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M. thermoresistible (build 8) TH_2838 (-)

annotation: AMP-dependent synthetase and ligase
coordinates: 3588516 - 3589910
length: 465

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_2838--100% (465)AMP-dependent synthetase and ligase
M. thermoresistible (build 8)TH_3626-8e-5632.30% (483) PUTATIVE putative fatty-acid-CoA ligase
M. thermoresistible (build 8)TH_2854-6e-4532.89% (447) PUTATIVE putative AMP-dependent synthetase and ligase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1225fadD360.078.30% (470) acyl-CoA synthetase
M. gilvum PYR-GCKMflv_2175-0.076.07% (468) acyl-CoA synthetase
M. tuberculosis H37RvRv1193fadD360.078.30% (470) acyl-CoA synthetase
M. leprae Br4923MLBr_01051xclC0.077.80% (473) acyl-CoA synthetase
M. abscessus ATCC 19977MAB_1332-0.073.12% (465) acyl-CoA synthetase
M. marinum MMMAR_4243fadD360.078.25% (469) fatty-acid-CoA synthetase, FadD36
M. avium 104MAV_1343-0.079.57% (470) acyl-CoA synthetase
M. smegmatis MC2 155MSMEG_5114-0.081.25% (464) acyl-CoA synthetase
M. ulcerans Agy99MUL_0943fadD360.078.04% (469) acyl-CoA synthetase
M. vanbaalenii PYR-1Mvan_4522-0.078.85% (468) acyl-CoA synthetase

CLUSTAL 2.0.9 multiple sequence alignment


TH_2838|M.thermoresistible__bu      VLLASLNPAAVARGADIADAVRIDDTVFSRSDLVGAATSVAERIAGAP-R
MSMEG_5114|M.smegmatis_MC2_155      MLLASLNPAAVAAGADIADAVRIDGAVLSRSDLVGGATSVAERVAVAQ-R
Mflv_2175|M.gilvum_PYR-GCK          MLLASLNPAAVAAGADLGDAVRIDGVSLSRSDLVGAATSVAERVAGAS-R
Mvan_4522|M.vanbaalenii_PYR-1       MLLASLNPAAVAAGADLGDAVRIDGVSLSRSDLVGAATSVAERVGGAS-R
Mb1225|M.bovis_AF2122/97            MLLASLNPAVVSA-ADIADAVRIDGDVLSRSDLVGAATSVAERVAGAH-R
Rv1193|M.tuberculosis_H37Rv         MLLASLNPAVVSA-ADIADAVRIDGDVLSRSDLVGAATSVAERVAGAH-R
MMAR_4243|M.marinum_M               MLLASLNPAAVSA-DDIADAVCIDGVDLSRSDLLGAATAVAERIAGAH-R
MUL_0943|M.ulcerans_Agy99           MLLASLNPAAVSA-DDIADAVRIDGVDLSRSDLLGAATAVAERIAGAH-Q
MLBr_01051|M.leprae_Br4923          MLLASLNPSVVTA-TDIADAVCVDGVVLSRSGLVGAATSVAERVGGAR-L
MAV_1343|M.avium_104                MLLTSLNPSAVTA-TDIPDAVRIDGTVLSRADLLGAATSVAERVAGAG-R
MAB_1332|M.abscessus_ATCC_1997      MLLTSLHP----KSPDLADAVRIGEDSWGRGDLVGAATAAAERIGGASGP
                                    :**:**:*       *: *** :.    .*..*:*.**:.***:. *   

