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M. thermoresistible (build 8) TH_2338 (ribA2)

annotation: PROBABLE RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBA2 : GTP cyclohydrolase II + 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP synthase)
coordinates: 4579538 - 4580188
length: 217

aa seq not available

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. thermoresistible (build 8) TH_2338 ribA2 - 100% (217) PROBABLE RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBA2 : GTP cyclohydrolase II + 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP synthase)
M. thermoresistible (build 8) TH_1011 - 1e-35 58.65% (133) riboflavin biosynthesis protein ribAB

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb1450 ribA2 3e-36 57.58% (132) bifunctional 3,4-dihydroxy-2-butanone 4-phosphate
M. gilvum PYR-GCK Mflv_3719 - 1e-36 58.33% (132) bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP
M. tuberculosis H37Rv Rv1415 ribA2 3e-36 57.58% (132) bifunctional 3,4-dihydroxy-2-butanone 4-phosphate
M. leprae Br4923 MLBr_00559 ribA 4e-37 58.33% (132) bifunctional 3,4-dihydroxy-2-butanone 4-phosphate
M. abscessus ATCC 19977 MAB_2796c - 8e-35 55.30% (132) bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP
M. marinum M MMAR_2222 ribA2 7e-36 56.82% (132) riboflavin biosynthesis protein RibA2
M. avium 104 MAV_3365 - 9e-36 56.82% (132) bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP
M. smegmatis MC2 155 MSMEG_3072 - 2e-37 58.33% (132) bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP
M. ulcerans Agy99 MUL_1809 ribA2 5e-36 56.82% (132) bifunctional 3,4-dihydroxy-2-butanone 4-phosphate
M. vanbaalenii PYR-1 Mvan_2694 - 1e-35 57.58% (132) bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_3719|M.gilvum_PYR-GCK          ----------MTRLDS---VERAVADIAAGKAVVVIDDEDRENEGDLIFA
Mvan_2694|M.vanbaalenii_PYR-1       ----------MTRLDS---VERAVADIAAGKAVVVIDDEDRENEGDLIFA
MSMEG_3072|M.smegmatis_MC2_155      ----------MTRLDS---VERAIADIAAGKAVVVIDDEDRENEGDLIFA
MAB_2796c|M.abscessus_ATCC_199      ----------MTRLDS---IERAVADIAAGKAVVVVDDEDRENEGDLIFA
Mb1450|M.bovis_AF2122/97            ----------MTRLDS---VERAVADIAAGKAVIVIDDEDRENEGDLIFA
Rv1415|M.tuberculosis_H37Rv         ----------MTRLDS---VERAVADIAAGKAVIVIDDEDRENEGDLIFA
MAV_3365|M.avium_104                ----------MTRLDS---VERAVADIAAGKAVIVIDDEDRENEGDLIFA
MMAR_2222|M.marinum_M               ----------MTRLDS---VERAVADIGAGKAVIVIDDEDRENEGDLIFA
MUL_1809|M.ulcerans_Agy99           ----------MTRLDS---VERAVADIGAGKAVIVIDDEDRENEGDLIFA
MLBr_00559|M.leprae_Br4923          MGPFDSKVAKMTRLDS---VERAVADIAAGKAVVVIDDEDRENEGDLIFA
TH_2338|M.thermoresistible__bu      ----VTPKHPMSPSNTDGPVERAVAALAAGRAVVVADAADRENEGDLIAA
                                              *:  ::   :***:* :.**:**:* *  ********* *

Mflv_3719|M.gilvum_PYR-GCK          AEKATPELVAFMVRYTSGYLCVPLAGEICDRLGLLPMYAVNQDKHGTAYT
Mvan_2694|M.vanbaalenii_PYR-1       AEKATPELVAFMVRYTSGYLCVPLAGDICDRLGLLPMYAVNQDKHGTAYT
MSMEG_3072|M.smegmatis_MC2_155      AEKATPELVAFMVRYTSGYLCVPLDGEICDRLGLLPMYAVNQDKHGTAYT
MAB_2796c|M.abscessus_ATCC_199      AEKATPELVAFMVRYTSGYLCVPLAGEDCDRLGLLPQYAVNQDKHGTAYT
Mb1450|M.bovis_AF2122/97            AEKATPEMVAFMVRYTSGYLCVPLDGAICDRLGLLPMYAVNQDKHGTAYT
Rv1415|M.tuberculosis_H37Rv         AEKATPEMVAFMVRYTSGYLCVPLDGAICDRLGLLPMYAVNQDKHGTAYT
MAV_3365|M.avium_104                AEKATPEMVAFMVRYTSGYLCVPLDGAICDRLGLLPMYAVNQDKHGTAYT
MMAR_2222|M.marinum_M               AEKATPELVAFMVRYTSGYLCVPLDGAVCDRLGLLPMYAVNQDKHGTAYT
MUL_1809|M.ulcerans_Agy99           AEKATPELVAFMVRYTSGYLCVPLDGAVCDRLGLLPMYAVNQDKHGTAYT
MLBr_00559|M.leprae_Br4923          AEKATLEMVAFMVRYTSGYLCAPLDGAICDRLGLLPMFAVNQDKHGTAYT
TH_2338|M.thermoresistible__bu      AEHTTTELMAFFLRHGSGIVCTPMSDARANRLGLAPMVVHNTDNHSTAFT
                                    **::* *::**::*: ** :*.*: .  .:**** *  . * *:*.**:*

