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MEITGMTAPSLLLDTGRAVQQPVWENHVHLERVRSELSELPALVGADEIRTLRTLLSTVAQGRATIIQAG DCAEDPQESTPVHVARKVALLNILAGAMRMKTHRPVLRVGRIGGQYAKPRSKPTEMVGGVELASFRGHLV NGPQPHPVHRRANPDRMLAGYWAANRVMGHLGWRVPSSLSVIEPPVWTSHEALLLDYEVPQLRRDGENRM VLTSTHWPWIGDRTRHLDGPHVELFSRIANPVACKVGPSMTTEDLLALCEKLDPQRESGRLTLIARLGAA AVRSTLPELVAAVRDSGHPVIWLCDPLHANTVSTDSGYKTRHVQTAIDEVRGFRAALEEAGVHAGGLHLE ATPDDVVECVFDSSQNDEVGQRYSTLCDPRLNTAQATEVVSAW
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0295 | - | - | 100% (393) | putative phenazine biosynthesis protein PhzC |
| M. abscessus ATCC 19977 | MAB_1987 | - | 8e-72 | 35.70% (423) | 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase AroG |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2200c | aroG | 5e-72 | 37.97% (424) | 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase AroG |
| M. gilvum PYR-GCK | Mflv_2971 | - | 8e-70 | 36.51% (430) | phospho-2-dehydro-3-deoxyheptonate aldolase |
| M. tuberculosis H37Rv | Rv2178c | aroG | 9e-72 | 37.97% (424) | 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase AroG |
| M. leprae Br4923 | MLBr_00896 | aroG | 7e-69 | 36.30% (427) | 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (DAHP |
| M. marinum M | MMAR_3222 | aroG | 3e-72 | 38.44% (424) | 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase AroG |
| M. avium 104 | MAV_2317 | - | 4e-72 | 37.97% (424) | 3-deoxy-7-phosphoheptulonate synthase |
| M. smegmatis MC2 155 | MSMEG_4244 | - | 5e-73 | 37.09% (426) | 3-deoxy-7-phosphoheptulonate synthase |
| M. thermoresistible (build 8) | TH_1102 | aroG | 5e-74 | 37.59% (423) | Probable 3-deoxy-D-arabino-heptulosonate 7-phosphate |
| M. ulcerans Agy99 | MUL_3533 | aroG_1 | 7e-72 | 38.44% (424) | 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase |
| M. vanbaalenii PYR-1 | Mvan_3540 | - | 1e-71 | 36.98% (430) | phospho-2-dehydro-3-deoxyheptonate aldolase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2200c|M.bovis_AF2122/97 MNWTVDIPIDQLPSLPPLPTDLRTRLDAALAKPAAQQPTWP-ADQALAMR
Rv2178c|M.tuberculosis_H37Rv MNWTVDIPIDQLPSLPPLPTDLRTRLDAALAKPAAQQPTWP-ADQALAMR
