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KPDYDVLIIGSGFGGSVTALRLTEKGYRVGVLEAGRRFSDEEFAKTSWDLRKFLWAPRLGCYGIQRIHPL RNVMILAGAGVGGGSLNYANTLYVPPEPFFADQQWSHITDWRGELMPHYQQAQRMLGVVQNPTFTDADRI VKEVADEMGFGDTWVPTPVGVFFGPDGTKTPGKTVPDPYFGGAGPARTGCLECGCCMTGCRHGAKNTLVK NYLGLAESAGAQVIPMTTVKGFERRSDGLWEVRTVRTGSWLRRDRRTFTATQLVLAAGTWGTQHLLFKMR DRGRLPGLSKRLGVLTRTNSESIVGAATLKVNPDLDLTHGVAITSSIHPTADTHIEPVRYGKGSNAMGLL QTLMTDGSGPQGTDVPRWRQLLQTASQDPRGTIRMLNPRQWSERTVIALVMQHLDNSITTFTKRGKLGIR WYSSKQGHGEPNPTWIPIGNQVTRRIAAKIDGVAGGTWGELFNIPLTAHFLGGAVIGDDPEHGVIDPYHR VYGYPTLYVVDGAAISANLGVNPSLSIAAQAERAASLWPNKGETDRRPPQGEPYRRLAPIQPAHPVVPAD APGALRWLPIDPVSNAG*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. tuberculosis H37Rv | Rv3409c | choD | - | 100% (578) | PROBABLE CHOLESTEROL OXIDASE PRECURSOR CHOD (CHOLESTEROL-O2 OXIDOREDUCTASE) |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3443c | choD | 0.0 | 100.00% (578) | cholesterol oxidase precursor |
M. gilvum PYR-GCK | Mflv_4906 | - | 0.0 | 81.66% (578) | FAD dependent oxidoreductase |
M. leprae Br4923 | MLBr_00389 | choD | 0.0 | 88.75% (569) | putative cholesterol oxidase |
M. abscessus ATCC 19977 | MAB_3719c | - | 0.0 | 79.44% (574) | putative cholesterol oxidase ChoD |
M. marinum M | MMAR_1140 | choD | 0.0 | 90.78% (575) | cholesterol oxidase precursor ChoD |
M. avium 104 | MAV_4354 | - | 0.0 | 87.52% (577) | FAD dependent oxidoreductase |
M. smegmatis MC2 155 | MSMEG_1604 | - | 0.0 | 83.04% (578) | FAD dependent oxidoreductase |
M. thermoresistible (build 8) | TH_0480 | choD | 0.0 | 83.04% (578) | PROBABLE CHOLESTEROL OXIDASE PRECURSOR CHOD (CHOLESTEROL-O2 |
M. ulcerans Agy99 | MUL_0903 | choD | 0.0 | 90.78% (575) | cholesterol oxidase precursor ChoD |
M. vanbaalenii PYR-1 | Mvan_1514 | - | 0.0 | 83.04% (578) | FAD dependent oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_4906|M.gilvum_PYR-GCK ------------MRPDYDVLIIGSGFGGSVSALRLTEKGYRVGVLEAGRR Mvan_1514|M.vanbaalenii_PYR-1 ------------MKPDYDVLIIGSGFGGSVSALRLTEKGYRVGVLEAGRR MSMEG_1604|M.smegmatis_MC2_155 ------------MKPDYDVLVIGSGFGGSVSALRLTEKGYRVGVLEAGRR TH_0480|M.thermoresistible__bu ------------MQPDYDVLVIGSGFGGSVSALRLTEKGYRVGVLEAGRR Rv3409c|M.tuberculosis_H37Rv ------------MKPDYDVLIIGSGFGGSVTALRLTEKGYRVGVLEAGRR Mb3443c|M.bovis_AF2122/97 ------------MKPDYDVLIIGSGFGGSVTALRLTEKGYRVGVLEAGRR MMAR_1140|M.marinum_M ------------MKPDYDVLIIGSGFGGSVSALRLTEKGYRVGVLEAGRR MUL_0903|M.ulcerans_Agy99 ------------MKPDYDVLIIGSGFGGSVSALRLTEKGYRVGVLEAGRR MLBr_00389|M.leprae_Br4923 ------------MKPDYDVLIIGSGFGGSVSALRLTEKGYRVGVLEAGRR MAV_4354|M.avium_104 ------------MKPDYDVLIIGSGFGGSVSALRLTEKGYRVGVLEAGRR MAB_3719c|M.abscessus_ATCC_199 MSSPAAVPVKPEADTDFDVLIVGSGFGGSVTAMRLTEKGYRVGVLEAGRR .*:***::********:*:***************** Mflv_4906|M.gilvum_PYR-GCK YADDEFAKTSWNLRKFLWAPQFGMYGIQRIHLLRNVMILAGAGVGGGSLN Mvan_1514|M.vanbaalenii_PYR-1 YADDEFAKTSWNLRKFLWAPQFGMYGIQRIHLLRNVMILAGAGVGGGSLN MSMEG_1604|M.smegmatis_MC2_155 FSDEEFAKTSWQLRKFLWAPKLGCYGIQRIHLLRNVMILAGAGVGGGSLN TH_0480|M.thermoresistible__bu FADEDFAKTSWNLRKFLWAPKLGCYGIQRIHLLRNVMILAGAGVGGGSLN Rv3409c|M.tuberculosis_H37Rv FSDEEFAKTSWDLRKFLWAPRLGCYGIQRIHPLRNVMILAGAGVGGGSLN Mb3443c|M.bovis_AF2122/97 FSDEEFAKTSWDLRKFLWAPRLGCYGIQRIHPLRNVMILAGAGVGGGSLN MMAR_1140|M.marinum_M FSDAEFAKTSWDLRKFLWAPKLGCYGIQRIHPLKNVMILAGAGVGGGSLN MUL_0903|M.ulcerans_Agy99 FSDAEFAKTSWDLRKFLWAPKLGCYGIQRIHPLKNVMILAGAGVGGGSLN MLBr_00389|M.leprae_Br4923 FADEDFAKTSWDLRKFLWAPKLGCYGIQRIHLLRNVMILAGAGVGGGSLN MAV_4354|M.avium_104 FADEDFAETSWDLRKFLWAPKLGCYGIQRIHPLKNVLILAGAGVGGGSLN MAB_3719c|M.abscessus_ATCC_199 FADEEFAETSWDLRKFLWAPMFKCFGIQRIHLLSNCMILAGAGVGGGSLN ::* :**:***:******** : :****** * * :************* Mflv_4906|M.gilvum_PYR-GCK YANTLYVPPEPFFNDPQWRDITDWRAELMSHYDQAQRMLGVVTNPTFTDA Mvan_1514|M.vanbaalenii_PYR-1 YANTLYVPPEPFFNDPQWKDITDWRAELMSHYDQAQRMLGVVTNPTFTDA MSMEG_1604|M.smegmatis_MC2_155 YANTLYVPPEPFFADRQWAGITDWRAELTPHYDQAQRMLGVVTNPTFTDA TH_0480|M.thermoresistible__bu YANTLYVPPEPFFKDRQWAHITDWRDELMPHYDQAQRMLGVVTNPTFTDA Rv3409c|M.tuberculosis_H37Rv YANTLYVPPEPFFADQQWSHITDWRGELMPHYQQAQRMLGVVQNPTFTDA Mb3443c|M.bovis_AF2122/97 YANTLYVPPEPFFADQQWSHITDWRGELMPHYQQAQRMLGVVQNPTFTDA MMAR_1140|M.marinum_M YANTLYVPPDPFFNDQQWKHITDWRDELMPHYQQAQRMLGVVKNPTFTDA