Mflv_3719|M.gilvum_PYR-GCK          VTVDAKVGVGTGISASDRATTMRLLADPDSVADDFTKPGHVVPLRAKDGG
Mvan_2694|M.vanbaalenii_PYR-1       VTVDAKKGVGTGISAMDRATTMRLLADPDAVADDFTKPGHVVPLRAKDGG
MSMEG_3072|M.smegmatis_MC2_155      VTVDAKKDVGTGISASDRATTMRALANPGSVADDFTKPGHVVPLRAKDGG
MAB_2796c|M.abscessus_ATCC_199      VTVDAKNGIGTGISASDRAATMRLLADAASTADDFTKPGHVVPLRAKDGG
Mb1450|M.bovis_AF2122/97            VTVDARNGIGTGISASDRATTMRLLADPTSVADDFTRPGHVVPLRAKDGG
Rv1415|M.tuberculosis_H37Rv         VTVDARNGIGTGISASDRATTMRLLADPTSVADDFTRPGHVVPLRAKDGG
MAV_3365|M.avium_104                VTVDARNGVGTGISASDRATTMRLLADPTSIAEDFTRPGHVVPLRAKDGG
MMAR_2222|M.marinum_M               VTVDAKNGVGTGISASDRATTMRLLADPASVAEDFTRPGHVVPLRAKDGG
MUL_1809|M.ulcerans_Agy99           VTVDAKNGVGTGISASDRATTMRLLADPASVAEDFTRPGHVVPLRAKDGG
MLBr_00559|M.leprae_Br4923          VTVDARNGVGTGISASDRATTMRLLADPASVADDFTRPGHVVPLRAKDGG
TH_2338|M.thermoresistible__bu      VSVDHVD-TGTGISAADRARTVRSLCEPGLQPDELRRPGHVFPLRARPGG
                                    *:**     ****** *** *:* *.:.   .::: :****.****: **

Mflv_3719|M.gilvum_PYR-GCK          VLRRPGHTEAAVDLARLAGLQAAGTICEIVSQKDEGAMAQTDELRIFADE
Mvan_2694|M.vanbaalenii_PYR-1       VLRRPGHTEAAVDLARLAGLQPAGAICEIVSQKDEGAMAQTDELRIFADE
MSMEG_3072|M.smegmatis_MC2_155      VLRRPGHTEAAVDLARLAGLQPAGAICEIVSQKDEGDMARTDELRVFADD
MAB_2796c|M.abscessus_ATCC_199      VLRRPGHTEASVDLAKLAGLRPAAVICEIVSQKDEGAMAQTEELRVFADE
Mb1450|M.bovis_AF2122/97            VLRRPGHTEAAVDLARMAGLQPAGAICEIVSQKDEGSMAHTDELRVFADE
Rv1415|M.tuberculosis_H37Rv         VLRRPGHTEAAVDLARMAGLQPAGAICEIVSQKDEGSMAHTDELRVFADE
MAV_3365|M.avium_104                VLRRPGHTEAAVDLARMAGLQPAGAICEIVSQKDEGSMAQTDELRVFADE
MMAR_2222|M.marinum_M               VLRRPGHTEAAVDLARMAGLQPAGAICEIVSQKDEGSMAQTDELRVFADE
MUL_1809|M.ulcerans_Agy99           VLRRPGHTEAAVDLARMAGLQPAGAICEIVSRKDEGSMAQTDELRVFADE
MLBr_00559|M.leprae_Br4923          VLRRPGHTEAAVDLARLAGLQPAGAICEIVSQKDEGSMAQTDELRVFADE
TH_2338|M.thermoresistible__bu      VXXX----------------------------------------------
                                    *                                                 

