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M. thermoresistible (build 8) TH_2182 (sdhA)

annotation: PROBABLE SUCCINATE DEHYDROGENASE (FLAVOPROTEIN SUBUNIT) SDHA (SUCCINIC DEHYDROGENASE) (FUMARATE REDUCTASE) (FUMARATE DEHYDROGENASE) (FUMARIC HYDROGENASE)
coordinates: 4278068 - 4279822
length: 585

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_2182sdhA-100% (585)PROBABLE SUCCINATE DEHYDROGENASE (FLAVOPROTEIN SUBUNIT) SDHA (SUCCINIC DEHYDROGENASE) (FUMARATE REDUCTASE) (FUMARATE DEHYDROGENASE) (FUMARIC HYDROGENASE)
M. thermoresistible (build 8)TH_4672-1e-9238.32% (595) PUTATIVE succinate dehydrogenase subunit A
M. thermoresistible (build 8)TH_0808nadB2e-5236.24% (425) L-aspartate oxidase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3347sdhA0.090.51% (590) succinate dehydrogenase flavoprotein subunit
M. gilvum PYR-GCKMflv_4846sdhA0.092.98% (584) succinate dehydrogenase flavoprotein subunit
M. tuberculosis H37RvRv3318sdhA0.090.51% (590) succinate dehydrogenase flavoprotein subunit
M. leprae Br4923MLBr_00697sdhA0.090.41% (584) succinate dehydrogenase flavoprotein subunit
M. abscessus ATCC 19977MAB_3675sdhA0.092.12% (584) succinate dehydrogenase flavoprotein subunit
M. marinum MMMAR_1201sdhA0.092.12% (584) succinate dehydrogenase (flavoprotein subunit) SdhA
M. avium 104MAV_4299sdhA0.090.92% (584) succinate dehydrogenase flavoprotein subunit
M. smegmatis MC2 155MSMEG_1670sdhA0.093.66% (584) succinate dehydrogenase flavoprotein subunit
M. ulcerans Agy99MUL_1369sdhA0.091.78% (584) succinate dehydrogenase flavoprotein subunit
M. vanbaalenii PYR-1Mvan_1587sdhA0.093.15% (584) succinate dehydrogenase flavoprotein subunit

CLUSTAL 2.0.9 multiple sequence alignment


TH_2182|M.thermoresistible__bu      ----MIQEHRYDVVIVGAGGAGMRAAVEAGPRVRTAVLTKVYPTRSHTGA
MAB_3675|M.abscessus_ATCC_1997      MGSPIIQEHRYDVVIIGAGGAGMRAAVEAGPRARTAVLTKLYPTRSHTGA
Mflv_4846|M.gilvum_PYR-GCK          ----MIVEHRYDVVIVGAGGAGMRAAVEAGPRVRTAVLTKLYPTRSHTGA
Mvan_1587|M.vanbaalenii_PYR-1       ----MIVEHRYDVVIVGAGGAGMRAAVEAGPRARTAVLTKLYPTRSHTGA
MSMEG_1670|M.smegmatis_MC2_155      ----MIQEHRYDVVIVGAGGAGMRAAVEAGPRARTAVLTKLYPTRSHTGA
Mb3347|M.bovis_AF2122/97            ----MICQHRYDVVIVGAGGAGMRAAVEAGPRVRTAVLTKLYPTRSHTGA
Rv3318|M.tuberculosis_H37Rv         ----MICQHRYDVVIVGAGGAGMRAAVEAGPRVRTAVLTKLYPTRSHTGA
MLBr_00697|M.leprae_Br4923          ----MIQQHRYDVVIVGAGGAGMRAAVEAGPRVRTAVLTKLYPTRSHTGA
MAV_4299|M.avium_104                ----MIQQHRYDVVIVGAGGAGMRAAVEAGPRVRTAVLTKLYPTRSHTGA
MMAR_1201|M.marinum_M               ----MIQQHRYDVVIVGAGGAGMRAAVEAGPRVRTAVLTKLYPTRSHTGA
MUL_1369|M.ulcerans_Agy99           ----MIQQHRYDVVIVGAGGAGMRAAVEAGPRVRTAVLAKLYPTRSHTGA
                                        :* :*******:****************.*****:*:*********