TH_2838|M.thermoresistible__bu      VAVLATPTATTVLAVTGCLIAGVPVVPVPADVGVAERRHILTDSGAVAWL
MSMEG_5114|M.smegmatis_MC2_155      VAVLAKPTATTVLAITGCLIAGVTVVPVPADVGVAERRHMLEDSGAQAWL
Mflv_2175|M.gilvum_PYR-GCK          VAILARPSATTVLAVAGCLIAGVPFVPVPADVGAAERRHILTDSGAQGWL
Mvan_4522|M.vanbaalenii_PYR-1       VAVLATPTAATVLAVTGCLIAGVPVVPVPADVGAAERRHILADSRAQAWL
Mb1225|M.bovis_AF2122/97            VAVLATPTASTVLAITGCLIAGVPVVPVPADVGVTERRHMLTDSGVQAWL
Rv1193|M.tuberculosis_H37Rv         VAVLATPTASTVLAITGCLIAGVPVVPVPADVGVTERRHMLTDSGVQAWL
MMAR_4243|M.marinum_M               VAVLATPTVSTVLAVTGCLIAGVPVVPVPADVGVAERRHMLADSGAVAWL
MUL_0943|M.ulcerans_Agy99           VAVLATPTVSTVLAVTGCLIAGVPVVPVPADVGVAERRHMLADSGAVAWL
MLBr_01051|M.leprae_Br4923          VAVLATPTASTVLAITGCLIAGVPVVPVPADIGVVERRHMLTDSGAQAWL
MAV_1343|M.avium_104                VAVLATPTAATVLAVTGCLIAGVPFVPVPADVGAAERRHMLADSGVRAWL
MAB_1332|M.abscessus_ATCC_1997      IAVLARPSIDTVLAVVAGLIAGVPIVPVPADVGIAERRHILADSAAVAWL
                                    :*:** *:  ****:.. *****..******:* .****:* ** . .**

TH_2838|M.thermoresistible__bu      GESPA---DTEGLPVVPVRLHARSWHRYPEPAPESTALIMYTSGTTGPPK
MSMEG_5114|M.smegmatis_MC2_155      GERPD---DAEGLPHIPVRLHARSWHRYAEPPPESTAIIMYTSGTTGLPK
Mflv_2175|M.gilvum_PYR-GCK          GELPD---DADGLAHIPVRMHARSWHRYAEPPPDATAMIIYTSGTTGLPK
Mvan_4522|M.vanbaalenii_PYR-1       GELPE---EAEGLPHVPVRLHARSWHRYPEPSPDAAALIIYTSGTTGPPK
Mb1225|M.bovis_AF2122/97            GPLPD---DPAGLPHIPVRTHARSWHRYPEPSPGAIAMVVYTSGTTGPPK
Rv1193|M.tuberculosis_H37Rv         GPLPD---DPAGLPHIPVRTHARSWHRYPEPSPGAIAMVVYTSGTTGPPK
MMAR_4243|M.marinum_M               GPAPAQDAEPDGLPQIPVRLHARSWHRYPEPPPDSVAMVIYTSGTTGLPK
MUL_0943|M.ulcerans_Agy99           GPAPAQDAEPDGLPQIPVRLHARSWHRYPEPPPDSVAMVIYTSGTTGLPK
MLBr_01051|M.leprae_Br4923          GPGPSADSAPDGLPHIPVQLDARSWNRYPEPSPDATAMVIYTSGTTGPPK
MAV_1343|M.avium_104                GPLPD---EPDGLPHVPVRLHARSWHRYPEPSPDATAMIIYTSGTTGLPK
MAB_1332|M.abscessus_ATCC_1997      GESPD---ESEGLPHVPVRRHARSWHQYSEPNPESTALIVYTSGTTGAPK
                                    *  *     . **. :**: .****::*.** * : *:::******* **