Mflv_3719|M.gilvum_PYR-GCK          HDLALISIADLIEWRRKHEKHIARVAEARIPTRHGEFRAVGYTSIYEDVE
Mvan_2694|M.vanbaalenii_PYR-1       HDLALISIADLIEWRRKHEKHIARVAEARIPTRHGEFRAVGYTSIYEDVE
MSMEG_3072|M.smegmatis_MC2_155      HDLALISIADLIEWRRKHEKHIERIAEARIPTRHGEFRAVGYKSIYEDVE
MAB_2796c|M.abscessus_ATCC_199      HNLALVSIADLIEWRRKHEKHVQRIAEARIPTQHGEFRAVGYTSIYDDVE
Mb1450|M.bovis_AF2122/97            HGLALITIADLIEWRRKHEKHIERVAEARIPTRHGEFRAIGYTSIYEDVE
Rv1415|M.tuberculosis_H37Rv         HGLALITIADLIEWRRKHEKHIERVAEARIPTRHGEFRAIGYTSIYEDVE
MAV_3365|M.avium_104                HDLAMITIADLIEWRRKHEKHIERIAEARIPTRHGEFRAIGYTSIYEEVE
MMAR_2222|M.marinum_M               HGLALITIADLIEWRRKHEKHIERVAEARIPTRHGEFRAIGYTSIYEDVE
MUL_1809|M.ulcerans_Agy99           HGLALITIADLIEWRRKHEKHIERVAEARIPTRRGEFRAIGYTSIYENVE
MLBr_00559|M.leprae_Br4923          HDLALITIADLIAWRRKHEKHIERVAEARIPTRHGEFRAIGYTSIYDDVK
TH_2338|M.thermoresistible__bu      ------------------SRRMTSPPDQNEPTRRR---------------
                                                      .:::   .: . **::                

Mflv_3719|M.gilvum_PYR-GCK          HVALVKGDIAGPHGDGHDVLVRVHSECLTGDVFGSRRCDCGPQLDAALAM
Mvan_2694|M.vanbaalenii_PYR-1       HVALVKGEISGPHSDGHDVLVRVHSECLTGDVFGSRRCDCGPQLDAALAM
MSMEG_3072|M.smegmatis_MC2_155      HVALVRGEISGPGSDGDDVLVRVHSECLTGDVFGSRRCDCGPQLDAAMAM
MAB_2796c|M.abscessus_ATCC_199      HVALVLGDISGPDGDGNDVLVRVHSECLTGDVFGSRRCDCGPQLDAAMEM
Mb1450|M.bovis_AF2122/97            HVALVRGEIAGPNADGDDVLVRVHSECLTGDVFGSRRCDCGPQLDAALAM
Rv1415|M.tuberculosis_H37Rv         HVALVRGEIAGPNADGDDVLVRVHSECLTGDVFGSRRCDCGPQLDAALAM
MAV_3365|M.avium_104                HVALVRGEIAGPNSDGDDVLVRVHSECLTGDVFGSRRCDCGPQLDAAMAM
MMAR_2222|M.marinum_M               HVALVRGEIAGPNSDGDDVLVRVHSECLTGDVFGSRRCDCGPQLDAAMAM
MUL_1809|M.ulcerans_Agy99           HVALVRGEIAGPNSDGDDVLVRVHSECLTGDVFGSRRCDCGSQLDAAMAM
MLBr_00559|M.leprae_Br4923          HVALVRGEIAGSSGDGDDILVRVHSECLTGDVFGSRRCDCGTQLDAAMAM
TH_2338|M.thermoresistible__bu      -----AGTLLPP----------------VSSLFGHG------------GL
                                          * :  .                ...:**               :

Mflv_3719|M.gilvum_PYR-GCK          VAREGRGIVLYMRGHEGRGIGLMHKLQAYQLQDAGDDTVDANLKLGLPAD
Mvan_2694|M.vanbaalenii_PYR-1       VAREGRGVVLYMRGHEGRGIGLMHKLQAYQLQDAGDDTVDANLKLGLPAD
MSMEG_3072|M.smegmatis_MC2_155      VAREGRGVVLYMRGHEGRGIGLMHKLQAYQLQDAGEDTVDANLKLGLPAD
MAB_2796c|M.abscessus_ATCC_199      VAKEGRGIVLYMRGHEGRGIGLMHKLQAYQLQDAGEDTVDANLKLGLPAD
Mb1450|M.bovis_AF2122/97            VAREGRGVVLYMRGHEGRGIGLMHKLQAYQLQDAGADTVDANLKLGLPAD
Rv1415|M.tuberculosis_H37Rv         VAREGRGVVLYMRGHEGRGIGLMHKLQAYQLQDAGADTVDANLKLGLPAD
MAV_3365|M.avium_104                VAREGRGIVLYMRGHEGRGIGLMHKLQAYQLQDAGEDTVDANLKLGFPAD
MMAR_2222|M.marinum_M               VAREGRGVVLYMRGHEGRGIGLLHKLQAYQLQDAGDDTVDANLKLGLPAD
MUL_1809|M.ulcerans_Agy99           VAREGRGVVLYMRGHEGRGIGLLHKLQTYQLQDAGDDTVDANLKLGLPAD
MLBr_00559|M.leprae_Br4923          VAREGRGVVLYMRGHEGRGIGLMHKLQAYQLQDAGADTVDANIKLGFPSD
TH_2338|M.thermoresistible__bu      SNRTG------APGASRRGCGDPDGTANTGMRDRGHLTM-----------
                                      : *        * . ** *  .      ::* *  *:           

