For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MSVSTQAVSGQPFARVVGADTKVPLAHGGWVRYANFDYAASAPALCDVADRVTELLPYYASVHRGAGYAS RVCTRLYEGARETVGRFVGARADHHVIFTRNTTDSLNLLASAVPGEVVVLDIEHHANLLTWQRYGARVVA HRTTVPDTVAALDEELARRPTALLAVTGASNVTGEVLPLGELAAAAHRNGARIAVDGAQLAPHRRIDLAA AGIDYLAFSGHKLYAPFGAGVLVGQADWLDTARPYLAGGGAVRNVDIDEAQWFTGPQRHEAGTPNVVGVA AIAAACEALTVLGDLGHAEDALTVQLRDGLEAIEGVDTLRIWEGDRDVLGIVSFTVAGYAPSVVAAYLSA EHGIGLRDGRFCAHPLLARLGAPGGALRASIGLGTTAGDIARLLGAINELVRRGPGLAYIERDGQIGPVD DPRPLPDFLAA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0512 | - | - | 100% (431) | aminotransferase/cysteine desulfurase |
| M. abscessus ATCC 19977 | MAB_0217c | - | 2e-50 | 33.93% (389) | cysteine desulfurase |
| M. abscessus ATCC 19977 | MAB_2746c | - | 9e-48 | 36.31% (358) | cysteine desulfurase/aminotransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1499 | csd | 1e-47 | 34.38% (381) | cysteine desulfurase |
| M. gilvum PYR-GCK | Mflv_3674 | - | 1e-46 | 34.02% (391) | SufS subfamily cysteine desulfurase |
| M. tuberculosis H37Rv | Rv1464 | csd | 1e-47 | 34.38% (381) | cysteine desulfurase |
| M. leprae Br4923 | MLBr_00842 | - | 1e-47 | 32.82% (387) | hypothetical protein MLBr_00842 |
| M. marinum M | MMAR_2269 | csd | 2e-44 | 34.20% (383) | cysteine desulfurase Csd |
| M. avium 104 | MAV_2055 | - | 4e-48 | 33.16% (389) | cysteine desulphurases, SufS |
| M. smegmatis MC2 155 | MSMEG_4538 | - | 2e-51 | 34.47% (380) | cysteine desulphurase, SufS |
| M. thermoresistible (build 8) | TH_3033 | - | 8e-50 | 35.46% (392) | PUTATIVE cysteine desulfurases, SufS subfamily |
| M. ulcerans Agy99 | MUL_1865 | csd | 5e-44 | 33.94% (383) | cysteine desulfurase Csd |
| M. vanbaalenii PYR-1 | Mvan_2736 | - | 6e-43 | 31.95% (385) | SufS subfamily cysteine desulfurase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1499|M.bovis_AF2122/97 --------------------------------------------------
Rv1464|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2269|M.marinum_M --------------------------------------------------
MUL_1865|M.ulcerans_Agy99 --------------------------------------------------
TH_3033|M.thermoresistible__bu --------------------------------------------------
Mflv_3674|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2736|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00842|M.leprae_Br4923 --------------------------------------------------
