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M. thermoresistible (build 8) TH_3986 (hmgA)

annotation: putative homogentisate 1,2-dioxygenase
coordinates: 142939 - 144150
length: 404

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_3986hmgA-100% (404)putative homogentisate 1,2-dioxygenase
M. thermoresistible (build 8)TH_0903hmgA6e-2324.63% (337) homogentisate 1,2-dioxygenase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97-----
M. gilvum PYR-GCKMflv_4463-1e-2227.17% (357) homogentisate 1,2-dioxygenase
M. tuberculosis H37Rv-----
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_0890c-1e-12254.11% (401) putative homogentisate 1,2-dioxygenase
M. marinum MMMAR_1496-8e-2226.95% (334) oxidoreductase
M. avium 104MAV_4022hmgA5e-2426.43% (333) homogentisate 1,2-dioxygenase
M. smegmatis MC2 155MSMEG_2075hmgA2e-2225.49% (357) homogentisate 1,2-dioxygenase
M. ulcerans Agy99MUL_2443-1e-2127.63% (304) oxidoreductase
M. vanbaalenii PYR-1Mvan_1897-1e-2325.78% (353) homogentisate 1,2-dioxygenase

CLUSTAL 2.0.9 multiple sequence alignment


MMAR_1496|M.marinum_M               --------------MESFVHLRKGRTPRRLHADLDGLKDDELGRGGFTGR
MUL_2443|M.ulcerans_Agy99           MSLLVLYPTSPGAPMESFVHLRKGRTPRRLHADLDGLKDDELGRGGFTGR
MAV_4022|M.avium_104                --------------MESFIHLRKGRTPGRLHADLDGLKDDELGRGGFTGR
Mflv_4463|M.gilvum_PYR-GCK          --------------MESFVHLRKGKTPKRIHADLDGLKDDELGRGGFVGR
Mvan_1897|M.vanbaalenii_PYR-1       --------------MESFVHLRKGKTPKRIHADLDGLKDDELGRGGFVGR
MSMEG_2075|M.smegmatis_MC2_155      --------------MESFIHLRKGRTPKRLHADLEGLKDDELGRGGFTGR
TH_3986|M.thermoresistible__bu      ------------MYYRAVGEFPKTRHTVFTTADGRPTFEEFIGEEGFSGT
MAB_0890c|M.abscessus_ATCC_199      -----------MAHYMQVGSIPPKRHTQHRNAAGNLYYEELVGEDGFSSD
                                                     .  :   : .    *      :: :*. ** . 

MMAR_1496|M.marinum_M               TANLYRRHDPTAYRAVG-------------PLRPVDVLADQLEPSDAT--
MUL_2443|M.ulcerans_Agy99           TANLYRRHDPTAYRAVG-------------PLRPVDVLADQLEPSDAT--
MAV_4022|M.avium_104                TANMYRRHDPTAYRVQG-------------PLRPIDVLTSELKPSDAT--
Mflv_4463|M.gilvum_PYR-GCK          TANMYRRNDPTAYRTVG-------------PLRPTDVLSSELKPSDAT--
Mvan_1897|M.vanbaalenii_PYR-1       TANMYRRNDPTAYRTVG-------------PLRPTDVLSSELKPSDAT--
MSMEG_2075|M.smegmatis_MC2_155      TANMYRRNDPTAYRSVG-------------PLRPTDVLSSELKPSDAT--
TH_3986|M.thermoresistible__bu      ASHLYHLGVPANLVDTRTWEIGDLSTRPNVPLRPRHFRLPDLFPAGAERG
MAB_0890c|M.abscessus_ATCC_199      SALLYHRHIPAAIVDATPWELLDHSTCANRPLIPRHLRLHSLFPRDALAH
                                    :: :*:   *:                   ** * ..   .* * .*   

