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NLRIVSFAGADQWQPGVLIDDDTVAPLAPMLARHDIQVSSARELIALLPQISPLISDELAGGSFEPVPLD SVALGAPIPEPGQVIALGFNYPTHSDTDSPLPKMADPVVFMKSPTSISGPRDAVIAPRTSHALDYEIEIA VVIGKPGYRIERSQAIKHVAGYMLANDITARDVALPFGFGGSPLQAQVVRGKGYPTFCPTGPWLFTTGSD TTFETFDFELRINGELRQSGSTVDMTLGFAEVVETVSATIALRAGDIILTGTPGGCGFQFDPPRYLRPGD VIEAHSAKLGKMRLPVHDEKPIESASR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0915c | - | - | 100% (308) | 2-hydroxyhepta-2,4-diene-1, 7-dioateisomerase |
| M. abscessus ATCC 19977 | MAB_4355 | - | 6e-31 | 35.86% (237) | fumarylacetoacetate (FAA) hydrolase family protein |
| M. abscessus ATCC 19977 | MAB_3299c | - | 8e-29 | 35.50% (231) | hypothetical protein MAB_3299c |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3017c | - | 1e-30 | 35.50% (231) | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase |
| M. gilvum PYR-GCK | Mflv_4230 | - | 1e-29 | 34.63% (231) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase |
| M. tuberculosis H37Rv | Rv2993c | - | 1e-30 | 35.50% (231) | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase |
| M. leprae Br4923 | MLBr_01689 | - | 2e-28 | 33.91% (233) | putative hydrolase |
| M. marinum M | MMAR_1718 | - | 3e-30 | 35.32% (235) | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase |
| M. avium 104 | MAV_3844 | - | 1e-31 | 32.58% (264) | 5-carboxymethyl-2-hydroxymuconate delta-isomerase |
| M. smegmatis MC2 155 | MSMEG_2007 | - | 2e-30 | 35.24% (227) | putative HpcE protein |
| M. thermoresistible (build 8) | TH_3311 | - | 4e-31 | 33.05% (236) | PUTATIVE putative HpcE protein |
| M. ulcerans Agy99 | MUL_1956 | - | 4e-30 | 37.25% (204) | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase |
| M. vanbaalenii PYR-1 | Mvan_2132 | - | 2e-29 | 34.20% (231) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1718|M.marinum_M -----------MRLGRIASPDGVAFASIEGELD-------NPGAMTAREI
MUL_1956|M.ulcerans_Agy99 --------------------------------------------MTAREI
MAV_3844|M.avium_104 -----------MRLGRIASPDGVAFVSIEGELD-------NPAEMIAREI
Mb3017c|M.bovis_AF2122/97 --------------------------------------------MTAREI
Rv2993c|M.tuberculosis_H37Rv --------------------------------------------MTAREI
MLBr_01689|M.leprae_Br4923 --------------------------------------------MFAREL
Mflv_4230|M.gilvum_PYR-GCK -----------MRLGRIASPDGVAFVAVEGPPD-------DPAAAVAREI
Mvan_2132|M.vanbaalenii_PYR-1 -----------MRLGRIASPDGVAFVAIEGPPD-------DPGGAVAREI
MSMEG_2007|M.smegmatis_MC2_155 --MRLINLDGRIHLVTGDGVVDVAKASEQRFGP-------DPQDLYQHWD
TH_3311|M.thermoresistible__bu --MRLINQGGRLKIDVDGLAADVEKTSDYRFSA-------DPQEIYARWE
MAB_0915c|M.abscessus_ATCC_199 MNLRIVSFAGADQWQPGVLIDDDTVAPLAPMLARHDIQVSSARELIALLP
MMAR_1718|M.marinum_M AEHPFGTPNFTG---RSWPLADVRLLAPILAS-KVVCVGKNYTDHIAEMG
MUL_1956|M.ulcerans_Agy99 AEDPFGTPNFTG---RSWPLADVRLLAPILAS-KVVCVGKNYTGHIAEMG
MAV_3844|M.avium_104 AEHPFGTPNFTG---RSWPLADVRLLAPILAS-KVVCVGKNYADHIAEMG
Mb3017c|M.bovis_AF2122/97 AEHPFGTPTFTG---RSWPLADVRLLAPILAS-KVVCVGKNYADHIAEMG
Rv2993c|M.tuberculosis_H37Rv AEHPFGTPTFTG---RSWPLADVRLLAPILAS-KVVCVGKNYADHIAEMG
MLBr_01689|M.leprae_Br4923 AEYPFGELTFTG---RSWPLADVRLLAPMLAS-KVVCIGKNYADHIVEMG
Mflv_4230|M.gilvum_PYR-GCK AEHPFGTPTFTG---RQWPLADVRLLAPILAS-KVVCMGKNYAAHIEEMG
Mvan_2132|M.vanbaalenii_PYR-1 AEHPFGNPTFTG---RQWPLADVRLLAPILAS-KVVCMGKNYAAHIEEMG
MSMEG_2007|M.smegmatis_MC2_155 AFQEWARTAALP---APSARVG-TIGSPAPLPRQVFAVGLNYDDHATESG
TH_3311|M.thermoresistible__bu EFTAWASAADLS---GGDPIVEAELGPPVPRPAQVFAIGINYRDHMDEAG
MAB_0915c|M.abscessus_ATCC_199 QISPLISDELAGGSFEPVPLDSVALGAPIPEPGQVIALGFNYPTHSDTDS
. : .* . :*..:* ** * .
