For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
aa seq not available
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. thermoresistible (build 8) | TH_3146 | - | - | 100% (1139) | amino acid adenylation domain |
| M. thermoresistible (build 8) | TH_3730 | - | 4e-90 | 29.82% (1110) | PUTATIVE linear gramicidin synthetase subunit D |
| M. thermoresistible (build 8) | TH_3141 | - | 3e-85 | 28.97% (1032) | PUTATIVE amino acid adenylation domain |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2404c | mbtB | 0.0 | 60.58% (1144) | phenyloxazoline synthase MBTB (phenyloxazoline synthetase) |
| M. gilvum PYR-GCK | Mflv_2692 | - | 0.0 | 65.70% (1137) | amino acid adenylation domain-containing protein |
| M. tuberculosis H37Rv | Rv2383c | mbtB | 0.0 | 60.66% (1144) | phenyloxazoline synthase MBTB (phenyloxazoline synthetase) |
| M. leprae Br4923 | MLBr_00134 | fadD22 | 6e-23 | 24.80% (504) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_2124 | - | 0.0 | 49.13% (1144) | putative phenyloxazoline synthase MbtB |
| M. marinum M | MMAR_3689 | mbtB | 0.0 | 49.44% (1155) | phenyloxazoline synthase MbtB |
| M. avium 104 | MAV_2009 | - | 0.0 | 62.79% (1134) | MbtB protein |
| M. smegmatis MC2 155 | MSMEG_4515 | - | 0.0 | 59.95% (1141) | putative non-ribosomal peptide synthetase |
| M. ulcerans Agy99 | MUL_3632 | mbtB | 0.0 | 49.31% (1154) | phenyloxazoline synthase MbtB |
| M. vanbaalenii PYR-1 | Mvan_3849 | - | 0.0 | 68.29% (1132) | amino acid adenylation domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2692|M.gilvum_PYR-GCK -----MASTTAPSVRDEVAELLGIDPGGLDPEADLIASGLDSIRMMSLSG
Mvan_3849|M.vanbaalenii_PYR-1 ---MGLASTTAMSVRDEVAELLGVSPAELDPQADLIASGLDSIRMMTLSG
TH_3146|M.thermoresistible__bu --------------------------------------------MMTLSG
Mb2404c|M.bovis_AF2122/97 ---MVHATACSEIIRAEVAELLGVRADALHPGANLVGQGLDSIRMMSLVG
Rv2383c|M.tuberculosis_H37Rv ---MVHATACSEIIRAEVAELLGVRADALHPGANLVGQGLDSIRMMSLVG
MAV_2009|M.avium_104 ----MHAPARSEDIREEVAELLGVDVDAVQPGSNLIGQGLDSIRIMTLAG
MSMEG_4515|M.smegmatis_MC2_155 --MGDVAGANSQTIRAAVADLLGIGSEAVDPDADLIGQGLDSIRMMSLAG
MMAR_3689|M.marinum_M MEPLSTEWISRDEIRAAIAAQLDCPAADVADDDDLIQLGLNSIRMMSMAG
MUL_3632|M.ulcerans_Agy99 MEPLRTEWISRDEIRAAIAAQLDCPAADVADDDDLIQLGLNSIRMMSMAG
MAB_2124|M.abscessus_ATCC_1997 -----MEAISRDEIKLTVADLIGLTAQDISDGDDLITLGLDSIRMMTLAG
MLBr_00134|M.leprae_Br4923 -----MRSENLAALLARQAAEAGWYDKPAYFAPDVVTHGQIHDGAVRLGE
: :
Mflv_2692|M.gilvum_PYR-GCK RWRRQGIDVGFAALAANPTVAAWTELVADRS-APPIVDETAAPNVHGD--
Mvan_3849|M.vanbaalenii_PYR-1 RWRRQGVDVGFAALAANPTVAAWTELVSGRD-APPAADP-APDATTGP--
TH_3146|M.thermoresistible__bu RWRRQGIDVGFAALAAEPTVAAWTRLVAEHTGAPGSGEPTAGDPGAGDPD
Mb2404c|M.bovis_AF2122/97 RWRRKGIAVDFATLAATPTIEAWSQLVSAG---TGVAPTAVAAPGDAG--
Rv2383c|M.tuberculosis_H37Rv RWRRKGIAVDFATLAATPTIEAWSQLVSAG---TGVAPTAVAAPGDAG--
MAV_2009|M.avium_104 RWRRRGIAVDFATLAETPTIEAWAQLVTAGRQDTDSAAPPADSPGDP---
MSMEG_4515|M.smegmatis_MC2_155 RWRQQGIDIDFATLAANPTVSDWARLIAARSADSKASSAHANSRPSEA--
MMAR_3689|M.marinum_M RWRKRGADITFAQLAATATVQSWHELLNAD-QLGCAVTAPADRPESLL--
MUL_3632|M.ulcerans_Agy99 RWRKRGADITFAQLAATATVQSWHELLNAD-QLGCAVTAPADRPELLL--