MSMEG_4538|M.smegmatis_MC2_155 MSTSEYRSLNAESDLPISADELSALATQLFAAGIRPGPDTPPQTAPVAPR
MAV_2055|M.avium_104 MSTSEYRAVDAESDLPISAAELAALASQLYAASIRPGPDSPPQQAPVAPR
MAB_0512|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1499|M.bovis_AF2122/97 --------------------------------------------------
Rv1464|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2269|M.marinum_M --------------------------------------------------
MUL_1865|M.ulcerans_Agy99 --------------------------------------------------
TH_3033|M.thermoresistible__bu --------------------------------------------------
Mflv_3674|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2736|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00842|M.leprae_Br4923 --------------------------------------------------
MSMEG_4538|M.smegmatis_MC2_155 GNVPGTAHPVAP-----------PTEFVAVPSAVWSVPAHTSPVPEP---
MAV_2055|M.avium_104 GSVPDATAAISAGRTAAGTADVYPGPVPQVGGRDVYLPPPASPAPEAPPQ
MAB_0512|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1499|M.bovis_AF2122/97 --------------------------------------------------
Rv1464|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2269|M.marinum_M --------------------------------------------------
MUL_1865|M.ulcerans_Agy99 --------------------------------------------------
TH_3033|M.thermoresistible__bu --------------------------------------------------
Mflv_3674|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2736|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00842|M.leprae_Br4923 --------------------------------------------------
MSMEG_4538|M.smegmatis_MC2_155 --------------------------------------------------
MAV_2055|M.avium_104 AAPPAPRGSAPDATAATSAGRAAAGTSDVYSSWVPQLGVADIYLGAPTPA
MAB_0512|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1499|M.bovis_AF2122/97 --------------------------------------------------
Rv1464|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2269|M.marinum_M --------------------------------------------------
MUL_1865|M.ulcerans_Agy99 --------------------------------------------------
TH_3033|M.thermoresistible__bu --------------------------------------------------
Mflv_3674|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2736|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00842|M.leprae_Br4923 --------------------------------------------------
