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aa seq not available
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. thermoresistible (build 8) | TH_2629 | - | - | 100% (522) | putative GMC oxidoreductase |
| M. thermoresistible (build 8) | TH_0480 | choD | 2e-32 | 27.21% (555) | PROBABLE CHOLESTEROL OXIDASE PRECURSOR CHOD (CHOLESTEROL-O2 |
| M. thermoresistible (build 8) | TH_4673 | - | 5e-11 | 27.65% (311) | PUTATIVE - |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3443c | choD | 4e-31 | 29.13% (515) | cholesterol oxidase precursor |
| M. gilvum PYR-GCK | Mflv_4475 | - | 1e-112 | 46.68% (527) | GMC oxidoreductase |
| M. tuberculosis H37Rv | Rv3409c | choD | 4e-31 | 29.13% (515) | cholesterol oxidase precursor |
| M. leprae Br4923 | MLBr_00389 | choD | 4e-27 | 31.25% (288) | putative cholesterol oxidase |
| M. abscessus ATCC 19977 | MAB_3719c | - | 4e-29 | 31.82% (286) | putative cholesterol oxidase ChoD |
| M. marinum M | MMAR_3824 | choD_1 | 1e-36 | 29.87% (549) | cholesterol oxidase precursor ChoD_1 |
| M. avium 104 | MAV_4354 | - | 2e-32 | 28.54% (536) | FAD dependent oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_1604 | - | 4e-34 | 27.54% (541) | FAD dependent oxidoreductase |
| M. ulcerans Agy99 | MUL_3749 | choD_1 | 4e-36 | 29.58% (551) | cholesterol oxidase precursor ChoD_1 |
| M. vanbaalenii PYR-1 | Mvan_1514 | - | 2e-36 | 29.49% (529) | FAD dependent oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_1604|M.smegmatis_MC2_155 --------------MKPDYDVLVIGSGFGGSVSALRLTEK------GYRV
Mvan_1514|M.vanbaalenii_PYR-1 --------------MKPDYDVLIIGSGFGGSVSALRLTEK------GYRV
Mb3443c|M.bovis_AF2122/97 --------------MKPDYDVLIIGSGFGGSVTALRLTEK------GYRV
Rv3409c|M.tuberculosis_H37Rv --------------MKPDYDVLIIGSGFGGSVTALRLTEK------GYRV
MLBr_00389|M.leprae_Br4923 --------------MKPDYDVLIIGSGFGGSVSALRLTEK------GYRV
MAV_4354|M.avium_104 --------------MKPDYDVLIIGSGFGGSVSALRLTEK------GYRV
MAB_3719c|M.abscessus_ATCC_199 --MSSPAAVPVKPEADTDFDVLIVGSGFGGSVTAMRLTEK------GYRV
TH_2629|M.thermoresistible__bu -------MSYRTGDVPDRTEVLIIGSGFGGAVFAERLSAA------GVGV
Mflv_4475|M.gilvum_PYR-GCK -------MELQNGPCVDEVNYLIIGSGFGGSVMAAELATR------RRGV
MMAR_3824|M.marinum_M MADTAAVLACNTDALRSEYDVVILGSGYGGAITAARLATANAAAGGKLDI
MUL_3749|M.ulcerans_Agy99 MADTAAVLACNTDALRSEYDVVILGSGYGGAITAARLATANAAAGGKLDI
: :::***:**:: * .*: :
MSMEG_1604|M.smegmatis_MC2_155 GVLEAGRRFSDEEFAKTSWQLRKFLWAPKLGCYGIQRIHLLRNVMILAGA
Mvan_1514|M.vanbaalenii_PYR-1 GVLEAGRRYADDEFAKTSWNLRKFLWAPQFGMYGIQRIHLLRNVMILAGA