MAB_2124|M.abscessus_ATCC_1997 GWRKRGSRVTFAQLAAEPSVDSWYALLRADDEVAPDEEAAADETD-----
MLBr_00134|M.leprae_Br4923 VLRNRGLSAGDRVLLCLPDSPDLVQLLLAC--------------------
*.:* * . *:
Mflv_2692|M.gilvum_PYR-GCK ----------DVSDTFPLAPIQHAMWVGRNDDQQLGGVGAHLYVEFDGAG
Mvan_3849|M.vanbaalenii_PYR-1 ----------GEGDTFPLAPIQHAMWIGRNEDQQLGGVAAHLYVEFDGAG
TH_3146|M.thermoresistible__bu RENAGQASADDPNAPFPLAPIQHALWVGRDELTELGGVAAHLYVEFDGVG
Mb2404c|M.bovis_AF2122/97 --------LSQEGEPFPLAPMQHAMWVGRHDHQQLGGVAGHLYVEFDGAR
Rv2383c|M.tuberculosis_H37Rv --------LSQEGEPFPLAPMQHAMWVGRHDHQQLGGVAGHLYVEFDGAR
MAV_2009|M.avium_104 ---------SGENEPFALAPMQHAMWVGRQDNQQLGGVAGHLYVEFDAGL
MSMEG_4515|M.smegmatis_MC2_155 --------GEQAGAPFPLAPMQHAMWVGREDDQQLGGVAGHLYVEFDGTG
MMAR_3689|M.marinum_M -------EPEAPQAPFPLATMQHAYWIGRSDEQELGGVAAHLYVEFDGTG
MUL_3632|M.ulcerans_Agy99 -------EPEAPQAPFPLATMQHAYWIGRADEQELGGVAAHLYVEFDGTG
MAB_2124|M.abscessus_ATCC_1997 -------GQDGEDAPFPLATMQHAYWIGRSEDQELGGVAAHLYVEFDGGA
MLBr_00134|M.leprae_Br4923 -----------------LARGIMAFLANPELHR-----DDYAFPERD---
** * . : : * *
Mflv_2692|M.gilvum_PYR-GCK VDPVRLREAAGRLAQRHPMLRVEILPDGMQRIS----DRGLPVTVYDLRD
Mvan_3849|M.vanbaalenii_PYR-1 VDPDRLRDAAAKLAARHPMLRVEILPDGTQRIG----DRGLPVTVYDLRD
TH_3146|M.thermoresistible__bu VDPERLGAAAAKLARRHPMLRVEILGDGTQRIS----DRTLPVKVTDLRH
Mb2404c|M.bovis_AF2122/97 VDPDRLRAAATRLALRHPMLRVQFLPDGTQRIPPAAGSRDFPISVADLRH
Rv2383c|M.tuberculosis_H37Rv VDPDRLRAAATRLALRHPMLRVQFLPDGTQRIPPAAGSRDFPISVADLRH
MAV_2009|M.avium_104 LDPGRLRAAATALARRHPMLRVRFLPDGTQRITPAVECGDFPVHVEDLRE
MSMEG_4515|M.smegmatis_MC2_155 VDPERLRRAATALAERHPMLRVEFLPDGTQRIGAPAN--EFPVTVEDLRT
MMAR_3689|M.marinum_M IDPERLERAVSDLVAVHPMLRTRFLADGTQQTMPS--PGRPVFALVDLRG
MUL_3632|M.ulcerans_Agy99 IDPERLERAVSDLVAVHPMLRTRFLADGTQQTMPS--PGRPVFALVDLRG
MAB_2124|M.abscessus_ATCC_1997 IDPDRLKAAVERLVAAHPMLRTKFLPDGTQQTMAA--PGRDVFTVVDLRG
MLBr_00134|M.leprae_Br4923 --------TAAALVITNGSLRDRFQSS-----------------------
:. *. : ** .: .
Mflv_2692|M.gilvum_PYR-GCK LDAATAEHRLDEIRHEKSHQML---HGEVLQLSLSLLADGRTRVHVDMDM
Mvan_3849|M.vanbaalenii_PYR-1 LDLLAAAERLEGIRDEKSHQMM---HGEVLQISLSLLADGRTRLHVDMDM
TH_3146|M.thermoresistible__bu LDEAAAEQQLEEIRQAKSHQML---HGEVLELALTLLPGGRTRLHVDLDM
Mb2404c|M.bovis_AF2122/97 VAPDVVDQRLAGIRDAKSHQQL---DGAVFELALTLLPGERTRLHVDLDM
Rv2383c|M.tuberculosis_H37Rv VAPDVVDQRLAGIRDAKSHQQL---DGAVFELALTLLPGERTRLHVDLDM
MAV_2009|M.avium_104 LGTDEVERRLTALREAKSHQQL---DGAVFELTVTLLPGGRSRLHVDLDM
MSMEG_4515|M.smegmatis_MC2_155 ATPDEVARRLSEIQRAKSHQQL---QGEVFELTLSLLPSGATRLHVDLDM
MMAR_3689|M.marinum_M QSPDEVESALLQMRERNGHQRLAIEDGQVIDFTLTLWDGDRSRLHLDVDM
MUL_3632|M.ulcerans_Agy99 QSADEVESALLQMRERNGHQRLAIEDGQVIDFTLTLWDGDRSRLHLDVDM
MAB_2124|M.abscessus_ATCC_1997 RAAGEVDAALAELREHKTHQRLAIEDGQVLDVTLTLRDDNNSRLHLDVDM
MLBr_00134|M.leprae_Br4923 ----------------------------NVVEPAELLSDATRVEPSDYEP
. . * . * :
Mflv_2692|M.gilvum_PYR-GCK QASDAVSYRNFMADLAEFYS-GADLPELGYTYREYRAELAATT----AES
Mvan_3849|M.vanbaalenii_PYR-1 QAADAVSYRNFMADLADFYS-GVTLPELGYTYREYRAALTSTT----VES
TH_3146|M.thermoresistible__bu QAADAVSYRNFMADLARFYK-GVELPELGYTYREYRAALTATEP---ADA
Mb2404c|M.bovis_AF2122/97 QAADAMSYRILLADLAALYD-GREPPALGYTYQEYRQAIEAEETLPQPVR
