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MSLLVLYPTSPGAPMESFVHLRKGRTPRRLHADLDGLKDDELGRGGFTGRTANLYRRHDPTAYRAVGPLR PVDVLADQLEPSDATDANGGPLLMFSNADCRILLSRRHQVMPFYNRHVDGDLLCFVHDGAGLLETEFGPL RYRTGDWVYIPKATTWRQLPDTETTLLMVEATDEFRVPAPGALGRHFPFDPSQGVIPEPAPVDNPPGLGA RDEYQVRLVHEGGPTTLFYQHNATDVEGWRGYNFAFTFNIADYNVITSDSVHLPPTVHLFMQATGVCVMN FLPKPAEGVPGTERTPWYHRNVDYDEIAFFHGGSLYGIPMPPGLISHAPQGVHHSAPERARERARRKFAE YSRVDWEVIAVDTRRRLTPSLAVLAHDLGQH
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_2443 | - | - | 100% (381) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_4463 | - | 1e-178 | 77.90% (371) | homogentisate 1,2-dioxygenase |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0890c | - | 4e-34 | 32.08% (371) | putative homogentisate 1,2-dioxygenase |
| M. marinum M | MMAR_1496 | - | 0.0 | 98.09% (367) | oxidoreductase |
| M. avium 104 | MAV_4022 | hmgA | 0.0 | 85.83% (367) | homogentisate 1,2-dioxygenase |
| M. smegmatis MC2 155 | MSMEG_2075 | hmgA | 0.0 | 81.47% (367) | homogentisate 1,2-dioxygenase |
| M. thermoresistible (build 8) | TH_0903 | hmgA | 1e-167 | 75.47% (375) | homogentisate 1,2-dioxygenase |
| M. vanbaalenii PYR-1 | Mvan_1897 | - | 0.0 | 79.56% (367) | homogentisate 1,2-dioxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_2443|M.ulcerans_Agy99 MSLLVLYPTSPGAPMESFVHLR---KGRTPRRLHADLDGLKDDELGRGGF
MMAR_1496|M.marinum_M --------------MESFVHLR---KGRTPRRLHADLDGLKDDELGRGGF
MAV_4022|M.avium_104 --------------MESFIHLR---KGRTPGRLHADLDGLKDDELGRGGF
Mflv_4463|M.gilvum_PYR-GCK --------------MESFVHLR---KGKTPKRIHADLDGLKDDELGRGGF
Mvan_1897|M.vanbaalenii_PYR-1 --------------MESFVHLR---KGKTPKRIHADLDGLKDDELGRGGF
MSMEG_2075|M.smegmatis_MC2_155 --------------MESFIHLR---KGRTPKRLHADLEGLKDDELGRGGF
TH_0903|M.thermoresistible__bu --------------MESFVHLR---KGRTPRRLHADLDGLKDDELGRGGF
MAB_0890c|M.abscessus_ATCC_199 --------------MAHYMQVGSIPPKRHTQHRNAAGNLYYEELVGEDGF
* :::: : . : :* : :: :*..**
MUL_2443|M.ulcerans_Agy99 TGRTANLYRRHDPTAYRAVG-------------PLRPVDVLADQLEPSD-
MMAR_1496|M.marinum_M TGRTANLYRRHDPTAYRAVG-------------PLRPVDVLADQLEPSD-
MAV_4022|M.avium_104 TGRTANMYRRHDPTAYRVQG-------------PLRPIDVLTSELKPSD-
Mflv_4463|M.gilvum_PYR-GCK VGRTANMYRRNDPTAYRTVG-------------PLRPTDVLSSELKPSD-
Mvan_1897|M.vanbaalenii_PYR-1 VGRTANMYRRNDPTAYRTVG-------------PLRPTDVLSSELKPSD-