TH_2182|M.thermoresistible__bu      AQGGMCAALANVEEDNWEWHAFDTVKGGDYLADQDAVEIMCREAIDAVLD
MAB_3675|M.abscessus_ATCC_1997      AQGGMCAALANVEEDNWEWHTFDTVKGGDYLADQDAVEIMCKEAIDAVLD
Mflv_4846|M.gilvum_PYR-GCK          AQGGMCAALANVEEDNWEWHTFDTVKGGDYLADQDAVEIMAKEAIDAVLD
Mvan_1587|M.vanbaalenii_PYR-1       AQGGMCAALANVEEDNWEWHTFDTVKGGDYLADQDAVEIMAKEAIDAVLD
MSMEG_1670|M.smegmatis_MC2_155      AQGGMCAALANVEEDNWEWHTFDTVKGGDYLADQDAVEIMCKEAIDAVLD
Mb3347|M.bovis_AF2122/97            AQGGMCAALANVEDDNWEWHTFDTVKGGDYLADQDAVEIMCKEAIDAVLD
Rv3318|M.tuberculosis_H37Rv         AQGGMCAALANVEDDNWEWHTFDTVKGGDYLADQDAVEIMCKEAIDAVLD
MLBr_00697|M.leprae_Br4923          AQGGMCAALANVEDDNWEWHAFDTVKGGDYLADQDAVEIMCKEAIDAVLD
MAV_4299|M.avium_104                AQGGMCAALANVEEDNWEWHTFDTVKGGDYLADQDAVEIMCKEAIDAVLD
MMAR_1201|M.marinum_M               AQGGMCAALANVEDDNWEWHTFDTVKGGDYLADQDAVEIMCKEAIDAVLD
MUL_1369|M.ulcerans_Agy99           AQGGMCAALANVEDDNWEWHTFDTVKGGDYLADQDAVEIMCKEAIDAVLD
                                    *************:******:*******************.:********

TH_2182|M.thermoresistible__bu      LEKMGMPFNRTPEGKIDQRRFGGHTRDHGKAPVRRACYAADRTGHMILQT
MAB_3675|M.abscessus_ATCC_1997      LEKMGMPFNRTPQGRIDQRRFGGHTRDHGKAPVRRACYAADRTGHMILQT
Mflv_4846|M.gilvum_PYR-GCK          LEKMGMPFNRTPEGRIDQRRFGGHTRDHGKAPVRRACYAADRTGHMILQT
Mvan_1587|M.vanbaalenii_PYR-1       LEKMGMPFNRTPEGRIDQRRFGGHTRDHGKAPVRRACYAADRTGHMILQT
MSMEG_1670|M.smegmatis_MC2_155      LEKMGMPFNRTPEGRIDQRRFGGHTRDHGKAPVRRACYAADRTGHMILQT
Mb3347|M.bovis_AF2122/97            LEKMGMPFNRTPEGRIDQRRFGGHTRDHGKAPVRRACYAADRTGHMILQT
Rv3318|M.tuberculosis_H37Rv         LEKMGMPFNRTPEGRIDQRRFGGHTRDHGKAPVRRACYAADRTGHMILQT
MLBr_00697|M.leprae_Br4923          LEKMGMPFNRTPEGRIDQRRFGGHTRDHGKAPVRRACYAADRTGHMILQT
MAV_4299|M.avium_104                LEKMGMPFNRTPEGRIDQRRFGGHTRDHGKAPVRRACYAADRTGHMILQT
MMAR_1201|M.marinum_M               LEKMGMPFNRTPEGRIDQRRFGGHTRDHGKAPVRRACYAADRTGHMILQT
MUL_1369|M.ulcerans_Agy99           LEKMGMPFNRTPEGRIDQRRFGGHTRDHGKAPVRRACYAADRTGHMILQT
                                    ************:*:***********************************

