN-ESRRRVAVLGGNRIPFARSDGAYA
MAB_1002|M.abscessus_ATCC_1997 -----------------------MTGSAKRRAVIVAGARTPFVRAFGEFT
TH_0255|M.thermoresistible__bu ----------------------------MRETVIVEAVRTAVGKRNGALA
.:: . * .. : * :
Mb0249|M.bovis_AF2122/97 DASNQDMFTAALSGLVDRFGLAGERLDMVVGGAVLKHS-RDFNLMRECVL
Rv0243|M.tuberculosis_H37Rv DASNQDMFTAALSGLVDRFGLAGERLDMVVGGAVLKHS-RDFNLMRECVL
MMAR_0504|M.marinum_M EASNQDMFTAALAGLVDRFDLRGQRLGAVVGGAVLKHS-RDFNLMRECVL
MUL_1167|M.ulcerans_Agy99 EASNQDMFTAALAGLVDRFDLRGQRLGAVVGGAVLKHS-RDFNLMRECVL
MAV_4915|M.avium_104 EASNQDMLTAALEGLVDRFGLAGERLGVVVGGAVLKHS-RDFNLTRECVL
MLBr_02564|M.leprae_Br4923 EASNQDMFSAALSGLVDRFGLAGERLDMVIGGAVLKHS-RDFNLMRECVL
Mflv_0411|M.gilvum_PYR-GCK QASNQDMFTAVLDGLADRFNLKGEKLDAVIGGAVLKHS-RDFNLMRECVL
Mvan_0260|M.vanbaalenii_PYR-1 KASNQDMFTATLDGLADRFNLKGEKLDAVIGGAVLKHS-RDFNLMRECVL
MSMEG_0373|M.smegmatis_MC2_155 NASNQDMFTAALGGLIDRFNLAGEQLGAVIGGAVLKHS-RDFNLMRECVL
MAB_1002|M.abscessus_ATCC_1997 RMDTIALADEAVRGLLDNTKVSSSEIEAIVWGGVILPA-GAPNVAREIAL
TH_0255|M.thermoresistible__bu DVHAADLSAVVLSELVERAGIDPELIDDVIWGCVSQVGDQSSNIGRYAVL
: .: * :. : . : :: * * . *: * .*
Mb0249|M.bovis_AF2122/97 GSELSPYTPAFDLQQACGTGLQAAIAAADGIAAGRYEVAAAGGVDTTSDP
Rv0243|M.tuberculosis_H37Rv GSELSPYTPAFDLQQACGTGLQAAIAAADGIAAGRYEVAAAGGVDTTSDP
MMAR_0504|M.marinum_M GSELSPYTAACDLQQACGTGLQAAIAAADGIAAGRYEVAAAGGVDTTSDP
MUL_1167|M.ulcerans_Agy99 GSELSPYTAACDLQQACGTGLQAAIAAADGIAAGRYEVAAAGGVDTTSDP
MAV_4915|M.avium_104 GSQLSSYTPAFDLQQACGTGLQAAIAAAEGIAAGRYDVAAAGGVDTTSDA
MLBr_02564|M.leprae_Br4923 GSQLSPYTPAFDLQQACATGLQAAIVAADGIAAGRYEVAVAGGVDTTSDV
Mflv_0411|M.gilvum_PYR-GCK GSSLSSYTPAFDLQQACGTGLQSAIAAADGIARGRYDVAAAGGVDTASDA
Mvan_0260|M.vanbaalenii_PYR-1 GSSLSSATPAFDLQQACGTGLQAAIAAADGIARGRYEVAAAGGVDTASDA
MSMEG_0373|M.smegmatis_MC2_155 GSALSPYTPAFDIQQACGTGLQAAIAAADGIAAGRYESAAAGGVDTASDA
MAB_1002|M.abscessus_ATCC_1997 DLKLGHGVEGHTVTRACASGLQAITTAAAAIERGEYDVMIAGGSDSTSNA
