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M. thermoresistible (build 8) TH_2815 (-)

annotation: Carboxyl transferase domain protein
coordinates: 1545216 - 1546715
length: 500

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_2815--100% (500)Carboxyl transferase domain protein
M. thermoresistible (build 8)TH_4304-2e-7434.49% (519) PUTATIVE propionyl-CoA carboxylase beta chain
M. thermoresistible (build 8)TH_1608-3e-7133.53% (504) PROBABLE PROPIONYL-CoA CARBOXYLASE BETA CHAIN 4 ACCD4 (PCCASE)

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2530caccD10.083.23% (507) acetyl-/propionyl-CoA carboxylase subunit beta
M. gilvum PYR-GCKMflv_2552-0.090.58% (499) propionyl-CoA carboxylase
M. tuberculosis H37RvRv2502caccD10.083.43% (507) acetyl-/propionyl-CoA carboxylase subunit beta
M. leprae Br4923MLBr_00731accD59e-6933.53% (504) acetyl/propionyl CoA carboxylase beta subunit
M. abscessus ATCC 19977MAB_4540c-0.082.45% (507) putative acetyl-CoA carboxylase beta subunit AccD
M. marinum MMMAR_3849accD10.083.83% (507) acetyl-/propionyl-CoA carboxylase (beta subunit) AccD1
M. avium 104MAV_1670-0.084.42% (507) carboxyl transferase domain-containing protein
M. smegmatis MC2 155MSMEG_4717-0.091.38% (499) carboxyl transferase domain-containing protein
M. ulcerans Agy99MUL_4705accD21e-13750.69% (509) acetyl-/propionyl-CoA carboxylase (beta subunit) AccD2
M. vanbaalenii PYR-1Mvan_4091-0.091.18% (499) propionyl-CoA carboxylase

CLUSTAL 2.0.9 multiple sequence alignment


Mb2530c|M.bovis_AF2122/97           ---------MTTPSIAIAPSFADEHRRLVAELNNKLAAAALGGNERARKR
Rv2502c|M.tuberculosis_H37Rv        ---------MTTPSIAIAPSFADEHRRLVAELNNKLAAAALGGNERARKR
MMAR_3849|M.marinum_M               ---------MTT---IAAPSFADEHRRLVAELNTKLAAAALGGNERARER
MAV_1670|M.avium_104                -----MDKVMAAPAKAARVSFADEHRRLVGELNAKLAAAALGGNERARER
Mflv_2552|M.gilvum_PYR-GCK          --------------MAARASHRDDHVALVDQLRTKLAAAALGGSQRARER
Mvan_4091|M.vanbaalenii_PYR-1       --------------MAARASHRDSHVALVDQLRTKLAAAALGGPERARER
MSMEG_4717|M.smegmatis_MC2_155      -----------------MSSHRDEHLALVAELRSKLAAAALGGPERARER
TH_2815|M.thermoresistible__bu      -------------------------------LRSKLAAAARGGPERARER
MAB_4540c|M.abscessus_ATCC_199      -------------MTLVGEQNRAEHARLVAELRERLAHAALGGNEQSRQR
MUL_4705|M.ulcerans_Agy99           -MRVTVLRSTLDPNGAAFSEAASAATTKLDEIDAELANALAGGGPKYVDR
MLBr_00731|M.leprae_Br4923          MTSVTDHSAHSMERAAEHTINIHTTAGKLAELHKRTEEALHPVGAAAFEK
                                                                   :  .   *         .:

Mb2530c|M.bovis_AF2122/97           HVSRGKLLPRERVDRLLDPGSPFLELAPLA-----AGGMYSDESPGAGII
Rv2502c|M.tuberculosis_H37Rv        HVSRGKLLPRERVDRLLDPGSPFLELAPLA-----AGGMYGDESPGAGII
MMAR_3849|M.marinum_M               HVSRGKLLPRERVYRLLDPGSPFLELAALA-----ANGMYGDESPGAGII
MAV_1670|M.avium_104                HVSRGKLLPRERVDRLLDPGSPFLELSPLA-----ADGMYDDESPGAGII
Mflv_2552|M.gilvum_PYR-GCK          HVSRGKLLPRDRVDGLLDPGSPFLELAALA-----ADGMYDDECPGAGMI
Mvan_4091|M.vanbaalenii_PYR-1       HVSRGKLLPRDRVDGLLDPGSPFLELAALA-----ADGMYDDECPGAGMI
MSMEG_4717|M.smegmatis_MC2_155      HVGRGKLLPRDRVDGLLDPGSPFLELAPLA-----AGGMYDDECPGAGMI
TH_2815|M.thermoresistible__bu      HVSRGKLLPRDRVDGLLDPGSPFLEVAPLA-----ANGMYDDECPGAGMI
MAB_4540c|M.abscessus_ATCC_199      HVDRGKLLPRDRVDALLDPGSPFLELSPLA-----ANGMYDDDAPGASMI
MUL_4705|M.ulcerans_Agy99           HHARGKLTPRERIELLVDPDSPFLELSPLA-----AWG--SAFKVGASTV
MLBr_00731|M.leprae_Br4923          VHAKGKFTARERIYALLDDDS-FVELDALARHRSTNFGLGENRPVGDGVV
                                       :**: .*:*:  *:* .* *:*: .**       *       * . :

Mb2530c|M.bovis_AF2122/97           TGIGRVSGRQCVIVANDATVKGGTYYPMTVKKHLRAQEVALQNMLPCIYL
Rv2502c|M.tuberculosis_H37Rv        TGIGRVSGRQCVIVANDATVKGGTYYPMTVKKHLRAQEVALQNMLPCIYL
MMAR_3849|M.marinum_M               TGIGRVSGRECVIVANDATVKGGTYYPMTVKKHLRAQEVALQNLLPCIYL
MAV_1670|M.avium_104                TGIGRVSERECVIVANDATVKGGTYYPMTVKKHLRAQEVALQNRLPCIYL
Mflv_2552|M.gilvum_PYR-GCK          AGIGRVSGRECMIVANDATVKGGTYYPVTVKKHLRAQEIALQNLLPCIYL
Mvan_4091|M.vanbaalenii_PYR-1       AGIGRVSGRECMIVANDATVKGGTYYPVTVKKHLRAQEIALQNQLPCIYL
MSMEG_4717|M.smegmatis_MC2_155      AGIGRVSGRECVIVANDATVKGGTYYPITVKKHLRAQEIALQNKLPCIYL
TH_2815|M.thermoresistible__bu      TGIGRVSGRECMIVANDATVKGGTYYPVTVKKHLRAQEIAAQNHLPCIYL
MAB_4540c|M.abscessus_ATCC_199      AGIGRVAGRECVIAANDATVKGGTYYPMTVKKHLRAQEVALQNRLPCIYL
MUL_4705|M.ulcerans_Agy99           TGIGVVAGVECMIVANDPTVKGGTSNPWTLKKILRANQIAFENRLPVVSL
MLBr_00731|M.leprae_Br4923          TGYGTIDGRDVCIFSQDVTVFGGSLGEVYGEKIVKVQELAIKTGRPLIGI
                                    :* * :   :  * ::* ** **:      :* ::.:::* :.  * : :