MUL_0903|M.ulcerans_Agy99 YANTLYVPPDPFFNDQQWKHITDWRDELMPHYQQAQRMLGVVKNPTFTDA MLBr_00389|M.leprae_Br4923 YANTLYVPPEPFFANQQWAHITDWHSELAPHYDQAQRMLGVVCNPTFTDA MAV_4354|M.avium_104 YANTLYVPPEPFFKDQQWAHITDWRDELMPHYDQAQRMLGVVTNPTFTDA MAB_3719c|M.abscessus_ATCC_199 YANTLYVPPDPFFNDPQWKGITDWRAELSPHYEQAQRMLGVVKNPTFTDA *********:*** : ** ****: ** .**:********* ******* Mflv_4906|M.gilvum_PYR-GCK DRIMKEVADDMGVGDTFVPTPVGVFFGPDGEKTPGKTVADPYFGGAGPAR Mvan_1514|M.vanbaalenii_PYR-1 DRIMKEVADDMGVGDTFVPTPVGVFFGPDGEKTPGKTVPDPYFGGAGPAR MSMEG_1604|M.smegmatis_MC2_155 DRVVKEVADDMGVGDTFVQTPVGVFFGPDGEKTPGKTVPDPYFGGVGPDR TH_0480|M.thermoresistible__bu DRVVKEVAEEMGVGHTFVPTPVGVFFGPDGQKTPGETVPDPYFGGVGPDR Rv3409c|M.tuberculosis_H37Rv DRIVKEVADEMGFGDTWVPTPVGVFFGPDGTKTPGKTVPDPYFGGAGPAR Mb3443c|M.bovis_AF2122/97 DRIVKEVADEMGFGDTWVPTPVGVFFGPDGTKTPGKTVPDPYFGGAGPAR MMAR_1140|M.marinum_M DRIVKEVADEMGFGDTWVPTPVGVFFGPDGTKTPGKTVPDPYFGGAGPAR MUL_0903|M.ulcerans_Agy99 DRIVKEVADEMGFGDTWVPTPVGVFFGPDGTKTPGKTVPDPYFGGAGPAR MLBr_00389|M.leprae_Br4923 DRILKEVVDEMGFGDTFVPTPVGVFFGPDGTQTPGRTVADPYFGGVGPVR MAV_4354|M.avium_104 DRIVKEVADEMGCGDTFVPTPVGVFFGPDGTKAPGKTVPDPYFGGAGPER MAB_3719c|M.abscessus_ATCC_199 DRLIKEVADDMGAGDTFVATPVGVYFGPDGTKTPGVKVPDPYFGGAGPDR **::***.::** *.*:* *****:***** ::** .*.******.** * Mflv_4906|M.gilvum_PYR-GCK TGCIECGSCMTGCRYGAKNTLVKNYLGLAEKAGAQVHPLTMVTGFEQRPD Mvan_1514|M.vanbaalenii_PYR-1 TGCIECGSCMTGCRYGAKNTLLKNYLGLAEKAGAHVHPLTMVTGFEQRPD MSMEG_1604|M.smegmatis_MC2_155 TGCIECGSCMTGCRYGAKNTLLKNYLGLAERGGAEVHPLRTVAGFEQLPD TH_0480|M.thermoresistible__bu TGCIECGSCMTGCRHNAKNTLVKNYLGLAEQAGTEVHAMTTVTGFEQLPD Rv3409c|M.tuberculosis_H37Rv TGCLECGCCMTGCRHGAKNTLVKNYLGLAESAGAQVIPMTTVKGFERRSD Mb3443c|M.bovis_AF2122/97 TGCLECGCCMTGCRHGAKNTLVKNYLGLAESAGAQVIPMTTVKGFERRSD MMAR_1140|M.marinum_M TGCTECGECMTGCRHGAKNTLVKNYLGLAESAGAEVIPMTTVKGFEQRPD MUL_0903|M.ulcerans_Agy99 TGCTECGECMTGCRHGAKNTLVKNYLGLAESAGAEVIPMTTVKGFEQRPD MLBr_00389|M.leprae_Br4923 TGCLECGCCMTGCRHGAKNTLVKNYLGLAESAGAQVIPMTTVKGFELRSE MAV_4354|M.avium_104 TGCLECGCCMTGCRYGAKNTLLKNYLGLAESAGAQVLPMTTVKAFEQRPD MAB_3719c|M.abscessus_ATCC_199 VGCTECGSCMTGCRVGAKNTLVKNYLGLAESNGAQVIPLTTVTAVQQGAD .