TH_0255|M.thermoresistible__bu AAGWPETIPGTTVNRACGSSQQALDFAVHAVMSGQQDVVVAGGVEVMSRV
. : :**.:. *: *. .: *. : *** : *
Mb0249|M.bovis_AF2122/97 PIGLGDDLRRTLLKLRRSRSN-VQRLKLVGTLP--ASLGVEIPANSEPRT
Rv0243|M.tuberculosis_H37Rv PIGLGDDLRRTLLKLRRSRSN-VQRLKLVGTLP--ASLGVEIPANSEPRT
MMAR_0504|M.marinum_M PIGLGEDLRRTLLRLRRAKSN-VHRLRLVGGLP--ANLGVEIPANSEPRT
MUL_1167|M.ulcerans_Agy99 PIGLGEDLRRTLLRLRRAKSN-VHRLRLVGGLP--ANLGVEIPANSEPRT
MAV_4915|M.avium_104 PIGLGDNLRRTLLKLRRAKSN-VQRLKLVGTLP--ATLGVEIPVNSEPRT
MLBr_02564|M.leprae_Br4923 PISLGDNLRRNLLKLRRSKSN-VQRLKLVGALP--ANIGVEIPANSEPRT
Mflv_0411|M.gilvum_PYR-GCK PIAFGDDLRKVLLGLRRAKSN-VDRLKLVGKLP--ASLGVEIPVNSEPRT
Mvan_0260|M.vanbaalenii_PYR-1 PIAFGDDLRRVLLGLRRAKSN-VERLKLVGKLP--AALGVEIPVNSEPRT
MSMEG_0373|M.smegmatis_MC2_155 PIAFGNDLRRVLLGLRRAKSN-VDRLKLVGKLP--ASLGVEIPVNSEPRT
MAB_1002|M.abscessus_ATCC_1997 GVNLPQKLIHAAAPLALGKPKPKDYLDAAWSLAPFTGLLPRRPKIEERTT
TH_0255|M.thermoresistible__bu PLGAARATGMPYGPKVLERYD---------------------------NF
: : .
Mb0249|M.bovis_AF2122/97 GLSMGEHAAVTAKQMGIKRVDQDELAAASHRNMADAYDRGFFDDLVSPFL
Rv0243|M.tuberculosis_H37Rv GLSMGEHAAVTAKQMGIKRVDQDELAAASHRNMADAYDRGFFDDLVSPFL
MMAR_0504|M.marinum_M GLSMGDHAAITAKQMGIKRVDQDELAAASHRNMADAYDRGFFDDLVTPFL
MUL_1167|M.ulcerans_Agy99 GLSMGDHAAITAKQMGIKRVDQDELAAASHRNMADAYDRGFFDDLVTPFL
MAV_4915|M.avium_104 GLSMGEHQAITAKQMGITRVAQDELAAASHRNMAAAYDRGFFDDLVTPFL
MLBr_02564|M.leprae_Br4923 GLSMGEHAAITAKKMGIKRVDQDELAAASHRNMASAYDRGFFDDLVTPFL
Mflv_0411|M.gilvum_PYR-GCK GMSMGEHAAVTAKEMGVKRVDQDELAAASHRNMSAAYDRGFFDDLVSPFL
Mvan_0260|M.vanbaalenii_PYR-1 GMSMGEHAAVTAKEMGVKRVDQDELAAASHRNMAAAYDRGFFDDLVTPFL
MSMEG_0373|M.smegmatis_MC2_155 GMSMGEHAAVTAKAMGIKRVEQDELAAASHRNMAAAYDAGFFDDLVTPFL
MAB_1002|M.abscessus_ATCC_1997 GEVMGESADKMAKIHGITRQAQDEFAVRSHRRAAAAIASGRFDREVVPVA
TH_0255|M.thermoresistible__bu GFNQGISAELIAERWNLSRTRLDEYSAQSHERAAAAQSSGAFKDQIVPVF
* * *: .:.* ** :. **.. : * * *. : *.