Rv2383c|M.tuberculosis_H37Rv QAADAMSYRILLADLAALYD-GREPPALGYTYREYRQAIEAEETLPQPVR
MAV_2009|M.avium_104 QAADAMSYRTLMADLAALYR-GCDLPELSYTYRQYRHAVEAQDAQPQPRR
MSMEG_4515|M.smegmatis_MC2_155 QAGDAMSYRTLMADLAALYNSGTSLPALGYTYREYR--LETPEG--GPAH
MMAR_3689|M.marinum_M LAGDAMSYRVLVSDLAQLYR-GATLQSPGFSYRRYRTEYEPDR----AAR
MUL_3632|M.ulcerans_Agy99 LAGDAMSYRVLVSDLAQLYR-GATLQSPGFSYRRYRTEYEPDR----AAR
MAB_2124|M.abscessus_ATCC_1997 LAGDAMSYRVLISDLAALYH-GGAQPELGYSYRRYRTEDRGDA----AAH
MLBr_00134|M.leprae_Br4923 VSGDAYAFATYTSGTTGKPK------------------------------
:.** :: :. :
Mflv_2692|M.gilvum_PYR-GCK DEDRRWWAERIPELPEGPTLPLVPRAEQQDPKRSRRRWHILDVAARDALF
Mvan_3849|M.vanbaalenii_PYR-1 DEDRRWWAERVPGLPEGPALPLVPRSEQADPKRARRRWHIFDVATRDALF
TH_3146|M.thermoresistible__bu EADRRWWTDRLPHLPEAPALPLVPRPEQRDPRRGTRRWRYLDGEMRDRLF
Mb2404c|M.bovis_AF2122/97 DADRDWWAQRIPQLPDPPALP-TRAGGERDRRRSTRRWHWLDPQTRDALF
Rv2383c|M.tuberculosis_H37Rv DADRDWWAQRIPQLPDPPALP-TRAGGERDRRRSTRRWHWLDPQTRDALF
MAV_2009|M.avium_104 DADRDWWARRLPELPDPPALP-ITAG--RGANRSTRRWHWLDPQTRDALF
MSMEG_4515|M.smegmatis_MC2_155 DADQKWWAERIPDLPDPPRLPLIPVAEQADPHHTTRRHHWLDPQTRDALF
MMAR_3689|M.marinum_M ERDRQWWQRRLPEMAGAPQLPTVAVREPGAPHRTERYEHWLAPEAKQQLM
MUL_3632|M.ulcerans_Agy99 ERDRQWWQRRLPEMAGAPQLPTVAVREPGAPHRTERYEHWLAPEAKQQLM
MAB_2124|M.abscessus_ATCC_1997 ERDRQWWQDRLADLPGAPELPVVPVSERTDQHRTVRYNYWLEPEAKQQLL
MLBr_00134|M.leprae_Br4923 ----------------------------AAIHRHADPFTFVDAMCRKALR
.: . :. *
Mflv_2692|M.gilvum_PYR-GCK AAAQRRGITPAMAVAASYAGTLARWSTQRRFLLNLPMFGREQFHPDVDKL
Mvan_3849|M.vanbaalenii_PYR-1 AAAHRRGITPAMAVAASYAGTLARWSTNRRFLLNLPMFGREQFHPDVDKL
TH_3146|M.thermoresistible__bu AAARNRGITPAMAFAASYAGTLARWSTNRHFLLNLPMFGREPFHPDVDKL
Mb2404c|M.bovis_AF2122/97 ARARARGITPAMTLAAAFANVLARWSASSRFLLNLPLFSRQALHPDVDLL
Rv2383c|M.tuberculosis_H37Rv ARARARGITPAMTLAAAFANVLARWSASSRFLLNLPLFSRQALHPDVDLL
MAV_2009|M.avium_104 ARAQARGITPAMALAAGFANTLARWSSNSRFLLNVPLFGRQPLHPDVDAL
MSMEG_4515|M.smegmatis_MC2_155 AAARKRGITPAMALAASFAEVLAGWSADQRFLLNVPLFGREQRHPDVDKI
MMAR_3689|M.marinum_M AGAHARGVTPAMALAAVFADTIGGWSEQGKFLLNVPLFQRESVHPDIDRV
MUL_3632|M.ulcerans_Agy99 AGAHARGVTPAMALAAVFADTIGGWSEQGKFLLNVPLFQRESVHPDIDRV
MAB_2124|M.abscessus_ATCC_1997 VAAHQRGITPAMAMAAVFAETIGGWSAQSRFLLNVPLFHRESVHPDIDRV
MLBr_00134|M.leprae_Br4923 LTPQDIGLCSARMYFAYGLGNSVWFP------------------------
.: *: .* * :.
Mflv_2692|M.gilvum_PYR-GCK VGDFTSSLMLDVDLTGADTPLARCRVLQETLHATARHAGYSGLSVLRDLT
Mvan_3849|M.vanbaalenii_PYR-1 VGDFTSSLMLDVDLSGADTPMARCRVLQETLHTTAQHSSYSGLSVLRDLT
TH_3146|M.thermoresistible__bu VGDFSSSLMLDVDFTAAHTPAERARVMQAALHTSAAHATYSGLSVLRDLS
Mb2404c|M.bovis_AF2122/97 VGDFTSSLLLDVDLTGARTAAARAQAVQEALRSAAGHSAYPGLSVLRDLS
Rv2383c|M.tuberculosis_H37Rv VGDFTSSLLLDVDLTGARTAAARAQAVQEALRSAAGHSAYPGLSVLRDLS
MAV_2009|M.avium_104 VGDFTSSLLLDVDLVGAHTAAARAQVVQDAMRTAAAHSAYSGLSVLRDLS
MSMEG_4515|M.smegmatis_MC2_155 IGDFTSSLLLDIDLTDTTTPTQRAKVVQDTFRAAAGHANYPGLSVLRDLG
MMAR_3689|M.marinum_M VGDFTSSIMLEVDVTEDVSVAQRARDIQRRMYESGSHAAYSGLEVLRDLG
MUL_3632|M.ulcerans_Agy99 VGDFTSSIMLEVDVTEDVSVAQRARDIQRRMYESGSHAAYSGLEVLRDLG
MAB_2124|M.abscessus_ATCC_1997 IGDFTSSIMLDVDLTEDMSVADRARALQRTMYESGAHSAYPGLNVLRDLG