MMAR_1718|M.marinum_M GQTGPTPADPVIFLKPNTAIVGPNVPIRLPANASPVHFEGELAIVIGRPC
MUL_1956|M.ulcerans_Agy99 GQTGPTPADPVIFLKSNTAIVGPNVPIRLPANASPVHFEGELAIVIGRPC
MAV_3844|M.avium_104 EATGPVPADPVIFLKPNTAIIGPNVPIRLPANASPVHFEGELAVVIGRPC
Mb3017c|M.bovis_AF2122/97 GRP---PADPVIFLKPNTAIIGPNTPIRLPANASPVHFEGELAIVIGRAC
Rv2993c|M.tuberculosis_H37Rv GRP---PADPVIFLKPNTAIIGPNTPIRLPANASPVHFEGELAIVIGRAC
MLBr_01689|M.leprae_Br4923 GQTGLASADPVIFLKPNTAIIGPNVPIRLPANASPVHFEGELALVVGRSC
Mflv_4230|M.gilvum_PYR-GCK GGT---FEDPIIFLKPNTAIIGPYTPIQLPADADPVHFEGELAAVIGRPC
Mvan_2132|M.vanbaalenii_PYR-1 GGT---FEDPIIFLKPNTAIIGPNTPIQLPADANPVHFEGELAAVIGRPC
MSMEG_2007|M.smegmatis_MC2_155 LSK---PEHPVIFTKFVSSITGPVETVQLPAGS--VDWEVELVVVMGRGG
TH_3311|M.thermoresistible__bu LSE---PEAPFVFTKFPAAITGPYDVIELPDGS--VDWEVELVAVIGRRA
MAB_0915c|M.abscessus_ATCC_199 PLP--KMADPVVFMKSPTSISGPRDAVIAPRTSHALDYEIEIAVVIGKPG
*.:* * ::* ** : * : :.:* *:. *:*:
MMAR_1718|M.marinum_M KDVSAAQAVDNILGYTIGNDVSARDQQKS--------DGQWTRAKGHDTF
MUL_1956|M.ulcerans_Agy99 KDVSAAQAVDNILGYTIGNDVSARDQQKS--------DGQWTRAKGHDTF
MAV_3844|M.avium_104 KDVSAAQAAENILGYTIGNDVSARDQQRS--------DGQWTRAKGHDTF
Mb3017c|M.bovis_AF2122/97 KDVPAAQAVDNILGYTIGNDVSARDQQQS--------DGQWTRAKGHDTF
Rv2993c|M.tuberculosis_H37Rv KDVPAAQAVDNILGYTIGNDVSARDQQQS--------DGQWTRAKGHDTF
MLBr_01689|M.leprae_Br4923 KDVPAVQAVDCILGYTIGNDMSARDQQRA--------DGQWTRAKGHDTF
Mflv_4230|M.gilvum_PYR-GCK KDVPASRAAENILGYTIANDVSARDQQKK--------DGQWMRAKGHDTF
Mvan_2132|M.vanbaalenii_PYR-1 KDVPASRAAENILGYTIANDVSARDQQQK--------DGQWMRAKGHDTF
MSMEG_2007|M.smegmatis_MC2_155 RNIPEDRAWEFVAGVSVGQDLSERDLQLAG-----PAP-QFSLAKSHAGF
TH_3311|M.thermoresistible__bu HRVSERDGWNYVAGLTVGQDLSERELQLSG-----PPPQQFNLGKSYTGF
MAB_0915c|M.abscessus_ATCC_199 YRIERSQAIKHVAGYMLANDITARDVALPFGFGGSPLQAQVVRGKGYPTF
: . . : * :.:*:: *: * .*.: *
MMAR_1718|M.marinum_M CPVGPWIVTDV---DPADLELRTEVNGAVKQHARTSLMIHDVGAIVEWIS
MUL_1956|M.ulcerans_Agy99 CPVGPWIVTDV---DPAGLELRTEVNGAVKQHARTSLMIHDVGAIVEWIS
MAV_3844|M.avium_104 CPVGPWIVTDLNPLDPGDLELRTEVNGEVKQRSRTSLLIHDIGSIVEWIS