Mb0249|M.bovis_AF2122/97 G----LYRDDNLRPNSSVEKLATLRPVFGVKAGDATMTAGNSTPLTDGAS
Rv0243|M.tuberculosis_H37Rv G----LYRDDNLRPNSSVEKLATLRPVFGVKAGDATMTAGNSTPLTDGAS
MMAR_0504|M.marinum_M G----LYRDDNLRPNSSVEKLASLRPVFGVKAGDATMTAGNSTPLTDGAS
MUL_1167|M.ulcerans_Agy99 G----LYRDDNLRPNSSVEKLASLRPVFGVKAGDATMTAGNSTPLTDGAS
MAV_4915|M.avium_104 G----LYRDDNLRPDSSPEKLAKLRPVFGVKAGDATMTAGNSTPLTDGAS
MLBr_02564|M.leprae_Br4923 G----LYRDDNLRPNSHVEKLATLRPVFGVQAGDATMTAGNSTSLTDGAS
Mflv_0411|M.gilvum_PYR-GCK G----LYRDNNLRPDSSAEKLAKLKPVFGVRNGDATMTAGNSTPLTDGAS
Mvan_0260|M.vanbaalenii_PYR-1 G----LYRDNNLRADSSVEKLAKLRPVFGVRSGDATMTAGNSTPLTDGAS
MSMEG_0373|M.smegmatis_MC2_155 G----VYRDNNLRADSSVEKLAKLKPVFGVKAGDATMTAGNSTPLTDGAS
MAB_1002|M.abscessus_ATCC_1997 G----VTRDGLVRENTSVEKLATLKPVFNR---DGTVTAGNASPLTDGAA
TH_0255|M.thermoresistible__bu TDDAVVTEDEGIRRGTTVEKLATLKPAFTEN---GVIHAGNSSQISDGAA
: .* :* .: ****.*:*.* ..: ***:: ::***:
Mb0249|M.bovis_AF2122/97 VALLASEQWAEAHSLAPLAYLVDAETAAVDYVNGNDGLLMAPTYAVPRLL
Rv0243|M.tuberculosis_H37Rv VALLASEQWAEAHSLAPLAYLVDAETAAVDYVNGNDGLLMAPTYAVPRLL
MMAR_0504|M.marinum_M VALLSSEQWAQEHSLSPLAYLVDAETAAVDYVNGNDGLLMAPTYAVPRLL
MUL_1167|M.ulcerans_Agy99 VALLSSEQWAQEHSLSPLAYLVDAETAAVDYVNGNDGLLMAPTYAVPRLL
MAV_4915|M.avium_104 VALLGTEEWAAAHSLTPLAYLVDAETAAVDYVNGRDGLLMAPTYAVPRLL
MLBr_02564|M.leprae_Br4923 VALLATEQWVAAHSLTPFAYWVDAEIAAVDYVSGNDGLLMAPTYAVPRLL
Mflv_0411|M.gilvum_PYR-GCK VALLSSEEWAAQHSIPVLAYLVDAETAAVDYVNGRDGLLMAPTYAVPRLL
Mvan_0260|M.vanbaalenii_PYR-1 VALLSSEEWAAEHSIPVLAYFVDGQTAAVDYVNGRDGLLMAPTYAVPRLL
MSMEG_0373|M.smegmatis_MC2_155 VALLAGEDWAQARGLEPLAYFVDAETAAVDYVNGPDGLLMAPTYAVPRLL
MAB_1002|M.abscessus_ATCC_1997 AVLLMSEEKARALGLRPLAAFRSWSYVSVDPA---DEVLIGPAISMPRAL
TH_0255|M.thermoresistible__bu ALLVMTAETAVTLGLTPIVRYRAGAVTGADPVL----MLTGPIPATEKVL
. *: : . .: :. ...* . :* .* : : *
Mb0249|M.bovis_AF2122/97 ARNGLSLQDFDFYEIHEAFASVVLAHLAAWESEEYCKRRLGLDAALGSID
Rv0243|M.tuberculosis_H37Rv ARNGLSLQDFDFYEIHEAFASVVLAHLAAWESEEYCKRRLGLDAALGSID
MMAR_0504|M.marinum_M ARNGLTLQDFDFYEIHEAFASVVLAHLQAWESEEYCKQRLGLDAALGSID