** *** ****** .*****:******** *:.* .: * ..: .: Mflv_4906|M.gilvum_PYR-GCK GLWEVHTARTGSKVRRRRKTFTAEHVILAAGTYGTQKLLFKMRDRGKLPK Mvan_1514|M.vanbaalenii_PYR-1 GLWEVRTARTGSKLRRRRRTFTAQHLILAAGTYGTQKLLFKMRDQGKLPE MSMEG_1604|M.smegmatis_MC2_155 GTWRVDTVRTGRWARKDKRSFTATHVVLAAGTWGTQRLLFKMRDTGKLPK TH_0480|M.thermoresistible__bu GTWRVDTVRTGRWLRKRRKSFTATHLILAAGTWGTQRLLFKMRDAGKLPN Rv3409c|M.tuberculosis_H37Rv GLWEVRTVRTGSWLRRDRRTFTATQLVLAAGTWGTQHLLFKMRDRGRLPG Mb3443c|M.bovis_AF2122/97 GLWEVRTVRTGSWLRRDRRTFTATQLVLAAGTWGTQHLLFKMRDRGRLPG MMAR_1140|M.marinum_M GLWEVRTVRTGSWARRDRRTFTASYLILAAGTWGTQHLLFKMRDKGKLPR MUL_0903|M.ulcerans_Agy99 GLWEVRTVRTGSWARRDRRTFTASYLILAAGTWGTQHLLFKMRDKGKLPR MLBr_00389|M.leprae_Br4923 GLWEVHTVRTGSWLRRGRRTFTAAHLLLAAGTWGTQRLLFRMRDQGKLPR MAV_4354|M.avium_104 GLWQVRTVRTGSWVRRDRRTYTAKHLILAAGTWGTQHLLFKMRDEGRLPR MAB_3719c|M.abscessus_ATCC_199 GVWRVSTKSTGRWVRKQRKTYTAKYVVLAAGTWGTQNLLFKMKDKGLLPK * *.* * ** *: ::::** ::*****:***.***:*:* * ** Mflv_4906|M.gilvum_PYR-GCK LSDKLGVLTRTNSESIVGAGRLTVGDDLNLTHGVAITSSIHPTADTHVEP Mvan_1514|M.vanbaalenii_PYR-1 LSDRLGVLTRTNSESIVGAGRLKVGDDLDLTHGVAITSSIHPTPDTHVEP MSMEG_1604|M.smegmatis_MC2_155 LSSRLGVLTRTNSESIVGAGRYEVTPDLDLTHGVAITSSIHPTPDTHIEP TH_0480|M.thermoresistible__bu LSKRLGVLTRTNSESIVGAGRYRVSDDLDLTHGVAITSSIHPTPDTHIEP Rv3409c|M.tuberculosis_H37Rv LSKRLGVLTRTNSESIVGAATLKVNPDLDLTHGVAITSSIHPTADTHIEP Mb3443c|M.bovis_AF2122/97 LSKRLGVLTRTNSESIVGAATLKVNPDLDLTHGVAITSSIHPTADTHIEP MMAR_1140|M.marinum_M LSKRLGVLTRTNSESIVGAATLKVNPDLDLTHGVAITSSIHPTPDTHVEP MUL_0903|M.ulcerans_Agy99 LSKRLGVLTRTNSESIVGAATLKVNPDLDLTHGVAITSSIHPTPDTHVEP MLBr_00389|M.leprae_Br4923 LSQRLGVLTRTNSESIVGAGTLNVMPDRDLTHGVAITSSIHPTSDTHIEP MAV_4354|M.avium_104 LSNRLGVLTRTNSESIVGAGKLEVDPNLDLTHGVAITSSIHPTPDTHIEP MAB_3719c|M.abscessus_ATCC_199 LSQRLGVLTRTNSESIVGAGRLEYKDDLDLTHGVAITSSFHPTSDTHIEP **.:***************. : :**********:***.