Mb2530c|M.bovis_AF2122/97           VDSGGAFLPRQDEVFPDREHFGRIFYNQATMSAKGIPQVAAVLGSCTAGG
Rv2502c|M.tuberculosis_H37Rv        VDSGGAFLPRQDEVFPDREHFGRIFYNQATMSAKGIPQVAAVLGSCTAGG
MMAR_3849|M.marinum_M               VDSGGAFLPHQDEVFPDREHFGRIFYNQATMSAKGIPQVAAVLGSCTAGG
MAV_1670|M.avium_104                VDSGGAFLPRQDEVFPDREHFGRIFYNQATMSAKGIPQVAAVLGSCTAGG
Mflv_2552|M.gilvum_PYR-GCK          VDSGGAFLPRQDEVFPDREHFGRIFYNQATMSAKGIAQIAAVLGSCTAGG
Mvan_4091|M.vanbaalenii_PYR-1       VDSGGAFLPRQDEVFPDREHFGRIFYNQATMSAKGIAQIAAVLGSCTAGG
MSMEG_4717|M.smegmatis_MC2_155      VDSGGAFLPRQDEVFPDRDHFGRIFYNQATMSAQGIAQIAAVLGSCTAGG
TH_2815|M.thermoresistible__bu      VDSGGAFLPRQDEVFPDRDHFGRIFYNQATLSAQGIPQIAAVMGSCTAGG
MAB_4540c|M.abscessus_ATCC_199      VDSGGAFLPKQDEVFPDREHFGRIFYNQATMSAKGIPQIAAVLGSCTAGG
MUL_4705|M.ulcerans_Agy99           VESGGADLPTQKEIFIPG---GRMFRDLTRLSAAGIPTIALVFGNSTAGG
MLBr_00731|M.leprae_Br4923          NDGAGARIQEG---VVSLGLYSRIFRN-NILASGVIPQISLIMGAAAGGH
                                     :..** :      .      .*:* :   :::  *. :: ::* .:.* 

Mb2530c|M.bovis_AF2122/97           AYVPAMSDEAVIVREQGTIFLGGPPLVKAATGEIVSAEELGGGDLHSRTS
Rv2502c|M.tuberculosis_H37Rv        AYVPAMSDEAVIVREQGTIFLGGPPLVKAATGEIVSAEELGGGDLHSRTS
MMAR_3849|M.marinum_M               AYVPAMSDEAVIVREQGTIFLGGPPLVKAATGEIVTAEELGGGDLHSRVS
MAV_1670|M.avium_104                AYVPAMSDEAVIVREQGTIFLGGPPLVKAATGEVVSAEELGGGDLHSRIS
Mflv_2552|M.gilvum_PYR-GCK          AYVPAMSDEAVIVRNQGTIFLGGPPLVKAATGEVVTAEDLGGGDLHSKVS
Mvan_4091|M.vanbaalenii_PYR-1       AYVPAMSDEAVIVRNQGTIFLGGPPLVKAATGEIVTAEELGGGDLHSKVS
MSMEG_4717|M.smegmatis_MC2_155      AYVPAMSDEAVIVRNQGTIFLGGPPLVKAATGEVVTAEELGGGDLHSKTS
TH_2815|M.thermoresistible__bu      AYVPAMSDEAVIVRNQGTIFLGGPPLVRAATGEVVTAEELGGGDLHAKTS
MAB_4540c|M.abscessus_ATCC_199      AYVPAMSDEAVIVRKQGTIFLGGPPLVKAATGEVVTAEELGGGDLHSRTS
MUL_4705|M.ulcerans_Agy99           AYVPGMSDHVVMIKERSKVFLAGPPLVKMATGEESDDESLGGAEMHARIS
MLBr_00731|M.leprae_Br4923          VYSPALTDFVVMVDQTSQMFITGPDVIKTVTGEDVTMEELGGAHTHMAKS
                                    .* *.::* .*:: : . :*: ** ::: .***    *.***.. *   *