MAV_2317|M.avium_104 MNWTVDIPIDQLPPLPPLPGDLRARLDAALAKPAAQQPSWP-TDQATAMR
MMAR_3222|M.marinum_M MNWTVDIPIDQLPSLPPLSDELRARLDAALAKPAAQQPSWP-VDQATAMR
MUL_3533|M.ulcerans_Agy99 MNWTVDIPIDQLPSLPPLSDELRARLDAALAKPAAQQPSWP-VDQATAMR
MLBr_00896|M.leprae_Br4923 MNWTVDIPIDQLP---PLPADLRARLDAALAKPAAQQPSWP-TDQAAAMR
Mflv_2971|M.gilvum_PYR-GCK MNWTVDVPIDQLPALPPLPADLRQRLDAALAKPALQQPSWD-AGQAAAMR
Mvan_3540|M.vanbaalenii_PYR-1 MNWTVDVPIDQLPALPPLPEDLRQRLDAALARPALQQPSWD-AGQAAAMR
MSMEG_4244|M.smegmatis_MC2_155 MNWTVDIPIDQLPPLPPLSDELRQRLDSALAKPAVQQPSWD-PDAAKAMR
TH_1102|M.thermoresistible__bu VNWTVDVPIDQLPALPPLPADLRQRLDAALAKPALQQPSWD-PDLAKAMR
MAB_0295|M.abscessus_ATCC_1997 ------MEITGMTAPSLLLDTGR----------AVQQPVWENHVHLERVR
: * :. * * * *** * :*
Mb2200c|M.bovis_AF2122/97 TVLESVPPVTVPSEIVRLQEQLAQVAKGEAFLLQGGDCAETFMDNTEPHI
Rv2178c|M.tuberculosis_H37Rv TVLESVPPVTVPSEIVRLQEQLAQVAKGEAFLLQGGDCAETFMDNTEPHI
MAV_2317|M.avium_104 TVLESVPPVTVPSEIVRLQEQLAQVARGEAFLLQGGDCAETFTENTEPHI
MMAR_3222|M.marinum_M KVLESVPPVTVPSEIIRLQEQLAQVARGEAFLLQGGDCAETFTDNTEPHI
MUL_3533|M.ulcerans_Agy99 KVLESVPPVTVPSEIIRLQEQLAQVAGGEAFLLQGGDCAETFTDNTEPHI
MLBr_00896|M.leprae_Br4923 TVLESVPPVTVPSEIIRLQEQLALVANGKAFLLQGGDCAETFVDNTEPHI
Mflv_2971|M.gilvum_PYR-GCK KVLESVPPVTVPSEIERLKGQLADVALGKAFLLQGGDCAETFVDNTEPHI
Mvan_3540|M.vanbaalenii_PYR-1 KVLESVPPVTVPSEIERLKSQLADVARGQAFLLQGGDCAETFVDNTEPHI
MSMEG_4244|M.smegmatis_MC2_155 TVLESVPPVTVPSEIEKLKGLLADVAQGKAFLLQGGDCAETFVDNTEPHI
TH_1102|M.thermoresistible__bu TVLESVPPITVPSEVERLKSLLGEVARGKAFLLQGGDCAETFVDNTEPHI
MAB_0295|M.abscessus_ATCC_1997 SELSELPALVGADEIRTLRTLLSTVAQGRATIIQAGDCAEDPQESTPVHV
. *..:*.:. ..*: *: *. ** *.* ::*.***** :.* *:
Mb2200c|M.bovis_AF2122/97 RGNVRALLQMAVVLTYGASMPVVKVARIAGQYAKPRSADIDALG---LRS
Rv2178c|M.tuberculosis_H37Rv RGNVRALLQMAVVLTYGASMPVVKVARIAGQYAKPRSADIDALG---LRS
MAV_2317|M.avium_104 RGNIRTLLQMAVVLTYGASMPVVKVARIAGQYAKPRSADIDALG---LKS
MMAR_3222|M.marinum_M RGNVRTLLQMAVVLTYGSSMPVVKVARIAGQYAKPRSADTDALG---LKS
MUL_3533|M.ulcerans_Agy99 RGNVRTLLQMAVVLTYGSSMPVVKVARIAGQYAKPRSADTDALG---LKS
MLBr_00896|M.leprae_Br4923 RSNVRTLLQMAVVLTYGASLPVVKVARIAGQYAKPRSADVDALG---LKS