MSMEG_2075|M.smegmatis_MC2_155 TGRTANMYRRNDPTAYRSVG-------------PLRPTDVLSSELKPSD-
TH_0903|M.thermoresistible__bu TGRTANFFRRHDPTDFRASG-------------PLRPMDVLSSELKPGD-
MAB_0890c|M.abscessus_ATCC_199 SSDSALLYHRHIPAAIVDATPWELLDHSTCANRPLIPRHLRLHSLFPRDA
. :* :::*: *: ** * .: .* * *
MUL_2443|M.ulcerans_Agy99 --ATDANGGPLLMFSNADCRILLSRRHQVMPFYNRHVDGDLLCFVHDGAG
MMAR_1496|M.marinum_M --ATDANGGPLLMFSNADCRILLSRRHQVMPFYNRHVDGDLLCFVHDGAG
MAV_4022|M.avium_104 --ATDATGGPLLMFANPDCRISLSRRSEPMPFYVRHVDGDLLCFVHGGAG
Mflv_4463|M.gilvum_PYR-GCK --ATDPRGGPLLMFSNADCQVLLSRRTEEMPFFVRYVDGDLLSFVHRGSG
Mvan_1897|M.vanbaalenii_PYR-1 --ATDANGGPLLMFSNADCLVLLSRRSEPMPFFVRYVDGDLLSFVHRGSG
MSMEG_2075|M.smegmatis_MC2_155 --ATDAHGGPLLMFSNPDCQVLLSRRSQEMPFFVRHVDGDLLSFVHKGSG
TH_0903|M.thermoresistible__bu --LTDPAGAPLLLFSNPDCRISLSRRSAEMPFHIRYVDGDLLIFVHAGSG
MAB_0890c|M.abscessus_ATCC_199 LAHTDVVTGRRLLLANADVRIYYVAAGAESPLYRNAIG-DEVVYVESGGG
** . *:::*.* : *:. . :. * : :*. *.*
MUL_2443|M.ulcerans_Agy99 LLETEFGPLRYRTGDWVYIPKATTWRQLP----DTETTLLMVEATDEFRV
MMAR_1496|M.marinum_M LLETEFGPLRYRTGDWVYIPKATTWRQLP----DTETTLLMVEATDEFRV
MAV_4022|M.avium_104 LLHTEFGPMPYRQGDWVYLPKATTWRQLP----DAETTLLMIEATDEFRV
Mflv_4463|M.gilvum_PYR-GCK SLETEFGPLTYRQGDWIYIPKACTWRQIPDPGPTGTTTLLMVQATEEFRV
Mvan_1897|M.vanbaalenii_PYR-1 SLETEFGPLDYRQGDWIYIPKACTWRQVP----SEETTLLMIQATDEFRV
MSMEG_2075|M.smegmatis_MC2_155 LLETEFGPLRYREGDWIYIPKACTWRQIP----DDESTLLMIQATDEFRV
TH_0903|M.thermoresistible__bu RMETEFGPLTYRPGDWVYLPKACTWRLIPDGTPSATSTLLMIEATDEFRV
MAB_0890c|M.abscessus_ATCC_199 LVETVFGWLRVRQGDYVVIPRATTHRWVPE---PGQPLRAYIIEANSHVA
:.* ** : * **:: :*:* * * :* . : ::.. .
MUL_2443|M.ulcerans_Agy99 PAPGALGRHFPFDPSQGVIPEPAPVDNPPGLGARDEYQVRLVHE----GG
MMAR_1496|M.marinum_M PAPGALGRHFPFDPSQAVIPEPAPVDNPPGLGARDEYQVRLVHE----GG
MAV_4022|M.avium_104 PPPGPLGRHFPFDPSQATIPEPQALDDDP---ARDEYEVRLVHE----GG
Mflv_4463|M.gilvum_PYR-GCK PPAGTLGRHFPFDPAQAVIPEPQPIDD----DGRDEYEVRLIHE----GG
Mvan_1897|M.vanbaalenii_PYR-1 PPAGTLGRHFPFDPAQVVIPEPQPIDD----DGRDEYEVRLIHE----GG
MSMEG_2075|M.smegmatis_MC2_155 PPPGTLGRHFPFDPSQAVIPDPQPIDDGTGPQTDGEYEVRLIHD----GG
TH_0903|M.thermoresistible__bu PEAGPLGRHFPFDPAQVSIPDPEPHED----DGRDSYEVRLMHRPIDGVD
MAB_0890c|M.abscessus_ATCC_199 PPKRYLSRFGQLLEHAPYCERDLHGPTDLISHDATDVDVFVKHRGSQGIT
* *.*. : . :* : *
MUL_2443|M.ulcerans_Agy99 PTTLFYQHNATDVEGWRGYNFAFTFNIADYNVITSDSVHLPPTVHLFMQA