MSMEG_4538|M.smegmatis_MC2_155 ---VAPQTDPLVPPG------------VADLTAFTVPGGIVPTLPGVLAG
MAV_2055|M.avium_104 GPEAPPQSAPPAPRGQVPDTTAAATAYGADLSAFAVPTGIVSTAPGVQAG
MAB_0512|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1499|M.bovis_AF2122/97 --------------------------------------------------
Rv1464|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2269|M.marinum_M --------------------------------------------------
MUL_1865|M.ulcerans_Agy99 --------------------------------------------------
TH_3033|M.thermoresistible__bu --------------------------------------------------
Mflv_3674|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2736|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00842|M.leprae_Br4923 --------------------------------------------------
MSMEG_4538|M.smegmatis_MC2_155 ARTAV--------------------------------PAAESPDYYFLRD
MAV_2055|M.avium_104 TVPPVPVVPRAATAPSWLPEAPSVADLGWSDAPAPDAPAGDEHDYHFLTK
MAB_0512|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1499|M.bovis_AF2122/97 -------MTAS--VNSLDLAAIRADFPILKRIMRGGNPLAYLDSGATSQR
Rv1464|M.tuberculosis_H37Rv -------MTAS--VNSLDLAAIRADFPILKRIMRGGNPLAYLDSGATSQR
MMAR_2269|M.marinum_M -------MTVS--VARLDLAAIRADFPILQRVMRSGNQLAYLDSGATSQR
MUL_1865|M.ulcerans_Agy99 -------MTVS--VARLDLAAIRADFPILQRVMRSGNQLAYLDSGATSQR
TH_3033|M.thermoresistible__bu -------MTVA--PNRLDLGAIRADFPILQRVMRGGSQLAYLDSGATAQR
Mflv_3674|M.gilvum_PYR-GCK -------MTTARTLDLTVLNRVRADFPILSRVMRGGQQLAYLDSGATSQK
Mvan_2736|M.vanbaalenii_PYR-1 -------MTAS---VDLDVAAIRADFPILKRVMRGGNTLAYLDSGATSQK
MLBr_00842|M.leprae_Br4923 ------------MVDVFDIQAVRADFPILQETVN-GKPLIWFDNAATTQK
MSMEG_4538|M.smegmatis_MC2_155 TRAHQPVPQFPDRHEIFDVNAIRADFPILRETVN-GKPLIWFDNAATTQK
MAV_2055|M.avium_104 T---DPVPQFRDEHEVFDVAAIRSDFPILKETVN-GKPLIWFDNAATTQK
MAB_0512|M.abscessus_ATCC_1997 ------MSVSTQAVSGQPFARVVGADTKVPLAHGGWVRYANFDYAASAPA
. : . . : :* .*::
Mb1499|M.bovis_AF2122/97 PLQVLDAEREFLTASNGAVHRGAHQLMEEATDAYEQGRADIALFVGAD-T
Rv1464|M.tuberculosis_H37Rv PLQVLDAEREFLTASNGAVHRGAHQLMEEATDAYEQGRADIALFVGAD-T
MMAR_2269|M.marinum_M PLQVLDAEREFLTTCNGAVHRGAHQLMEEATDAYEQGRADIAAFVGAE-P
MUL_1865|M.ulcerans_Agy99 PLQVLDAEREFLTTCNGAVHRGAHQLMEEATDAYEQGRADIAAFVGAE-P
TH_3033|M.thermoresistible__bu PVQVLDAEREFLTTSYGAVHRGAHQLMEEATDAYEEGRADIAAFVGAD-P
Mflv_3674|M.gilvum_PYR-GCK PLAVLDAERDFLLHSNGAVHRGAHQLMEESTDAYEHGREAIASFVGAD-S