TH_2182|M.thermoresistible__bu      LYQNCVKHDVQFFNEFYALDLAMTETPSGRVATGVIAYELATGDIHVFHA
MAB_3675|M.abscessus_ATCC_1997      LYQNCVKHDVEFFNEFYALDIALTETPNGPVATGVVAYELATGDIHVFHA
Mflv_4846|M.gilvum_PYR-GCK          LYQNCVKHDVEFFNEFYALDITMTETPSGPVATGVVAYELATGDIHVFHA
Mvan_1587|M.vanbaalenii_PYR-1       LYQNCVKHDVEFFNEFYALDITLTETASGPVATGVVAYELATGDIHIFHA
MSMEG_1670|M.smegmatis_MC2_155      LYQNCVKHDVEFFNEFYALDIALTETPAGPVATGVIAYELATGDIHVFHA
Mb3347|M.bovis_AF2122/97            LYQNCVKHDVEFFNEFYALDLALTQTPSGPVATGVIAYELATGDIHVFHA
Rv3318|M.tuberculosis_H37Rv         LYQNCVKHDVEFFNEFYALDLALTQTPSGPVATGVIAYELATGDIHVFHA
MLBr_00697|M.leprae_Br4923          LYQNCVKHDVEFFNEFYALDLVLTQTPSGPVTTGVVAYELATGDIHVFHT
MAV_4299|M.avium_104                LYQNCVRHDVQFFNEFYALDLVLTQTPSGPVASGVVAYELATGDIHVFHA
MMAR_1201|M.marinum_M               LYQNCVKHDVEFFNEFYALDLALTETPSGPVATGVIAYELATGDIHIFHA
MUL_1369|M.ulcerans_Agy99           LYQNCVKHDVEFFNEFYALDLALTETPSGPVATGVIAYELATGDIHIFHA
                                    ******:***:*********:.:*:*. * *::**:**********:**:

TH_2182|M.thermoresistible__bu      KAIVFATGGSGRMYKTTSNAHTLTGDGLGIVFRKGLPLEDMEFHQFHPTG
MAB_3675|M.abscessus_ATCC_1997      KAIVFATGGSGRMYKTTSNAHTLTGDGLGIVFRKGLPLEDMEFHQFHPTG
Mflv_4846|M.gilvum_PYR-GCK          KAIVFATGGSGRMYKTTSNAHTLTGDGLGIIFRKGLPLEDMEFHQFHPTG
Mvan_1587|M.vanbaalenii_PYR-1       KAIVFATGGSGRMYKTTSNAHTLTGDGLGIIFRKGLPLEDMEFHQFHPTG
MSMEG_1670|M.smegmatis_MC2_155      KAIVFATGGSGRMYKTTSNAHTLTGDGLGIVFRKGLPLEDMEFHQFHPTG
Mb3347|M.bovis_AF2122/97            KAVVIATGGSGRMYKTTSNAHTLTGDGIGIVFRKGLPLEDMEFHQFHPTG
Rv3318|M.tuberculosis_H37Rv         KAVVIATGGSGRMYKTTSNAHTLTGDGIGIVFRKGLPLEDMEFHQFHPTG
MLBr_00697|M.leprae_Br4923          KAVVIATGGSGRMYKTTSNAHTLTGDGIGIVFRKGLPLEDMEFHQFHPTG
MAV_4299|M.avium_104                KAVVLATGGSGRMYKTTSNAHTLTGDGIGIVFRKGLPLEDMEFHQFHPTG
MMAR_1201|M.marinum_M               KAIVLATGGSGRMYKTTSNAHTLTGDGIGIVFRKGLPLEDMEFHQFHPTG
MUL_1369|M.ulcerans_Agy99           KAIVLATGGSGRMYKTTSNAHTLTGDGIGIVFRKGLPLEDMEFHQFHPTG
                                    **:*:**********************:**:*******************