Mflv_3719|M.gilvum_PYR-GCK          ARDYGTGAQILVDLGVRSMRLLTNNPAKRVGLDGYGLHIIERVPLPVRAN
Mvan_2694|M.vanbaalenii_PYR-1       ARDYGTGAQILVDLGVRSMRLLTNNPAKRVGLDGYGLHIIERVPLPVRAN
MSMEG_3072|M.smegmatis_MC2_155      ARDYGIGAQILVDLGIRSMRLLTNNPAKRVGLDGYGLHIIERVPLPVRAN
MAB_2796c|M.abscessus_ATCC_199      ARDYGLGAQILVDLGVKSMRLLTNNPAKRVGLDGYGLHIIERVPLPVRAN
Mb1450|M.bovis_AF2122/97            ARDYGIGAQILVDLGVRSMRLLTNNPAKRVGLDGYGLHIIERVPLPVRAN
Rv1415|M.tuberculosis_H37Rv         ARDYGIGAQILVDLGVRSMRLLTNNPAKRVGLDGYGLHIIERVPLPVRAN
MAV_3365|M.avium_104                ARDYGIGAQILVDLGVRSMRLLTNNPAKRVGLDGYGLHIIERVPLPVRAN
MMAR_2222|M.marinum_M               ARDYGIGAQILVDLGVRSMRLLTNNPAKRVGLDGYGLHIIERVPLPVRAN
MUL_1809|M.ulcerans_Agy99           ARDYGIGAQILVDLGVRSMRLLTNNPAKRVGLDGYGLHIIERVPLPVRAN
MLBr_00559|M.leprae_Br4923          ARDYGIGAQILVDLGVRSMRLLTNNPAKRVGLDGYGLQIIERVPLPVRAN
TH_2338|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_3719|M.gilvum_PYR-GCK          AENIRYLMTKRDRMGHDLVGLDDFDEAV----------------PGEFGG
Mvan_2694|M.vanbaalenii_PYR-1       AENIRYLMTKRDRMGHDLVGLEDFDEAV----------------PGELGG
MSMEG_3072|M.smegmatis_MC2_155      KENIRYLMTKRDRMGHDLVGLDDYDEAVSMDDYDEAVYLLGDRRPTESGG
MAB_2796c|M.abscessus_ATCC_199      SENIRYLRTKRDRMGHDLADLDDHPEAD---------------------G
Mb1450|M.bovis_AF2122/97            AENIRYLMTKRDKLGHDLAGLDDFHESVH--------------LPGEFGG
Rv1415|M.tuberculosis_H37Rv         AENIRYLMTKRDKLGHDLAGLDDFHESVH--------------LPGEFGG
MAV_3365|M.avium_104                AENIRYLMTKRDKMGHDLAGLDDFHESVH--------------LPGEFGG
MMAR_2222|M.marinum_M               AENIRYLMTKRDRMGHDLTGLDDFHESVH--------------LPGEFGG
MUL_1809|M.ulcerans_Agy99           AENIRYLMTKRDRMGHDLTGLDDFHESVH--------------LPGEFGG
MLBr_00559|M.leprae_Br4923          ADNIRYLMTKRDKMGHDLGGLDDFHESNY--------------FPGEFGG
TH_2338|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_3719|M.gilvum_PYR-GCK          AV
Mvan_2694|M.vanbaalenii_PYR-1       AV
MSMEG_3072|M.smegmatis_MC2_155      AQ
MAB_2796c|M.abscessus_ATCC_199      A-
Mb1450|M.bovis_AF2122/97            AL
Rv1415|M.tuberculosis_H37Rv         AL
MAV_3365|M.avium_104                AL
MMAR_2222|M.marinum_M               AL
MUL_1809|M.ulcerans_Agy99           AL
MLBr_00559|M.leprae_Br4923          AL
TH_2338|M.thermoresistible__bu      --

species	id	gene	e-value	identity (len)	annotation
M. thermoresistible (build 8)	TH_2338	ribA2	-	100% (217)	PROBABLE RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBA2 : GTP cyclohydrolase II + 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP synthase)
M. thermoresistible (build 8)	TH_1011	-	1e-35	58.65% (133)	riboflavin biosynthesis protein ribAB