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M. thermoresistible (build 8) TH_2810 (-)

annotation: Triacylglycerol lipase
coordinates: 1688390 - 1690264
length: 625

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_2810--100% (625)Triacylglycerol lipase
M. thermoresistible (build 8)TH_3043-4e-2925.81% (399) PUTATIVE Triacylglycerol lipase
M. thermoresistible (build 8)TH_0465-6e-0624.62% (264) conserved hypothetical protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1618c-1e-17966.89% (441) hypothetical protein Mb1618c
M. gilvum PYR-GCKMflv_3621-0.074.55% (444) triacylglycerol lipase
M. tuberculosis H37RvRv1592c-1e-17966.89% (441) hypothetical protein Rv1592c
M. leprae Br4923MLBr_01751-9e-5056.47% (170) hypothetical protein MLBr_01751
M. abscessus ATCC 19977MAB_2676-1e-16062.50% (432) hypothetical protein MAB_2676
M. marinum MMMAR_2389-0.067.65% (442) hypothetical protein MMAR_2389
M. avium 104MAV_3194-0.067.49% (443) secretory lipase family protein
M. smegmatis MC2 155MSMEG_3197-1e-17166.22% (444) lipase
M. ulcerans Agy99MUL_1566-0.067.65% (442) hypothetical protein MUL_1566
M. vanbaalenii PYR-1Mvan_2796-0.073.65% (444) triacylglycerol lipase

CLUSTAL 2.0.9 multiple sequence alignment


Mb1618c|M.bovis_AF2122/97           ------------------------MVEPGNLAGATGAEWIGRP-------
Rv1592c|M.tuberculosis_H37Rv        ------------------------MVEPGNLAGATGAEWIGRP-------
MMAR_2389|M.marinum_M               ---------------MPKAMKGALMVKLGSLADARAAEWIGRP-------
MUL_1566|M.ulcerans_Agy99           ------------------------MVKLGSLADARAAGWIGRP-------
MAV_3194|M.avium_104                ------------------------MAELGNLAGTHGAEWIARP-------
MSMEG_3197|M.smegmatis_MC2_155      -------------------------MDLSSAAKAADAEWIGRA-------
MAB_2676|M.abscessus_ATCC_1997      --------------MNARDLEGSAGMASHDLAISADVKWIGEA-------
Mflv_3621|M.gilvum_PYR-GCK          -------------------------MDLGNVARSTGAEWIGQP-------
Mvan_2796|M.vanbaalenii_PYR-1       -------------------------MDLGNVARSTGAEWIGQP-------
TH_2810|M.thermoresistible__bu      -------------------------MDLGSAAQSTGAEWIGRP-------
MLBr_01751|M.leprae_Br4923          MAYGCNPRGAARVSDERDVSPYARVLALDDPADAAVLQRLRADSKVDFVD
                                                                 . * :     :          

Mb1618c|M.bovis_AF2122/97           PHEELQRKVRPLLPSDDP-------------------FYFPPAGYQHAVP
Rv1592c|M.tuberculosis_H37Rv        PHEELQRKVRPLLPSDDP-------------------FYFPPAGYQHAVP
MMAR_2389|M.marinum_M               PHEELQRKVRPLLPSDDP-------------------FYDPPAGYHHAEP
MUL_1566|M.ulcerans_Agy99           PHEELQRKVRPLLPSDDP-------------------FYDPPAGYHHAEP
MAV_3194|M.avium_104                PHEELQRKVRPLLPSDDP-------------------FYQPPLGFQHAEP
MSMEG_3197|M.smegmatis_MC2_155      PHEELDRDARPGLPGEDP-------------------FYLPPAGYHHAEP
MAB_2676|M.abscessus_ATCC_1997      PHQNVERGAPTLLPTEDP-------------------FYLPPLGYEHAAP
Mflv_3621|M.gilvum_PYR-GCK          RHEELRPRTRPVIPADDP-------------------FYEPPEGYEHARP
Mvan_2796|M.vanbaalenii_PYR-1       FHEPLRPRSRPMIPAKDD-------------------FYEPPAGFEHARP
TH_2810|M.thermoresistible__bu      THEALRR-TRPILPERDP-------------------FYEPPPGFEHARP
MLBr_01751|M.leprae_Br4923          HHERQLQELLSLLPTPDPQLIAEPCRWVYYPWRHVVVSMLGPRGFRAVRL
                                     *:       . :*  *                        * *:. .  