TH_2838|M.thermoresistible__bu      GVPISRAAIAADIDALAEAWQWSPDDTLVHGLPLFHVHGLVLGLLGSLRI
MSMEG_5114|M.smegmatis_MC2_155      GVPITRNAIAADIDGLAKAWEWTPEDTLVHGLPLFHVHGLVLGLIGSLRI
Mflv_2175|M.gilvum_PYR-GCK          GVVVSRRAIAADIDMLAQAWQWTSEDTLVHGLPMYHVHGLVLGLLGSLRI
Mvan_4522|M.vanbaalenii_PYR-1       GVVVSRRAIAADIDMLAQAWEWTPQDTLVHGLPLYHVHGLVLGLLGSLRV
Mb1225|M.bovis_AF2122/97            GVQLSRRAIAADLDALAEAWQWTAEDVLVHGLPLYHVHGLVLGLLGSLRF
Rv1193|M.tuberculosis_H37Rv         GVQLSRRAIAADLDALAEAWQWTAEDVLVHGLPLYHVHGLVLGLLGSLRF
MMAR_4243|M.marinum_M               GVQLSRRAIAADLDALAQAWQWNAEDVLVHGLPLYHVHGLVLGLLGSLRV
MUL_0943|M.ulcerans_Agy99           GVQLSRRAIAADLDALAQAWQWNAEDVLVHGLPLYHVHGLVLGLLGSLRV
MLBr_01051|M.leprae_Br4923          GVLLSRRAIAVDLDALAQAWQWTADDVLVHGLPLFHVHGLVLGLLGSLRI
MAV_1343|M.avium_104                GVVLSRRAIAADLDALAQAWQWTADDVLVHGLPLFHVHGLVLGLLGSLRI
MAB_1332|M.abscessus_ATCC_1997      GVRLSRRALAASLDGLADAWEWTADDVLVHGLPLFHVHGLVLGLLGSLRV
                                    ** ::* *:*..:* **.**:*..:*.******::*********:****.

TH_2838|M.thermoresistible__bu      GNRFVHTGRPTPEAYAAAG----GSLYFGVPTVWSRVVKDPSAARALSAA
MSMEG_5114|M.smegmatis_MC2_155      GNRFVHTGKPTPERYAEAK----GTLYFGVPTVWSRVVNNLDAALALSSA
Mflv_2175|M.gilvum_PYR-GCK          GNRFVHTGKPKPEAYAHAVSELGGTLLFGVPTVWSRIVEDGDAARALAPA
Mvan_4522|M.vanbaalenii_PYR-1       GNRFVHTGKPKPAAYARAVRELGGTLLFGVPTVWSRVVEDGDAARALAPA
Mb1225|M.bovis_AF2122/97            GNRFVHTGKPTPAGYAQACYEAHGTLFFGVPTVWSRVAADQAAAGALKPA
Rv1193|M.tuberculosis_H37Rv         GNRFVHTGKPTPAGYAQACYEAHGTLFFGVPTVWSRVAADQAAAGALKPA
MMAR_4243|M.marinum_M               GNRFVHTGKPTAAGYAQAG----GTLYFGVPTVWSRVAADRAAAEALRPA
MUL_0943|M.ulcerans_Agy99           GNRFVHTGKPTAAGYAQAG----GTLYFGVPTVWSRVAADRAAAEALRPA
MLBr_01051|M.leprae_Br4923          GNRFVHTGKPTPTAYAQACSEAGGSLYFGVPTVWSRLVADEAVARALRPA
MAV_1343|M.avium_104                GNRFVHTGKPTPAGYAQARTDFGGTLFFGVPTVWSRVVADEAAARALRPA
MAB_1332|M.abscessus_ATCC_1997      GNRFVHTVKPTPEAYAAAR----GSLYFGVPTVWLRVAGDESCARALSTA
                                    ******* :*..  ** *     *:* ******* *:. :   * ** .*

TH_2838|M.thermoresistible__bu      RLLVSGSAPLPVPVFDRLAELTGHRAVERYGSTESLITLSTRVDGERRAG
MSMEG_5114|M.smegmatis_MC2_155      RLLVSGSAPLPVPVFEQLTKLTGQPPVERYGSTESLITITTLVNGERRPG
Mflv_2175|M.gilvum_PYR-GCK          RLLVSGSAALPVPVFDGLAALTGHQPIERYGSTETLITLSTLVSGERRPG
Mvan_4522|M.vanbaalenii_PYR-1       RLLVSGSAALPVPVFDGLAALSGHRAIERYGSTETLITLSTFASGERRPG
Mb1225|M.bovis_AF2122/97            RLLVSGSAALPVPVFDKLVQLTGHRPVERYGASESLITLSTRADGERRPG
Rv1193|M.tuberculosis_H37Rv         RLLVSGSAALPVPVFDKLVQLTGHRPVERYGASESLITLSTRADGERRPG
MMAR_4243|M.marinum_M               RLLVSGSAALPVPVFDQLVHLAGHRPIERYGSSESLITLSTRADGERRAG
MUL_0943|M.ulcerans_Agy99           RLLVSGSAALPVPVFDQLVHLAGHRPIERYGSSESLITLSTRADGDRRAG
MLBr_01051|M.leprae_Br4923          RLLVSGSASLPVPVFDRLAHLTGHRPIERYGSTESLITLSTLADGERRAG
MAV_1343|M.avium_104                RLLVSGSAPLPVPVFDRLAGLTGHQPVERYGASESLITISTRADGERRPG
MAB_1332|M.abscessus_ATCC_1997      RLLVSGSAPLPVPVFDELCRLTGHAPIERYGATETVITLSTRADGERRAG
                                    ********.******: *  *:*: .:****::*::**::* ..*:**.*