MMAR_1496|M.marinum_M PTTLFYQHNPIDVEGWRGDNFAFTFNIADYNVITSDSVHLPPTVHLFMQA
MAV_4022|M.avium_104 PTTLLYQHNPLDVEGWRGDNFAFTFNIADYNVVTSDSVHLPPTVHLFMQA
Mflv_4463|M.gilvum_PYR-GCK PTSLFYKHHPLDVEGWRGDNFPFTFNIDDYTVITSDSVHLPPTVHLFMQA
Mvan_1897|M.vanbaalenii_PYR-1 PTSLFYQHHPLDVEGWRGDNFPFTFNIDDYTVVTSESVHLPPTVHLFMQA
MSMEG_2075|M.smegmatis_MC2_155 PTTLFYQHHPLDVEGWRGDNFAFTFNIEDYNVVTSDSVHLPPTVHLFMQA
TH_0903|M.thermoresistible__bu STTLRYPHHPLDVEGWRGDNFAFTFNIADYNVITSDTVHLPATAGLFMQA
MAB_0890c|M.abscessus_ATCC_199 GTRYVYAEHPFDVVGWDGCLYPYRFNISDFEPITGR-VHQPPPAHQVFEA
* * .:. ** ** * :.: *** *: :*. ** *... .::*
MUL_2443|M.ulcerans_Agy99 TGVCVMNFLPKPAEGVPGTERTPWYHRNVDYDEIAFFHGG---SLYGIPM
MMAR_1496|M.marinum_M TGVCVMNFLPKPAEGVPGTERTPWYHRNVDYDEIAFFHGG---SLYGIPM
MAV_4022|M.avium_104 TGVYVMNFLPKPAEGVPGTERTPWYHRNVDYDEIAFFHGG---SLYGIPM
Mflv_4463|M.gilvum_PYR-GCK TGVYIMNFLPKPAESVPGTERTPWYHRNVDFDEIAFFHDG---SLYGIPM
Mvan_1897|M.vanbaalenii_PYR-1 TGVYVMNFLPKPAESVPGTERTPWYHRNVDYDEIAFFHGG---SLYGIPM
MSMEG_2075|M.smegmatis_MC2_155 TGVYIMNFLPKPAEGVPGTERTPWYHHNVDYDEIAFFHGG---SLYGIPM
TH_0903|M.thermoresistible__bu TGVYVMNFLPKPAEGAPGTERTPWYHRNVDYDEIAFFHGG---SLYGIPM
MAB_0890c|M.abscessus_ATCC_199 NNFVICNFVPRKVDYHPLSVPVPYYHSNVDSDEVMFYVGGDYEARKGSGI
... : **:*: .: * : .*:** *** **: *: .* : * :
MUL_2443|M.ulcerans_Agy99 PPGLISHAPQGVHHSAPERARERARRKFAEYSRVDWEVIAVDTRRRLTPS
MMAR_1496|M.marinum_M PPGLISHAPQGVHHGAPERARERARRKFAEYSRVDWQVIAVDTRRRLTPS
MAV_4022|M.avium_104 PPGLISHAPQGVHHGAPEKARERARRKFDEYARVDWQVIAVDTRRRLTPS
Mflv_4463|M.gilvum_PYR-GCK PPGLVSHAPQGVHHGAPEKARERARRKFDDYDRVDWSVIAVDTRRRLIPS
Mvan_1897|M.vanbaalenii_PYR-1 PPGLVSHAPQGVHHGAPEKARERARRKFDDYDRVDWSVIAIDTRRRLMPS
MSMEG_2075|M.smegmatis_MC2_155 PPGLISHAPQGVHHGAPEKARERARRKFDEFDSVDWKVIAVDTRRRLIPS
TH_0903|M.thermoresistible__bu PPGLISHAPQGVHHGAPEKARERARRKFDEYDRVDWQVIAVDTRRRLVPS
MAB_0890c|M.abscessus_ATCC_199 AQGSVSVHPGGHAHGPQRGAYEAS----IGMEFFDELAVMVDTFRPLELG
. * :* * * *.. . * * : .* .: :** * * .
MUL_2443|M.ulcerans_Agy99 LAVLAHDLGQH------------
MMAR_1496|M.marinum_M PAVLAHDLGQH------------
MAV_4022|M.avium_104 AEVLAHDLGQH------------
Mflv_4463|M.gilvum_PYR-GCK PEILANDLGQH------------
Mvan_1897|M.vanbaalenii_PYR-1 AEILANDLGQH------------
MSMEG_2075|M.smegmatis_MC2_155 EEILANDLGQH------------
TH_0903|M.thermoresistible__bu AEVLANDLGQH------------
MAB_0890c|M.abscessus_ATCC_199 EAALACDDSTYAWSWAGRRLSRT
** * . :