Mb1618c|M.bovis_AF2122/97           G----TVLRSRDVELAFMGLIPQPVTATQLLYRTTNMYGNPEATVTTVIV
Rv1592c|M.tuberculosis_H37Rv        G----TVLRSRDVELAFMGLIPQPVTATQLLYRTTNMYGNPEATVTTVIV
MMAR_2389|M.marinum_M               G----TVLRSREVELAFLGLIPQSITATQLLYRTTDMYGNPEATVTTVIL
MUL_1566|M.ulcerans_Agy99           G----TVLRSREVELAFLGLIPQSITATQLLYRTTDMYGNPEATVTTVIL
MAV_3194|M.avium_104                G----TVLRSRDVELAFLGLIPQPIKAVQLLYRTMDMNGEPEATVTTVIV
MSMEG_3197|M.smegmatis_MC2_155      G----TVLRSRDVELAFLGLVPQALHATQLLYRTTDRNGAPEAAVTTVIM
MAB_2676|M.abscessus_ATCC_1997      G----TVLRSRDVEMAFLGVIPQRFTATQLLYRSNDLNRRADAAVTTVLI
Mflv_3621|M.gilvum_PYR-GCK          G----TVLRSRDVELAFLGLIPQKFSATQLLYRTTDLYGQPQATVTTVLA
Mvan_2796|M.vanbaalenii_PYR-1       G----TVLRSRDVELAFLGVIPQKFTATQLLYRTTDLNGEAQATVTTVVV
TH_2810|M.thermoresistible__bu      G----TVLRSRDVELAFMGLIPQKFTATQLLYRTTGFDGRPRATVTTVVV
MLBr_01751|M.leprae_Br4923          DRNRNEITAEEQVALGRLHIGVAGLSVGHVIAHTLAAQGLCGQLRLADFD
                                    .     :  ..:* :. : :    . . ::: ::            : . 

Mb1618c|M.bovis_AF2122/97           PAELAPGQTCPLLSYQCAID--AMSSRCFPSYALRRRAKALG--------
Rv1592c|M.tuberculosis_H37Rv        PAELAPGQTCPLLSYQCAID--AMSSRCFPSYALRRRAKALG--------
MMAR_2389|M.marinum_M               PAEVAPGQTYPLLSYQCAID--AMSSRCFPSYALRRGAKAIG--------
MUL_1566|M.ulcerans_Agy99           PAEVAPGQTYPLLSYQCAID--AMSSRCFPSYALRRGAKAIG--------
MAV_3194|M.avium_104                PADAVPGRPCPLLSYQCAID--AVSSRCFPSYALRRRAKALG--------
MSMEG_3197|M.smegmatis_MC2_155      PPDARAG--CPIVSYQCAID--AISATCFPSYALRRHAKVTG--------
MAB_2676|M.abscessus_ATCC_1997      PDHDDPATPVPIVSYQCAID--AVTDRCFPSYALRRGAQALG--------
Mflv_3621|M.gilvum_PYR-GCK          PTERTDRRPLPIVSYQCAID--AVAGRCFPSYALRRGAKALG--------
Mvan_2796|M.vanbaalenii_PYR-1       PSERTSDGPLPIVSYQCAID--AVAGRCFPSYALRRGAKALG--------
TH_2810|M.thermoresistible__bu      PAERDKNGRCPVVSYQCAID--AVTSRCFPSYALRRGARAVG--------
MLBr_01751|M.leprae_Br4923          RLELSNLNRVPATVFDLGLNKAEVAARRIAELDPYLTVRVFDNGLTFDTV
                                      .       *   :: .::   ::   :..      .:. .        

