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AHYMQVGSIPPKRHTQHRNAAGNLYYEELVGEDGFSSDSALLYHRHIPAAIVDATPWELLDHSTCANRPL IPRHLRLHSLFPRDALAHTDVVTGRRLLLANADVRIYYVAAGAESPLYRNAIGDEVVYVESGGGLVETVF GWLRVRQGDYVVIPRATTHRWVPEPGQPLRAYIIEANSHVAPPKRYLSRFGQLLEHAPYCERDLHGPTDL ISHDATDVDVFVKHRGSQGITGTRYVYAEHPFDVVGWDGCLYPYRFNISDFEPITGRVHQPPPAHQVFEA NNFVICNFVPRKVDYHPLSVPVPYYHSNVDSDEVMFYVGGDYEARKGSGIAQGSVSVHPGGHAHGPQRGA YEASIGMEFFDELAVMVDTFRPLELGEAALACDDSTYAWSWAGRRLSRT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0890c | - | - | 100% (400) | putative homogentisate 1,2-dioxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_4463 | - | 8e-35 | 31.06% (367) | homogentisate 1,2-dioxygenase |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_1496 | - | 9e-36 | 32.88% (371) | oxidoreductase |
| M. avium 104 | MAV_4022 | hmgA | 2e-36 | 32.07% (368) | homogentisate 1,2-dioxygenase |
| M. smegmatis MC2 155 | MSMEG_2075 | hmgA | 5e-36 | 31.17% (369) | homogentisate 1,2-dioxygenase |
| M. thermoresistible (build 8) | TH_3986 | - | 1e-123 | 54.11% (401) | PUTATIVE putative homogentisate 1,2-dioxygenase |
| M. ulcerans Agy99 | MUL_2443 | - | 3e-34 | 32.08% (371) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_1897 | - | 2e-33 | 30.68% (365) | homogentisate 1,2-dioxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1496|M.marinum_M --------------MESFVHLRKGRTPRRLHADLDGLKDDELGRGGFTGR
MUL_2443|M.ulcerans_Agy99 MSLLVLYPTSPGAPMESFVHLRKGRTPRRLHADLDGLKDDELGRGGFTGR
MAV_4022|M.avium_104 --------------MESFIHLRKGRTPGRLHADLDGLKDDELGRGGFTGR
Mflv_4463|M.gilvum_PYR-GCK --------------MESFVHLRKGKTPKRIHADLDGLKDDELGRGGFVGR
Mvan_1897|M.vanbaalenii_PYR-1 --------------MESFVHLRKGKTPKRIHADLDGLKDDELGRGGFVGR
MSMEG_2075|M.smegmatis_MC2_155 --------------MESFIHLRKGRTPKRLHADLEGLKDDELGRGGFTGR
MAB_0890c|M.abscessus_ATCC_199 -----------MAHYMQVGSIPPKRHTQHRNAAGNLYYEELVGEDGFSSD
TH_3986|M.thermoresistible__bu ------------MYYRAVGEFPKTRHTVFTTADGRPTFEEFIGEEGFSGT
. : : . * :: :*. ** .
MMAR_1496|M.marinum_M TANLYRRHDPTAYRAVG-------------PLRPVDVLADQLEPSDAT--
MUL_2443|M.ulcerans_Agy99 TANLYRRHDPTAYRAVG-------------PLRPVDVLADQLEPSDAT--
MAV_4022|M.avium_104 TANMYRRHDPTAYRVQG-------------PLRPIDVLTSELKPSDAT--
Mflv_4463|M.gilvum_PYR-GCK TANMYRRNDPTAYRTVG-------------PLRPTDVLSSELKPSDAT--
Mvan_1897|M.vanbaalenii_PYR-1 TANMYRRNDPTAYRTVG-------------PLRPTDVLSSELKPSDAT--
MSMEG_2075|M.smegmatis_MC2_155 TANMYRRNDPTAYRSVG-------------PLRPTDVLSSELKPSDAT--
MAB_0890c|M.abscessus_ATCC_199 SALLYHRHIPAAIVDATPWELLDHSTCANRPLIPRHLRLHSLFPRDALAH
TH_3986|M.thermoresistible__bu ASHLYHLGVPANLVDTRTWEIGDLSTRPNVPLRPRHFRLPDLFPAGAERG
:: :*: *: ** * .. .* * .*
MMAR_1496|M.marinum_M -DANGGPLLMFSNADCRILLSRRHQVMPFYNRHVDGDLLCFVHDGAGLLE
MUL_2443|M.ulcerans_Agy99 -DANGGPLLMFSNADCRILLSRRHQVMPFYNRHVDGDLLCFVHDGAGLLE
MAV_4022|M.avium_104 -DATGGPLLMFANPDCRISLSRRSEPMPFYVRHVDGDLLCFVHGGAGLLH
Mflv_4463|M.gilvum_PYR-GCK -DPRGGPLLMFSNADCQVLLSRRTEEMPFFVRYVDGDLLSFVHRGSGSLE
Mvan_1897|M.vanbaalenii_PYR-1 -DANGGPLLMFSNADCLVLLSRRSEPMPFFVRYVDGDLLSFVHRGSGSLE
MSMEG_2075|M.smegmatis_MC2_155 -DAHGGPLLMFSNPDCQVLLSRRSQEMPFFVRHVDGDLLSFVHKGSGLLE
MAB_0890c|M.abscessus_ATCC_199 TDVVTGRRLLLANADVRIYYVAAGAESPLYRNAIG-DEVVYVESGGGLVE
TH_3986|M.thermoresistible__bu KDVVRHRRLILANDDVRISYVVADTPSPLYSNGLG-DEVVYIESGEADVE
* *:::* * : *:: . :. * : ::. * . :.