Mvan_2736|M.vanbaalenii_PYR-1 PLQVLDAERQFLTTSYGAVHRGAHQLMEESTDAYEQGRADIAAFVGAA-P
MLBr_00842|M.leprae_Br4923 PQVVIDRLSYFYAHENSNIHRAAHELAARATDAYEEARETARRFIGAAKA
MSMEG_4538|M.smegmatis_MC2_155 PQAVIDRLSHFYAHENSNIHRAAHELAARATDAYEDAREAVRRFIGAAKA
MAV_2055|M.avium_104 PQVVIDRLSHFYAHENSNIHRAAHELAARATDAYEEARDTVAEFIGAPSS
MAB_0512|M.abscessus_ATCC_1997 LCDVADRVTELLPY-YASVHRGAGYASRVCTRLYEGARETVGRFVGARAD
* * : . :**.* .* ** .* *:**
Mb1499|M.bovis_AF2122/97 DELVFTKNATEALNLVSYVLGDSRFERAVGPGDVIVTTELEHHANLIPWQ
Rv1464|M.tuberculosis_H37Rv DELVFTKNATEALNLVSYVLGDSRFERAVGPGDVIVTTELEHHANLIPWQ
MMAR_2269|M.marinum_M DELVFTKNATESLNLVSYVLGDSRFDRAIGPGDVIVTTELEHHANLIPWQ
MUL_1865|M.ulcerans_Agy99 DELVFTKNATESLNLVSYVLGDSRFDRAIGPGDVIVTTELEHHANLIPWQ
TH_3033|M.thermoresistible__bu DELVFTKNATEALNLVAYVLGDDRFDRAVGPGDVIVTTELEHHANLIPWQ
Mflv_3674|M.gilvum_PYR-GCK DELVFTKNATEAINLVAYALGDKRFENAIGPGDVIVTTELEHHANLVPWQ
Mvan_2736|M.vanbaalenii_PYR-1 GELVFTKNATEALNLVSYVLGDDRSGFAVGPGDVIVVTEMEHHANLIPWQ
MLBr_00842|M.leprae_Br4923 QEIIFVRGTTEAINLVAYAWG----GKHLQPGDEVVITHLEHHANIVPWQ
MSMEG_4538|M.smegmatis_MC2_155 EEIIFLRGTTEAINLVAHAWG----GKHLGPGDEIVITHLEHHANIVPWQ
MAV_2055|M.avium_104 ENIVFVRGTTEAINLVAHAWG----AKHLQPGDEIVITHLEHHANIVPWQ
MAB_0512|M.abscessus_ATCC_1997 HHVIFTRNTTDSLNLLASAVP-----------GEVVVLDIEHHANLLTWQ
.::* :.:*:::**:: . . :* .:*****::.**
Mb1499|M.bovis_AF2122/97 ELARRTGATLRWYGVTDDGRIDLDSLY--LDDRVKVVAFTHHSNVTGVLT
Rv1464|M.tuberculosis_H37Rv ELARRTGATLRWYGVTDDGRIDLDSLY--LDDRVKVVAFTHHSNVTGVLT
MMAR_2269|M.marinum_M ELARRTGATLRWYSVTDEGRIDLDSLQ--LDERVKVVTFTHHSNVTGALA
MUL_1865|M.ulcerans_Agy99 ELARRTGATLRWYSVTDEGRIDLDSLQ--LDERVKVVTFTHHSNVTGALA
TH_3033|M.thermoresistible__bu ELARRTGAELRWYSVTDDGRIDLDSLE--LDERVKVVAFTHHSNVTGAIA
Mflv_3674|M.gilvum_PYR-GCK ELVLRTGATLKWYGVTAEGRIDLDSLV--LDERVKVVAFSHHSNVTGAIA
Mvan_2736|M.vanbaalenii_PYR-1 ELARRTGATLRWFGLTDDGEVDLDSLK--LDERVKVVSFSHHSNVTGVGV
MLBr_00842|M.leprae_Br4923 LLSSQTGAILKVAPVDDAGNLLMSEFEDLLGPRTKLVAATQVSNALGTVT
MSMEG_4538|M.smegmatis_MC2_155 LLSRQTGAVLKVAPVDDAGNLLLGEFEDLLGPRTKLVAATQVSNALGTVT
MAV_2055|M.avium_104 LISQKTGAILKVAPIDDAGNLLLSEFEGLLGPRTKLVAASHVSNALGTVV
MAB_0512|M.abscessus_ATCC_1997 RYGAR--VVAHRTTVPDTVAALDEELAR---RPTALLAVTGASNVTGEVL
: . : : .: . ::: : **. *
Mb1499|M.bovis_AF2122/97 PVSELVSRAHQSGALTVLDACQSVPHQPVDLHELGVDFAAFSGHKMLGPN
Rv1464|M.tuberculosis_H37Rv PVSELVSRAHQSGALTVLDACQSVPHQPVDLHELGVDFAAFSGHKMLGPN
