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NWTVDVPIDQLPALPPLPEDLRQRLDAALARPALQQPSWDAGQAAAMRKVLESVPPVTVPSEIERLKSQL ADVARGQAFLLQGGDCAETFVDNTEPHIRANIRTLLQMAVVLTYGASMPVVKVARIAGQYAKPRSSDTDA LGLKSYRGDMVNGFAPDAAVREHDPSRLVRAYANASAAMNLVRALTSSGMASLHQVHDWNREFVRTSPAG ARYEALAGEIDRGLRFMSACRVDDRNLDTAEIYASHEALVLDYERAMLRMNIADSADPASDGPPKLYDLS AHYVWIGERTRQLDGAHVAFAEVIANPVGIKIGPTTSPELAVEYVERLDPNNEPGRLTLVSRMGNHKVRD VLPPIIEKVQASGHQVVWQCDPMHGNTHESSTGYKTRHFDRIVDEVQGFFEVHHALGTHPGGIHVEITGE NVTECLGGAQDISDTDLAGRYETACDPRLNTQQSLELAFLVAEMLRG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3540 | - | - | 100% (468) | phospho-2-dehydro-3-deoxyheptonate aldolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2200c | aroG | 0.0 | 86.08% (467) | 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase AroG |
| M. gilvum PYR-GCK | Mflv_2971 | - | 0.0 | 95.93% (467) | phospho-2-dehydro-3-deoxyheptonate aldolase |
| M. tuberculosis H37Rv | Rv2178c | aroG | 0.0 | 86.30% (467) | 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase AroG |
| M. leprae Br4923 | MLBr_00896 | aroG | 0.0 | 85.87% (467) | 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (DAHP |
| M. abscessus ATCC 19977 | MAB_1987 | - | 0.0 | 86.72% (467) | 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase AroG |
| M. marinum M | MMAR_3222 | aroG | 0.0 | 86.30% (467) | 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase AroG |
| M. avium 104 | MAV_2317 | - | 0.0 | 86.94% (467) | 3-deoxy-7-phosphoheptulonate synthase |
| M. smegmatis MC2 155 | MSMEG_4244 | - | 0.0 | 88.46% (468) | 3-deoxy-7-phosphoheptulonate synthase |
| M. thermoresistible (build 8) | TH_1102 | aroG | 0.0 | 89.29% (467) | Probable 3-deoxy-D-arabino-heptulosonate 7-phosphate |
| M. ulcerans Agy99 | MUL_3533 | aroG_1 | 0.0 | 85.87% (467) | 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_3540|M.vanbaalenii_PYR-1 MNWTVDVPIDQLPALPPLPEDLRQRLDAALARPALQQPSWDAGQAAAMRK
Mflv_2971|M.gilvum_PYR-GCK MNWTVDVPIDQLPALPPLPADLRQRLDAALAKPALQQPSWDAGQAAAMRK
MSMEG_4244|M.smegmatis_MC2_155 MNWTVDIPIDQLPPLPPLSDELRQRLDSALAKPAVQQPSWDPDAAKAMRT
TH_1102|M.thermoresistible__bu VNWTVDVPIDQLPALPPLPADLRQRLDAALAKPALQQPSWDPDLAKAMRT
MMAR_3222|M.marinum_M MNWTVDIPIDQLPSLPPLSDELRARLDAALAKPAAQQPSWPVDQATAMRK
MUL_3533|M.ulcerans_Agy99 MNWTVDIPIDQLPSLPPLSDELRARLDAALAKPAAQQPSWPVDQATAMRK
Mb2200c|M.bovis_AF2122/97 MNWTVDIPIDQLPSLPPLPTDLRTRLDAALAKPAAQQPTWPADQALAMRT
Rv2178c|M.tuberculosis_H37Rv MNWTVDIPIDQLPSLPPLPTDLRTRLDAALAKPAAQQPTWPADQALAMRT
MAV_2317|M.avium_104 MNWTVDIPIDQLPPLPPLPGDLRARLDAALAKPAAQQPSWPTDQATAMRT
MLBr_00896|M.leprae_Br4923 MNWTVDIPIDQLP---PLPADLRARLDAALAKPAAQQPSWPTDQAAAMRT
MAB_1987|M.abscessus_ATCC_1997 MNWTVDVPIDQLPELPPLPADLRERLDAALAKPAAQQPSWPANQAAAMRT
:*****:****** **. :** ***:***:** ***:* . * ***.