MMAR_1496|M.marinum_M TEFGPLRYRTGDWVYIPKATTWRQLP-----DTETTLLMVEATDEFRVPA
MUL_2443|M.ulcerans_Agy99 TEFGPLRYRTGDWVYIPKATTWRQLP-----DTETTLLMVEATDEFRVPA
MAV_4022|M.avium_104 TEFGPMPYRQGDWVYLPKATTWRQLP-----DAETTLLMIEATDEFRVPP
Mflv_4463|M.gilvum_PYR-GCK TEFGPLTYRQGDWIYIPKACTWRQIPDP-GPTGTTTLLMVQATEEFRVPP
Mvan_1897|M.vanbaalenii_PYR-1 TEFGPLDYRQGDWIYIPKACTWRQVP-----SEETTLLMIQATDEFRVPP
MSMEG_2075|M.smegmatis_MC2_155 TEFGPLRYREGDWIYIPKACTWRQIP-----DDESTLLMIQATDEFRVPP
MAB_0890c|M.abscessus_ATCC_199 TVFGWLRVRQGDYVVIPRATTHRWVPE---PGQPLRAYIIEANSHVAPPK
TH_3986|M.thermoresistible__bu SVFGTLSVGQGDNVVIPRVAIHRWIPKNVDTAGPLKAYCVEGNGHIEIPA
: ** : ** : :*:. * :* ::.. .. *
MMAR_1496|M.marinum_M --PGALGRHFPFDP-SQAVIPEPAPVDNPPGLGARDEYQVRLVHEGGP--
MUL_2443|M.ulcerans_Agy99 --PGALGRHFPFDP-SQGVIPEPAPVDNPPGLGARDEYQVRLVHEGGP--
MAV_4022|M.avium_104 --PGPLGRHFPFDP-SQATIPEPQALDDDP---ARDEYEVRLVHEGGP--
Mflv_4463|M.gilvum_PYR-GCK --AGTLGRHFPFDP-AQAVIPEPQPIDD----DGRDEYEVRLIHEGGP--
Mvan_1897|M.vanbaalenii_PYR-1 --AGTLGRHFPFDP-AQVVIPEPQPIDD----DGRDEYEVRLIHEGGP--
MSMEG_2075|M.smegmatis_MC2_155 --PGTLGRHFPFDP-SQAVIPDPQPIDDGTGPQTDGEYEVRLIHDGGP--
MAB_0890c|M.abscessus_ATCC_199 RYLSRFGQLLEHAPYCERDLHGPTD--LISHDATDVD--VFVKHRGSQGI
TH_3986|M.thermoresistible__bu KYLTRFGQFIEGAPLTERDIRGPVGPLLAAADEADQDTEVYVKHGHGSEV
:*: : * : : * : * : * .
