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TTPSIAIAPSFADEHRRLVAELNNKLAAAALGGNERARKRHVSRGKLLPRERVDRLLDPGSPFLELAPLA AGGMYGDESPGAGIITGIGRVSGRQCVIVANDATVKGGTYYPMTVKKHLRAQEVALQNMLPCIYLVDSGG AFLPRQDEVFPDREHFGRIFYNQATMSAKGIPQVAAVLGSCTAGGAYVPAMSDEAVIVREQGTIFLGGPP LVKAATGEIVSAEELGGGDLHSRTSGVTDHLADDDEDALRIVRAIADTFGPCEPAQWDVRRSVEPKYPQA ELYDVVPPDPRVPYDVHEVVVRIVDGSEFSEFKAKYGKTLVTAFARVHGHPVGIVANNGVLFSESALKGA HFIELCDKRKIPLLFLQNIAGFMVGRDYEAGGIAKHGAKMVTAVACARVPKLTVVIGGSYGAGNYSMCGR AYSPRFLWMWPNARISVMGGEQAASVLATVRGEQLSAAGTPWSPDEEEAFKAPIRAQYEDQGNPYYSTAR LWDDGIIDPADTRTVVGLALSLCAHAPLDQVGYGVFRM*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2502c | accD1 | - | 100% (529) | PROBABLE ACETYL-/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD1 |
| M. tuberculosis H37Rv | Rv0974c | accD2 | e-137 | 50.00% (512) | acetyl-/propionyl-CoA carboxylase subunit beta |
| M. tuberculosis H37Rv | Rv3280 | accD5 | 4e-69 | 33.53% (513) | propionyl-CoA carboxylase beta chain |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2530c | accD1 | 0.0 | 99.62% (529) | acetyl-/propionyl-CoA carboxylase subunit beta |
| M. gilvum PYR-GCK | Mflv_2552 | - | 0.0 | 81.68% (524) | propionyl-CoA carboxylase |
| M. leprae Br4923 | MLBr_00731 | accD5 | 2e-65 | 32.95% (522) | acetyl/propionyl CoA carboxylase beta subunit |
| M. abscessus ATCC 19977 | MAB_4540c | - | 0.0 | 81.55% (515) | putative acetyl-CoA carboxylase beta subunit AccD |
| M. marinum M | MMAR_3849 | accD1 | 0.0 | 92.13% (521) | acetyl-/propionyl-CoA carboxylase (beta subunit) AccD1 |
| M. avium 104 | MAV_1670 | - | 0.0 | 90.55% (529) | carboxyl transferase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_4717 | - | 0.0 | 84.01% (519) | carboxyl transferase domain-containing protein |
| M. thermoresistible (build 8) | TH_2815 | - | 0.0 | 83.43% (507) | PUTATIVE Carboxyl transferase domain protein |
| M. ulcerans Agy99 | MUL_4705 | accD2 | 1e-136 | 49.80% (512) | acetyl-/propionyl-CoA carboxylase (beta subunit) AccD2 |