Mb1618c|M.bovis_AF2122/97           ---------SLTQMELLMISAALAEGWAVS------VPDHEGPKGLWGSP
Rv1592c|M.tuberculosis_H37Rv        ---------SLTQMELLMISAALAEGWAVS------VPDHEGPKGLWGSP
MMAR_2389|M.marinum_M               ---------SLTQLELLLITAAVAEGWAVS------VPDHEGVRGLWGTP
MUL_1566|M.ulcerans_Agy99           ---------SLTQLELLLITAAVAEGWAVS------VPDHEGVRGLWGTP
MAV_3194|M.avium_104                ---------SIGQFELFLITAAVAEGWAVS------VPDHEGLRGLWGAP
MSMEG_3197|M.smegmatis_MC2_155      ---------GLAQFELLLITAALAEGWAVS------VPDHEGLDGMWGAP
MAB_2676|M.abscessus_ATCC_1997      ---------SFTQFELLLIAALLAQGWAVS------IPDHEGVDGSWGAP
Mflv_3621|M.gilvum_PYR-GCK          ---------AVAQFEFLLIAAALAEGWAVS------VPDHEGTTGMWGAP
Mvan_2796|M.vanbaalenii_PYR-1       ---------SFAQFEFLLVAAALAEGWAVS------VPDHEGTSGMWGAP
TH_2810|M.thermoresistible__bu      ---------ALAQFEFLLIAAALAEGWAVS------VPDHEGPDGSWGAP
MLBr_01751|M.leprae_Br4923          DQFLEGLDVVVEQCDSLDIKALLREGARSHGIPVLMATSDRGLIDVERFD
                                              . * : : : * : :*           ....*  .     

Mb1618c|M.bovis_AF2122/97           YEPGYRVLDGIRAALNSERVGLSPATPIG--LWGYSGGGLASAWAAEACG
Rv1592c|M.tuberculosis_H37Rv        YEPGYRVLDGIRAALNSERVGLSPATPIG--LWGYSGGGLASAWAAEACG
MMAR_2389|M.marinum_M               YEPGYRVLDGIRAALSAERLALPQSAPIG--LWGYSGGGLASAWAAEMCG
MUL_1566|M.ulcerans_Agy99           YEPGYRVLDGIRAALSAERLALPQSAPIG--LWGYSGGGLASAWAAEMCG
MAV_3194|M.avium_104                YEPGYRVLDGIRAALGSERLGLSPSAPIG--LWGYSGGGLASAWAAETCA
MSMEG_3197|M.smegmatis_MC2_155      YEPGYHVLDGLRAALNSERLPLTDASPIG--LWGYSGGGLASGWAAEMSG
MAB_2676|M.abscessus_ATCC_1997      DEPGYRTLDGIRAALNCDRLGLSRQAPIG--LWGYSGGGLATAWAAEASA
Mflv_3621|M.gilvum_PYR-GCK          FEPGYHVLDGIRAAVNHRPLGLAEDAPVG--LWGYSGGGLASAWAAEVHD
Mvan_2796|M.vanbaalenii_PYR-1       HEPGYHVLDGVRAALNHGPLGLSPDAPVG--LWGYSGGGLASAWAAEVQD
TH_2810|M.thermoresistible__bu      LEPGYHILDGLRAALGYERLNLAVDAPVG--LWGYSGGGLASAWAAEVCR
MLBr_01751|M.leprae_Br4923          LEPRRSILHGLLGELDIRLLPEMSNREKIPYILRFLEAERLSPRTATTLV
                                     **    *.*: . :.   :           :  :  .   :  :*    