Mflv_2971|M.gilvum_PYR-GCK RANIRTLLQMAVVLTYGASMPVVKVARIAGQYAKPRSSDVDALG---LKS
Mvan_3540|M.vanbaalenii_PYR-1 RANIRTLLQMAVVLTYGASMPVVKVARIAGQYAKPRSSDTDALG---LKS
MSMEG_4244|M.smegmatis_MC2_155 RANIRTLLQMAVVLTYGASMPVVKVARIAGQYAKPRSSDVDALG---LKS
TH_1102|M.thermoresistible__bu KANIRTLLQMAVVLTYGASTPVVKMARIAGQYAKPRSSDTDALG---LKS
MAB_0295|M.abscessus_ATCC_1997 ARKVALLNILAGAMRMKTHRPVLRVGRIGGQYAKPRSKPTEMVGGVELAS
:: * :* .: : **:::.**.******** : :* * *
Mb2200c|M.bovis_AF2122/97 YRGDMINGFAPDAAAREHDPSRLVRAYANASAAMNLVRALTSSGLASLHL
Rv2178c|M.tuberculosis_H37Rv YRGDMINGFAPDAAAREHDPSRLVRAYANASAAMNLVRALTSSGLASLHL
MAV_2317|M.avium_104 YRGDMINGFAPNAAVREHDPSRLVRAYANASAAMNLVRALTSSGLASLHL
MMAR_3222|M.marinum_M YRGDMINGFPPDAAAREHDPSRLVRAYANASAAMNLVRALTSSGLASLHL
MUL_3533|M.ulcerans_Agy99 YRGDMINGFPPDAAAREHDPSRLVRAYANASAAMNLVRALTSSGLASLHL
MLBr_00896|M.leprae_Br4923 YRGDMINGFAPDAAAREHDPSRLVRAYANSSAAMNLVRALTSSGLASLHL
Mflv_2971|M.gilvum_PYR-GCK YRGDMVNGFAPDAAVRDHDPSRLVRAYANASAAMNLVRALTSSGMASLHQ
Mvan_3540|M.vanbaalenii_PYR-1 YRGDMVNGFAPDAAVREHDPSRLVRAYANASAAMNLVRALTSSGMASLHQ
MSMEG_4244|M.smegmatis_MC2_155 YRGDMINGFAPDAAAREHDPSRLVRAYANASAAMNLMRALTSSGLASLHL
TH_1102|M.thermoresistible__bu YRGDMINGFAPDASAREHDPSRLVRAYANASAAMNLVRALTSSGLASLHL
MAB_0295|M.abscessus_ATCC_1997 FRGHLVNGPQPHPVHRRANPDRMLAGYWAANRVMGHLGWRVPSSLS----
:**.::** *.. * :*.*:: .* :. .*. : ..*.::
Mb2200c|M.bovis_AF2122/97 VHDWNREFVRTSPAGARYEALATEIDRGLRFMSACGVADRNLQTAEIYAS
Rv2178c|M.tuberculosis_H37Rv VHDWNREFVRTSPAGARYEALATEIDRGLRFMSACGVADRNLQTAEIYAS
MAV_2317|M.avium_104 VHDWNREFVRTSPAGARYEALATEIDRGLRFMSACGVADRNLQTAEIYAS
MMAR_3222|M.marinum_M VHDWNREFVRTSPAGARYEALANEIDRGLRFMSACGVADRNLQTAEIYAS
MUL_3533|M.ulcerans_Agy99 VHDWNREFVRTSPAGARYEALANEIDRGLRFMSACGVADRNLQTAEIYAS
MLBr_00896|M.leprae_Br4923 VHDWNREFVRTSPAGARYEALAGEIGRGLAFMSACGVADRNLQTAEIYAS
Mflv_2971|M.gilvum_PYR-GCK VHDWNREFVRTSPAGARYEALAGEIDRGLRFMSACRVDDRNLDTAEIYAS
Mvan_3540|M.vanbaalenii_PYR-1 VHDWNREFVRTSPAGARYEALAGEIDRGLRFMSACRVDDRNLDTAEIYAS
MSMEG_4244|M.smegmatis_MC2_155 VHEWNREFVRTSPAGARYEALAGEIDRGLNFMSACGVADRNLQTAEIFAS
TH_1102|M.thermoresistible__bu VHDWNREFVRTSPAGARYEALAGEIDRGLRFMSACGVADRNLQTAEIYAS