MMAR_2269|M.marinum_M PVAELVSRAKAVGALTVLDACQSVPHQPVDFHKLDVDFAAFSGHKMLGPN
MUL_1865|M.ulcerans_Agy99 PVAELVSRAKAVGALTVLDACQSVPHQPVDFHKLDVDFAAFSGHKMLGPN
TH_3033|M.thermoresistible__bu PVEELVSRARAVGALTVLDACQSVPHQPVDLHALGVDYAAWSGHKMLGPN
Mflv_3674|M.gilvum_PYR-GCK PVSELVARARAVGALVVLDACQSVPHQPVDFHALDVDFAAFSGHKMLGPT
Mvan_2736|M.vanbaalenii_PYR-1 PVADMVARAKAVGALTVLDSCQAVPHQPVDFHALDVDFAAFSGHKMLGPT
MLBr_00842|M.leprae_Br4923 QGEKIVELGHRYGARVLIDGAQSIPHLPINVSELGADFFVFSGHKIYGPT
MSMEG_4538|M.smegmatis_MC2_155 PVETIVELGHRYGARVLIDGAQSIPHMPIDVAALGADFFVFSGHKIYGPT
MAV_2055|M.avium_104 PVDKIVELGHRYGARVLIDGAQSIQHIPIDVAELGADFFVFSGHKIYGPT
MAB_0512|M.abscessus_ATCC_1997 PLGELAAAAHRNGARIAVDGAQLAPHRRIDLAAAGIDYLAFSGHKLYAPF
:. .: ** :*..* * ::. . *: .:****: .*
Mb1499|M.bovis_AF2122/97 GIGVLYGRRELLAQMPPFLTGGSMIETVTMEGATYAPAPQRFEAGTPMTS
Rv1464|M.tuberculosis_H37Rv GIGVLYGRRELLAQMPPFLTGGSMIETVTMEGATYAPAPQRFEAGTPMTS
MMAR_2269|M.marinum_M GIGVLYGRRELLAAMPPFLTGGSMIETVTMEASTYAPAPQRFEAGTPMTS
MUL_1865|M.ulcerans_Agy99 GIGELYGRRELLAAMPPFLTGGSMIETVTMEASTYAPAPQRFEAGTPMTS
TH_3033|M.thermoresistible__bu GIGALYGRRELLEAMPPFLTGGSMIETVSMEGATYAPAPQRFEAGTPMTS
Mflv_3674|M.gilvum_PYR-GCK GIGVLYGRRALLNALPPFLTGGSMIETVTMEATTFAPAPQRFEAGTPMTS
Mvan_2736|M.vanbaalenii_PYR-1 GIGALYGRARLLEQLPPFLTGGSMIETVTMEGATYAPPPQRFEAGTQMIS
MLBr_00842|M.leprae_Br4923 GIGVLYGCEDVLTEMPPWQGGGNMIVDVTLERSLYQGPPNKFEAGTGNIA
MSMEG_4538|M.smegmatis_MC2_155 GIGVLYGREDALAETPPWQGGGNMIADVTLERSLYQGPPNKFEAGTGNIA
MAV_2055|M.avium_104 GIGALYGTEEALTETPPWQGGGHMIADVTLERSLYQGPPTKFEAGTGNIA
MAB_0512|M.abscessus_ATCC_1997 GAGVLVGQADWLDTARPYLAGGGAVRNVDIDEAQWFTGPQRHEAGTPNVV
* * * * * *: ** : * :: : : * :.****
Mb1499|M.bovis_AF2122/97 QVVGLAAAARYLGAIGMAAVEAHERELVAAAIEGLSGIDGVRILGPT-SM
Rv1464|M.tuberculosis_H37Rv QVVGLAAAARYLGAIGMAAVEAHERELVAAAIEGLSGIDGVRILGPT-SM
MMAR_2269|M.marinum_M QVVGLAAASRYLDAIGMDVIEAHERDLVAAAIEGLSAIEGVRIIGPT-SM
MUL_1865|M.ulcerans_Agy99 QVVGLAAASRYLDAIGMDVIEAHERDLVAAAIEGLSAIEGVRIIGPT-SM
TH_3033|M.thermoresistible__bu QVVGLAAAARYLSAIGMDAVQAHEAELVAAALEGLSGIEQVRIIGPT-SM
Mflv_3674|M.gilvum_PYR-GCK QVVGLGAAARYLDALGMPAVEEHERELVAAALAGLSEVPGVRVIGPA-SM
Mvan_2736|M.vanbaalenii_PYR-1 QVVGLGAATRYLGGIGMSAVEEHEHRLVTATLEGLAAIPGVRIIGPA-TA
MLBr_00842|M.leprae_Br4923 DAVGLGEALRYVERVGVQRIASHEQALLDYATPRLADIPGVRLVG---TA
MSMEG_4538|M.smegmatis_MC2_155 DAVGLGEAIRYVERVGIERIAAYEHALLEYATPRLAAIPGVRIVG---TA