Mvan_3540|M.vanbaalenii_PYR-1 VLESVPPVTVPSEIERLKSQLADVARGQAFLLQGGDCAETFVDNTEPHIR
Mflv_2971|M.gilvum_PYR-GCK VLESVPPVTVPSEIERLKGQLADVALGKAFLLQGGDCAETFVDNTEPHIR
MSMEG_4244|M.smegmatis_MC2_155 VLESVPPVTVPSEIEKLKGLLADVAQGKAFLLQGGDCAETFVDNTEPHIR
TH_1102|M.thermoresistible__bu VLESVPPITVPSEVERLKSLLGEVARGKAFLLQGGDCAETFVDNTEPHIK
MMAR_3222|M.marinum_M VLESVPPVTVPSEIIRLQEQLAQVARGEAFLLQGGDCAETFTDNTEPHIR
MUL_3533|M.ulcerans_Agy99 VLESVPPVTVPSEIIRLQEQLAQVAGGEAFLLQGGDCAETFTDNTEPHIR
Mb2200c|M.bovis_AF2122/97 VLESVPPVTVPSEIVRLQEQLAQVAKGEAFLLQGGDCAETFMDNTEPHIR
Rv2178c|M.tuberculosis_H37Rv VLESVPPVTVPSEIVRLQEQLAQVAKGEAFLLQGGDCAETFMDNTEPHIR
MAV_2317|M.avium_104 VLESVPPVTVPSEIVRLQEQLAQVARGEAFLLQGGDCAETFTENTEPHIR
MLBr_00896|M.leprae_Br4923 VLESVPPVTVPSEIIRLQEQLALVANGKAFLLQGGDCAETFVDNTEPHIR
MAB_1987|M.abscessus_ATCC_1997 VLESVPPITVPAEIQRLQRQLAQVARGEAFLLQGGDCAETFADNTEPHIR
*******:***:*: :*: *. ** *:************* :******:
Mvan_3540|M.vanbaalenii_PYR-1 ANIRTLLQMAVVLTYGASMPVVKVARIAGQYAKPRSSDTDALGLKSYRGD
Mflv_2971|M.gilvum_PYR-GCK ANIRTLLQMAVVLTYGASMPVVKVARIAGQYAKPRSSDVDALGLKSYRGD
MSMEG_4244|M.smegmatis_MC2_155 ANIRTLLQMAVVLTYGASMPVVKVARIAGQYAKPRSSDVDALGLKSYRGD
TH_1102|M.thermoresistible__bu ANIRTLLQMAVVLTYGASTPVVKMARIAGQYAKPRSSDTDALGLKSYRGD
MMAR_3222|M.marinum_M GNVRTLLQMAVVLTYGSSMPVVKVARIAGQYAKPRSADTDALGLKSYRGD
MUL_3533|M.ulcerans_Agy99 GNVRTLLQMAVVLTYGSSMPVVKVARIAGQYAKPRSADTDALGLKSYRGD
Mb2200c|M.bovis_AF2122/97 GNVRALLQMAVVLTYGASMPVVKVARIAGQYAKPRSADIDALGLRSYRGD
Rv2178c|M.tuberculosis_H37Rv GNVRALLQMAVVLTYGASMPVVKVARIAGQYAKPRSADIDALGLRSYRGD
MAV_2317|M.avium_104 GNIRTLLQMAVVLTYGASMPVVKVARIAGQYAKPRSADIDALGLKSYRGD
MLBr_00896|M.leprae_Br4923 SNVRTLLQMAVVLTYGASLPVVKVARIAGQYAKPRSADVDALGLKSYRGD
MAB_1987|M.abscessus_ATCC_1997 ANIRALLQMAVVLTYGASMPVVKLARIAGQYAKPRSSDTDALGLKSYRGD
.*:*:***********:* ****:************:* *****:*****
Mvan_3540|M.vanbaalenii_PYR-1 MVNGFAPDAAVREHDPSRLVRAYANASAAMNLVRALTSSGMASLHQVHDW
Mflv_2971|M.gilvum_PYR-GCK MVNGFAPDAAVRDHDPSRLVRAYANASAAMNLVRALTSSGMASLHQVHDW