***:** Mflv_4906|M.gilvum_PYR-GCK VRYGKGSNAMGLLQTLMTDGTGPEGTDVPRWRQLLDTARNDRKGTLRLLN Mvan_1514|M.vanbaalenii_PYR-1 VRYGKGSNAMGLLQTLMTDGTGPQGTDVPRWRQLIETARDDPRGTLRLLN MSMEG_1604|M.smegmatis_MC2_155 VRYGKGSNAMGLLQTLMTDGDGPDGAGIPRWKQLLRNAAEDPRGTLRLLN TH_0480|M.thermoresistible__bu VRYGKGSNAMGLLQTLMTDGPGPEGTDVPRWKQLFHNAAEDPRGTLRLLN Rv3409c|M.tuberculosis_H37Rv VRYGKGSNAMGLLQTLMTDGSGPQGTDVPRWRQLLQTASQDPRGTIRMLN Mb3443c|M.bovis_AF2122/97 VRYGKGSNAMGLLQTLMTDGSGPQGTDVPRWRQLLQTASQDPRGTIRMLN MMAR_1140|M.marinum_M VRYGKGSNAMGLLQTLMTDGSGPSGTDVARWRQLLDQAGESPRRMFRLIN MUL_0903|M.ulcerans_Agy99 VRYGKGSNAMGLLQTLMTDGSGPSGTDVARWRQLLDQAGESPRRMFRLIN MLBr_00389|M.leprae_Br4923 IRYGKGSNAMGLLQTLMTDGPGPEGTDVPRWRQLLHQASEDPRRMLRLIN MAV_4354|M.avium_104 VRYGKGSNAMGLLQTLMTDGAGPQGTDVPRWKQLLDQAREDPRRLMRLLN MAB_3719c|M.abscessus_ATCC_199 VRYGKGSNAMGLLQTLMTDGDGPK----SRWRQLIENARADWRGTFRMFN :******************* **. .**:**: * . : :*::* Mflv_4906|M.gilvum_PYR-GCK PRRWSERTMIALVMQHLDNSITTYTRKTKFGFRMLDSKQGHGEPNPSWIP Mvan_1514|M.vanbaalenii_PYR-1 PRRWSERTMIALVMQHLDNSITTFTRKTRFGFRMLDSRQGHGEPNPSWIP MSMEG_1604|M.smegmatis_MC2_155 VHRWSERTLIALVMQHLDNSITTYTKRNRLGIRRYLSKQGHGAPNPTWIP TH_0480|M.thermoresistible__bu VRRWSERTLIALVMQHLDNSITTYTKRGLFGIRRYSSKQGHGQPNPTWIP Rv3409c|M.tuberculosis_H37Rv PRQWSERTVIALVMQHLDNSITTFTKRGKLGIRWYSSKQGHGEPNPTWIP Mb3443c|M.bovis_AF2122/97 PRQWSERTVIALVMQHLDNSITTFTKRGKLGIRWYSSKQGHGEPNPTWIP MMAR_1140|M.marinum_M PRQWSERTVIALVMQHLDNSITTFTKRGKLGIRWYSSKQGHGEPNPTWIP MUL_0903|M.ulcerans_Agy99 PRQWSERTVIALVMQHLDNSITTFTKRGKLGIRWYSSKQGHGEPNPTWIP MLBr_00389|M.leprae_Br4923 PRRWSERTVIALVMQHLDNSITTFTKRGKLGIRWYSSKQGNGEPNPSWIP MAV_4354|M.avium_104 VHQWSERTLIALVMQHLDNSITTFTKRGRLGIRWYTSKQGHGEPNPTWIP MAB_3719c|M.abscessus_ATCC_199 VTQWSERTVIALVMQHLDNSITTFTKKTLF-WRRLDSKQGHGEPNPTWIP :*****:**************:*:: : * *:**:* ***:*** Mflv_4906|M.gilvum_PYR-GCK AGNEVTRRIAEKIDGVAGGTWGELFNIPLTAHFLGGAAIADSPERGVIDP Mvan_1514|M.vanbaalenii_PYR-1 AGNEVTRRIAKKIDGVAGGTWGELFNIPLTAHFLGGAAIGDSAETGVIDP MSMEG_1604|M.smegmatis_MC2_155 VGNEVTRRIAKKIDGVAGGTWGELFNIPLTAHFLGGAAIGDSPETGVIDP TH_0480|M.thermoresistible__bu VGNEVTRRIAEKIDGVAGGTWGELFNIPLTAHFLGGAAIGDSPEHGVIDP Rv3409c|M.tuberculosis_H37Rv IGNQVTRRIAAKIDGVAGGTWGELFNIPLTAHFLGGAVIGDDPEHGVIDP Mb3443c|M.bovis_AF2122/97 IGNQVTRRIAAKIDGVAGGTWGELFNIPLTAHFLGGAVIGDDPEHGVIDP MMAR_1140|M.marinum_M