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LLASLNPAAVAAGADLGDAVRIDGVSLSRSDLVGAATSVAERVGGASRVAVLATPTAATVLAVTGCLIAG VPVVPVPADVGAAERRHILADSRAQAWLGELPEEAEGLPHVPVRLHARSWHRYPEPSPDAAALIIYTSGT TGPPKGVVVSRRAIAADIDMLAQAWEWTPQDTLVHGLPLYHVHGLVLGLLGSLRVGNRFVHTGKPKPAAY ARAVRELGGTLLFGVPTVWSRVVEDGDAARALAPARLLVSGSAALPVPVFDGLAALSGHRAIERYGSTET LITLSTFASGERRPGWVGLPLQGVTTRLVADDGTELPHDGESIGQLHVQSPTLFDGYLNRPDATAEVLGD DGWYHTGDVAVIDSSGMHRIVGRESVDLIKSGGFRIGAGEIETVLLQHAGVREAAVIGAPDADLGQRIIA FVVGDAQPDELIDYVAQQLSVHKRPREVRVVESLPRNAMGKLLKKELAQWV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4522 | - | - | 100% (472) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_4133 | - | 1e-41 | 33.13% (489) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_0970 | - | 2e-41 | 33.61% (363) | AMP-dependent synthetase and ligase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1225 | fadD36 | 0.0 | 76.60% (470) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_2175 | - | 0.0 | 87.08% (472) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv1193 | fadD36 | 0.0 | 76.60% (470) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_01051 | xclC | 0.0 | 74.63% (473) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_1332 | - | 0.0 | 71.22% (469) | acyl-CoA synthetase |
| M. marinum M | MMAR_4243 | fadD36 | 0.0 | 76.11% (473) | fatty-acid-CoA synthetase, FadD36 |
| M. avium 104 | MAV_1343 | - | 0.0 | 78.09% (470) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_5114 | - | 0.0 | 76.01% (471) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_2838 | - | 0.0 | 78.85% (468) | PUTATIVE AMP-dependent synthetase and ligase |
| M. ulcerans Agy99 | MUL_0943 | fadD36 | 0.0 | 75.90% (473) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4522|M.vanbaalenii_PYR-1 MLLASLNPAAVAAGADLGDAVRIDGVSLSRSDLVGAATSVAERVGGAS-R
Mflv_2175|M.gilvum_PYR-GCK MLLASLNPAAVAAGADLGDAVRIDGVSLSRSDLVGAATSVAERVAGAS-R
MSMEG_5114|M.smegmatis_MC2_155 MLLASLNPAAVAAGADIADAVRIDGAVLSRSDLVGGATSVAERVAVAQ-R
TH_2838|M.thermoresistible__bu VLLASLNPAAVARGADIADAVRIDDTVFSRSDLVGAATSVAERIAGAP-R
Mb1225|M.bovis_AF2122/97 MLLASLNPAVVSA-ADIADAVRIDGDVLSRSDLVGAATSVAERVAGAH-R