MMAR_1496|M.marinum_M --TTLFYQHNPIDVEGWRGDNFAFTFNIADYNVITSDSVHLPPTVHLFMQ
MUL_2443|M.ulcerans_Agy99 --TTLFYQHNATDVEGWRGYNFAFTFNIADYNVITSDSVHLPPTVHLFMQ
MAV_4022|M.avium_104 --TTLLYQHNPLDVEGWRGDNFAFTFNIADYNVVTSDSVHLPPTVHLFMQ
Mflv_4463|M.gilvum_PYR-GCK --TSLFYKHHPLDVEGWRGDNFPFTFNIDDYTVITSDSVHLPPTVHLFMQ
Mvan_1897|M.vanbaalenii_PYR-1 --TSLFYQHHPLDVEGWRGDNFPFTFNIDDYTVVTSESVHLPPTVHLFMQ
MSMEG_2075|M.smegmatis_MC2_155 --TTLFYQHHPLDVEGWRGDNFAFTFNIEDYNVVTSDSVHLPPTVHLFMQ
MAB_0890c|M.abscessus_ATCC_199 TGTRYVYAEHPFDVVGWDGCLYPYRFNISDFEPITGR-VHQPPPAHQVFE
TH_3986|M.thermoresistible__bu HGSIVVYDHHPFDVVGWDGYLYPYAFNYRDFSPVTGK-IIQPPPTYQILE
: .* .:. ** ** * :.: ** *: :*. : **..: .::
MMAR_1496|M.marinum_M ATGVCVMNFLPKPAEGVPGTERTPWYHRNVDYDEIAFFHGG---SLYGIP
MUL_2443|M.ulcerans_Agy99 ATGVCVMNFLPKPAEGVPGTERTPWYHRNVDYDEIAFFHGG---SLYGIP
MAV_4022|M.avium_104 ATGVYVMNFLPKPAEGVPGTERTPWYHRNVDYDEIAFFHGG---SLYGIP
Mflv_4463|M.gilvum_PYR-GCK ATGVYIMNFLPKPAESVPGTERTPWYHRNVDFDEIAFFHDG---SLYGIP
Mvan_1897|M.vanbaalenii_PYR-1 ATGVYVMNFLPKPAESVPGTERTPWYHRNVDYDEIAFFHGG---SLYGIP
MSMEG_2075|M.smegmatis_MC2_155 ATGVYIMNFLPKPAEGVPGTERTPWYHHNVDYDEIAFFHGG---SLYGIP
MAB_0890c|M.abscessus_ATCC_199 ANNFVICNFVPRKVDYHPLSVPVPYYHSNVDSDEVMFYVGGDYEARKGSG
TH_3986|M.thermoresistible__bu GPNFVVCNFVPRMLEYGEGAITVPYYHSNVDADEVMFYYAGETAARKGTG
. .. : **:*: : : .*:** *** **: *: * : *
MMAR_1496|M.marinum_M MPPGLISHAPQGVHHGAPERARERARRKFAEYSRVDWQVIAVDTRRRLTP
MUL_2443|M.ulcerans_Agy99 MPPGLISHAPQGVHHSAPERARERARRKFAEYSRVDWEVIAVDTRRRLTP
MAV_4022|M.avium_104 MPPGLISHAPQGVHHGAPEKARERARRKFDEYARVDWQVIAVDTRRRLTP
Mflv_4463|M.gilvum_PYR-GCK MPPGLVSHAPQGVHHGAPEKARERARRKFDDYDRVDWSVIAVDTRRRLIP
Mvan_1897|M.vanbaalenii_PYR-1 MPPGLVSHAPQGVHHGAPEKARERARRKFDDYDRVDWSVIAIDTRRRLMP
MSMEG_2075|M.smegmatis_MC2_155 MPPGLISHAPQGVHHGAPEKARERARRKFDEFDSVDWKVIAVDTRRRLIP
MAB_0890c|M.abscessus_ATCC_199 IAQGSVSVHPGGHAHGPQRGAYEAS----IGMEFFDELAVMVDTFRPLEL
TH_3986|M.thermoresistible__bu IGNASVSLHPAAYTHGPTREAYLNS----VGATESKEMAFMVDTFNSLRL
: . :* * . *.. . * : . .. :** . *
MMAR_1496|M.marinum_M SPAVLAHDLGQH------------
MUL_2443|M.ulcerans_Agy99 SLAVLAHDLGQH------------
MAV_4022|M.avium_104 SAEVLAHDLGQH------------
Mflv_4463|M.gilvum_PYR-GCK SPEILANDLGQH------------
Mvan_1897|M.vanbaalenii_PYR-1 SAEILANDLGQH------------
MSMEG_2075|M.smegmatis_MC2_155 SEEILANDLGQH------------
MAB_0890c|M.abscessus_ATCC_199 GEAALACDDSTYAWSWAGRRLSRT
TH_3986|M.thermoresistible__bu GEGALACDVDDYPWTWAGRRA---
. ** * . :