Mb3443c|M.bovis_AF2122/97 GVLEAGRRFSDEEFAKTSWDLRKFLWAPRLGCYGIQRIHPLRNVMILAGA
Rv3409c|M.tuberculosis_H37Rv GVLEAGRRFSDEEFAKTSWDLRKFLWAPRLGCYGIQRIHPLRNVMILAGA
MLBr_00389|M.leprae_Br4923 GVLEAGRRFADEDFAKTSWDLRKFLWAPKLGCYGIQRIHLLRNVMILAGA
MAV_4354|M.avium_104 GVLEAGRRFADEDFAETSWDLRKFLWAPKLGCYGIQRIHPLKNVLILAGA
MAB_3719c|M.abscessus_ATCC_199 GVLEAGRRFADEEFAETSWDLRKFLWAPMFKCFGIQRIHLLSNCMILAGA
TH_2629|M.thermoresistible__bu CVIERGRAYPPGSFPRTPAEFARNFWAPHDNLYGLFDIWSFRGLEAIVSS
Mflv_4475|M.gilvum_PYR-GCK CLFERGKAYPPGSFPRRVKEIDDSIWAPGSGKHGMFDLWSFDGIDAVTAS
MMAR_3824|M.marinum_M AVLERGAEHPTGTFPETEKAALGELRS-RSNPLGLIEIERFKTIDVIHAS
MUL_3749|M.ulcerans_Agy99 AVLERGAEHPTGTFPETEKAALGELRS-RSNPLGLIEIERFKTIDVIHAS
::* * .. *.. : : *: : : : .:
MSMEG_1604|M.smegmatis_MC2_155 GVGGGSLNYANTLYVPPEPFFA-------DRQWAGITDWRAELTPHYDQA
Mvan_1514|M.vanbaalenii_PYR-1 GVGGGSLNYANTLYVPPEPFFN-------DPQWKDITDWRAELMSHYDQA
Mb3443c|M.bovis_AF2122/97 GVGGGSLNYANTLYVPPEPFFA-------DQQWSHITDWRGELMPHYQQA
Rv3409c|M.tuberculosis_H37Rv GVGGGSLNYANTLYVPPEPFFA-------DQQWSHITDWRGELMPHYQQA
MLBr_00389|M.leprae_Br4923 GVGGGSLNYANTLYVPPEPFFA-------NQQWAHITDWHSELAPHYDQA
MAV_4354|M.avium_104 GVGGGSLNYANTLYVPPEPFFK-------DQQWAHITDWRDELMPHYDQA
MAB_3719c|M.abscessus_ATCC_199 GVGGGSLNYANTLYVPPDPFFN-------DPQWKGITDWRAELSPHYEQA
TH_2629|M.thermoresistible__bu GLGGGSLIYANVMLRKPAEWFTQPHP-HRPGVWERWSFTREDLDPHYDAV
Mflv_4475|M.gilvum_PYR-GCK GLGGGSLIYANVMLEKPAQWFTQPVP-DGNGKTETWSFTHRDLRDHYRAV
MMAR_3824|M.marinum_M GLGGTSLINFNVAIVPDREVFLASWPREFRALVEQQREGVGGLDEYFGRA
MUL_3749|M.ulcerans_Agy99 GLGGTSLINFNVAIVPDREVFLASWPREFRALVEQQREGVGGLDEYFGRA
*:** ** *. * * :: .
MSMEG_1604|M.smegmatis_MC2_155 QRMLGVVTNPTFT----DADRVVKEVADDMGVGDTFVQTPVGVFFGPDGE
Mvan_1514|M.vanbaalenii_PYR-1 QRMLGVVTNPTFT----DADRIMKEVADDMGVGDTFVPTPVGVFFGPDGE
Mb3443c|M.bovis_AF2122/97 QRMLGVVQNPTFT----DADRIVKEVADEMGFGDTWVPTPVGVFFGPDGT
Rv3409c|M.tuberculosis_H37Rv QRMLGVVQNPTFT----DADRIVKEVADEMGFGDTWVPTPVGVFFGPDGT
MLBr_00389|M.leprae_Br4923 QRMLGVVCNPTFT----DADRILKEVVDEMGFGDTFVPTPVGVFFGPDGT
MAV_4354|M.avium_104 QRMLGVVTNPTFT----DADRIVKEVADEMGCGDTFVPTPVGVFFGPDGT
MAB_3719c|M.abscessus_ATCC_199 QRMLGVVKNPTFT----DADRLIKEVADDMGAGDTFVATPVGVYFGPDGT
TH_2629|M.thermoresistible__bu GEFLDLETTPVSKDPADPFHLPKTAAFRAAAGPDTELAPLAVRFRDVAGN
Mflv_4475|M.gilvum_PYR-GCK REVLQVQEIPRS---LHEEHSKKTTKFLDAG---SVLAPLAVRFDGAEG-
MMAR_3824|M.marinum_M RRMLGAVPYAEN------VPLRRVEAFTQIAK------------NAGAQL
MUL_3749|M.ulcerans_Agy99 RRMLGAVPYAEN------VPLRRVEAFTQIAK------------NAGAQL
..* . .