Rv1193|M.tuberculosis_H37Rv MLLASLNPAVVSA-ADIADAVRIDGDVLSRSDLVGAATSVAERVAGAH-R
MMAR_4243|M.marinum_M MLLASLNPAAVSA-DDIADAVCIDGVDLSRSDLLGAATAVAERIAGAH-R
MUL_0943|M.ulcerans_Agy99 MLLASLNPAAVSA-DDIADAVRIDGVDLSRSDLLGAATAVAERIAGAH-Q
MLBr_01051|M.leprae_Br4923 MLLASLNPSVVTA-TDIADAVCVDGVVLSRSGLVGAATSVAERVGGAR-L
MAV_1343|M.avium_104 MLLTSLNPSAVTA-TDIPDAVRIDGTVLSRADLLGAATSVAERVAGAG-R
MAB_1332|M.abscessus_ATCC_1997 MLLTSLHP----KSPDLADAVRIGEDSWGRGDLVGAATAAAERIGGASGP
:**:**:* *: *** :. .*..*:*.**:.***:. *
Mvan_4522|M.vanbaalenii_PYR-1 VAVLATPTAATVLAVTGCLIAGVPVVPVPADVGAAERRHILADSRAQAWL
Mflv_2175|M.gilvum_PYR-GCK VAILARPSATTVLAVAGCLIAGVPFVPVPADVGAAERRHILTDSGAQGWL
MSMEG_5114|M.smegmatis_MC2_155 VAVLAKPTATTVLAITGCLIAGVTVVPVPADVGVAERRHMLEDSGAQAWL
TH_2838|M.thermoresistible__bu VAVLATPTATTVLAVTGCLIAGVPVVPVPADVGVAERRHILTDSGAVAWL
Mb1225|M.bovis_AF2122/97 VAVLATPTASTVLAITGCLIAGVPVVPVPADVGVTERRHMLTDSGVQAWL
Rv1193|M.tuberculosis_H37Rv VAVLATPTASTVLAITGCLIAGVPVVPVPADVGVTERRHMLTDSGVQAWL
MMAR_4243|M.marinum_M VAVLATPTVSTVLAVTGCLIAGVPVVPVPADVGVAERRHMLADSGAVAWL
MUL_0943|M.ulcerans_Agy99 VAVLATPTVSTVLAVTGCLIAGVPVVPVPADVGVAERRHMLADSGAVAWL
MLBr_01051|M.leprae_Br4923 VAVLATPTASTVLAITGCLIAGVPVVPVPADIGVVERRHMLTDSGAQAWL
MAV_1343|M.avium_104 VAVLATPTAATVLAVTGCLIAGVPFVPVPADVGAAERRHMLADSGVRAWL
MAB_1332|M.abscessus_ATCC_1997 IAVLARPSIDTVLAVVAGLIAGVPIVPVPADVGIAERRHILADSAAVAWL
:*:** *: ****:.. *****..******:* .****:* ** . .**
Mvan_4522|M.vanbaalenii_PYR-1 GELPE---EAEGLPHVPVRLHARSWHRYPEPSPDAAALIIYTSGTTGPPK
Mflv_2175|M.gilvum_PYR-GCK GELPD---DADGLAHIPVRMHARSWHRYAEPPPDATAMIIYTSGTTGLPK
MSMEG_5114|M.smegmatis_MC2_155 GERPD---DAEGLPHIPVRLHARSWHRYAEPPPESTAIIMYTSGTTGLPK
TH_2838|M.thermoresistible__bu GESPA---DTEGLPVVPVRLHARSWHRYPEPAPESTALIMYTSGTTGPPK
Mb1225|M.bovis_AF2122/97 GPLPD---DPAGLPHIPVRTHARSWHRYPEPSPGAIAMVVYTSGTTGPPK
Rv1193|M.tuberculosis_H37Rv GPLPD---DPAGLPHIPVRTHARSWHRYPEPSPGAIAMVVYTSGTTGPPK
MMAR_4243|M.marinum_M GPAPAQDAEPDGLPQIPVRLHARSWHRYPEPPPDSVAMVIYTSGTTGLPK
MUL_0943|M.ulcerans_Agy99 GPAPAQDAEPDGLPQIPVRLHARSWHRYPEPPPDSVAMVIYTSGTTGLPK
MLBr_01051|M.leprae_Br4923 GPGPSADSAPDGLPHIPVQLDARSWNRYPEPSPDATAMVIYTSGTTGPPK