TH_2838|M.thermoresistible__bu      WVGLPLAGVQTRLLDEDGAETPHDGETIGRLQVCGPMVFDGYLNRPDATA
MSMEG_5114|M.smegmatis_MC2_155      WVGVPIEGVRTRLVDENGAEVPHDGETIGRLQIKGPTVFEGYLNRPEATA
Mflv_2175|M.gilvum_PYR-GCK          WVGMALPGVQTRVVAEDGTALPHDAESIGQLHVQSPTLFDGYLNRADATA
Mvan_4522|M.vanbaalenii_PYR-1       WVGLPLQGVTTRLVADDGTELPHDGESIGQLHVQSPTLFDGYLNRPDATA
Mb1225|M.bovis_AF2122/97            WVGLPLAGVQTRLVDDDGGEVPHDGETVGKLQVRGPTLFDGYLNQPDATA
Rv1193|M.tuberculosis_H37Rv         WVGLPLAGVQTRLVDDDGGEVPHDGETVGKLQVRGPTLFDGYLNQPDATA
MMAR_4243|M.marinum_M               WVGLPLAGVQTRLVDDHGNPVPHDGETVGKLQVRGSTLFDGYLNRPEATA
MUL_0943|M.ulcerans_Agy99           WVGLPLAGVQTRLVDDHGNPVPHDGETVGKLQVRGSTLFDGYLNRPEATA
MLBr_01051|M.leprae_Br4923          WVGLPLAGVQTRLVDESGGPVPYDGETVGRLQVRSPTMFGGYLNRPEATA
MAV_1343|M.avium_104                WVGLPLTGVQTRVVDDDGNPVPHDGETVGKLLVRGPMMFDGYLNRPDATA
MAB_1332|M.abscessus_ATCC_1997      WVGHPLTGVRTRLLAENGSPAAHDGETVGQLQIQGPTLFSGYHNLPEKTA
                                    *** .: ** **:: : *   .:*.*::*:* : .. :* ** * .: **

TH_2838|M.thermoresistible__bu      EAFDD-GWYRTGDVAVIDDTGMHRIVGRESVDLIKTGGYRVGAGEVEAAL
MSMEG_5114|M.smegmatis_MC2_155      EAFDDDGWFRTGDVAVIDAGGMHRIVGRESVDLIKSGGYRIGAGEIETVL
Mflv_2175|M.gilvum_PYR-GCK          EVLGEDGWYRTGDVAVIDPDGMHRIVGRESVDLIKSGGFRIGAGEIETVL
Mvan_4522|M.vanbaalenii_PYR-1       EVLGDDGWYHTGDVAVIDSSGMHRIVGRESVDLIKSGGFRIGAGEIETVL
Mb1225|M.bovis_AF2122/97            AAFDADSWYRTGDVAVVDGSGMHRIVGRESVDLIKSGGYRVGAGEIETVL
Rv1193|M.tuberculosis_H37Rv         AAFDADSWYRTGDVAVVDGSGMHRIVGRESVDLIKSGGYRVGAGEIETVL
MMAR_4243|M.marinum_M               EAFDADGWYRTGDVAVVDDGGMHRIVGRESVDLIKSGGYRIGAGEIETVL
MUL_0943|M.ulcerans_Agy99           EAFDADGWYRTGDVAVVDDGGMHRIVGRESVDLIKSGGYRIGAGEIETVL
MLBr_01051|M.leprae_Br4923          EAFDEDGWYRTGDVAVVDSGGMHRIVGRESVDLIKLGGYRIGAGEIEMAL
MAV_1343|M.avium_104                EAFDADGWYRTGDVAVVDDAGMHRIVGRESVDLIKSGGYRIGAGEIETAL
MAB_1332|M.abscessus_ATCC_1997      EVLTEDGWYRTGDVAVIDAGGMHRIVGRESVDLIKSGGYRIGAGEIETVL
                                     .:   .*::******:*  *************** **:*:****:* .*