MLBr_00134|M.leprae_Br4923 LATGGSAVISSVPVSAESAAMLSTRFEPSVLYGVPSFFARVVGACSPDSF
:. *::: .: . : : : . *
Mflv_2692|M.gilvum_PYR-GCK RHHGTPVLAPIVYTSAIGLGDLFAGKVTEHFGRPVWTISQGPQVLLDAQA
Mvan_3849|M.vanbaalenii_PYR-1 RHHGTPTLAPVVYTSALGLGDLFAGKVTEHFGRPVWTISQGPQVLLDAQA
TH_3146|M.thermoresistible__bu RLHGKPQLAPFVFTSALGLGDLFAGDVTEQFGTPVWHISQGPQVLVDAQV
Mb2404c|M.bovis_AF2122/97 RHRGTQVLAPVVFTSALGLGDLFCPDVTEQFGTPGWIISQGPQVLLDAQV
Rv2383c|M.tuberculosis_H37Rv RHRGTQVLAPVVFTSALGLGDLFCPDVTEQFGTPGWIISQGPQVLLDAQV
MAV_2009|M.avium_104 RHRGTQVLAPVVFTSALGLGELFSPEVTDQFGTPAWIISQGPQVLLDAQV
MSMEG_4515|M.smegmatis_MC2_155 RHRGTQVIAPVVYTSALGLGELFATEVTDAFGKPVWINSQGPQVLLDAQV
MMAR_3689|M.marinum_M RCRGEPVLAPVVFTSALDLGELFADEVIETFGDPVWIISQGPQVLLDAQV
MUL_3632|M.ulcerans_Agy99 RYRGEPMLAPVVFTSALDLGELFADEVIETFGDPVWIISQGPQVLLDAQV
MAB_2124|M.abscessus_ATCC_1997 RHRGEPVLAPIVYTSALNLGELFAEPVMQTFGEPVWIISQGPQVLLDAQV
MLBr_00134|M.leprae_Br4923 RS------LRCVVTAGEALEPALAERLVEFFGG-----------------
* * *:. * :. : : **
Mflv_2692|M.gilvum_PYR-GCK TPVAEGLMINWDTREDAFRPGVADAMFAHHIAELERLATDESAWDTIDPT
Mvan_3849|M.vanbaalenii_PYR-1 TPVAEGLMINWDTREDAFRPGVADAMFAYHLAELERLATDESAWDAADPS
TH_3146|M.thermoresistible__bu TPFDGGLLVNWDVREDAFRPGVVDAMFAYQLAELERLAADDAAWDAPDPP
Mb2404c|M.bovis_AF2122/97 TEFDGGVLVNWDVREGVFAPGVIDAMFTHQVDELLRLAAGDDAWDAPSPS
Rv2383c|M.tuberculosis_H37Rv TEFDGGVLVNWDVREGVFAPGVIDAMFTHQVDELLRLAAGDDAWDAPSPS
MAV_2009|M.avium_104 TEFDGGVLVNWDVREGFFPPGVIDAMFAYHIDELLRLASADDAWDAPGPA
MSMEG_4515|M.smegmatis_MC2_155 TEFDGGVLVNWDVREDAFRPGVIDAMFARHIAELRRLATDDTAWDIPSPP
MMAR_3689|M.marinum_M TELRGGLLVNWDARESAFPPGLIDTMFNRFTDAVKRLADGDAGWDASAPV
MUL_3632|M.ulcerans_Agy99 TELRGGLLVNWDARESAFPPGLIDTMFNRFTDAVKRLADGDAGWDASAPV
MAB_2124|M.abscessus_ATCC_1997 TEVRGGLLLNWDVRESAFPHGMVAAMFERYTDAVAALCTGADGWNSDAAV
MLBr_00134|M.leprae_Br4923 -------------------IPILDGIGSSEVGQTFVSNSVDDWRVGTLGK
: :
Mflv_2692|M.gilvum_PYR-GCK AVPADQQAARDAVNTVADAASGDTLHDGFFRRAQARPDAPAVWSHDGA--
Mvan_3849|M.vanbaalenii_PYR-1 AVTAQQQAARDVVNAVTRTPSGDVLHAGFFRNAEAYPDAPAVWCRDGD--
TH_3146|M.thermoresistible__bu AVPAEQLAVRAGLNSVTAGPSGEALHDGFFRRAQAAPDAVAVISSAGQ--
Mb2404c|M.bovis_AF2122/97 ALPAAQRAVRAALNGRTAAPSTEALHDGFFRQAQQQPDAPAVFASSGD--
Rv2383c|M.tuberculosis_H37Rv ALPAAQRAVRAALNGRTAAPSTEALHDGFFRQAQQQPDAPAVFASSGD--
MAV_2009|M.avium_104 ALPEAQRAVREAINGRTAPPSGEALHDGFFRQAERQPDAPAVFAGSGD--
MSMEG_4515|M.smegmatis_MC2_155 LLPQSQRDVRDAVNARSAAPSGRALHDGFFEQAAMRPGAVALIGSNGP--
MMAR_3689|M.marinum_M QLPAAQAATRAATNATDGPASEKCLHQGFFEHAAANPDAPAVVWDVGDDG
MUL_3632|M.ulcerans_Agy99 QLPAAQAATRAATNATDGPASEKCLHQGFFEHGAANPDAPAVVWDVGDDG
MAB_2124|M.abscessus_ATCC_1997 RLPASQERVRRAVNATAGPVTGRRLHEGFFDFAQSNPGMPAVVWGFGDED
MLBr_00134|M.leprae_Br4923 VLPPYEIRVVAPDGATAGSGIEGNLWVRGPSIAQSYWNRPDSLLENGD--
:. : . . * . . *
Mflv_2692|M.gilvum_PYR-GCK --LTYGELRATVLDVAAALQVAGIRHGDAVAVMGPKNHEQVIALLAISAL
Mvan_3849|M.vanbaalenii_PYR-1 --LTYGELREQVLAVAAALHVAGVRRADTVAVMGPKNFEQIVALLAISAI
TH_3146|M.thermoresistible__bu --LTYAQLREQVLAVAGALRVAGIKPGDTVSVVGPKGVDQVIALLGIHAA
Mb2404c|M.bovis_AF2122/97 --LSYAQLRDQASAVAAALRAAGLRVGDTVAVLGPKTGEQVAAVLGILAA
Rv2383c|M.tuberculosis_H37Rv --LSYAQLRDQASAVAAALRAAGLRVGDTVAVLGPKTGEQVAAVLGILAA