Mb2530c|M.bovis_AF2122/97           GVTDHLADDDEDALRIVRAIADTFGPCEPAQWDVRRSVEPK--------Y
Rv2502c|M.tuberculosis_H37Rv        GVTDHLADDDEDALRIVRAIADTFGPCEPAQWDVRRSVEPK--------Y
MMAR_3849|M.marinum_M               GVTDHLADDDEDALRIVRAIAATFGPREPAQWEIGPSVEPK--------H
MAV_1670|M.avium_104                GVTDHLADDDEHALRIVRSIAATFGPREPSPWQVRTPLPPK--------A
Mflv_2552|M.gilvum_PYR-GCK          GVTDHLAHDDRDALRIVRRIVGTLAPKAAPPWDVAPPVDAV--------A
Mvan_4091|M.vanbaalenii_PYR-1       GVTDHLAHDDRDALRIVRRIVGTLAPKADPPWEVAPTVDAV--------A
MSMEG_4717|M.smegmatis_MC2_155      GVTDHLAHDDRDALRIVRNIVATLGPAEPPPWQVLPAVDPI--------A
TH_2815|M.thermoresistible__bu      GVTDHLAHDDRDALRIVRRIVATLGPRHPSPWEIAPTVDPV--------A
MAB_4540c|M.abscessus_ATCC_199      GVTDHLAADDKDALRIVRRIVSTLAPRTESPWPVVEAIAPE--------R
MUL_4705|M.ulcerans_Agy99           GLADYFAVDEFDAIRIGRRIVARLNWVKQGP-APAPVTEPL--------F
MLBr_00731|M.leprae_Br4923          GTAHYVASGEQDAFDWVRDVLSYLPSNNFTDAPRYSKPVPHGSIEDNLTA
                                    * :.:.* .: .*:   * :   :               .          

Mb2530c|M.bovis_AF2122/97           PQAELYDVVPPDPRVPYDVHEVVVRIVDGSEFSEFKAKYGKTLVTAFARV
Rv2502c|M.tuberculosis_H37Rv        PQAELYDVVPPDPRVPYDVHEVVVRIVDGSEFSEFKAKYGKTLVTAFARV
MMAR_3849|M.marinum_M               AQTELYDVVPPDPRVPYDVHDVIVRLVDGGEFSEFKANYGKSLVTGFARI
MAV_1670|M.avium_104                AQNELYDVVPPDPRVPYDVHEVIVRLVDGGEFSEFKANYGKTLVTGFAHI
Mflv_2552|M.gilvum_PYR-GCK          DQTELYDVVPVDSRVPYDVHEVITRIVDGGDFAEFKAAYGTTLVTGFARI
Mvan_4091|M.vanbaalenii_PYR-1       DQAELYDVVPVDSRVPYDVHEVITRIVDGGEFAEFKAEYGTTLVTGFARI
MSMEG_4717|M.smegmatis_MC2_155      DQTELYDVVPVDARVPYDVHEVITRIVDGGEFGEFKAEYGTTLVTGFARI
TH_2815|M.thermoresistible__bu      DQTELYDVVPVDPRIPYDVHEVVDRIVDGGDFAEFKAEYGATLVTGFARI
MAB_4540c|M.abscessus_ATCC_199      DPGTLYDVVPTDPRIPYDVHEVIVRLVDGGTFTEFKAEYGKSVVTGTARL
MUL_4705|M.ulcerans_Agy99           DAEELIGIVPSDLRVPFEPREVIARIVDGSEFDEFKPLYGSSLVTGWARL
MLBr_00731|M.leprae_Br4923          KDLELDTLIPDSPNQPYDMHEVVTRLLDEEEFLEVQAGYATNIVVGLGRI
                                        *  ::* . . *:: ::*: *::*   * *.:. *. .:*.. .::