MSMEG_4244|M.smegmatis_MC2_155 MINGFAPDAAAREHDPSRLVRAYANASAAMNLMRALTSSGLASLHLVHEW
TH_1102|M.thermoresistible__bu MINGFAPDASAREHDPSRLVRAYANASAAMNLVRALTSSGLASLHLVHDW
MMAR_3222|M.marinum_M MINGFPPDAAAREHDPSRLVRAYANASAAMNLVRALTSSGLASLHLVHDW
MUL_3533|M.ulcerans_Agy99 MINGFPPDAAAREHDPSRLVRAYANASAAMNLVRALTSSGLASLHLVHDW
Mb2200c|M.bovis_AF2122/97 MINGFAPDAAAREHDPSRLVRAYANASAAMNLVRALTSSGLASLHLVHDW
Rv2178c|M.tuberculosis_H37Rv MINGFAPDAAAREHDPSRLVRAYANASAAMNLVRALTSSGLASLHLVHDW
MAV_2317|M.avium_104 MINGFAPNAAVREHDPSRLVRAYANASAAMNLVRALTSSGLASLHLVHDW
MLBr_00896|M.leprae_Br4923 MINGFAPDAAAREHDPSRLVRAYANSSAAMNLVRALTSSGLASLHLVHDW
MAB_1987|M.abscessus_ATCC_1997 MVNGFAPDATLREHDPSRLVRAYANASAAMNLVRALTGSGMASLALVHDW
*:***.*:*: *:************:******:****.**:*** **:*
Mvan_3540|M.vanbaalenii_PYR-1 NREFVRTSPAGARYEALAGEIDRGLRFMSACRVDDRNLDTAEIYASHEAL
Mflv_2971|M.gilvum_PYR-GCK NREFVRTSPAGARYEALAGEIDRGLRFMSACRVDDRNLDTAEIYASHEAL
MSMEG_4244|M.smegmatis_MC2_155 NREFVRTSPAGARYEALAGEIDRGLNFMSACGVADRNLQTAEIFASHEAL
TH_1102|M.thermoresistible__bu NREFVRTSPAGARYEALAGEIDRGLRFMSACGVADRNLQTAEIYASHEAL
MMAR_3222|M.marinum_M NREFVRTSPAGARYEALANEIDRGLRFMSACGVADRNLQTAEIYASHEAL
MUL_3533|M.ulcerans_Agy99 NREFVRTSPAGARYEALANEIDRGLRFMSACGVADRNLQTAEIYASHEAL
Mb2200c|M.bovis_AF2122/97 NREFVRTSPAGARYEALATEIDRGLRFMSACGVADRNLQTAEIYASHEAL
Rv2178c|M.tuberculosis_H37Rv NREFVRTSPAGARYEALATEIDRGLRFMSACGVADRNLQTAEIYASHEAL
MAV_2317|M.avium_104 NREFVRTSPAGARYEALATEIDRGLRFMSACGVADRNLQTAEIYASHEAL
MLBr_00896|M.leprae_Br4923 NREFVRTSPAGARYEALAGEIGRGLAFMSACGVADRNLQTAEIYASHEAL
MAB_1987|M.abscessus_ATCC_1997 NREFVRTSPAGARYEALAGEIDRGLKFMSACGVVDSNLDTAEIYASHEAL
****************** **.*** ***** * * **:****:******
Mvan_3540|M.vanbaalenii_PYR-1 VLDYERAMLRMNIADSADPASDGPPKLYDLSAHYVWIGERTRQLDGAHVA
Mflv_2971|M.gilvum_PYR-GCK VLDYERAMLRMETGDLADPALSSEPKLYDLSAHYVWIGERTRQLDGAHVA
MSMEG_4244|M.smegmatis_MC2_155 VLDYERAMLRLSN----PAETDGAAKLYDQSAHYLWIGERTRQLDGAHVA