MAV_2009|M.avium_104 --LSYAQLRDQALAVAAALCAAGAGAGDTVAVVGPKSAEQIPAVLGILSV
MSMEG_4515|M.smegmatis_MC2_155 --LTYAELREQALAVATALRVAGVRRGESVAVMGPKGPDQIPALLGILAA
MMAR_3689|M.marinum_M GVWSYRELRRQSLAVAATLHECGVRPGDAVAVQLPKGRAQIPAVLGVLAA
MUL_3632|M.ulcerans_Agy99 GVWSYRELRRQSLAVAATLHECGVRPGDAVAVQLPKGRAQIPAVLGVLAA
MAB_2124|M.abscessus_ATCC_1997 GVWSYRDVAAQALAVAGALRERGVRPGDCVAVQLPKGRDQIPAVLGVLAA
MLBr_00134|M.leprae_Br4923 ----WLNTRDRVRIDGDGWVTYGCRADDTEIVGGVN--------------
: : . * : * :
Mflv_2692|M.gilvum_PYR-GCK GAVYVPVGVEHPAERATRMLANGRVRMALVCGD-EPVTTMCSLTVQEAIR
Mvan_3849|M.vanbaalenii_PYR-1 GAAYVPVGVDHPAERAARMLANGAVRMALVCGD-RPPTTLPALTVAEALR
TH_3146|M.thermoresistible__bu GAAYVPVGADQPADRAAGILRNARARMALVCAGGDLPADLPALTVAEALR
Mb2404c|M.bovis_AF2122/97 GGVYLPIGVDQPRDRAERILATGSVNLALVCGPPCQVR-VPVPTLLLADV
Rv2383c|M.tuberculosis_H37Rv GGVYLPIGVDQPRDRAERILATGSVNLALVCGPPCQVR-VPVPTLLLADV
MAV_2009|M.avium_104 GAAYLPIGADQPRDRAERILQSGRVRLALVCGG-RQLS-LPVPGLVLADV
MSMEG_4515|M.smegmatis_MC2_155 GAVYVPVGVDQPTDRAERMLADAGVRMALFCGDGTPTW-LPALTVTEAVL
MMAR_3689|M.marinum_M GGTYVPIGFDQPEARRAKILQTADVVAALTVEGARMGDAIPCVSIDTARD
MUL_3632|M.ulcerans_Agy99 GGTYVPIGFDQPEARRAKILQTANVVAALTVEGARMGDAIPCVSIDTARD
MAB_2124|M.abscessus_ATCC_1997 GATYVPIGFDQPAQRRAAILETGGISVALTTADSDM--PIDHLSIDAARQ
MLBr_00134|M.leprae_Br4923 ---------INPREVERLIIEADAVAEAAVVGVREFTG------------
:* :: *
Mflv_2692|M.gilvum_PYR-GCK VGRRA--TGFTLPAVEPTDLAYILFTSGSTGEPKGVEMTHAASMNTVEFI
Mvan_3849|M.vanbaalenii_PYR-1 VGRRE--TEFTLPAVDPADLAYILFTSGSTGEPKGVEMSHDAAMNTVEFI
TH_3146|M.thermoresistible__bu VGSHE--TGVTPAAIDPQQIAYVLFTSGSTGEPKGVEVSHDAAMNTVEFI
Mb2404c|M.bovis_AF2122/97 LAAAP--AEFVPGPSDPTALAYVLFTSGSTGEPKGVEVAHDAAMNTVETF
Rv2383c|M.tuberculosis_H37Rv LAAAP--AEFVPGPSDPTALAYVLFTSGSTGEPKGVEVAHDAAMNTVETF
MAV_2009|M.avium_104 LGGAPADAEIACARVDPGELAYVLFTSGSTGEPKGVEVTHDAAMNTVEFI
MSMEG_4515|M.smegmatis_MC2_155 VGRRH--ETVEPVSAAPDDLAYVLFTSGSTGEPKGVEVTHDAAMNTVETL
MMAR_3689|M.marinum_M HPKPL----PEPVFPDIGEIAYVIFTSGSTGLPKGVDVPHCAAMNTIDAV
MUL_3632|M.ulcerans_Agy99 HPKPS----PEPVFPDIGEIAYVIFTSGSTGLPKGVDVPHSAAMNTIDAV
MAB_2124|M.abscessus_ATCC_1997 YPEPL----REPVLPDASQIAYVLFTSGSTGTPKGVDVSHAAAMNTIDAL
MLBr_00134|M.leprae_Br4923 ---------------ASTLQAFLVPAVGAFIDESVMRDVHRRLLTQLTAF
*::: : *: . : * :. : .
Mflv_2692|M.gilvum_PYR-GCK NGHFEIGPDDRCLALSTLECDLSVLDVFGMLRAGGSIVVVDEEHRRDAEV
Mvan_3849|M.vanbaalenii_PYR-1 NAHFDIGPADRCLALSTLECDLSVLDVFGMLGAGGSIVVVDEEHRRDPDV
TH_3146|M.thermoresistible__bu NAHFGIGPDDRCLALSTLEGDLSVLDIFGMLRAGAALVVVDEADRRNPDA
Mb2404c|M.bovis_AF2122/97 IRHFELGAADRWLALATLECDMSVLDIFAALRSGGAIVVVDEAQRRDPDA
Rv2383c|M.tuberculosis_H37Rv IRHFELGAADRWLALATLECDMSVLDIFAALRSGGAIVVVDEAQRRDPDA
MAV_2009|M.avium_104 GRHFEIGPADRCLALSTLEGDISVMDVFVTLRTGGAIVVVDEAQRRDPDA
MSMEG_4515|M.smegmatis_MC2_155 NTYFGTGPGDSVLALTHLESDLSVLDVFGTLAAGGSIVMVDEADRRNPDH
MMAR_3689|M.marinum_M NEWFGVGSADRVLALSALEFDASVYDIFGMFAVGGSLVAVDAEQKSAPTS
MUL_3632|M.ulcerans_Agy99 NEWFGVGSADRVLALSALEFDASVYDIFGMFAVGGSLVAVDAEQKSAPTT
MAB_2124|M.abscessus_ATCC_1997 NDEFEVVTSDRALGLSALEFDLSVYDIFGMFSVGAAVVAVDAAQRAEATT
MLBr_00134|M.leprae_Br4923 K----------------VPHRFAIIERLPRSTNGKLLRNVLRAQSPTKPI
: :: : : * : * .