MUL_1167|M.ulcerans_Agy99 ARNGLTLQDFDFYEIHEAFASVVLAHLQAWESEEYCKQRLGLDAALGSID
MAV_4915|M.avium_104 ARNGLSLQDFDFYEIHEAFASVVLAHLQAWESEDYCKERLGLDAALGSID
MLBr_02564|M.leprae_Br4923 ARNGLSFQDFDFYEIHEAFASVVLAHLQAWESEEYCRQCLGLDTALGPID
Mflv_0411|M.gilvum_PYR-GCK TRNGLTLQDFDYYEIHEAFASVVLATLAAWESDEYCKERLGLDKALGSID
Mvan_0260|M.vanbaalenii_PYR-1 ARNGLTLQDFDFYEIHEAFASVVLATLAAWKSDEYCKERLGLDKALGSID
MSMEG_0373|M.smegmatis_MC2_155 ARNNLTLQDFDFYEIHEAFASVVLAHLQAWESDEYCKERLGLDKALGSID
MAB_1002|M.abscessus_ATCC_1997 EKAGLDLDDVDYIDIHEAFAAQTLSVLEALGSKKWATDRLGRSEAVGTPD
TH_0255|M.thermoresistible__bu RKTGLNIDDIGVFEVNEAFAPVPLAWQAETG-----------------AD
: .* ::*.. :::****. *: *
Mb0249|M.bovis_AF2122/97 RSKLNVNGSSLAAGHPFAATGGRILAQTAKQLAEKKAAKKG-GGPLRGLI
Rv0243|M.tuberculosis_H37Rv RSKLNVNGSSLAAGHPFAATGGRILAQTAKQLAEKKAAKKG-GGPLRGLI
MMAR_0504|M.marinum_M RSKLNVNGSSLAAGHPFAATGGRILAQTAKQLAEKKAERKGSAQPVRALI
MUL_1167|M.ulcerans_Agy99 RSKLNVNGSSLAAGHPFAATGGRILAQTAKQLAEKKAERKGSAQPVRALI
MAV_4915|M.avium_104 RSKLNVNGSSLAAGHPFAATGGRILAQAAKQVAQRKAELKGADKPVRALI
MLBr_02564|M.leprae_Br4923 RSKLNVNGSSLAAGHPFAATGGRILVQTAKQLAEQKATQKG-CGPMRALI
Mflv_0411|M.gilvum_PYR-GCK RSKLNVNGSSLAAGHPFAATGGRIVAQLAKQLAEKKK-QTG--QPVRGLI
Mvan_0260|M.vanbaalenii_PYR-1 RSKLNVNGSSLAAGHPFAATGGRIVAQLAKQLAEKKA-ETG--KPVRGLI
MSMEG_0373|M.smegmatis_MC2_155 RTKLNVNGSSLAAGHPFAATGGRIVAQLAKQLAEKKK-STG--RPVRGLI
MAB_1002|M.abscessus_ATCC_1997 IDKVNVHGGSVSIGHPFGATGARMVTTMANELALSGKG--------TALL
TH_0255|M.thermoresistible__bu PAKLNPLGGAIALGHPLGASGAVLMTRMVHHMRANGIR--------YGLQ
*:* *.::: ***:.*:*. ::. .:.: .*
Mb0249|M.bovis_AF2122/97 SICAAGGQGVAAILEA--
Rv0243|M.tuberculosis_H37Rv SICAAGGQGVAAILEA--
MMAR_0504|M.marinum_M SICAAGGQGVAAILEA--
MUL_1167|M.ulcerans_Agy99 SICAAGGQGVAAILEA--
MAV_4915|M.avium_104 SICAAGGQGVAAILEA--
MLBr_02564|M.leprae_Br4923 SVCAAGGQGVAVILEA--
Mflv_0411|M.gilvum_PYR-GCK SVCAAGGQGVTAILEA--
Mvan_0260|M.vanbaalenii_PYR-1 SVCAAGGQGVTAILEA--
MSMEG_0373|M.smegmatis_MC2_155 SICAAGGQGVAAILEA--
MAB_1002|M.abscessus_ATCC_1997 GICAAGGHGASAVLERVD
TH_0255|M.thermoresistible__bu TMCEGGGTANATVVELLA
:* .** . :.::*