Mb1618c|M.bovis_AF2122/97           EYAPDLDIVGAVLGSPVG---DLGHTFRRLNG--TLLAGLPALVVAALQH
Rv1592c|M.tuberculosis_H37Rv        EYAPDLDIVGAVLGSPVG---DLGHTFRRLNG--TLLAGLPALVVAALQH
MMAR_2389|M.marinum_M               EYAPELNIVGAVLGSPVG---DLGNTFRRLNG--TLLAGLPAMVVAALGH
MUL_1566|M.ulcerans_Agy99           EYAPDLNIVGAVLGSPVG---DLGNTFRRLNG--TLLAGLPAMVVAALGH
MAV_3194|M.avium_104                EYAPELNVVGAVLGSPVG---DLGNTFRRLNG--SFLSGLPALVVAALAH
MSMEG_3197|M.smegmatis_MC2_155      SYAPELNIVGAVLGSPVG---DLGHTFRRLNG--TVFSGLPALVVAALAD
MAB_2676|M.abscessus_ATCC_1997      DYAPELSITGAVLGSPVG---DLGHTFRRLNG--GLFAALPGLVVAALSH
Mflv_3621|M.gilvum_PYR-GCK          SYAPELNVVGAVLGSPVG---DLGHAFRRLNG--SIYSGLPAMVVAALTH
Mvan_2796|M.vanbaalenii_PYR-1       AYAPELNVVGAVLGSPVG---DLGHTFRRLNG--SIYAGLPALVVAALTH
TH_2810|M.thermoresistible__bu      DYAPDLNVVGAVLGSPVG---DLGSAFRRLNG--SLYAGLPAMVVAALAH
MLBr_01751|M.leprae_Br4923          EIDRSLSTWPQLAGDVALGATAVAEAVRRIGLGEELRSGRARIDVASALN
                                        .*.    : *. .     :. :.**:.    . :. . : **:  .

Mb1618c|M.bovis_AF2122/97           SY--PGLARVIKEHANDEGRQLLEQLTEMTTVDAVIRMAGRDMGDFLDEP
Rv1592c|M.tuberculosis_H37Rv        SY--PGLARVIKEHANDEGRQLLEQLTEMTTVDAVIRMAGRDMGDFLDEP
MMAR_2389|M.marinum_M               AY--PGLDRVIKQHANEDGIELLERLEQMTTAEAVIRMANNDLGHYLDEP
MUL_1566|M.ulcerans_Agy99           AY--PGLDRVIKQHANEDGIELLERLEQMTTAEAVIRMANNDLGHYLDEP
MAV_3194|M.avium_104                IY--PDLDRVIKEHANEEGRALLDSLEKMTTVEAVIRMAGKNMGDYLDAP
MSMEG_3197|M.smegmatis_MC2_155      IY--PGLNRVIAEHATTEGRKLLQRLHKMSTIEAVLRLARKDMDDLVDLP
MAB_2676|M.abscessus_ATCC_1997      VY--PGLERVIEEHATTKGKEFLGRLEDMPTFRAIIAMAFKDMDDLVDRP
Mflv_3621|M.gilvum_PYR-GCK          VY--PDLNRIIQQHATVEGKAMLARIEKMTTAHAMLSLVGKDMAHWVDRP
Mvan_2796|M.vanbaalenii_PYR-1       IY--PDLHRVIQEHATEDGKVMLARIEKMTTAHAMISLVGRDMAHMIDRP
TH_2810|M.thermoresistible__bu      IF--PEVDQIIDEHATETGKAMLQRVEKMTTAHAVLRMIGMDMGKLVDQP
MLBr_01751|M.leprae_Br4923          QLTEPDMARHRPANPTQCSELALSGIEGVIATAAIRAPSGGNLQPWHIDA
                                        * : :    :..  .   *  :  : :  *:      ::      .

Mb1618c|M.bovis_AF2122/97           LEDILSTPEVSHVFGDTKLGSAVPTPPVLIVQAVHDYLIDVSDIDALADS
Rv1592c|M.tuberculosis_H37Rv        LEDILSTPEISHVFGDTKLGSAVPTPPVLIVQAVHDYLIDVSDIDALADS
MMAR_2389|M.marinum_M               LDDVLSTPEVVHVFDDIKLGAAVPAPPVLIVQAVHDYLISVDDIDTLAES
MUL_1566|M.ulcerans_Agy99           LEDVLSTPEVVHVFDDIKLGAAVPAPPVLIVQAVHDYLISVDDIDTLAES
MAV_3194|M.avium_104                LEQILSTPEVTYVFDHIRLGAAVPTPPVLIVQAVHDYLIDVHDIDVLADA
MSMEG_3197|M.smegmatis_MC2_155      LEQILDSPEVTEVFDDIKLGVATPNPPVLLIQAVHDELISVSSIDELAEK
MAB_2676|M.abscessus_ATCC_1997      LEQLLQTPEVRHVFDSIKLGKTVPTPPVLIVQAVHDEIISTSCIDELADT
Mflv_3621|M.gilvum_PYR-GCK          LEEILLTPEVQHVFDSIKLGTSAPKVPVLIVQAVHDRIISVDDIDELTET
Mvan_2796|M.vanbaalenii_PYR-1       LEEILLSPEVQHVFDSIKLGTAAPKVPLLIVQAVHDRIISVDDIDALTET
TH_2810|M.thermoresistible__bu      LEEILQTPAMQRVFDRIKLGSAIPAPPVLLVQACHDRIVSVDDIDTLADT
MLBr_01751|M.leprae_Br4923          GPDALVIRIAPEHTDSLDVGFRG--SAVAVGAALFNARVAAAAHGVLGPV
                                      : *         .   :*      .: :  * .:  : .   . *   