Mb3017c|M.bovis_AF2122/97 CPVGPWIVTDLAPFDPADLELRTVVNGDVKQHARTSLMIHDIGAIVEWIS
Rv2993c|M.tuberculosis_H37Rv CPVGPWIVTDLAPFDPADLELRTVVNGDVKQHARTSLMIHDIGAIVEWIS
MLBr_01689|M.leprae_Br4923 CPVGPWIVTDLGPLDPADLELRTAVNGEVKQHSRTSLMIHGIGAIMEWIS
Mflv_4230|M.gilvum_PYR-GCK CPVGPWIVTDI---DPSDLEIRTEVNGELKQHSRTSLMIHDIGAIIEWIS
Mvan_2132|M.vanbaalenii_PYR-1 CPVGPWIVTDL---DPSDLEIRTEVNGDVKQRSRTSLMIHDIGAIIEWIS
MSMEG_2007|M.smegmatis_MC2_155 SPIGPELVTVDELPDPDDLELGAEINGETVQHSRTSQLIFPVSNLIAYLS
TH_3311|M.thermoresistible__bu APIGPAVVTLDEFADPADVEISTTLSGELMQLARTRDVFFSVPQLVAYLS
MAB_0915c|M.abscessus_ATCC_199 CPTGPWLFTTGSDTTFETFDFELRINGELRQSGSTVDMTLGFAEVVETVS
.* ** :.* .:: :.* * . * : . :: :*
MMAR_1718|M.marinum_M AVMTLLPGDLILTGTPAGVGP-------IEDGDTVSITIEGIGTLTNPVV
MUL_1956|M.ulcerans_Agy99 AVMTLLPGDLILTGTPAGVGP-------IEDGDTVSITIEGIDTLTNPVV
MAV_3844|M.avium_104 AVMTLLPGDLILTGTPAGVGP-------IEDGDTVSITIEGIGTLTNPVV
Mb3017c|M.bovis_AF2122/97 AIMTLLPGDLILTGTPAGVGP-------IEDGDTVSITIEGIGTLTNPVV
Rv2993c|M.tuberculosis_H37Rv AIMTLLPGDLILTGTPAGVGP-------IEDGDTVSITIEGIGTLTNPVV
MLBr_01689|M.leprae_Br4923 AVMTLLPGDLILTGTPAGVGP-------VEDGDIVSITVEGIGTLTNPVV
Mflv_4230|M.gilvum_PYR-GCK SVMTLLPGDLILTGTPEGVGP-------LEHGDTVSITVEGIGTLSNPVV
Mvan_2132|M.vanbaalenii_PYR-1 AVMTLLPGDLILTGTPEGVGP-------LEHGDSVSITVEGIGTLTNPVV
MSMEG_2007|M.smegmatis_MC2_155 DTVELYPGDVIFTGTPSGVGMGRNPKRFLAPGDELRTYITGVGEFTQRFV
TH_3311|M.thermoresistible__bu QILPLLPGDLIFTGTPSGIGWARTPKRFIDSDDELVTRAEGIGEMRHRFT
MAB_0915c|M.abscessus_ATCC_199 ATIALRAGDIILTGTPGGCGFQFDPPRYLRPGDVIEAHSAKLGKMRLPVH
: * .**:*:**** * * : .* : :. : .
MMAR_1718|M.marinum_M RKGKS---------
MUL_1956|M.ulcerans_Agy99 RKGKS---------
MAV_3844|M.avium_104 RKGKS---------
Mb3017c|M.bovis_AF2122/97 RKGKP---------
Rv2993c|M.tuberculosis_H37Rv RKGKP---------
MLBr_01689|M.leprae_Br4923 RKGKS---------
Mflv_4230|M.gilvum_PYR-GCK RKGKS---------
Mvan_2132|M.vanbaalenii_PYR-1 RKGRS---------
MSMEG_2007|M.smegmatis_MC2_155 TAD-SASVAPRS--
TH_3311|M.thermoresistible__bu RADRSVAKGNRING
MAB_0915c|M.abscessus_ATCC_199 DEKPIESASR----