Mflv_2692|M.gilvum_PYR-GCK WAHLIEQHGVTVLHFMPGWLEMLTEVGGDL----SSVRVVPTGGDWVRPD
Mvan_3849|M.vanbaalenii_PYR-1 WARLVERHGVTVLHFMPGWLEMLAEVDGDL----SSLRVVPTGGDWVRPE
TH_3146|M.thermoresistible__bu WARMIAEHRVTVLHWMPGWLEMLLSVTDSL----STVRVVPTGGDWVRAE
Mb2404c|M.bovis_AF2122/97 WARLIDTYEVTALNFMPGWLDMLLEVGGGR---LSSLRAVAVGGDWVRPD
Rv2383c|M.tuberculosis_H37Rv WARLIDTYEVTALNFMPGWLDMLLEVGGGR---LSSLRAVAVGGDWVRPD
MAV_2009|M.avium_104 WARLIDTHRVTVLHFMPGWLEMLVEVGRGR---LSSVRVVPTGGDWVRPE
MSMEG_4515|M.smegmatis_MC2_155 WVAQINAHGVTTLNFLPGSLEMLVETAWSTRTPMPSLRAVPTGGDWVRTT
MMAR_3689|M.marinum_M WVELLVHHRVSILNCVPSMLDMILDLGGDRLG--NSLRAVTLGGDWVGAD
MUL_3632|M.ulcerans_Agy99 WVELLVHHRVSILNCVPSMLDMILDLGGDRLG--NSLRAVTLGGDWVGAD
MAB_2124|M.abscessus_ATCC_1997 WVELIRRHRVSIINCVPGLLDMILAMGGGELG--DSLRAVILGGDWVSSD
MLBr_00134|M.leprae_Br4923 WELSLTESQSATKAQLDG----------------------RPASNAHAQA
* : : : . ..:
Mflv_2692|M.gilvum_PYR-GCK MVRALRKRAPGMRFAGLGGATETATHNTICEIVGD--IPQEWTSIPLGVP
Mvan_3849|M.vanbaalenii_PYR-1 MVRALRKRAPHMRFAGLGGATETATHNTICEVE-D--IPAEWTSVPLGVP
TH_3146|M.thermoresistible__bu MVRALRRAAPDVRFAGLGGATETAIHNTICEPPDP--LPDTWTAVPFGRP
Mb2404c|M.bovis_AF2122/97 LARRLQVQAPSARFAGLGGATETAVHATIFEVQDAANLPPDWASVPYGVP
Rv2383c|M.tuberculosis_H37Rv LARRLQVQAPSARFAGLGGATETAVHATIFEVQDAANLPPDWASVPYGVP
MAV_2009|M.avium_104 VVRRLRAEAPGLRFAGLGGATETPVHNTIFEVTEP--IPADCTALPFGVP
MSMEG_4515|M.smegmatis_MC2_155 MVRKLQQLSPGVVLTGLGGATETAIHATLFEAKEL---PEHWTAVPYGAP
MMAR_3689|M.marinum_M LARRLARQVPGCRFSGLGGATETAIHNTICEVVGE--PPAHWATVPFGRP
MUL_3632|M.ulcerans_Agy99 LARRLARQVPGCRFSGLGGATETAIHNTICEVVGE--PPAHWATVPFGRP
MAB_2124|M.abscessus_ATCC_1997 LARRLAAQVPGCRFTGLGGATEAAIHSTICEVLGD--PPQHWATIPFGVP
MLBr_00134|M.leprae_Br4923 AVGHAAGATLKQRLSALQQERERLVVEAVCAEAVK---------------
. ::.* * ::
Mflv_2692|M.gilvum_PYR-GCK LPNNACRVVGPDGRDCPDWVPGELWVGGRGIARGYCARPDLTAERFVRYQ
Mvan_3849|M.vanbaalenii_PYR-1 LPNNTCRVVGPDGRDCPDWVPGELWVGGRGVARGYCARPDLTAERFVEYD
TH_3146|M.thermoresistible__bu LPNNACRVVAADGSDCPDWVPGELWVSGRGIARGYRGRDDLTAERFVEHD
Mb2404c|M.bovis_AF2122/97 FPNNACRVVADSGDDCPDWVAGELWVSGRGIARGYRGRPELTAERFVEHD
Rv2383c|M.tuberculosis_H37Rv FPNNACRVVADSGDDCPDWVAGELWVSGRGIARGYRGRPELTAERFVEHD
MAV_2009|M.avium_104 LPNNVCRVVGDTGGDCPDWVPGELWVSGRGIARGYRGRPDLTAQRFVEHD
MSMEG_4515|M.smegmatis_MC2_155 FPNNACRVVNAAGQDCPDWVPGELWIGGRGIARGYRGKPDLTAEKFVTWC
MMAR_3689|M.marinum_M LRNVRCRIVSPSGRDCLDWVAGELWVGGANVAARYRNDPQRTAERFVEHQ
MUL_3632|M.ulcerans_Agy99 LRNVRCRIVSPSGRDCLDWVAGELWVGGANVAARYRNDPQRTAERFVEHQ
MAB_2124|M.abscessus_ATCC_1997 LRNVRCRVVSQAGRDCLDWVPGELWIGGDSVASGYRNDPERTAERFVEHD
MLBr_00134|M.leprae_Br4923 -----MLGESDPGLINRDLAFSDLGFDSQMTVTLCNRLAVVTGLRLPETV
* * . .:* ... . *. ::
Mflv_2692|M.gilvum_PYR-GCK DQNWYRTGDLVRYRTGGVIEFVGRVDHRVKISGYRVELGEVESALRRIPG
Mvan_3849|M.vanbaalenii_PYR-1 GRTWYRTGDLVRYRPGGVIEFVGRADHRIKISGYRVELGEVESALRRIPG
TH_3146|M.thermoresistible__bu GRIWYRTGDLVRYLPDGQIDFVGRADHRVKVSGYRIELGEVEAALRRVAG
Mb2404c|M.bovis_AF2122/97 GRTWYRTGDLARYWHDGTLEFVGRADHRVKISGYRVELGEIEAALQRLPG
Rv2383c|M.tuberculosis_H37Rv GRTWYRTGDLARYWHDGTLEFVGRADHRVKISGYRVELGEIEAALQRLPG
MAV_2009|M.avium_104 GRTWYRTGDLVRYRPDGTLEFVGRADHRVKISGYRVELGEIESALRRVPG
MSMEG_4515|M.smegmatis_MC2_155 GRRWYRTGDLARYWPDGTLEFVGRADHRVKLSGYRIELGEVEAALQRLPG
MMAR_3689|M.marinum_M GIRWYKTGDMARYWPDGTIEFLGRADHQVQIRGYRVELGEVENALRAVSG
MUL_3632|M.ulcerans_Agy99 GIRWYKTGDMARYWPDGTIEFLGRADHQVQIRGYRVELGEVENALRAVSG
MAB_2124|M.abscessus_ATCC_1997 GLRWYRTGDMARYWPDGTIEFLGRADHQVKIRGYRVELGEVESALRLIPG
MLBr_00134|M.leprae_Br4923 GWDYGSISGLSRYLEAELSGVRSRPETPLSANSGAKGLSPIDEELKKVEE
. : ..: ** . .* : :. . *. :: *: :
Mflv_2692|M.gilvum_PYR-GCK VESAVAAMVPADG-GRDVLAALIEPVAGAAVDAAGVIAAMGQLVAPHMIP
Mvan_3849|M.vanbaalenii_PYR-1 VDSAVAAVVAADG-GRDVLAALISGVA----DPQKVTTAMAEVVPPHMIP
TH_3146|M.thermoresistible__bu VDGAVAAVLPAPGDGRGEQLAAIVRVTDPQLTVEELTARMGELVPPHMVP