MSMEG_1604|M.smegmatis_MC2_155 KTPGKTVPDPYFG---GVGPDRTGCIECGSCMTGCRYGAKNTLLKNYLG-
Mvan_1514|M.vanbaalenii_PYR-1 KTPGKTVPDPYFG---GAGPARTGCIECGSCMTGCRYGAKNTLLKNYLG-
Mb3443c|M.bovis_AF2122/97 KTPGKTVPDPYFG---GAGPARTGCLECGCCMTGCRHGAKNTLVKNYLG-
Rv3409c|M.tuberculosis_H37Rv KTPGKTVPDPYFG---GAGPARTGCLECGCCMTGCRHGAKNTLVKNYLG-
MLBr_00389|M.leprae_Br4923 QTPGRTVADPYFG---GVGPVRTGCLECGCCMTGCRHGAKNTLVKNYLG-
MAV_4354|M.avium_104 KAPGKTVPDPYFG---GAGPERTGCLECGCCMTGCRYGAKNTLLKNYLG-
MAB_3719c|M.abscessus_ATCC_199 KTPGVKVPDPYFG---GAGPDRVGCTECGSCMTGCRVGAKNTLVKNYLG-
TH_2629|M.thermoresistible__bu PAVGAPLPDADYPNIFG--AHRRSCALIGECDIGCNEGAKNSLDHTYLSA
Mflv_4475|M.gilvum_PYR-GCK PAKGAPLPPADYPNIHGDDVERTTCTMCGECDVGCNRGAKSSLDHTYLS-
MMAR_3824|M.marinum_M QILDITVSAEDRVTRYG--VQRRRCPNHGGDGTGDNTGSKNTLMTNYLP-
MUL_3749|M.ulcerans_Agy99 QILDITVSAEDRVTRYG--VQRRRCPNHGGDGTGDNTGSKNTLMTNYLP-
. :. * * * * * . *:*.:* .**
MSMEG_1604|M.smegmatis_MC2_155 LAERGGAEVHPLRTVAGFEQLPDGTWRVDTVRTGRWARKDKRS------F
Mvan_1514|M.vanbaalenii_PYR-1 LAEKAGAHVHPLTMVTGFEQRPDGLWEVRTARTGSKLRRRRRT------F
Mb3443c|M.bovis_AF2122/97 LAESAGAQVIPMTTVKGFERRSDGLWEVRTVRTGSWLRRDRRT------F
Rv3409c|M.tuberculosis_H37Rv LAESAGAQVIPMTTVKGFERRSDGLWEVRTVRTGSWLRRDRRT------F
MLBr_00389|M.leprae_Br4923 LAESAGAQVIPMTTVKGFELRSEGLWEVHTVRTGSWLRRGRRT------F
MAV_4354|M.avium_104 LAESAGAQVLPMTTVKAFEQRPDGLWQVRTVRTGSWVRRDRRT------Y
MAB_3719c|M.abscessus_ATCC_199 LAESNGAQVIPLTTVTAVQQGADGVWRVSTKSTGRWVRKQRKT------Y
TH_2629|M.thermoresistible__bu VAARPNASIHVRVEAETIERRPDGT---FAVGVRTHDAVGNRT---DTTV
Mflv_4475|M.gilvum_PYR-GCK VAAHHGAQICVRTEVREIAPCTDDSDYLFEVAYVVHPECRNKSEPVERVI
MMAR_3824|M.marinum_M MAAHHGAQMFCGIEAERIEAADDGRWRVIAGRTGRKGQGSRKGQDGDVVI
MUL_3749|M.ulcerans_Agy99 MAAHHGAQMFCGIEAERIEAADDGRWRVIAGRTGRKGQGSHKGQDGDVVI
:* .* : . . :. .:
MSMEG_1604|M.smegmatis_MC2_155 TATHVVLAAGTWGTQRLLFKMRDTGKLPKLSSRLGVLTRTNSESIVGAGR
Mvan_1514|M.vanbaalenii_PYR-1 TAQHLILAAGTYGTQKLLFKMRDQGKLPELSDRLGVLTRTNSESIVGAGR
Mb3443c|M.bovis_AF2122/97 TATQLVLAAGTWGTQHLLFKMRDRGRLPGLSKRLGVLTRTNSESIVGAAT
Rv3409c|M.tuberculosis_H37Rv TATQLVLAAGTWGTQHLLFKMRDRGRLPGLSKRLGVLTRTNSESIVGAAT
MLBr_00389|M.leprae_Br4923 TAAHLLLAAGTWGTQRLLFRMRDQGKLPRLSQRLGVLTRTNSESIVGAGT
MAV_4354|M.avium_104 TAKHLILAAGTWGTQHLLFKMRDEGRLPRLSNRLGVLTRTNSESIVGAGK
MAB_3719c|M.abscessus_ATCC_199 TAKYVVLAAGTWGTQNLLFKMKDKGLLPKLSQRLGVLTRTNSESIVGAGR
TH_2629|M.thermoresistible__bu IADQVVVSAGTFGSTFLLLRNRARLDLR-PDGPLGTRFCGNGDLLGLILK
Mflv_4475|M.gilvum_PYR-GCK RAKRVILAAGTLGSTYLMLRS-KKLGLS-DCAALGKRFCGNGDLLGFALP
MMAR_3824|M.marinum_M TARHVVVCAGALGSNGILMRS-RDAGLK-LSGRLGKNFSGNGDNFAIAYN
MUL_3749|M.ulcerans_Agy99 TARHVVVCAGALGSNGILMRS-RDAGLK-LSGRLGKNFSGNGDNFAIAYN
* :::.**: *: :::: * ** *.: :
MSMEG_1604|M.smegmatis_MC2_155 YEVTPDLDLTH------------GVAITSSIHPTPDTHIEPVRYGKGSNA
Mvan_1514|M.vanbaalenii_PYR-1 LKVGDDLDLTH------------GVAITSSIHPTPDTHVEPVRYGKGSNA
Mb3443c|M.bovis_AF2122/97 LKVNPDLDLTH------------GVAITSSIHPTADTHIEPVRYGKGSNA
Rv3409c|M.tuberculosis_H37Rv LKVNPDLDLTH------------GVAITSSIHPTADTHIEPVRYGKGSNA
MLBr_00389|M.leprae_Br4923 LNVMPDRDLTH------------GVAITSSIHPTSDTHIEPIRYGKGSNA
MAV_4354|M.avium_104 LEVDPNLDLTH------------GVAITSSIHPTPDTHIEPVRYGKGSNA
MAB_3719c|M.abscessus_ATCC_199 LEYKDDLDLTH------------GVAITSSFHPTSDTHIEPVRYGKGSNA
TH_2629|M.thermoresistible__bu AP--TVLAGTR------------GPVITASHRY----DDAHG-MYLQDAG
Mflv_4475|M.gilvum_PYR-GCK DGDDDELLPSG------------GPVITTYRSF----DAGDRRILLQDGG
MMAR_3824|M.marinum_M TDMRTDTQTWATTDGPPRSELTCGPSITAVMRFGADQSDVRKRFTVEDLS
MUL_3749|M.ulcerans_Agy99 TDMRTDTQTWATTDGPPRSELTCGPSITAVMRFGADQSDVRKRFTVEDLS
* **: . .