TH_2182|M.thermoresistible__bu      LAGLGILISEAVRGEGGRLLNGEGERFMERYAPTIVDLAPRDIVARSMVL
MAB_3675|M.abscessus_ATCC_1997      LAGLGILISEAVRGEGGRLLNADGERFMERYAPTIVDLAPRDIVARSMVL
Mflv_4846|M.gilvum_PYR-GCK          LAGLGILISEAVRGEGGRLLNGDGERFMERYAPTIVDLAPRDIVARSMVL
Mvan_1587|M.vanbaalenii_PYR-1       LAGLGILISEAVRGEGGRLLNGEGERFMERYAPTIVDLAPRDIVARSMVL
MSMEG_1670|M.smegmatis_MC2_155      LAGLGILISEAVRGEGGRLLNGEGERFMERYAPTIVDLAPRDIVARSMVL
Mb3347|M.bovis_AF2122/97            LAGLGILISEAVRGEGGRLLNGEGERFMERYAPTIVDLAPRDIVARSMVL
Rv3318|M.tuberculosis_H37Rv         LAGLGILISEAVRGEGGRLLNGEGERFMERYAPTIVDLAPRDIVARSMVL
MLBr_00697|M.leprae_Br4923          LAGLGILISEAVRGEGGRLLNGENERFMEHYAPTIVDLAPRDIVARSMVL
MAV_4299|M.avium_104                LAGLGILISEAVRGEGGRLLNGEGERFMERYAPTIVDLAPRDIVARSMVL
MMAR_1201|M.marinum_M               LAGLGILISEAVRGEGGRLLNGEGERFMERYAPTIVDLAPRDIVARSMVL
MUL_1369|M.ulcerans_Agy99           LAGLGILISEAVRGEGGRLLNGEGERFMERYAPTIVDLAPRDIVARSMVL
                                    *********************.:.*****:********************

TH_2182|M.thermoresistible__bu      EVLEGRGAGPNKDYVYIDVRHLGEDVLEAKLPDITEFARTYLGVDPVTEL
MAB_3675|M.abscessus_ATCC_1997      EVLEGRGAGPNKDYVYIDVRHLGADVLEAKLPDITEFARTYLGVDPVTEL
Mflv_4846|M.gilvum_PYR-GCK          EVLEGRGAGPNKDYVYIDVRHLGEDVLEAKLPDITEFARTYLGVDPVKEL
Mvan_1587|M.vanbaalenii_PYR-1       EVLEGRGAGPNKDYVYIDVRHLGEDVLEAKLPDITEFARTYLGVDPVKEL
MSMEG_1670|M.smegmatis_MC2_155      EVLEGRGAGPNKDYVYIDVRHLGEDVLEAKLPDITEFARTYLGVDPVKEL
Mb3347|M.bovis_AF2122/97            EVLEGRGAGPLKDYVYIDVRHLGEEVLEAKLPDITEFARTYLGVDPVTEL
Rv3318|M.tuberculosis_H37Rv         EVLEGRGAGPLKDYVYIDVRHLGEEVLEAKLPDITEFARTYLGVDPVTEL
MLBr_00697|M.leprae_Br4923          EVLEGRGAGPHKDYVYIDVRHLGEEVLESKLPDITEFSRTYLGVDPVHEL
MAV_4299|M.avium_104                EVLEGRGAGPHKDYVYIDVRHLGEDVLESKLPDITEFARTYLGVDPVHEL
MMAR_1201|M.marinum_M               EVLEGRGAGPHKDYVYIDVRHLGEDVLEAKLPDITEFARTYLGVDPVHEL
MUL_1369|M.ulcerans_Agy99           EVLEGRGAGPHKDYVYIDVRHLGEDVLEAKLPDITEFARTYLGVDPVHEL
                                    ********** ************ :***:********:********* **