MAB_0295|M.abscessus_ATCC_1997 -----------------------------------------VIEPPVWTS
: . :::*
Mb2200c|M.bovis_AF2122/97 HEALVLDYERAMLRLS------DGEDGEPQLFDLSAHTVWIGERTRQIDG
Rv2178c|M.tuberculosis_H37Rv HEALVLDYERAMLRLS------DGDDGEPQLFDLSAHTVWIGERTRQIDG
MAV_2317|M.avium_104 HEALVLDYERAMLRLS------DSDAGEPQLYDLSAHTVWIGERTRQLDG
MMAR_3222|M.marinum_M HEALVLDYERAMLRLG------EGENGEPQLYDLSAHTVWIGERTRQLDG
MUL_3533|M.ulcerans_Agy99 HEALVLDYERVMLRLG------EGENGEPQLYDLSAHTVWIGERTRQLDG
MLBr_00896|M.leprae_Br4923 HEALVLDYERAMLRLAG---APEGPDDGLQLYDLSAHTVWIGERTRQLDG
Mflv_2971|M.gilvum_PYR-GCK HEALVLDYERAMLRMETGDLADPALSSEPKLYDLSAHYVWIGERTRQLDG
Mvan_3540|M.vanbaalenii_PYR-1 HEALVLDYERAMLRMNIADSADPASDGPPKLYDLSAHYVWIGERTRQLDG
MSMEG_4244|M.smegmatis_MC2_155 HEALVLDYERAMLRLSN----PAETDGAAKLYDQSAHYLWIGERTRQLDG
TH_1102|M.thermoresistible__bu HEALVLDYERAMLRLS-------EETGEPKLYDLSAHYLWIGERTRQLDG
MAB_0295|M.abscessus_ATCC_1997 HEALLLDYEVPQLRRD----------GENRMVLTSTHWPWIGDRTRHLDG
****:**** ** . :: *:* ***:***::**
Mb2200c|M.bovis_AF2122/97 AHIAFAQVIANPVGVKLGPNMTPELAVEYVERLDPHNKPGRLTLVSRMGN
Rv2178c|M.tuberculosis_H37Rv AHIAFAQVIANPVGVKLGPNMTPELAVEYVERLDPHNKPGRLTLVSRMGN
MAV_2317|M.avium_104 AHIAFAEVIANPIGVKIGPTITPELAVEYVERLDPHNKPGRLTLVSRMGN
MMAR_3222|M.marinum_M AHVAFAEVIANPIGVKIGPTMTPELAVEYVERLDPHNKAGRLTLVSRLGN
MUL_3533|M.ulcerans_Agy99 AHVAFAEVIANPIGVKIGPTMTPELAVEYVERLDPHNKAGRLTLVSRLGN
MLBr_00896|M.leprae_Br4923 AHVAFAEVIANPIGVKMGATMTPELAVEYVERLDPHNKPGRLTLVSRLGN
Mflv_2971|M.gilvum_PYR-GCK AHVAFAEVIANPIGIKIGPTTSPELAVEYVERLDPNNEPGRLTLVSRMGN
Mvan_3540|M.vanbaalenii_PYR-1 AHVAFAEVIANPVGIKIGPTTSPELAVEYVERLDPNNEPGRLTLVSRMGN
MSMEG_4244|M.smegmatis_MC2_155 AHVAFAEVIANPIGVKLGPTTTPELAVEYVERLDPNNEPGRLTLVTRMGN
TH_1102|M.thermoresistible__bu AHIAFAEVIANPIGVKIGPTTTPEVAAEYVERLDPNNEPGRLTLVSRLGN
MAB_0295|M.abscessus_ATCC_1997 PHVELFSRIANPVACKVGPSMTTEDLLALCEKLDPQRESGRLTLIARLGA
.*: : . ****:. *:*.. :.* *:***:.:.*****::*:*
Mb2200c|M.bovis_AF2122/97 HKVRDLLPPIVEKVQATGHQVIWQCDPMHGNTHESSTGFKTRHFDRIVDE
Rv2178c|M.tuberculosis_H37Rv HKVRDLLPPIVEKVQATGHQVIWQCDPMHGNTHESSTGFKTRHFDRIVDE
MAV_2317|M.avium_104 SKVRDLLPPIVEKVQATGHQVIWQCDPMHGNTHESSNGYKTRHFDRIVDE