TH_1102|M.thermoresistible__bu VLDYERAMLRLS-------EETGEPKLYDLSAHYLWIGERTRQLDGAHIA
MMAR_3222|M.marinum_M VLDYERAMLRLG------EGENGEPQLYDLSAHTVWIGERTRQLDGAHVA
MUL_3533|M.ulcerans_Agy99 VLDYERVMLRLG------EGENGEPQLYDLSAHTVWIGERTRQLDGAHVA
Mb2200c|M.bovis_AF2122/97 VLDYERAMLRLS------DGEDGEPQLFDLSAHTVWIGERTRQIDGAHIA
Rv2178c|M.tuberculosis_H37Rv VLDYERAMLRLS------DGDDGEPQLFDLSAHTVWIGERTRQIDGAHIA
MAV_2317|M.avium_104 VLDYERAMLRLS------DSDAGEPQLYDLSAHTVWIGERTRQLDGAHIA
MLBr_00896|M.leprae_Br4923 VLDYERAMLRLAG---APEGPDDGLQLYDLSAHTVWIGERTRQLDGAHVA
MAB_1987|M.abscessus_ATCC_1997 VLDYERAMLRLG------EDENGEPALYDLSAHYLWIGDRTRQLDHAHVA
******.***: . *:* *** :***:****:* **:*
Mvan_3540|M.vanbaalenii_PYR-1 FAEVIANPVGIKIGPTTSPELAVEYVERLDPNNEPGRLTLVSRMGNHKVR
Mflv_2971|M.gilvum_PYR-GCK FAEVIANPIGIKIGPTTSPELAVEYVERLDPNNEPGRLTLVSRMGNHKVR
MSMEG_4244|M.smegmatis_MC2_155 FAEVIANPIGVKLGPTTTPELAVEYVERLDPNNEPGRLTLVTRMGNNKVR
TH_1102|M.thermoresistible__bu FAEVIANPIGVKIGPTTTPEVAAEYVERLDPNNEPGRLTLVSRLGNHKVR
MMAR_3222|M.marinum_M FAEVIANPIGVKIGPTMTPELAVEYVERLDPHNKAGRLTLVSRLGNNKVR
MUL_3533|M.ulcerans_Agy99 FAEVIANPIGVKIGPTMTPELAVEYVERLDPHNKAGRLTLVSRLGNNKVR
Mb2200c|M.bovis_AF2122/97 FAQVIANPVGVKLGPNMTPELAVEYVERLDPHNKPGRLTLVSRMGNHKVR
Rv2178c|M.tuberculosis_H37Rv FAQVIANPVGVKLGPNMTPELAVEYVERLDPHNKPGRLTLVSRMGNHKVR
MAV_2317|M.avium_104 FAEVIANPIGVKIGPTITPELAVEYVERLDPHNKPGRLTLVSRMGNSKVR
MLBr_00896|M.leprae_Br4923 FAEVIANPIGVKMGATMTPELAVEYVERLDPHNKPGRLTLVSRLGNNKVR
MAB_1987|M.abscessus_ATCC_1997 FAEIIANPIGMKIGPTTTPDQAVEYVERLDPHNKPGRLTFVSRMGNSKVR
**::****:*:*:*.. :*: *.********:*:.****:*:*:** ***
Mvan_3540|M.vanbaalenii_PYR-1 DVLPPIIEKVQASGHQVVWQCDPMHGNTHESSTGYKTRHFDRIVDEVQGF
Mflv_2971|M.gilvum_PYR-GCK DVLPPIIEKVQASGHRVIWQCDPMHGNTHESSTGYKTRHFDRIVDEVQGF
MSMEG_4244|M.smegmatis_MC2_155 DLLPPIIEKVQATGHQVIWQCDPMHGNTHESSTGYKTRHFDRIVDEVQGF
TH_1102|M.thermoresistible__bu DLLPPIIEKVQATGHTVIWQCDPMHGNTHESSTGYKTRHFDRIVDEVQGF
MMAR_3222|M.marinum_M DLLPPIVEKVQAAGHQVIWQCDPMHGNTHESSTGYKTRHFDRIVDEVQGF