MAV_1343|M.avium_104 GPLPD---EPDGLPHVPVRLHARSWHRYPEPSPDATAMIIYTSGTTGLPK
MAB_1332|M.abscessus_ATCC_1997 GESPD---ESEGLPHVPVRRHARSWHQYSEPNPESTALIVYTSGTTGAPK
* * . **. :**: .****::*.** * : *:::******* **
Mvan_4522|M.vanbaalenii_PYR-1 GVVVSRRAIAADIDMLAQAWEWTPQDTLVHGLPLYHVHGLVLGLLGSLRV
Mflv_2175|M.gilvum_PYR-GCK GVVVSRRAIAADIDMLAQAWQWTSEDTLVHGLPMYHVHGLVLGLLGSLRI
MSMEG_5114|M.smegmatis_MC2_155 GVPITRNAIAADIDGLAKAWEWTPEDTLVHGLPLFHVHGLVLGLIGSLRI
TH_2838|M.thermoresistible__bu GVPISRAAIAADIDALAEAWQWSPDDTLVHGLPLFHVHGLVLGLLGSLRI
Mb1225|M.bovis_AF2122/97 GVQLSRRAIAADLDALAEAWQWTAEDVLVHGLPLYHVHGLVLGLLGSLRF
Rv1193|M.tuberculosis_H37Rv GVQLSRRAIAADLDALAEAWQWTAEDVLVHGLPLYHVHGLVLGLLGSLRF
MMAR_4243|M.marinum_M GVQLSRRAIAADLDALAQAWQWNAEDVLVHGLPLYHVHGLVLGLLGSLRV
MUL_0943|M.ulcerans_Agy99 GVQLSRRAIAADLDALAQAWQWNAEDVLVHGLPLYHVHGLVLGLLGSLRV
MLBr_01051|M.leprae_Br4923 GVLLSRRAIAVDLDALAQAWQWTADDVLVHGLPLFHVHGLVLGLLGSLRI
MAV_1343|M.avium_104 GVVLSRRAIAADLDALAQAWQWTADDVLVHGLPLFHVHGLVLGLLGSLRI
MAB_1332|M.abscessus_ATCC_1997 GVRLSRRALAASLDGLADAWEWTADDVLVHGLPLFHVHGLVLGLLGSLRV
** ::* *:*..:* **.**:*..:*.******::*********:****.
Mvan_4522|M.vanbaalenii_PYR-1 GNRFVHTGKPKPAAYARAVRELGGTLLFGVPTVWSRVVEDGDAARALAPA
Mflv_2175|M.gilvum_PYR-GCK GNRFVHTGKPKPEAYAHAVSELGGTLLFGVPTVWSRIVEDGDAARALAPA
MSMEG_5114|M.smegmatis_MC2_155 GNRFVHTGKPTPERYAEAK----GTLYFGVPTVWSRVVNNLDAALALSSA
TH_2838|M.thermoresistible__bu GNRFVHTGRPTPEAYAAAG----GSLYFGVPTVWSRVVKDPSAARALSAA
Mb1225|M.bovis_AF2122/97 GNRFVHTGKPTPAGYAQACYEAHGTLFFGVPTVWSRVAADQAAAGALKPA
Rv1193|M.tuberculosis_H37Rv GNRFVHTGKPTPAGYAQACYEAHGTLFFGVPTVWSRVAADQAAAGALKPA
MMAR_4243|M.marinum_M GNRFVHTGKPTAAGYAQAG----GTLYFGVPTVWSRVAADRAAAEALRPA
MUL_0943|M.ulcerans_Agy99 GNRFVHTGKPTAAGYAQAG----GTLYFGVPTVWSRVAADRAAAEALRPA
MLBr_01051|M.leprae_Br4923 GNRFVHTGKPTPTAYAQACSEAGGSLYFGVPTVWSRLVADEAVARALRPA
MAV_1343|M.avium_104 GNRFVHTGKPTPAGYAQARTDFGGTLFFGVPTVWSRVVADEAAARALRPA
MAB_1332|M.abscessus_ATCC_1997 GNRFVHTVKPTPEAYAAAR----GSLYFGVPTVWLRVAGDESCARALSTA
******* :*.. ** * *:* ******* *:. : * ** .*
Mvan_4522|M.vanbaalenii_PYR-1 RLLVSGSAALPVPVFDGLAALSGHRAIERYGSTETLITLSTFASGERRPG