TH_2182|M.thermoresistible__bu      VPVYPTCHYLMGGIPTTVHGQVLADNTTIVPGLYAAGECACVSVHGANRL
MAB_3675|M.abscessus_ATCC_1997      VPVYPTCHYVMGGIPTNIHGQVLRDNDNVVPGLYAAGECACVSVHGANRL
Mflv_4846|M.gilvum_PYR-GCK          VPVYPTCHYVMGGIPTTVNGQVLSDNTTVVPGLYAAGECACVSVHGANRL
Mvan_1587|M.vanbaalenii_PYR-1       VPVYPTCHYVMGGIPTTVNGQVLADNTTIIPGLYAAGECACVSVHGANRL
MSMEG_1670|M.smegmatis_MC2_155      VPVYPTCHYVMGGIPTTVNGQVLRDNTNVIPGLYAAGECACVSVHGANRL
Mb3347|M.bovis_AF2122/97            VPVYPTCHYLMGGIPTTVTGQVLRDNTSVVPGLYAAGECACVSVHGANRL
Rv3318|M.tuberculosis_H37Rv         VPVYPTCHYLMGGIPTTVTGQVLRDNTSVVPGLYAAGECACVSVHGANRL
MLBr_00697|M.leprae_Br4923          VPVYPTCHYVMGGIPTTVTGQVLRDNTSTVPGLYAAGECACVSVHGANRL
MAV_4299|M.avium_104                VPVYPTCHYVMGGIPTTVTGQVLRDNTSTVPGLYAAGECACVSVHGANRL
MMAR_1201|M.marinum_M               VPVYPTCHYVMGGIPTTVTGQVLRDNTHVVPGLFAAGECACVSVHGANRL
MUL_1369|M.ulcerans_Agy99           VPVYPTCHYVMGGIPTTVTGQVLRDNTHVVPGLFAAGECACVSVHGANRL
                                    *********:******.: **** **   :***:****************

TH_2182|M.thermoresistible__bu      GTNSLLDINVFGRRAGLAAADYAQNHDFVPLPDNPAGMVTEWIAHILSEH
MAB_3675|M.abscessus_ATCC_1997      GTNSLLDINVFGRRAGIAAAEYAEAHDFIDLPENPATMVTEWVADVLSEH
Mflv_4846|M.gilvum_PYR-GCK          GTNSLLDINVFGRRAGIAAANYALGHDFVELPESPAEMVVGWVGDILSEH
Mvan_1587|M.vanbaalenii_PYR-1       GTNSLLDINVFGRRAGIAAANYALGHDFVDLPENPAEMVVGWVGDILSEH
MSMEG_1670|M.smegmatis_MC2_155      GTNSLLDINVFGRRAGIAAAEYAQNHNFVDMPENPAEMVVGWVGDILSEH
Mb3347|M.bovis_AF2122/97            GTNSLLDINVFGRRAGIAAASYAQGHDFVDMPPNPEAMVVGWVSDILSEH
Rv3318|M.tuberculosis_H37Rv         GTNSLLDINVFGRRAGIAAASYAQGHDFVDMPPNPEAMVVGWVSDILSEH
MLBr_00697|M.leprae_Br4923          GTNSLLDINVFGRRSGIAAASYASANDFVDMPPNPAEMVISWVANILSEH
MAV_4299|M.avium_104                GTNSLLDINVFGRRAGIAAANYARGHDFVDMPPDPAAMVVRWVADILSEH
MMAR_1201|M.marinum_M               GTNSLLDINVFGRRAGIAAARYARGHDFVDMPAEPASMVVSWVADILSEH
MUL_1369|M.ulcerans_Agy99           GTNSLLDINVFGRRAGIAAARYARGHDFVDMPAEPASMVVSWVADILSEH
                                    **************:*:*** **  ::*: :* .*  **  *:..:****

TH_2182|M.thermoresistible__bu      GHERVADIRGALQQTMDNNAAVFRTEETLKTALSDIHRLKERYSRITVQD
MAB_3675|M.abscessus_ATCC_1997      GDERVADIRTELQQSMDNNAAVFRTEDTLKQALNDIHALKERYSRITVHD
Mflv_4846|M.gilvum_PYR-GCK          GNERVADIRGALQQSMDNNAAVFRTEETLKQALTDIHALKERYSRITVQD
Mvan_1587|M.vanbaalenii_PYR-1       GNERVADIRGALQQSMDNNAAVFRTEETLKQALTDIHALKERYSRITVQD
MSMEG_1670|M.smegmatis_MC2_155      GNERVADIRGALQQSMDNNAAVFRTEETLKQALTDIHALKERYSRITVHD
Mb3347|M.bovis_AF2122/97            GNERVADIRGALQQSMDNNAAVFRTEETLKQALTDIHALKERYSRITVHD
Rv3318|M.tuberculosis_H37Rv         GNERVADIRGALQQSMDNNAAVFRTEETLKQALTDIHALKERYSRITVHD
MLBr_00697|M.leprae_Br4923          GNERVADIRGALQQTMDNNAAVFRTEETLKQALTDIHSLKERYSRITVHD
MAV_4299|M.avium_104                GNERVADIRGTLQQSMDNNAAVFRTEETLKQALTDIHACKERYSRIRIHD
MMAR_1201|M.marinum_M               GTERVADIRGALQQTMDNNAAVFRTEETLKQALTDIHALKERYSRITVHD
MUL_1369|M.ulcerans_Agy99           GNEPVADIRGALQQTMDNNAAVFRTEETLKQALTDIHALKERYSRITVHD
                                    * * *****  ***:***********:*** **.***  ******* ::*