Mb1618c|M.bovis_AF2122/97           YTAGGANVTYHRDLFSEHVSLHPLSAPMTLRWLTDRFAGKPLTDHRVRTT
Rv1592c|M.tuberculosis_H37Rv        YTAGGANVTYHRDLFSEHVSLHPLSAPMTLRWLTDRFAGKPLTDHRVRTT
MMAR_2389|M.marinum_M               YSTGGARVTYHRDAFNEHMMLHPLSAPMTLRWLTDRFAGLPLTEHVIRTT
MUL_1566|M.ulcerans_Agy99           YSTGGARVTYHRDAFNEHMMLHPLSAPMTLRWLTDRFAGLPLTEHVIRTT
MAV_3194|M.avium_104                YSAGGAQVTYHRDAFNEHMMLHPLSAPMTLRWLTDRFEGRPVTEHLIRTT
MSMEG_3197|M.smegmatis_MC2_155      YLTGGASVTYHRDLFSEHLLLHPMSAPMALRWLTDRFAARPLTANLVRSK
MAB_2676|M.abscessus_ATCC_1997      YRGGGADVAYHRDLLNEHILLHPMSAPMSMEWLSARFRGEPLPTGPRRTS
Mflv_3621|M.gilvum_PYR-GCK          YTAGGASVTYHRDMFSEHLLLHPMSAPMTLRWLRDRFAGRPISAHIARTK
Mvan_2796|M.vanbaalenii_PYR-1       YTSGGASVTYHRDMLSEHLLLHPMSAPMTLRWLRDRFAGRPLRTHISRTK
TH_2810|M.thermoresistible__bu      YIEGGVRVTYHRDMFSEHMLLHPMSAPMTLRWLRDRFAGQPLKHNLTRTK
MLBr_01751|M.leprae_Br4923          SLAENVDGAPLRVTLSLGDGWNPDLAAVYEPMLVRETNRNHGKPTMVLTE
                                        ..  :  *  :.     :*  *.:    *  .            : 

Mb1618c|M.bovis_AF2122/97           WPTIFNPMTYAGMARLAVIAAK-------VITGRKLSRRPL---------
Rv1592c|M.tuberculosis_H37Rv        WPTIFNPMTYAGMARLAVIAAK-------VITGRKLSRRPL---------
MMAR_2389|M.marinum_M               WPTMFNPMTYAGMARLAVIAAK-------MITGRKIHRRPL---------
MUL_1566|M.ulcerans_Agy99           WPTMFNPMTYAGMARLAVTAAK-------MITGRKIHRRPL---------
MAV_3194|M.avium_104                WPTMFNPMTYVGMARLLKIAAK-------VVTGRKIHRRPL---------
MSMEG_3197|M.smegmatis_MC2_155      WPTLLNPVTYVGMARLAGIAAK-------VVTGRALRRSPL---------
MAB_2676|M.abscessus_ATCC_1997      WPLAFKPSTYLGLLKLGWIGAK-------VLGGRSL--------------
Mflv_3621|M.gilvum_PYR-GCK          WPTLLNPSTYRGMLTLGKITAK-------VVLGRRVERQPLS-QFDL---
Mvan_2796|M.vanbaalenii_PYR-1       WPTLLNPSTYRGMLTLGKITAK-------VMLGRRVERQPLS-RFDQ---
TH_2810|M.thermoresistible__bu      WPTMFNPSTYRGMLRLGLITAK-------VLTGRRVDRRPXXXRLHAEMI
MLBr_01751|M.leprae_Br4923          TIDVLHAAAVAEGARLHLLTARDDIVRAATILAAADRSRYLTPRLHEEMI
                                        ::. :      *    *:        : .                 