TH_2838|M.thermoresistible__bu      LGHPGVAEAAVVGLPDDDLGQRIVAFIVG--DAEPDELIEYVAQQLSVHK
MSMEG_5114|M.smegmatis_MC2_155      LGHPGVKEAAVVGVPDDDLGQRIVAYVVG--DAESDTLIDFVAKQLSVHK
Mflv_2175|M.gilvum_PYR-GCK          LGHPGVREAAVIGAPDEDLGQRIVAFVVG--EAQPDELIDHVARELSVHK
Mvan_4522|M.vanbaalenii_PYR-1       LQHAGVREAAVIGAPDADLGQRIIAFVVG--DAQPDELIDYVAQQLSVHK
Mb1225|M.bovis_AF2122/97            LGHPDVAEAAVVGVPDDDLGQRIVAYVVGSANVDADGLINFVAQQLSVHK
Rv1193|M.tuberculosis_H37Rv         LGHPDVAEAAVVGVPDDDLGQRIVAYVVGSANVDADGLINFVAQQLSVHK
MMAR_4243|M.marinum_M               LGHPEVQEAAVVGLPDEDLGQRIVAYIVGSDRIDPDVLIDFVAQQLSVHK
MUL_0943|M.ulcerans_Agy99           LGHPEVQEAAVVGLPDEDLGQRIVAYIVGSDRIDPDVLIDFVAQQLSVHK
MLBr_01051|M.leprae_Br4923          LGHPDVREVAVVGLPDEDLGQRIVAFVVGAEALDADELINYVAQQLSIHK
MAV_1343|M.avium_104                LGHPGVAEAAVVGMPDEDLGQRIVAFVVPAGRVNPDDLIDHVAQQLSIHK
MAB_1332|M.abscessus_ATCC_1997      LGHPGIVEVAVVGVPDDDLGQRIVAYVVG--DVAEDDVIGFVAQQLSVHK
                                    * *. : *.**:* ** ******:*::*       * :* .**::**:**

TH_2838|M.thermoresistible__bu      RPREVRVVDSLPRNAMGKVLKKQLR---
MSMEG_5114|M.smegmatis_MC2_155      RPREVRIVDSLPRNAMGKVLKKELAQWR
Mflv_2175|M.gilvum_PYR-GCK          RPREVRIVDGLPRNAMGKVMKKELAQWV
Mvan_4522|M.vanbaalenii_PYR-1       RPREVRVVESLPRNAMGKLLKKELAQWV
Mb1225|M.bovis_AF2122/97            RPREVRIVDALPRNALGKVLKKQLLSEG
Rv1193|M.tuberculosis_H37Rv         RPREVRIVDALPRNALGKVLKKQLLSEG
MMAR_4243|M.marinum_M               RPREVRIVESLPRNALGKVLKKQLLSEG
MUL_0943|M.ulcerans_Agy99           RPREVRIVESLPRNALGKVLKKQLLSEG
MLBr_01051|M.leprae_Br4923          RPREVRFVDALPRNAMGKVLKKQLLFEG
MAV_1343|M.avium_104                RPREVRVVDALPRNAMGKVLKKQLLSDG
MAB_1332|M.abscessus_ATCC_1997      RPREVRRVDALPRNAMGKVLKKELIT--
                                    ****** *:.*****:**::**:*