| M. vanbaalenii PYR-1 | Mvan_4091 | - | 0.0 | 83.21% (524) | propionyl-CoA carboxylase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2502c|M.tuberculosis_H37Rv ---------MTTPSIAIAPSFADEHRRLVAELNNKLAAAALGGNERARKR
Mb2530c|M.bovis_AF2122/97 ---------MTTPSIAIAPSFADEHRRLVAELNNKLAAAALGGNERARKR
MMAR_3849|M.marinum_M ---------MTT---IAAPSFADEHRRLVAELNTKLAAAALGGNERARER
MAV_1670|M.avium_104 -----MDKVMAAPAKAARVSFADEHRRLVGELNAKLAAAALGGNERARER
Mflv_2552|M.gilvum_PYR-GCK --------------MAARASHRDDHVALVDQLRTKLAAAALGGSQRARER
Mvan_4091|M.vanbaalenii_PYR-1 --------------MAARASHRDSHVALVDQLRTKLAAAALGGPERARER
MSMEG_4717|M.smegmatis_MC2_155 -----------------MSSHRDEHLALVAELRSKLAAAALGGPERARER
TH_2815|M.thermoresistible__bu -------------------------------LRSKLAAAARGGPERARER
MAB_4540c|M.abscessus_ATCC_199 -------------MTLVGEQNRAEHARLVAELRERLAHAALGGNEQSRQR
MUL_4705|M.ulcerans_Agy99 -MRVTVLRSTLDPNGAAFSEAASAATTKLDEIDAELANALAGGGPKYVDR
MLBr_00731|M.leprae_Br4923 MTSVTDHSAHSMERAAEHTINIHTTAGKLAELHKRTEEALHPVGAAAFEK
: . * .:
Rv2502c|M.tuberculosis_H37Rv HVSRGKLLPRERVDRLLDPGSPFLELAPLA-----AGGMYGDESPGAGII
Mb2530c|M.bovis_AF2122/97 HVSRGKLLPRERVDRLLDPGSPFLELAPLA-----AGGMYSDESPGAGII
MMAR_3849|M.marinum_M HVSRGKLLPRERVYRLLDPGSPFLELAALA-----ANGMYGDESPGAGII
MAV_1670|M.avium_104 HVSRGKLLPRERVDRLLDPGSPFLELSPLA-----ADGMYDDESPGAGII
Mflv_2552|M.gilvum_PYR-GCK HVSRGKLLPRDRVDGLLDPGSPFLELAALA-----ADGMYDDECPGAGMI
Mvan_4091|M.vanbaalenii_PYR-1 HVSRGKLLPRDRVDGLLDPGSPFLELAALA-----ADGMYDDECPGAGMI
MSMEG_4717|M.smegmatis_MC2_155 HVGRGKLLPRDRVDGLLDPGSPFLELAPLA-----AGGMYDDECPGAGMI
TH_2815|M.thermoresistible__bu HVSRGKLLPRDRVDGLLDPGSPFLEVAPLA-----ANGMYDDECPGAGMI
MAB_4540c|M.abscessus_ATCC_199 HVDRGKLLPRDRVDALLDPGSPFLELSPLA-----ANGMYDDDAPGASMI
MUL_4705|M.ulcerans_Agy99 HHARGKLTPRERIELLVDPDSPFLELSPLA-----AWG--SAFKVGASTV
MLBr_00731|M.leprae_Br4923 VHAKGKFTARERIYALLDDDS-FVELDALARHRSTNFGLGENRPVGDGVV
:**: .*:*: *:* .* *:*: .** * * . :
Rv2502c|M.tuberculosis_H37Rv TGIGRVSGRQCVIVANDATVKGGTYYPMTVKKHLRAQEVALQNMLPCIYL
Mb2530c|M.bovis_AF2122/97 TGIGRVSGRQCVIVANDATVKGGTYYPMTVKKHLRAQEVALQNMLPCIYL
MMAR_3849|M.marinum_M TGIGRVSGRECVIVANDATVKGGTYYPMTVKKHLRAQEVALQNLLPCIYL