MSMEG_1604|M.smegmatis_MC2_155 MGLLQTLMTDGDGPDGAGIPRWKQLLRNAAEDPRGTLRLLNVH-------
Mvan_1514|M.vanbaalenii_PYR-1 MGLLQTLMTDGTGPQGTDVPRWRQLIETARDDPRGTLRLLNPR-------
Mb3443c|M.bovis_AF2122/97 MGLLQTLMTDGSGPQGTDVPRWRQLLQTASQDPRGTIRMLNPR-------
Rv3409c|M.tuberculosis_H37Rv MGLLQTLMTDGSGPQGTDVPRWRQLLQTASQDPRGTIRMLNPR-------
MLBr_00389|M.leprae_Br4923 MGLLQTLMTDGPGPEGTDVPRWRQLLHQASEDPRRMLRLINPR-------
MAV_4354|M.avium_104 MGLLQTLMTDGAGPQGTDVPRWKQLLDQAREDPRRLMRLLNVH-------
MAB_3719c|M.abscessus_ATCC_199 MGLLQTLMTDGDGPK----SRWRQLIENARADWRGTFRMFNVT-------
TH_2629|M.thermoresistible__bu FPNFAAWL-IETRFG---AGHYRRLAKFTGKRLWAALTRRGQTSIAGDIA
Mflv_4475|M.gilvum_PYR-GCK LPNLATWG-WGP------DDLREALAKLSVPRFASAWLWR----------
MMAR_3824|M.marinum_M LPRALVDS-FRLGLMGLAAASYRDLRPTKLDRWRRDVTFNTDG-------
MUL_3749|M.ulcerans_Agy99 LPRALVDS-FRLGLMGLAAASYRDLRPTKLDRWRRDVTFNTDG-------
: . . *
MSMEG_1604|M.smegmatis_MC2_155 -------RWSERTLIALVMQHLDNSITTYTKRNRLGIRRYLSKQGHGAPN
Mvan_1514|M.vanbaalenii_PYR-1 -------RWSERTMIALVMQHLDNSITTFTRKTRFGFRMLDSRQGHGEPN
Mb3443c|M.bovis_AF2122/97 -------QWSERTVIALVMQHLDNSITTFTKRGKLGIRWYSSKQGHGEPN
Rv3409c|M.tuberculosis_H37Rv -------QWSERTVIALVMQHLDNSITTFTKRGKLGIRWYSSKQGHGEPN
MLBr_00389|M.leprae_Br4923 -------RWSERTVIALVMQHLDNSITTFTKRGKLGIRWYSSKQGNGEPN
MAV_4354|M.avium_104 -------QWSERTLIALVMQHLDNSITTFTKRGRLGIRWYTSKQGHGEPN
MAB_3719c|M.abscessus_ATCC_199 -------QWSERTVIALVMQHLDNSITTFTKKT-LFWRRLDSKQGHGEPN
TH_2629|M.thermoresistible__bu RLLGDGRFTDCGMPVLGMGRDVPDGRLFLRGDD--VLESDWTSTTSAAHF
Mflv_4475|M.gilvum_PYR-GCK --------LRWPLPLLGMGADIPDGQLCLKDSDDTKMTCTWKKHTSDNHF
MMAR_3824|M.marinum_M -------AMNHSLGFLIMVHDNSDGELVLRKNG--TVKVDWPGAPTEAVY
MUL_3749|M.ulcerans_Agy99 -------AMNHSLGFLIMVHDNSDGELVLRKNG--TVKVDWPGAPTEAVY
. : . :.
MSMEG_1604|M.smegmatis_MC2_155 PTWIPVGNEVTRRIAKKIDGVAGGTWGELFNIPLTAHFLGGAAIGDSPET
Mvan_1514|M.vanbaalenii_PYR-1 PSWIPAGNEVTRRIAKKIDGVAGGTWGELFNIPLTAHFLGGAAIGDSAET
Mb3443c|M.bovis_AF2122/97 PTWIPIGNQVTRRIAAKIDGVAGGTWGELFNIPLTAHFLGGAVIGDDPEH
Rv3409c|M.tuberculosis_H37Rv PTWIPIGNQVTRRIAAKIDGVAGGTWGELFNIPLTAHFLGGAVIGDDPEH
MLBr_00389|M.leprae_Br4923 PSWIPIGNEVTRRLAAKIDGVAGGTWGELFNIPLTAHFLGGAVIGDNAEH
MAV_4354|M.avium_104 PTWIPVGNEVTRRIAAKIDGVAGGTWGELFNIPLTAHFLGGAVIGQDAEH
MAB_3719c|M.abscessus_ATCC_199 PTWIPAGNEATRRLAAKIDGVAGGTWGELFNIPLTAHFLGGAVIGTSPEN
TH_2629|M.thermoresistible__bu DALIGRMRAVATALGGTFTPNPTYL---LKKRVITVHPLGGCPADTSEST
Mflv_4475|M.gilvum_PYR-GCK QDVARRMEALTKDLGAGFLPNFLWD---FINEVITVHPLGGCPADTSAEE
MMAR_3824|M.marinum_M RDVDAIMKPAVEAIGGTYIKNPRWDKRFLGKHLITAHPMGGCATADNVDA
MUL_3749|M.ulcerans_Agy99 RDVDAIMKPAVEAIGGTYIKNPRWDKRFLGKHLITAHPMGGCATADNVDA
. . :. : : :*.* :**. . .