MMAR_1496|M.marinum_M               -DANGGPLLMFSNADCRILLSRRHQVMPFYNRHVDGDLLCFVHDGAGLLE
MUL_2443|M.ulcerans_Agy99           -DANGGPLLMFSNADCRILLSRRHQVMPFYNRHVDGDLLCFVHDGAGLLE
MAV_4022|M.avium_104                -DATGGPLLMFANPDCRISLSRRSEPMPFYVRHVDGDLLCFVHGGAGLLH
Mflv_4463|M.gilvum_PYR-GCK          -DPRGGPLLMFSNADCQVLLSRRTEEMPFFVRYVDGDLLSFVHRGSGSLE
Mvan_1897|M.vanbaalenii_PYR-1       -DANGGPLLMFSNADCLVLLSRRSEPMPFFVRYVDGDLLSFVHRGSGSLE
MSMEG_2075|M.smegmatis_MC2_155      -DAHGGPLLMFSNPDCQVLLSRRSQEMPFFVRHVDGDLLSFVHKGSGLLE
TH_3986|M.thermoresistible__bu      KDVVRHRRLILANDDVRISYVVADTPSPLYSNGLG-DEVVYIESGEADVE
MAB_0890c|M.abscessus_ATCC_199      TDVVTGRRLLLANADVRIYYVAAGAESPLYRNAIG-DEVVYVESGGGLVE
                                     *      *:::* *  :         *:: . :. * : ::. * . :.

MMAR_1496|M.marinum_M               TEFGPLRYRTGDWVYIPKATTWRQLP-----DTETTLLMVEATDEFRVPA
MUL_2443|M.ulcerans_Agy99           TEFGPLRYRTGDWVYIPKATTWRQLP-----DTETTLLMVEATDEFRVPA
MAV_4022|M.avium_104                TEFGPMPYRQGDWVYLPKATTWRQLP-----DAETTLLMIEATDEFRVPP
Mflv_4463|M.gilvum_PYR-GCK          TEFGPLTYRQGDWIYIPKACTWRQIPDP-GPTGTTTLLMVQATEEFRVPP
Mvan_1897|M.vanbaalenii_PYR-1       TEFGPLDYRQGDWIYIPKACTWRQVP-----SEETTLLMIQATDEFRVPP
MSMEG_2075|M.smegmatis_MC2_155      TEFGPLRYREGDWIYIPKACTWRQIP-----DDESTLLMIQATDEFRVPP
TH_3986|M.thermoresistible__bu      SVFGTLSVGQGDNVVIPRVAIHRWIPKNVDTAGPLKAYCVEGNGHIEIPA
MAB_0890c|M.abscessus_ATCC_199      TVFGWLRVRQGDYVVIPRATTHRWVPE---PGQPLRAYIIEANSHVAPPK
                                    : ** :    ** : :*:.   * :*             ::.. ..  * 

MMAR_1496|M.marinum_M               --PGALGRHFPFDP-SQAVIPEPAPVDNPPGLGARDEYQVRLVHEGGP--
MUL_2443|M.ulcerans_Agy99           --PGALGRHFPFDP-SQGVIPEPAPVDNPPGLGARDEYQVRLVHEGGP--
MAV_4022|M.avium_104                --PGPLGRHFPFDP-SQATIPEPQALDDDP---ARDEYEVRLVHEGGP--
Mflv_4463|M.gilvum_PYR-GCK          --AGTLGRHFPFDP-AQAVIPEPQPIDD----DGRDEYEVRLIHEGGP--
Mvan_1897|M.vanbaalenii_PYR-1       --AGTLGRHFPFDP-AQVVIPEPQPIDD----DGRDEYEVRLIHEGGP--
MSMEG_2075|M.smegmatis_MC2_155      --PGTLGRHFPFDP-SQAVIPDPQPIDDGTGPQTDGEYEVRLIHDGGP--
TH_3986|M.thermoresistible__bu      KYLTRFGQFIEGAPLTERDIRGPVGPLLAAADEADQDTEVYVKHGHGSEV
MAB_0890c|M.abscessus_ATCC_199      RYLSRFGQLLEHAPYCERDLHGPTD--LISHDATDVD--VFVKHRGSQGI
                                         :*: :   *  :  :  *             :  * : *  .   