Mb1618c|M.bovis_AF2122/97           --------------------------------------------------
Rv1592c|M.tuberculosis_H37Rv        --------------------------------------------------
MMAR_2389|M.marinum_M               --------------------------------------------------
MUL_1566|M.ulcerans_Agy99           --------------------------------------------------
MAV_3194|M.avium_104                --------------------------------------------------
MSMEG_3197|M.smegmatis_MC2_155      --------------------------------------------------
MAB_2676|M.abscessus_ATCC_1997      --------------------------------------------------
Mflv_3621|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2796|M.vanbaalenii_PYR-1       --------------------------------------------------
TH_2810|M.thermoresistible__bu      AELRWPGDPDPDSGIDIWAMELDPGQLAVLDILRRPDVMTALTEWDAGDA
MLBr_01751|M.leprae_Br4923          SELRWPGDSFPDTGIDVRSLEMDWHQLAAFDVLRRTDVMELLAQWNVGAA
                                                                                      

Mb1618c|M.bovis_AF2122/97           --------------------------------------------------
Rv1592c|M.tuberculosis_H37Rv        --------------------------------------------------
MMAR_2389|M.marinum_M               --------------------------------------------------
MUL_1566|M.ulcerans_Agy99           --------------------------------------------------
MAV_3194|M.avium_104                --------------------------------------------------
MSMEG_3197|M.smegmatis_MC2_155      --------------------------------------------------
MAB_2676|M.abscessus_ATCC_1997      --------------------------------------------------
Mflv_3621|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2796|M.vanbaalenii_PYR-1       --------------------------------------------------
TH_2810|M.thermoresistible__bu      LGDYTRERIRSSSALAVVTVEGREPADYLRGGSALEAVWIRAQQRGLAVH
MLBr_01751|M.leprae_Br4923          LGQDTHDRVVASSALAVISVPGHALADYARGGSAVEAIWVAAQRYGFAVQ
                                                                                      

Mb1618c|M.bovis_AF2122/97           --------------------------------------------------
Rv1592c|M.tuberculosis_H37Rv        --------------------------------------------------
MMAR_2389|M.marinum_M               --------------------------------------------------
MUL_1566|M.ulcerans_Agy99           --------------------------------------------------
MAV_3194|M.avium_104                --------------------------------------------------
MSMEG_3197|M.smegmatis_MC2_155      --------------------------------------------------
MAB_2676|M.abscessus_ATCC_1997      --------------------------------------------------
Mflv_3621|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2796|M.vanbaalenii_PYR-1       --------------------------------------------------
TH_2810|M.thermoresistible__bu      PVSPLFLYAHEEDELRALSPRFASSLVNLRREFHDLAGTRRGESQIIVFR
MLBr_01751|M.leprae_Br4923          PISPVFLYAHSVDELHALSAQFADELGQLGKDFRSLARIPADNSLVLVLR
                                                                                      

Mb1618c|M.bovis_AF2122/97           -----------------------
Rv1592c|M.tuberculosis_H37Rv        -----------------------
MMAR_2389|M.marinum_M               -----------------------
MUL_1566|M.ulcerans_Agy99           -----------------------
MAV_3194|M.avium_104                -----------------------
MSMEG_3197|M.smegmatis_MC2_155      -----------------------
MAB_2676|M.abscessus_ATCC_1997      -----------------------
Mflv_3621|M.gilvum_PYR-GCK          -----------------------
Mvan_2796|M.vanbaalenii_PYR-1       -----------------------
TH_2810|M.thermoresistible__bu      LFEAPPASVRSRRRSGGIGVD--
MLBr_01751|M.leprae_Br4923          LTVAGPASVRSRRSFERIRLLSG