Mflv_2175|M.gilvum_PYR-GCK RLLVSGSAALPVPVFDGLAALTGHQPIERYGSTETLITLSTLVSGERRPG
MSMEG_5114|M.smegmatis_MC2_155 RLLVSGSAPLPVPVFEQLTKLTGQPPVERYGSTESLITITTLVNGERRPG
TH_2838|M.thermoresistible__bu RLLVSGSAPLPVPVFDRLAELTGHRAVERYGSTESLITLSTRVDGERRAG
Mb1225|M.bovis_AF2122/97 RLLVSGSAALPVPVFDKLVQLTGHRPVERYGASESLITLSTRADGERRPG
Rv1193|M.tuberculosis_H37Rv RLLVSGSAALPVPVFDKLVQLTGHRPVERYGASESLITLSTRADGERRPG
MMAR_4243|M.marinum_M RLLVSGSAALPVPVFDQLVHLAGHRPIERYGSSESLITLSTRADGERRAG
MUL_0943|M.ulcerans_Agy99 RLLVSGSAALPVPVFDQLVHLAGHRPIERYGSSESLITLSTRADGDRRAG
MLBr_01051|M.leprae_Br4923 RLLVSGSASLPVPVFDRLAHLTGHRPIERYGSTESLITLSTLADGERRAG
MAV_1343|M.avium_104 RLLVSGSAPLPVPVFDRLAGLTGHQPVERYGASESLITISTRADGERRPG
MAB_1332|M.abscessus_ATCC_1997 RLLVSGSAPLPVPVFDELCRLTGHAPIERYGATETVITLSTRADGERRAG
********.******: * *:*: .:****::*::**::* ..*:**.*
Mvan_4522|M.vanbaalenii_PYR-1 WVGLPLQGVTTRLVADDGTELPHDGESIGQLHVQSPTLFDGYLNRPDATA
Mflv_2175|M.gilvum_PYR-GCK WVGMALPGVQTRVVAEDGTALPHDAESIGQLHVQSPTLFDGYLNRADATA
MSMEG_5114|M.smegmatis_MC2_155 WVGVPIEGVRTRLVDENGAEVPHDGETIGRLQIKGPTVFEGYLNRPEATA
TH_2838|M.thermoresistible__bu WVGLPLAGVQTRLLDEDGAETPHDGETIGRLQVCGPMVFDGYLNRPDATA
Mb1225|M.bovis_AF2122/97 WVGLPLAGVQTRLVDDDGGEVPHDGETVGKLQVRGPTLFDGYLNQPDATA
Rv1193|M.tuberculosis_H37Rv WVGLPLAGVQTRLVDDDGGEVPHDGETVGKLQVRGPTLFDGYLNQPDATA
MMAR_4243|M.marinum_M WVGLPLAGVQTRLVDDHGNPVPHDGETVGKLQVRGSTLFDGYLNRPEATA
MUL_0943|M.ulcerans_Agy99 WVGLPLAGVQTRLVDDHGNPVPHDGETVGKLQVRGSTLFDGYLNRPEATA
MLBr_01051|M.leprae_Br4923 WVGLPLAGVQTRLVDESGGPVPYDGETVGRLQVRSPTMFGGYLNRPEATA
MAV_1343|M.avium_104 WVGLPLTGVQTRVVDDDGNPVPHDGETVGKLLVRGPMMFDGYLNRPDATA
MAB_1332|M.abscessus_ATCC_1997 WVGHPLTGVRTRLLAENGSPAAHDGETVGQLQIQGPTLFSGYHNLPEKTA
*** .: ** **:: : * .:*.*::*:* : .. :* ** * .: **
Mvan_4522|M.vanbaalenii_PYR-1 EVLGDDGWYHTGDVAVIDSSGMHRIVGRESVDLIKSGGFRIGAGEIETVL
Mflv_2175|M.gilvum_PYR-GCK EVLGEDGWYRTGDVAVIDPDGMHRIVGRESVDLIKSGGFRIGAGEIETVL
MSMEG_5114|M.smegmatis_MC2_155 EAFDDDGWFRTGDVAVIDAGGMHRIVGRESVDLIKSGGYRIGAGEIETVL
TH_2838|M.thermoresistible__bu EAFDD-GWYRTGDVAVIDDTGMHRIVGRESVDLIKTGGYRVGAGEVEAAL