MMAR_1496|M.marinum_M               --TTLFYQHNPIDVEGWRGDNFAFTFNIADYNVITSDSVHLPPTVHLFMQ
MUL_2443|M.ulcerans_Agy99           --TTLFYQHNATDVEGWRGYNFAFTFNIADYNVITSDSVHLPPTVHLFMQ
MAV_4022|M.avium_104                --TTLLYQHNPLDVEGWRGDNFAFTFNIADYNVVTSDSVHLPPTVHLFMQ
Mflv_4463|M.gilvum_PYR-GCK          --TSLFYKHHPLDVEGWRGDNFPFTFNIDDYTVITSDSVHLPPTVHLFMQ
Mvan_1897|M.vanbaalenii_PYR-1       --TSLFYQHHPLDVEGWRGDNFPFTFNIDDYTVVTSESVHLPPTVHLFMQ
MSMEG_2075|M.smegmatis_MC2_155      --TTLFYQHHPLDVEGWRGDNFAFTFNIEDYNVVTSDSVHLPPTVHLFMQ
TH_3986|M.thermoresistible__bu      HGSIVVYDHHPFDVVGWDGYLYPYAFNYRDFSPVTGK-IIQPPPTYQILE
MAB_0890c|M.abscessus_ATCC_199      TGTRYVYAEHPFDVVGWDGCLYPYRFNISDFEPITGR-VHQPPPAHQVFE
                                      :  .* .:. ** ** *  :.: **  *:  :*.  :  **..: .::

MMAR_1496|M.marinum_M               ATGVCVMNFLPKPAEGVPGTERTPWYHRNVDYDEIAFFHGG---SLYGIP
MUL_2443|M.ulcerans_Agy99           ATGVCVMNFLPKPAEGVPGTERTPWYHRNVDYDEIAFFHGG---SLYGIP
MAV_4022|M.avium_104                ATGVYVMNFLPKPAEGVPGTERTPWYHRNVDYDEIAFFHGG---SLYGIP
Mflv_4463|M.gilvum_PYR-GCK          ATGVYIMNFLPKPAESVPGTERTPWYHRNVDFDEIAFFHDG---SLYGIP
Mvan_1897|M.vanbaalenii_PYR-1       ATGVYVMNFLPKPAESVPGTERTPWYHRNVDYDEIAFFHGG---SLYGIP
MSMEG_2075|M.smegmatis_MC2_155      ATGVYIMNFLPKPAEGVPGTERTPWYHHNVDYDEIAFFHGG---SLYGIP
TH_3986|M.thermoresistible__bu      GPNFVVCNFVPRMLEYGEGAITVPYYHSNVDADEVMFYYAGETAARKGTG
MAB_0890c|M.abscessus_ATCC_199      ANNFVICNFVPRKVDYHPLSVPVPYYHSNVDSDEVMFYVGGDYEARKGSG
                                    . .. : **:*:  :    :  .*:** *** **: *:  *   :  *  

MMAR_1496|M.marinum_M               MPPGLISHAPQGVHHGAPERARERARRKFAEYSRVDWQVIAVDTRRRLTP
MUL_2443|M.ulcerans_Agy99           MPPGLISHAPQGVHHSAPERARERARRKFAEYSRVDWEVIAVDTRRRLTP
MAV_4022|M.avium_104                MPPGLISHAPQGVHHGAPEKARERARRKFDEYARVDWQVIAVDTRRRLTP
Mflv_4463|M.gilvum_PYR-GCK          MPPGLVSHAPQGVHHGAPEKARERARRKFDDYDRVDWSVIAVDTRRRLIP
Mvan_1897|M.vanbaalenii_PYR-1       MPPGLVSHAPQGVHHGAPEKARERARRKFDDYDRVDWSVIAIDTRRRLMP
MSMEG_2075|M.smegmatis_MC2_155      MPPGLISHAPQGVHHGAPEKARERARRKFDEFDSVDWKVIAVDTRRRLIP
TH_3986|M.thermoresistible__bu      IGNASVSLHPAAYTHGPTREAYLNS----VGATESKEMAFMVDTFNSLRL
MAB_0890c|M.abscessus_ATCC_199      IAQGSVSVHPGGHAHGPQRGAYEAS----IGMEFFDELAVMVDTFRPLEL
                                    :  . :*  * .  *.. . *   :          .  .. :** . *  

MMAR_1496|M.marinum_M               SPAVLAHDLGQH------------
MUL_2443|M.ulcerans_Agy99           SLAVLAHDLGQH------------
MAV_4022|M.avium_104                SAEVLAHDLGQH------------
Mflv_4463|M.gilvum_PYR-GCK          SPEILANDLGQH------------
Mvan_1897|M.vanbaalenii_PYR-1       SAEILANDLGQH------------
MSMEG_2075|M.smegmatis_MC2_155      SEEILANDLGQH------------
TH_3986|M.thermoresistible__bu      GEGALACDVDDYPWTWAGRRA---
MAB_0890c|M.abscessus_ATCC_199      GEAALACDDSTYAWSWAGRRLSRT
                                    .   ** * . :