MMAR_3222|M.marinum_M NKVRDLLPPIVEKVQAAGHQVIWQCDPMHGNTHESSTGYKTRHFDRIVDE
MUL_3533|M.ulcerans_Agy99 NKVRDLLPPIVEKVQAAGHQVIWQCDPMHGNTHESSTGYKTRHFDRIVDE
MLBr_00896|M.leprae_Br4923 NKVRDVLPPIVEKVKATGHQVIWQCDPMHGNTHESSTGYKTRHFDRVVDE
Mflv_2971|M.gilvum_PYR-GCK HKVRDVLPPIIEKVQASGHRVIWQCDPMHGNTHESSTGYKTRHFDRIVDE
Mvan_3540|M.vanbaalenii_PYR-1 HKVRDVLPPIIEKVQASGHQVVWQCDPMHGNTHESSTGYKTRHFDRIVDE
MSMEG_4244|M.smegmatis_MC2_155 NKVRDLLPPIIEKVQATGHQVIWQCDPMHGNTHESSTGYKTRHFDRIVDE
TH_1102|M.thermoresistible__bu HKVRDLLPPIIEKVQATGHTVIWQCDPMHGNTHESSTGYKTRHFDRIVDE
MAB_0295|M.abscessus_ATCC_1997 AAVRSTLPELVAAVRDSGHPVIWLCDPLHANTVSTDSGYKTRHVQTAIDE
**. ** :: *: :** *:* ***:*.** .:..*:****.: :**
Mb2200c|M.bovis_AF2122/97 VQGFFEVHRALGTHPGGIHVEITGENVTECLGGAQDISETDLAGRYETAC
Rv2178c|M.tuberculosis_H37Rv VQGFFEVHRALGTHPGGIHVEITGENVTECLGGAQDISETDLAGRYETAC
MAV_2317|M.avium_104 VQGFFEVHRALGTHPGGIHVEITGDNVTECLGGAQDISDMDLVGRYETAC
MMAR_3222|M.marinum_M VQGFFEVHRGLGTHPGGIHVEITGENVTECLGGAQDISDSDLSGRYETAC
MUL_3533|M.ulcerans_Agy99 VQGFFEVHRGLGTHPGGIHVEITGENVTECLGGAQDISDSDLSGRYETAC
MLBr_00896|M.leprae_Br4923 VQGFFEVHRALGTYPGGIHVEITGEDVTECLGGAQDISDTDLAGRYETAC
Mflv_2971|M.gilvum_PYR-GCK VQGFFEVHRALGTHPGGIHVEITGENVTECLGGAQDISDTDLAGRYETAC
Mvan_3540|M.vanbaalenii_PYR-1 VQGFFEVHHALGTHPGGIHVEITGENVTECLGGAQDISDTDLAGRYETAC
MSMEG_4244|M.smegmatis_MC2_155 VQGFFEVHHALGTHPGGIHVEITGENVTECLGGAQDISDSDLAGRYETAC
TH_1102|M.thermoresistible__bu VQGFFEVHRALGTHPGGIHVEITGENVTECLGGAQDISDTDLAGRYETAC
MAB_0295|M.abscessus_ATCC_1997 VRGFRAALEEAGVHAGGLHLEATPDDVVECVFDSS--QNDEVGQRYSTLC
*:** . . *.:.**:*:* * ::*.**: .:. .: :: **.* *
Mb2200c|M.bovis_AF2122/97 DPRLNTQQSLELAFLVAEMLRD
Rv2178c|M.tuberculosis_H37Rv DPRLNTQQSLELAFLVAEMLRD
MAV_2317|M.avium_104 DPRLNTQQSLELAFLVAEMLRD
MMAR_3222|M.marinum_M DPRLNTQQSLELAFLVAEMLRD
MUL_3533|M.ulcerans_Agy99 DPRLNTQQSLELAFLVAEMLRD
MLBr_00896|M.leprae_Br4923 DPRLNTQQSLELAFLVAEMLRD
Mflv_2971|M.gilvum_PYR-GCK DPRLNTQQSLELAFLVAEMLRD
Mvan_3540|M.vanbaalenii_PYR-1 DPRLNTQQSLELAFLVAEMLRG
MSMEG_4244|M.smegmatis_MC2_155 DPRLNTQQSLELAFLVAEMLRD
TH_1102|M.thermoresistible__bu DPRLNTQQSLELAFLVAEMLRD
MAB_0295|M.abscessus_ATCC_1997 DPRLNTAQATEVVSAW------
****** *: *:.