MAV_1670|M.avium_104 TGIGRVSERECVIVANDATVKGGTYYPMTVKKHLRAQEVALQNRLPCIYL
Mflv_2552|M.gilvum_PYR-GCK AGIGRVSGRECMIVANDATVKGGTYYPVTVKKHLRAQEIALQNLLPCIYL
Mvan_4091|M.vanbaalenii_PYR-1 AGIGRVSGRECMIVANDATVKGGTYYPVTVKKHLRAQEIALQNQLPCIYL
MSMEG_4717|M.smegmatis_MC2_155 AGIGRVSGRECVIVANDATVKGGTYYPITVKKHLRAQEIALQNKLPCIYL
TH_2815|M.thermoresistible__bu TGIGRVSGRECMIVANDATVKGGTYYPVTVKKHLRAQEIAAQNHLPCIYL
MAB_4540c|M.abscessus_ATCC_199 AGIGRVAGRECVIAANDATVKGGTYYPMTVKKHLRAQEVALQNRLPCIYL
MUL_4705|M.ulcerans_Agy99 TGIGVVAGVECMIVANDPTVKGGTSNPWTLKKILRANQIAFENRLPVVSL
MLBr_00731|M.leprae_Br4923 TGYGTIDGRDVCIFSQDVTVFGGSLGEVYGEKIVKVQELAIKTGRPLIGI
:* * : : * ::* ** **: :* ::.:::* :. * : :
Rv2502c|M.tuberculosis_H37Rv VDSGGAFLPRQDEVFPDREHFGRIFYNQATMSAKGIPQVAAVLGSCTAGG
Mb2530c|M.bovis_AF2122/97 VDSGGAFLPRQDEVFPDREHFGRIFYNQATMSAKGIPQVAAVLGSCTAGG
MMAR_3849|M.marinum_M VDSGGAFLPHQDEVFPDREHFGRIFYNQATMSAKGIPQVAAVLGSCTAGG
MAV_1670|M.avium_104 VDSGGAFLPRQDEVFPDREHFGRIFYNQATMSAKGIPQVAAVLGSCTAGG
Mflv_2552|M.gilvum_PYR-GCK VDSGGAFLPRQDEVFPDREHFGRIFYNQATMSAKGIAQIAAVLGSCTAGG
Mvan_4091|M.vanbaalenii_PYR-1 VDSGGAFLPRQDEVFPDREHFGRIFYNQATMSAKGIAQIAAVLGSCTAGG
MSMEG_4717|M.smegmatis_MC2_155 VDSGGAFLPRQDEVFPDRDHFGRIFYNQATMSAQGIAQIAAVLGSCTAGG
TH_2815|M.thermoresistible__bu VDSGGAFLPRQDEVFPDRDHFGRIFYNQATLSAQGIPQIAAVMGSCTAGG
MAB_4540c|M.abscessus_ATCC_199 VDSGGAFLPKQDEVFPDREHFGRIFYNQATMSAKGIPQIAAVLGSCTAGG
MUL_4705|M.ulcerans_Agy99 VESGGADLPTQKEIFIPG---GRMFRDLTRLSAAGIPTIALVFGNSTAGG
MLBr_00731|M.leprae_Br4923 NDGAGARIQEG---VVSLGLYSRIFRN-NILASGVIPQISLIMGAAAGGH
:..** : . .*:* : ::: *. :: ::* .:.*
Rv2502c|M.tuberculosis_H37Rv AYVPAMSDEAVIVREQGTIFLGGPPLVKAATGEIVSAEELGGGDLHSRTS
Mb2530c|M.bovis_AF2122/97 AYVPAMSDEAVIVREQGTIFLGGPPLVKAATGEIVSAEELGGGDLHSRTS
MMAR_3849|M.marinum_M AYVPAMSDEAVIVREQGTIFLGGPPLVKAATGEIVTAEELGGGDLHSRVS
MAV_1670|M.avium_104 AYVPAMSDEAVIVREQGTIFLGGPPLVKAATGEVVSAEELGGGDLHSRIS
Mflv_2552|M.gilvum_PYR-GCK AYVPAMSDEAVIVRNQGTIFLGGPPLVKAATGEVVTAEDLGGGDLHSKVS
Mvan_4091|M.vanbaalenii_PYR-1 AYVPAMSDEAVIVRNQGTIFLGGPPLVKAATGEIVTAEELGGGDLHSKVS
MSMEG_4717|M.smegmatis_MC2_155 AYVPAMSDEAVIVRNQGTIFLGGPPLVKAATGEVVTAEELGGGDLHSKTS