Mb2530c|M.bovis_AF2122/97           HGHPVGIVANN-----GVLLSESALKGAHFIELCDKRKIPLLFLQNIAGF
Rv2502c|M.tuberculosis_H37Rv        HGHPVGIVANN-----GVLFSESALKGAHFIELCDKRKIPLLFLQNIAGF
MMAR_3849|M.marinum_M               HGHPVGIIANN-----GVLFSESAVKGAHFIELCDKRKTPLLFLQNIAGF
MAV_1670|M.avium_104                HGHPVGIVANN-----GVLFSESALKGAHFIELCDKRKVPLLFLQNIAGF
Mflv_2552|M.gilvum_PYR-GCK          HGHPVGIVANN-----GVLFGESAVKGAHFIELCDKRNTPLLFLQNISGF
Mvan_4091|M.vanbaalenii_PYR-1       HGHPVGIVANN-----GVLFGESAVKGAHFIELCDKRVVPLLFLQNISGF
MSMEG_4717|M.smegmatis_MC2_155      HGHPVGIIANN-----GVLFGESAVKGAHFIELCDKRKTPLLFLQNISGF
TH_2815|M.thermoresistible__bu      HGHPVGIIANN-----GVLFSESALKGAHFIELCDKRKIPLLFLQNISGF
MAB_4540c|M.abscessus_ATCC_199      HGHPVGIIANN-----GVLFAESAMKAAHFIELCDQRRIPLLFLQNISGF
MUL_4705|M.ulcerans_Agy99           HGYPVGILANAR----GVLFSEESQKATQFIQLANRADTPLLFLHNTTGY
MLBr_00731|M.leprae_Br4923          DDRPVGIVANQPIQFAGCLDINASEKAARFVRVCDCFNIPIVMLVDVPGF
                                    .. ****:**      * *  : : *.::*:.:.:    *:::* : .*:

Mb2530c|M.bovis_AF2122/97           MVGRDYEAGGIAKHGAKMVTAVACARVPKLTVVIGGSYGAGNYSMCGRAY
Rv2502c|M.tuberculosis_H37Rv        MVGRDYEAGGIAKHGAKMVTAVACARVPKLTVVIGGSYGAGNYSMCGRAY
MMAR_3849|M.marinum_M               MVGRDYEAGGIAKHGAKMVTAVACARVPKLTVVIGGSYGAGNYSMCGRAY
MAV_1670|M.avium_104                MVGRDYEAGGIAKHGAKMVTAVACARVPKLTVVIGGSYGAGNYSMCGRAY
Mflv_2552|M.gilvum_PYR-GCK          MVGRDYEAGGIAKHGAKMVTAVACARVPKLTVVIGGSYGAGNYSMCGRAY
Mvan_4091|M.vanbaalenii_PYR-1       MVGRDYEAGGIAKHGAKMVTAVACARVPKLTVVIGGSYGAGNYSMCGRAY
MSMEG_4717|M.smegmatis_MC2_155      MVGRDYEAGGIAKHGAKMVTAVACARVPKLTVVIGGSYGAGNYSMCGRAY
TH_2815|M.thermoresistible__bu      MVGREYEAGGIAKHGAKMVTAVACARVPKLTVVIGGSYGAGNYSMCGRAY
MAB_4540c|M.abscessus_ATCC_199      MVGRDYEAAGIAKHGAKMVTAVACARVPKLTVVIGGSYGAGNYSMCGRAY
MUL_4705|M.ulcerans_Agy99           MVGKDYEEGGMIKHASMMINAVSNSKVPHISLLLGASYGAGHYGMCGRAY
MLBr_00731|M.leprae_Br4923          LPGTEQEYDGIIRRGAKLLFAYGEATVPKITVITRKAYGGAYCVMGSKNM
                                    : * : *  *: ::.: :: * . : **:::::   :**..   * .:  