Mb2404c|M.bovis_AF2122/97 VHAAAATVLPGG----SDVLAAAVCVDDAGVTAESIRQQLADLVPAHMIP
Rv2383c|M.tuberculosis_H37Rv VHAAAATVLPGG----SDVLAAAVCVDDAGVTAESIRQQLADLVPAHMIP
MAV_2009|M.avium_104 VRTAVAALIAGAG--ESDVLAAQVGTDDPALTGEQVRQYLADLVPAHMIP
MSMEG_4515|M.smegmatis_MC2_155 VHAAVADIVDTP---AGDLLAAVVGLDDTSVTDADLRAGLAELLPPHMVP
MMAR_3689|M.marinum_M VRHAVAAVVGAS------APKLVAAVAADPNTVGDISAVLADLLPSYMVP
MUL_3632|M.ulcerans_Agy99 VRHAVAAVVGAS------APKLVAAVAADPNTVGDITAVLADLLPSYMVP
MAB_2124|M.abscessus_ATCC_1997 IRHAVAAVVGAD------APNLVAAVAGTPDPAADYAALLGDLLPGYMIP
MLBr_00134|M.leprae_Br4923 MVVAIGASEKQR-------------------VADRLRALLGIIVDGEAGL
: * . :. ::
Mflv_2692|M.gilvum_PYR-GCK KIVEPAPRIPFTAGGKIDRQAVAKLLGQARSPQSR----AHRAPVTSLEC
Mvan_3849|M.vanbaalenii_PYR-1 QIIVAADHIPYTLGGKIDRAAVTRMLADADLQCGT----GYRAPATPLES
TH_3146|M.thermoresistible__bu SHLLTVEQIPFTVGGKIDRRAVSALLADSLAEKADNRAPSYRAPSTPLER
Mb2404c|M.bovis_AF2122/97 RHVTLLDRIPFTDSGKIDRAEVGALLAAEVERSGDRSAPYA-APRTVLQR
Rv2383c|M.tuberculosis_H37Rv RHVTLLDRIPFTDSGKIDRAEVGALLAAEVERSGDRSAPYA-APRTVLQR
MAV_2009|M.avium_104 RHVEVVERIGFTAAGKLDRRAVARELHSVVGQS--RSPGHR-AASTPLEG
MSMEG_4515|M.smegmatis_MC2_155 RHFELTGKVPFTVGGKTDRRAVARLLAEAVEQAQAGGRGTARRPETSLER
MMAR_3689|M.marinum_M TRTVFFERFPLTANGKLDRRAVTALLEPEACTTEDR------APRNDVEA
MUL_3632|M.ulcerans_Agy99 TRTVFFERFPLTANGKLDRRAVTALLEPEACTTEDR------APRNDVEA
MAB_2124|M.abscessus_ATCC_1997 ARIELLEQMPLTSNGKMDRRAVTALLEQVAVGGADA------GPRHDLDA
MLBr_00134|M.leprae_Br4923 SKRIQAASTPDEIFQLIDSELCE---------------------------
*
Mflv_2692|M.gilvum_PYR-GCK ALADILGGVLDGV--ALGADDDFFACGGDSVLATQAVSRIRTWLDTSTVA
Mvan_3849|M.vanbaalenii_PYR-1 ALCDIIGTVLGRA--AVGADDDFFASGGDSVLATQVVARVRTWLDTPAVA
TH_3146|M.thermoresistible__bu ALAHIVAKVLGRD--RVGLDDDFFELGGDSVLATQTVARIRDWLDSPGVM
Mb2404c|M.bovis_AF2122/97 ALRRIVADILGRANDAVGVHDDFFALGGDSVLATQVVAGIRRWLDSPSLM
Rv2383c|M.tuberculosis_H37Rv ALRRIVADILGRANDAVGVHDDFFALGGDSVLATQVVAGIRRWLDSPSLM
MAV_2009|M.avium_104 ALALILGDLLGR--DDVGVDDDFFALGGDSVLATQAVARIRAWLDAPDVM
MSMEG_4515|M.smegmatis_MC2_155 ALAAILGELLSVA--DVGADEDFFELGGDSVLATAAVARIRDWLDTPTVM
MMAR_3689|M.marinum_M ALAEIVAEVLDQA--SVGVHDDFFALGGDSVLATAVIARIRDWLDIDHVV
MUL_3632|M.ulcerans_Agy99 ALAEIVAEVLDQA--SIGVHDDFFALGGDSVLATAVIARIRDWLDIDHVV
MAB_2124|M.abscessus_ATCC_1997 ALVDLVSGVLGIE--SMGVHDDFFARGGDSVLATAVIARVRDWLSVDHAL
MLBr_00134|M.leprae_Br4923 --------------------------------------------------
Mflv_2692|M.gilvum_PYR-GCK VADIFGARTVSALAERLTARD------ERLEKVAEMYLDVARMDAADVVS
Mvan_3849|M.vanbaalenii_PYR-1 VADIFATRTAAALAARLSAGEPEG---TRLAEVAELYLQVAGMDGAEVVS
TH_3146|M.thermoresistible__bu VTDIFAARDVGSLARRLIDAESGR---ERLDEVARVYLEVMEMTAADVAS
Mb2404c|M.bovis_AF2122/97 VADMFAARTIAALAQLLTGREANA---DRLELVAEVYLEIANMTSADVMA
Rv2383c|M.tuberculosis_H37Rv VADMFAARTIAALAQLLTGREANA---DRLELVAEVYLEIANMTSADVMA
MAV_2009|M.avium_104 VADIFANRTVSALAAVLRAAEDDP---DRLDHVAELYLEVIGMDAESVLA
MSMEG_4515|M.smegmatis_MC2_155 VPDIFATRTVEKLASRLVAREADG---SRLEQVAELYLEVAAMDDAAVMS
MMAR_3689|M.marinum_M VADLFAARTVGALAQRLQDREAARGTPERLSVIARHYLDVAALTDEEVLA
MUL_3632|M.ulcerans_Agy99 VADLFAARTVGALAQRLQDREAARGTPERLSVIARHYLDVAALTDEEVLA
MAB_2124|M.abscessus_ATCC_1997 VGDFFATRTVAGLADRLLQREADRGTPDRLAVVAGHYLEIAAMTDEEVLA
MLBr_00134|M.leprae_Br4923 --------------------------------------------------
Mflv_2692|M.gilvum_PYR-GCK TLETTAAQ------------------------------------------
Mvan_3849|M.vanbaalenii_PYR-1 ALESGR--------------------------------------------
TH_3146|M.thermoresistible__bu ELESTSAKAS----------------------------------------
Mb2404c|M.bovis_AF2122/97 ALDPIEQPAQPAFKPWVKRFTGTDKPGAVLVFPHAGGAAAAYRWLAKSLV
Rv2383c|M.tuberculosis_H37Rv ALDPIEQPAQPAFKPWVKRFTGTDKPGAVLVFPHAGGAAAAYRWLAKSLV
MAV_2009|M.avium_104 ATRQITKS------------------------------------------
MSMEG_4515|M.smegmatis_MC2_155 ALDTAATS------------------------------------------