TH_2182|M.thermoresistible__bu      KGKRYNSDLLEAIELGFLLELAEVTVVGALNRKETRGGHAREDYPNRDDT
MAB_3675|M.abscessus_ATCC_1997      KGKRYNSDLLEAIELGFLLELAEVTVVGALNRKESRGGHAREDYPNRDDT
Mflv_4846|M.gilvum_PYR-GCK          KGKRYNSDLLEAIELGFLLELAEVTVVGALNRKESRGGHAREDYPNRDDT
Mvan_1587|M.vanbaalenii_PYR-1       KGKRYNSDLLEAIELGFLLELAEVTVVGALNRKESRGGHAREDYPNRDDT
MSMEG_1670|M.smegmatis_MC2_155      KGKRYNSDLLEAIELGFLLELAEVTVVGALNRKESRGGHAREDYPNRDDT
Mb3347|M.bovis_AF2122/97            KGKRFNTDLLEAIELGFLLELAEVTVVGALNRKESRGGHAREDYPNRDDV
Rv3318|M.tuberculosis_H37Rv         KGKRFNTDLLEAIELGFLLELAEVTVVGALNRKESRGGHAREDYPNRDDV
MLBr_00697|M.leprae_Br4923          KGKSFNSDLLEAIELGFLLELAEVTVVGALNRKESRGGHAREDYPHRDDT
MAV_4299|M.avium_104                KGKRFNSDLLEAIELGFLLELAEVTVVGALNRKESRGGHAREDYPNRDDV
MMAR_1201|M.marinum_M               KGKRFNSDLLEAIELGFLLELAEVTVVGALNRKESRGGHAREDYPNRDDV
MUL_1369|M.ulcerans_Agy99           KGKRFNSDLLEAIELGFLLELAEVTVVGALNRKESRGGHAREDYPNRDDV
                                    *** :*:***************************:**********:***.

TH_2182|M.thermoresistible__bu      NYMRHTMAY------KQGTELLSDIRLDYKPVVQTRYEPMERKY
MAB_3675|M.abscessus_ATCC_1997      NYMRHTMAY------KQGAELLSDIRLDYKPVVQTRYEPMERKY
Mflv_4846|M.gilvum_PYR-GCK          NYMRHTMAY------KEGSDLLSDIRLDYKPVVMTRYEPMERKY
Mvan_1587|M.vanbaalenii_PYR-1       NYMRHTMAY------KEGTDLLSDIRLDYKPVVQTRYEPMERKY
MSMEG_1670|M.smegmatis_MC2_155      NYMRHTMAY------KQGTDLLSDIRLDYKPVVQTRYEPMERKY
Mb3347|M.bovis_AF2122/97            NYMRHTMAYKEIGADKEGPELRSDVRLDFKPVVQTRYEPKERKY
Rv3318|M.tuberculosis_H37Rv         NYMRHTMAYKEIGADKEGPELRSDVRLDFKPVVQTRYEPKERKY
MLBr_00697|M.leprae_Br4923          NYMRHTMAY------KQGTDLLSDIALDFKPVVQTRYEPQERKY
MAV_4299|M.avium_104                NYMRHTMAY------KQGTDLLSDIALDFKPVVQTRYEPKERKY
MMAR_1201|M.marinum_M               NYMRHTMAY------KEGTDLLSDIRLDFKPVVQTRYEPKERKY
MUL_1369|M.ulcerans_Agy99           NYMRHTMAY------KEGTDLLSDIRLDFKPVVQTRYEPKERKY
                                    *********      *:*.:* **: **:**** ***** ****