Mb2530c|M.bovis_AF2122/97           SPRFLWMWPNARISVMGGEQAASVLATVRGEQLSAAGTPWSPDEEEAFKA
Rv2502c|M.tuberculosis_H37Rv        SPRFLWMWPNARISVMGGEQAASVLATVRGEQLSAAGTPWSPDEEEAFKA
MMAR_3849|M.marinum_M               SPRFMWMWPNARISVMGGEQAASVLATVRGEQLSASGKPWSSDEEEQFKA
MAV_1670|M.avium_104                SPRFLWMWPNARISVMGGEQAASVLATVRGEQLTAAGKPWSAEEEEAFKA
Mflv_2552|M.gilvum_PYR-GCK          SPRFLWMWPNARISVMGGEQAASVLATVRGD--------MTPEEEEAFKA
Mvan_4091|M.vanbaalenii_PYR-1       SPRFLWMWPNARISVMGGEQAASVLATVRGD--------MTPDEEEAFKA
MSMEG_4717|M.smegmatis_MC2_155      SPRFLWMWPNARISVMGGEQAASVLATVRGE--------MTDAEAEEFKA
TH_2815|M.thermoresistible__bu      SPRFLWMWPNARISVMGGEQAASVLATVRGD--------MTPEEEEAFKV
MAB_4540c|M.abscessus_ATCC_199      SPRFLWMWPNARISVMGGEQAASVLATVRADQSAASGKKFTEAEQEAFKA
MUL_4705|M.ulcerans_Agy99           DPRFLFAWPSAKSAVMGGAQLSGVLSIVARAAAEARGQQVDEAADAAMRA
MLBr_00731|M.leprae_Br4923          GCDVNLAWPTAQIAVMGASGAVGFVYRKELAQAAKNG-----ANVDELRL
                                    .  .   **.*: :***.    ..:                      :: 

Mb2530c|M.bovis_AF2122/97           PIRAQYEDQGN-PYYSTARLWDDGIIDPADTRTVVGLALSLCAHAPLDQV
Rv2502c|M.tuberculosis_H37Rv        PIRAQYEDQGN-PYYSTARLWDDGIIDPADTRTVVGLALSLCAHAPLDQV
MMAR_3849|M.marinum_M               PIREQYENQGN-PYYSTARLWDDGIIDPADTRTVVGLALSVCAHAPLESV
MAV_1670|M.avium_104                PIRAQYEDQGN-PYYSTARLWDDGIIDPADTRTFVGLALSVCAQAPLEPV
Mflv_2552|M.gilvum_PYR-GCK          PIRAQYESQGN-PYYSTARLWDDGVIDPADTRDVVGLALSVTGQAPLEPV
Mvan_4091|M.vanbaalenii_PYR-1       PIRAQYEDQGN-PYYSTARLWDDGVIDPADTRTVVGLALSVTAQAPLEPV
MSMEG_4717|M.smegmatis_MC2_155      PIREQYEHQGN-PYYSTARLWDDGVIDPADTRTVVGLALSVVGQAPLEPV
TH_2815|M.thermoresistible__bu      PIRQQYEDQGN-PYYSTARLWDDGVIDPADTRTVVGLALSIVGQAPLEPV
MAB_4540c|M.abscessus_ATCC_199      PIREQYEQQGN-PYYSTARLWDDGVIDPADTRTVLGLALGICANAPLEPV
MUL_4705|M.ulcerans_Agy99           AVDGQIEAESL-PLVLSGMLYDDGVIDPRDTRTVLGMCLSAIANGPIKGT
MLBr_00731|M.leprae_Br4923          QLQQEYEDTLVNPYIAAERGYVDAVIPPSHTRGYIATALHLLERKIAHLP
                                     :  : *     *   :   : *.:* * .**  :. .*    .   .  

Mb2530c|M.bovis_AF2122/97           G--YGVFRM
Rv2502c|M.tuberculosis_H37Rv        G--YGVFRM
MMAR_3849|M.marinum_M               S--YGVFRM
MAV_1670|M.avium_104                G--YGVFRM
Mflv_2552|M.gilvum_PYR-GCK          S--YGVFRM
Mvan_4091|M.vanbaalenii_PYR-1       S--YGVFRM
MSMEG_4717|M.smegmatis_MC2_155      S--YGVFRM
TH_2815|M.thermoresistible__bu      S--YGVFRM
MAB_4540c|M.abscessus_ATCC_199      S--YGVFRM
MUL_4705|M.ulcerans_Agy99           SN-FGVFRM
MLBr_00731|M.leprae_Br4923          PKKHGNIPL
                                       .* : :