MUL_3533|M.ulcerans_Agy99 DLLPPIVEKVQAAGHQVIWQCDPMHGNTHESSTGYKTRHFDRIVDEVQGF
Mb2200c|M.bovis_AF2122/97 DLLPPIVEKVQATGHQVIWQCDPMHGNTHESSTGFKTRHFDRIVDEVQGF
Rv2178c|M.tuberculosis_H37Rv DLLPPIVEKVQATGHQVIWQCDPMHGNTHESSTGFKTRHFDRIVDEVQGF
MAV_2317|M.avium_104 DLLPPIVEKVQATGHQVIWQCDPMHGNTHESSNGYKTRHFDRIVDEVQGF
MLBr_00896|M.leprae_Br4923 DVLPPIVEKVKATGHQVIWQCDPMHGNTHESSTGYKTRHFDRVVDEVQGF
MAB_1987|M.abscessus_ATCC_1997 DLLPPIIEKVRATGHQVVWQCDPMHGNTHESPSGYKTRHFDRIVDEVQGY
*:****:***:*:** *:*************..*:*******:******:
Mvan_3540|M.vanbaalenii_PYR-1 FEVHHALGTHPGGIHVEITGENVTECLGGAQDISDTDLAGRYETACDPRL
Mflv_2971|M.gilvum_PYR-GCK FEVHRALGTHPGGIHVEITGENVTECLGGAQDISDTDLAGRYETACDPRL
MSMEG_4244|M.smegmatis_MC2_155 FEVHHALGTHPGGIHVEITGENVTECLGGAQDISDSDLAGRYETACDPRL
TH_1102|M.thermoresistible__bu FEVHRALGTHPGGIHVEITGENVTECLGGAQDISDTDLAGRYETACDPRL
MMAR_3222|M.marinum_M FEVHRGLGTHPGGIHVEITGENVTECLGGAQDISDSDLSGRYETACDPRL
MUL_3533|M.ulcerans_Agy99 FEVHRGLGTHPGGIHVEITGENVTECLGGAQDISDSDLSGRYETACDPRL
Mb2200c|M.bovis_AF2122/97 FEVHRALGTHPGGIHVEITGENVTECLGGAQDISETDLAGRYETACDPRL
Rv2178c|M.tuberculosis_H37Rv FEVHRALGTHPGGIHVEITGENVTECLGGAQDISETDLAGRYETACDPRL
MAV_2317|M.avium_104 FEVHRALGTHPGGIHVEITGDNVTECLGGAQDISDMDLVGRYETACDPRL
MLBr_00896|M.leprae_Br4923 FEVHRALGTYPGGIHVEITGEDVTECLGGAQDISDTDLAGRYETACDPRL
MAB_1987|M.abscessus_ATCC_1997 FEVHNALGTHPGGIHVEITGENVTECLGGAQDISDDDLAGRYETACDPRL
****..***:**********::************: ** ***********
Mvan_3540|M.vanbaalenii_PYR-1 NTQQSLELAFLVAEMLRG
Mflv_2971|M.gilvum_PYR-GCK NTQQSLELAFLVAEMLRD
MSMEG_4244|M.smegmatis_MC2_155 NTQQSLELAFLVAEMLRD
TH_1102|M.thermoresistible__bu NTQQSLELAFLVAEMLRD
MMAR_3222|M.marinum_M NTQQSLELAFLVAEMLRD
MUL_3533|M.ulcerans_Agy99 NTQQSLELAFLVAEMLRD
Mb2200c|M.bovis_AF2122/97 NTQQSLELAFLVAEMLRD
Rv2178c|M.tuberculosis_H37Rv NTQQSLELAFLVAEMLRD
MAV_2317|M.avium_104 NTQQSLELAFLVAEMLRD
MLBr_00896|M.leprae_Br4923 NTQQSLELAFLVAEMLRD
MAB_1987|M.abscessus_ATCC_1997 NTQQSLELAFLVAEMLRD
*****************.