TH_2815|M.thermoresistible__bu AYVPAMSDEAVIVRNQGTIFLGGPPLVRAATGEVVTAEELGGGDLHAKTS
MAB_4540c|M.abscessus_ATCC_199 AYVPAMSDEAVIVRKQGTIFLGGPPLVKAATGEVVTAEELGGGDLHSRTS
MUL_4705|M.ulcerans_Agy99 AYVPGMSDHVVMIKERSKVFLAGPPLVKMATGEESDDESLGGAEMHARIS
MLBr_00731|M.leprae_Br4923 VYSPALTDFVVMVDQTSQMFITGPDVIKTVTGEDVTMEELGGAHTHMAKS
.* *.::* .*:: : . :*: ** ::: .*** *.***.. * *
Rv2502c|M.tuberculosis_H37Rv GVTDHLADDDEDALRIVRAIADTFGPCEPAQWDVRRSVEPK--------Y
Mb2530c|M.bovis_AF2122/97 GVTDHLADDDEDALRIVRAIADTFGPCEPAQWDVRRSVEPK--------Y
MMAR_3849|M.marinum_M GVTDHLADDDEDALRIVRAIAATFGPREPAQWEIGPSVEPK--------H
MAV_1670|M.avium_104 GVTDHLADDDEHALRIVRSIAATFGPREPSPWQVRTPLPPK--------A
Mflv_2552|M.gilvum_PYR-GCK GVTDHLAHDDRDALRIVRRIVGTLAPKAAPPWDVAPPVDAV--------A
Mvan_4091|M.vanbaalenii_PYR-1 GVTDHLAHDDRDALRIVRRIVGTLAPKADPPWEVAPTVDAV--------A
MSMEG_4717|M.smegmatis_MC2_155 GVTDHLAHDDRDALRIVRNIVATLGPAEPPPWQVLPAVDPI--------A
TH_2815|M.thermoresistible__bu GVTDHLAHDDRDALRIVRRIVATLGPRHPSPWEIAPTVDPV--------A
MAB_4540c|M.abscessus_ATCC_199 GVTDHLAADDKDALRIVRRIVSTLAPRTESPWPVVEAIAPE--------R
MUL_4705|M.ulcerans_Agy99 GLADYFAVDEFDAIRIGRRIVARLNWVKQGP-APAPVTEPL--------F
MLBr_00731|M.leprae_Br4923 GTAHYVASGEQDAFDWVRDVLSYLPSNNFTDAPRYSKPVPHGSIEDNLTA
* :.:.* .: .*: * : : .
Rv2502c|M.tuberculosis_H37Rv PQAELYDVVPPDPRVPYDVHEVVVRIVDGSEFSEFKAKYGKTLVTAFARV
Mb2530c|M.bovis_AF2122/97 PQAELYDVVPPDPRVPYDVHEVVVRIVDGSEFSEFKAKYGKTLVTAFARV
MMAR_3849|M.marinum_M AQTELYDVVPPDPRVPYDVHDVIVRLVDGGEFSEFKANYGKSLVTGFARI
MAV_1670|M.avium_104 AQNELYDVVPPDPRVPYDVHEVIVRLVDGGEFSEFKANYGKTLVTGFAHI
Mflv_2552|M.gilvum_PYR-GCK DQTELYDVVPVDSRVPYDVHEVITRIVDGGDFAEFKAAYGTTLVTGFARI
Mvan_4091|M.vanbaalenii_PYR-1 DQAELYDVVPVDSRVPYDVHEVITRIVDGGEFAEFKAEYGTTLVTGFARI
MSMEG_4717|M.smegmatis_MC2_155 DQTELYDVVPVDARVPYDVHEVITRIVDGGEFGEFKAEYGTTLVTGFARI
TH_2815|M.thermoresistible__bu DQTELYDVVPVDPRIPYDVHEVVDRIVDGGDFAEFKAEYGATLVTGFARI
MAB_4540c|M.abscessus_ATCC_199 DPGTLYDVVPTDPRIPYDVHEVIVRLVDGGTFTEFKAEYGKSVVTGTARL
MUL_4705|M.ulcerans_Agy99 DAEELIGIVPSDLRVPFEPREVIARIVDGSEFDEFKPLYGSSLVTGWARL