Mb1225|M.bovis_AF2122/97 AAFDADSWYRTGDVAVVDGSGMHRIVGRESVDLIKSGGYRVGAGEIETVL
Rv1193|M.tuberculosis_H37Rv AAFDADSWYRTGDVAVVDGSGMHRIVGRESVDLIKSGGYRVGAGEIETVL
MMAR_4243|M.marinum_M EAFDADGWYRTGDVAVVDDGGMHRIVGRESVDLIKSGGYRIGAGEIETVL
MUL_0943|M.ulcerans_Agy99 EAFDADGWYRTGDVAVVDDGGMHRIVGRESVDLIKSGGYRIGAGEIETVL
MLBr_01051|M.leprae_Br4923 EAFDEDGWYRTGDVAVVDSGGMHRIVGRESVDLIKLGGYRIGAGEIEMAL
MAV_1343|M.avium_104 EAFDADGWYRTGDVAVVDDAGMHRIVGRESVDLIKSGGYRIGAGEIETAL
MAB_1332|M.abscessus_ATCC_1997 EVLTEDGWYRTGDVAVIDAGGMHRIVGRESVDLIKSGGYRIGAGEIETVL
.: .*::******:* *************** **:*:****:* .*
Mvan_4522|M.vanbaalenii_PYR-1 LQHAGVREAAVIGAPDADLGQRIIAFVVG--DAQPDELIDYVAQQLSVHK
Mflv_2175|M.gilvum_PYR-GCK LGHPGVREAAVIGAPDEDLGQRIVAFVVG--EAQPDELIDHVARELSVHK
MSMEG_5114|M.smegmatis_MC2_155 LGHPGVKEAAVVGVPDDDLGQRIVAYVVG--DAESDTLIDFVAKQLSVHK
TH_2838|M.thermoresistible__bu LGHPGVAEAAVVGLPDDDLGQRIVAFIVG--DAEPDELIEYVAQQLSVHK
Mb1225|M.bovis_AF2122/97 LGHPDVAEAAVVGVPDDDLGQRIVAYVVGSANVDADGLINFVAQQLSVHK
Rv1193|M.tuberculosis_H37Rv LGHPDVAEAAVVGVPDDDLGQRIVAYVVGSANVDADGLINFVAQQLSVHK
MMAR_4243|M.marinum_M LGHPEVQEAAVVGLPDEDLGQRIVAYIVGSDRIDPDVLIDFVAQQLSVHK
MUL_0943|M.ulcerans_Agy99 LGHPEVQEAAVVGLPDEDLGQRIVAYIVGSDRIDPDVLIDFVAQQLSVHK
MLBr_01051|M.leprae_Br4923 LGHPDVREVAVVGLPDEDLGQRIVAFVVGAEALDADELINYVAQQLSIHK
MAV_1343|M.avium_104 LGHPGVAEAAVVGMPDEDLGQRIVAFVVPAGRVNPDDLIDHVAQQLSIHK
MAB_1332|M.abscessus_ATCC_1997 LGHPGIVEVAVVGVPDDDLGQRIVAYVVG--DVAEDDVIGFVAQQLSVHK
* *. : *.**:* ** ******:*::* * :* .**::**:**
Mvan_4522|M.vanbaalenii_PYR-1 RPREVRVVESLPRNAMGKLLKKELAQWV
Mflv_2175|M.gilvum_PYR-GCK RPREVRIVDGLPRNAMGKVMKKELAQWV
MSMEG_5114|M.smegmatis_MC2_155 RPREVRIVDSLPRNAMGKVLKKELAQWR
TH_2838|M.thermoresistible__bu RPREVRVVDSLPRNAMGKVLKKQLR---
Mb1225|M.bovis_AF2122/97 RPREVRIVDALPRNALGKVLKKQLLSEG
Rv1193|M.tuberculosis_H37Rv RPREVRIVDALPRNALGKVLKKQLLSEG
MMAR_4243|M.marinum_M RPREVRIVESLPRNALGKVLKKQLLSEG
MUL_0943|M.ulcerans_Agy99 RPREVRIVESLPRNALGKVLKKQLLSEG
MLBr_01051|M.leprae_Br4923 RPREVRFVDALPRNAMGKVLKKQLLFEG
MAV_1343|M.avium_104 RPREVRVVDALPRNAMGKVLKKQLLSDG
MAB_1332|M.abscessus_ATCC_1997 RPREVRRVDALPRNAMGKVLKKELIT--
****** *:.*****:**::**:*