MMAR_3689|M.marinum_M ES------------------------------------------------
MUL_3632|M.ulcerans_Agy99 ES------------------------------------------------
MAB_2124|M.abscessus_ATCC_1997 GTV-----------------------------------------------
MLBr_00134|M.leprae_Br4923 --------------------------------------------------
Mflv_2692|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3849|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3146|M.thermoresistible__bu --------------------------------------------------
Mb2404c|M.bovis_AF2122/97 ANDVDTFVVQYPQRADRRSHPAADSIEALALELFEAGDWHLTAPLTLFGH
Rv2383c|M.tuberculosis_H37Rv ANDVDTFVVQYPQRADRRSHPAADSIEALALELFEAGDWHLTAPLTLFGH
MAV_2009|M.avium_104 --------------------------------------------------
MSMEG_4515|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_3689|M.marinum_M --------------------------------------------------
MUL_3632|M.ulcerans_Agy99 --------------------------------------------------
MAB_2124|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00134|M.leprae_Br4923 --------------------------------------------------
Mflv_2692|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3849|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3146|M.thermoresistible__bu --------------------------------------------------
Mb2404c|M.bovis_AF2122/97 CMGAIVAFEFARLAERNGVPVRALWASSGQAPSTVAASGPLPTADRDVLA
Rv2383c|M.tuberculosis_H37Rv CMGAIVAFEFARLAERNGVPVRALWASSGQAPSTVAASGPLPTADRDVLA
MAV_2009|M.avium_104 --------------------------------------------------
MSMEG_4515|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_3689|M.marinum_M --------------------------------------------------
MUL_3632|M.ulcerans_Agy99 --------------------------------------------------
MAB_2124|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00134|M.leprae_Br4923 --------------------------------------------------
Mflv_2692|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3849|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3146|M.thermoresistible__bu --------------------------------------------------
Mb2404c|M.bovis_AF2122/97 DMVDLGGTDPVLLEDEEFVELLVPAVKADYRALSGYSCPPDVRIRANIHA
Rv2383c|M.tuberculosis_H37Rv DMVDLGGTDPVLLEDEEFVELLVPAVKADYRALSGYSCPPDVRIRANIHA
MAV_2009|M.avium_104 --------------------------------------------------
MSMEG_4515|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_3689|M.marinum_M --------------------------------------------------
MUL_3632|M.ulcerans_Agy99 --------------------------------------------------
MAB_2124|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00134|M.leprae_Br4923 --------------------------------------------------
Mflv_2692|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3849|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3146|M.thermoresistible__bu --------------------------------------------------
Mb2404c|M.bovis_AF2122/97 VGGNRDHRISREMLTSWETHTSGRFTLSHFDGGHFYLNDHLDAVARMVSA
Rv2383c|M.tuberculosis_H37Rv VGGNRDHRISREMLTSWETHTSGRFTLSHFDGGHFYLNDHLDAVARMVSA
MAV_2009|M.avium_104 --------------------------------------------------
MSMEG_4515|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_3689|M.marinum_M --------------------------------------------------
MUL_3632|M.ulcerans_Agy99 --------------------------------------------------
MAB_2124|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00134|M.leprae_Br4923 --------------------------------------------------
Mflv_2692|M.gilvum_PYR-GCK ---
Mvan_3849|M.vanbaalenii_PYR-1 ---
TH_3146|M.thermoresistible__bu ---
Mb2404c|M.bovis_AF2122/97 DVR
Rv2383c|M.tuberculosis_H37Rv DVR
MAV_2009|M.avium_104 ---
MSMEG_4515|M.smegmatis_MC2_155 ---
MMAR_3689|M.marinum_M ---
MUL_3632|M.ulcerans_Agy99 ---
MAB_2124|M.abscessus_ATCC_1997 ---
MLBr_00134|M.leprae_Br4923 ---