MAV_2055|M.avium_104 DAVGLTEALRYVQRLGVERIAAYEHALLEYATPRLADIPGVRLIG---TA
MAB_0512|M.abscessus_ATCC_1997 GVAAIAAACEALTVLG--DLGHAEDALTVQLRDGLEAIEGVDTLRIWEGD
...: * . : :* : * * * : * :
Mb1499|M.bovis_AF2122/97 RDRGSPVAFVVEGVHAHDVGQVLDDG-GVAVRVGHHCALPLHRRFGLAA-
Rv1464|M.tuberculosis_H37Rv RDRGSPVAFVVEGVHAHDVGQVLDDG-GVAVRVGHHCALPLHRRFGLAA-
MMAR_2269|M.marinum_M ENRGSPVSFVVDGVHAHDVGQVLDDE-GVAVRVGHHCALPLHRKFGVAA-
MUL_1865|M.ulcerans_Agy99 ENRGSPVSFVVDGVHAHDVGQVLDDE-GVAVRVGHHCALPLHRKFGVAA-
TH_3033|M.thermoresistible__bu ELRGSPVSFVVDGVHAHDVGQVLDDD-GVAVRVGHHCAWPLHQRFGIAA-
Mflv_3674|M.gilvum_PYR-GCK DDRGSPVSFVVDGVHAHDVGQVLDDD-GVAVRVGHHCAWPLHRRFGIAA-
Mvan_2736|M.vanbaalenii_PYR-1 ERR-SPVAFVVDGVHAHDVGQVLDDD-GVAVRVGHHCAAPLHRRFGIAA-
MLBr_00842|M.leprae_Br4923 TEKASVLSFVLAGHEPLEVGKALNAE-GIAVRAGHHCAQPVLRRLGLEA-
MSMEG_4538|M.smegmatis_MC2_155 QEKASVLSFVLAGHEPLEVGKALNAE-GIAVRAGHHCAQPILRRMGLEA-
MAV_2055|M.avium_104 QEKASVLSFVLAGHEPLEVGKALNAE-GIAVRAGHHCAQPALRRLGLEA-
MAB_0512|M.abscessus_ATCC_1997 RDVLGIVSFTVAGYAPSVVAAYLSAEHGIGLRDGRFCAHPLLARLGAPGG
. ::*.: * . *. *. *:.:* *:.** * ::* .
Mb1499|M.bovis_AF2122/97 TARASFAVYNTADEVDRLVAGVRRSRHFFGRA------------------
Rv1464|M.tuberculosis_H37Rv TARASFAVYNTADEVDRLVAGVRRSRHFFGRA------------------
MMAR_2269|M.marinum_M TARASFAVYNTRDEVNRLLAGVQRSLNFFGRG------------------
MUL_1865|M.ulcerans_Agy99 TARASFAVYNTRDEVNRLLAGVQRSLNFFGRG------------------
TH_3033|M.thermoresistible__bu TARASFAVYNTLDEVDRLVAGVRRAVEFFGDR------------------
Mflv_3674|M.gilvum_PYR-GCK TARASFAVYNTVDEVDRLVAGVRRAVEFFGRE------------------
Mvan_2736|M.vanbaalenii_PYR-1 TVRASFAVYNTLDEVDRLIAGVQRAIEFFGRD------------------
MLBr_00842|M.leprae_Br4923 TVRPSFAFYNTYEEIDVFINVVRRIAEGGTNIG-----------------
MSMEG_4538|M.smegmatis_MC2_155 TVRPSFAFYNTFDEIDVFIDAVRRIAEGSV--------------------
MAV_2055|M.avium_104 TVRPSFAFYNTFEEIDVFLRAVRRIAEGGANVG-----------------
MAB_0512|M.abscessus_ATCC_1997 ALRASIGLGTTAGDIARLLGAINELVRRGPGLAYIERDGQIGPVDDPRPL
: *.*:.. .* :: :: :.. .
Mb1499|M.bovis_AF2122/97 ------
Rv1464|M.tuberculosis_H37Rv ------
MMAR_2269|M.marinum_M ------
MUL_1865|M.ulcerans_Agy99 ------
TH_3033|M.thermoresistible__bu ------
Mflv_3674|M.gilvum_PYR-GCK ------
Mvan_2736|M.vanbaalenii_PYR-1 ------
MLBr_00842|M.leprae_Br4923 ------
MSMEG_4538|M.smegmatis_MC2_155 ------
MAV_2055|M.avium_104 ------
MAB_0512|M.abscessus_ATCC_1997 PDFLAA