VGNQVTRRIAEKIDGVAGGTWGELFNIPLTAHFLGGAVIGDNPDSGVIDP MUL_0903|M.ulcerans_Agy99 VGNQVTRRIAEKIDGVAGGTWGELFNIPLTAHFLGGAVIGDNPDSGVIDP MLBr_00389|M.leprae_Br4923 IGNEVTRRLAAKIDGVAGGTWGELFNIPLTAHFLGGAVIGDNAEHGVIDP MAV_4354|M.avium_104 VGNEVTRRIAAKIDGVAGGTWGELFNIPLTAHFLGGAVIGQDAEHGVIDP MAB_3719c|M.abscessus_ATCC_199 AGNEATRRLAAKIDGVAGGTWGELFNIPLTAHFLGGAVIGTSPENGVIDP **:.***:* **************************.*. ..: ***** Mflv_4906|M.gilvum_PYR-GCK YQRVWNYPTLSVMDGAAVSANLGVNPSLSITAQAERAAALWPNKGEEDLR Mvan_1514|M.vanbaalenii_PYR-1 YQRVYGYPTLSVMDGAAISANLGVNPSLSITAQAERAASLWPNKGEDDLR MSMEG_1604|M.smegmatis_MC2_155 YQRVYNYPTLHVMDGAAISANLGVNPSLSITAQAERATSLWPNKGEQDQR TH_0480|M.thermoresistible__bu YHRVYGYPTLYVTDGAAISANLGVNPSLSITAQAERAASLWPNKGEQDLR Rv3409c|M.tuberculosis_H37Rv YHRVYGYPTLYVVDGAAISANLGVNPSLSIAAQAERAASLWPNKGETDRR Mb3443c|M.bovis_AF2122/97 YHRVYGYPTLYVVDGAAISANLGVNPSLSIAAQAERAASLWPNKGETDRR MMAR_1140|M.marinum_M YHRVYGYPTMFVVDGAAISANLGVNPSLSITAQAERAASLWPNKGQNDER MUL_0903|M.ulcerans_Agy99 YHRVYGYPTMFVVDGAAISANLGVNPSLSITAQAERAASLWPNKGQNDER MLBr_00389|M.leprae_Br4923 YHRVYGYPTLYVVDGAAISANLGVNPSLSIAAQAERAASLWPNKGQHDQR MAV_4354|M.avium_104 YHRVYGYPTLYVVDGAAISANLGVNPSLSITAQAERAAALWPNNGENDQR MAB_3719c|M.abscessus_ATCC_199 YHRVYGYPTMYVVDGASISANLGVNPSLSITAQAERAASLWPNKGETDLR *:**:.***: * ***::************:******::****:*: * * Mflv_4906|M.gilvum_PYR-GCK PEQGQPYRRLSPIEPKHPVVPADAPAALRRIPIEPVT---SAG Mvan_1514|M.vanbaalenii_PYR-1 PAQGEPYRRLSPIAPVRPVVPAEAPAALRRIPIEPVT---STG MSMEG_1604|M.smegmatis_MC2_155 PAQGEPYRRLAPIAPVRPVVPADAPGALRRLPIEPVS---SAG TH_0480|M.thermoresistible__bu PAQGEPYRRLDPIPPKNPVVPAHAPAALRRNPTESVD---ATG Rv3409c|M.tuberculosis_H37Rv PPQGEPYRRLAPIQPAHPVVPADAPGALRWLPIDPVS---NAG Mb3443c|M.bovis_AF2122/97 PPQGEPYRRLAPIQPAHPVVPADAPGALRWLPIDPVS---NAG MMAR_1140|M.marinum_M PLQGDGYSRLSPVQPEHPVVPADAPGALRWLPIDPVSRVSSAG MUL_0903|M.ulcerans_Agy99 PLQGDGYSRLSPVQPEHPVVPADAPGALRWLPIDPVSRVSSAG MLBr_00389|M.leprae_Br4923 PRQGESYRRLAPIAPDHPVVPAEAPGALRWL------------ MAV_4354|M.avium_104 PAQGEPYRRMDPIAPKAPVVPAEAPGALRWTPTKPVS---SAS MAB_3719c|M.abscessus_ATCC_199 PEQGLPYQRMAPVPPVHPVVPADAPGALRRLPIEPVS---SAS * ** * *: *: * *****.**.***