MSMEG_1604|M.smegmatis_MC2_155 GVIDPYQRVYNYPT-----LHVMDGAAISANLGVNPSLSITAQAERATSL
Mvan_1514|M.vanbaalenii_PYR-1 GVIDPYQRVYGYPT-----LSVMDGAAISANLGVNPSLSITAQAERAASL
Mb3443c|M.bovis_AF2122/97 GVIDPYHRVYGYPT-----LYVVDGAAISANLGVNPSLSIAAQAERAASL
Rv3409c|M.tuberculosis_H37Rv GVIDPYHRVYGYPT-----LYVVDGAAISANLGVNPSLSIAAQAERAASL
MLBr_00389|M.leprae_Br4923 GVIDPYHRVYGYPT-----LYVVDGAAISANLGVNPSLSIAAQAERAASL
MAV_4354|M.avium_104 GVIDPYHRVYGYPT-----LYVVDGAAISANLGVNPSLSITAQAERAAAL
MAB_3719c|M.abscessus_ATCC_199 GVIDPYHRVYGYPT-----MYVVDGASISANLGVNPSLSITAQAERAASL
TH_2629|M.thermoresistible__bu GVVDGYGRVHGVP-----------GDLGRSRIG-----------------
Mflv_4475|M.gilvum_PYR-GCK GVVDSYGRVRGVPG-----LWIADGSVMPGPVGANPSLTIAAFARRAAHE
MMAR_3824|M.marinum_M GVVDHAGRVYRPDGGTYDGLYVCDASVIPRAIGVNPFLTISMFAERTAEL
MUL_3749|M.ulcerans_Agy99 GVVDHAGHVYHPDGGTYDGLYVCDASVIPRAIGVNPFLTISMFAERTAEL
**:* :* . :*
MSMEG_1604|M.smegmatis_MC2_155 WPNKGEQDQRPAQGEPYRRLAPIAPVRPVVPADAPGALRRLPIEPVSSAG
Mvan_1514|M.vanbaalenii_PYR-1 WPNKGEDDLRPAQGEPYRRLSPIAPVRPVVPAEAPAALRRIPIEPVTSTG
Mb3443c|M.bovis_AF2122/97 WPNKGETDRRPPQGEPYRRLAPIQPAHPVVPADAPGALRWLPIDPVSNAG
Rv3409c|M.tuberculosis_H37Rv WPNKGETDRRPPQGEPYRRLAPIQPAHPVVPADAPGALRWLPIDPVSNAG
MLBr_00389|M.leprae_Br4923 WPNKGQHDQRPRQGESYRRLAPIAPDHPVVPAEAPGALRWL---------
MAV_4354|M.avium_104 WPNNGENDQRPAQGEPYRRMDPIAPKAPVVPAEAPGALRWTPTKPVSSAS
MAB_3719c|M.abscessus_ATCC_199 WPNKGETDLRPEQGLPYQRMAPVPPVHPVVPADAPGALRRLPIEPVSSAS
TH_2629|M.thermoresistible__bu --------------------------------------------------
Mflv_4475|M.gilvum_PYR-GCK LRKEDLATPSLPAPFIPQPYGDSDRSG-----------------------
MMAR_3824|M.marinum_M MRRELGLPGYDPVTELDDRV------------------------------
MUL_3749|M.ulcerans_Agy99 MRRELGLPGYDPVTELDDRV------------------------------