MLBr_00731|M.leprae_Br4923 KDLELDTLIPDSPNQPYDMHEVVTRLLDEEEFLEVQAGYATNIVVGLGRI
* ::* . . *:: ::*: *::* * *.:. *. .:*.. .::
Rv2502c|M.tuberculosis_H37Rv HGHPVGIVANN-----GVLFSESALKGAHFIELCDKRKIPLLFLQNIAGF
Mb2530c|M.bovis_AF2122/97 HGHPVGIVANN-----GVLLSESALKGAHFIELCDKRKIPLLFLQNIAGF
MMAR_3849|M.marinum_M HGHPVGIIANN-----GVLFSESAVKGAHFIELCDKRKTPLLFLQNIAGF
MAV_1670|M.avium_104 HGHPVGIVANN-----GVLFSESALKGAHFIELCDKRKVPLLFLQNIAGF
Mflv_2552|M.gilvum_PYR-GCK HGHPVGIVANN-----GVLFGESAVKGAHFIELCDKRNTPLLFLQNISGF
Mvan_4091|M.vanbaalenii_PYR-1 HGHPVGIVANN-----GVLFGESAVKGAHFIELCDKRVVPLLFLQNISGF
MSMEG_4717|M.smegmatis_MC2_155 HGHPVGIIANN-----GVLFGESAVKGAHFIELCDKRKTPLLFLQNISGF
TH_2815|M.thermoresistible__bu HGHPVGIIANN-----GVLFSESALKGAHFIELCDKRKIPLLFLQNISGF
MAB_4540c|M.abscessus_ATCC_199 HGHPVGIIANN-----GVLFAESAMKAAHFIELCDQRRIPLLFLQNISGF
MUL_4705|M.ulcerans_Agy99 HGYPVGILANAR----GVLFSEESQKATQFIQLANRADTPLLFLHNTTGY
MLBr_00731|M.leprae_Br4923 DDRPVGIVANQPIQFAGCLDINASEKAARFVRVCDCFNIPIVMLVDVPGF
.. ****:** * * : : *.::*:.:.: *:::* : .*:
Rv2502c|M.tuberculosis_H37Rv MVGRDYEAGGIAKHGAKMVTAVACARVPKLTVVIGGSYGAGNYSMCGRAY
Mb2530c|M.bovis_AF2122/97 MVGRDYEAGGIAKHGAKMVTAVACARVPKLTVVIGGSYGAGNYSMCGRAY
MMAR_3849|M.marinum_M MVGRDYEAGGIAKHGAKMVTAVACARVPKLTVVIGGSYGAGNYSMCGRAY
MAV_1670|M.avium_104 MVGRDYEAGGIAKHGAKMVTAVACARVPKLTVVIGGSYGAGNYSMCGRAY
Mflv_2552|M.gilvum_PYR-GCK MVGRDYEAGGIAKHGAKMVTAVACARVPKLTVVIGGSYGAGNYSMCGRAY
Mvan_4091|M.vanbaalenii_PYR-1 MVGRDYEAGGIAKHGAKMVTAVACARVPKLTVVIGGSYGAGNYSMCGRAY
MSMEG_4717|M.smegmatis_MC2_155 MVGRDYEAGGIAKHGAKMVTAVACARVPKLTVVIGGSYGAGNYSMCGRAY
TH_2815|M.thermoresistible__bu MVGREYEAGGIAKHGAKMVTAVACARVPKLTVVIGGSYGAGNYSMCGRAY
MAB_4540c|M.abscessus_ATCC_199 MVGRDYEAAGIAKHGAKMVTAVACARVPKLTVVIGGSYGAGNYSMCGRAY
MUL_4705|M.ulcerans_Agy99 MVGKDYEEGGMIKHASMMINAVSNSKVPHISLLLGASYGAGHYGMCGRAY
MLBr_00731|M.leprae_Br4923 LPGTEQEYDGIIRRGAKLLFAYGEATVPKITVITRKAYGGAYCVMGSKNM
: * : * *: ::.: :: * . : **::::: :**.. * .:
Rv2502c|M.tuberculosis_H37Rv SPRFLWMWPNARISVMGGEQAASVLATVRGEQLSAAGTPWSPDEEEAFKA
Mb2530c|M.bovis_AF2122/97 SPRFLWMWPNARISVMGGEQAASVLATVRGEQLSAAGTPWSPDEEEAFKA
MMAR_3849|M.marinum_M SPRFMWMWPNARISVMGGEQAASVLATVRGEQLSASGKPWSSDEEEQFKA
MAV_1670|M.avium_104 SPRFLWMWPNARISVMGGEQAASVLATVRGEQLTAAGKPWSAEEEEAFKA
Mflv_2552|M.gilvum_PYR-GCK SPRFLWMWPNARISVMGGEQAASVLATVRGD--------MTPEEEEAFKA
Mvan_4091|M.vanbaalenii_PYR-1 SPRFLWMWPNARISVMGGEQAASVLATVRGD--------MTPDEEEAFKA
MSMEG_4717|M.smegmatis_MC2_155 SPRFLWMWPNARISVMGGEQAASVLATVRGE--------MTDAEAEEFKA
TH_2815|M.thermoresistible__bu SPRFLWMWPNARISVMGGEQAASVLATVRGD--------MTPEEEEAFKV
MAB_4540c|M.abscessus_ATCC_199 SPRFLWMWPNARISVMGGEQAASVLATVRADQSAASGKKFTEAEQEAFKA
MUL_4705|M.ulcerans_Agy99 DPRFLFAWPSAKSAVMGGAQLSGVLSIVARAAAEARGQQVDEAADAAMRA
MLBr_00731|M.leprae_Br4923 GCDVNLAWPTAQIAVMGASGAVGFVYRKELAQAAKNG-----ANVDELRL
. . **.*: :***. ..: ::
Rv2502c|M.tuberculosis_H37Rv PIRAQYEDQGN-PYYSTARLWDDGIIDPADTRTVVGLALSLCAHAPLDQV
Mb2530c|M.bovis_AF2122/97 PIRAQYEDQGN-PYYSTARLWDDGIIDPADTRTVVGLALSLCAHAPLDQV
MMAR_3849|M.marinum_M PIREQYENQGN-PYYSTARLWDDGIIDPADTRTVVGLALSVCAHAPLESV
MAV_1670|M.avium_104 PIRAQYEDQGN-PYYSTARLWDDGIIDPADTRTFVGLALSVCAQAPLEPV
Mflv_2552|M.gilvum_PYR-GCK PIRAQYESQGN-PYYSTARLWDDGVIDPADTRDVVGLALSVTGQAPLEPV
Mvan_4091|M.vanbaalenii_PYR-1 PIRAQYEDQGN-PYYSTARLWDDGVIDPADTRTVVGLALSVTAQAPLEPV
MSMEG_4717|M.smegmatis_MC2_155 PIREQYEHQGN-PYYSTARLWDDGVIDPADTRTVVGLALSVVGQAPLEPV
TH_2815|M.thermoresistible__bu PIRQQYEDQGN-PYYSTARLWDDGVIDPADTRTVVGLALSIVGQAPLEPV
MAB_4540c|M.abscessus_ATCC_199 PIREQYEQQGN-PYYSTARLWDDGVIDPADTRTVLGLALGICANAPLEPV
MUL_4705|M.ulcerans_Agy99 AVDGQIEAESL-PLVLSGMLYDDGVIDPRDTRTVLGMCLSAIANGPIKGT
MLBr_00731|M.leprae_Br4923 QLQQEYEDTLVNPYIAAERGYVDAVIPPSHTRGYIATALHLLERKIAHLP
: : * * : : *.:* * .** :. .* . .
Rv2502c|M.tuberculosis_H37Rv G--YGVFRM
Mb2530c|M.bovis_AF2122/97 G--YGVFRM
MMAR_3849|M.marinum_M S--YGVFRM
MAV_1670|M.avium_104 G--YGVFRM
Mflv_2552|M.gilvum_PYR-GCK S--YGVFRM
Mvan_4091|M.vanbaalenii_PYR-1 S--YGVFRM
MSMEG_4717|M.smegmatis_MC2_155 S--YGVFRM
TH_2815|M.thermoresistible__bu S--YGVFRM
MAB_4540c|M.abscessus_ATCC_199 S--YGVFRM
MUL_4705|M.ulcerans_Agy99 SN-FGVFRM
MLBr_00731|M.leprae_Br4923 PKKHGNIPL
.* : :