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MIQQHRYDVVIVGAGGAGMRAAVEAGPRVRTAVLTKLYPTRSHTGAAQGGMCAALANVEEDNWEWHTFDT VKGGDYLADQDAVEIMCKEAIDAVLDLEKMGMPFNRTPEGRIDQRRFGGHTRDHGKAPVRRACYAADRTG HMILQTLYQNCVRHDVQFFNEFYALDLVLTQTPSGPVASGVVAYELATGDIHVFHAKAVVLATGGSGRMY KTTSNAHTLTGDGIGIVFRKGLPLEDMEFHQFHPTGLAGLGILISEAVRGEGGRLLNGEGERFMERYAPT IVDLAPRDIVARSMVLEVLEGRGAGPHKDYVYIDVRHLGEDVLESKLPDITEFARTYLGVDPVHELVPVY PTCHYVMGGIPTTVTGQVLRDNTSTVPGLYAAGECACVSVHGANRLGTNSLLDINVFGRRAGIAAANYAR GHDFVDMPPDPAAMVVRWVADILSEHGNERVADIRGTLQQSMDNNAAVFRTEETLKQALTDIHACKERYS RIRIHDKGKRFNSDLLEAIELGFLLELAEVTVVGALNRKESRGGHAREDYPNRDDVNYMRHTMAYKQGTD LLSDIALDFKPVVQTRYEPKERKY
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. avium 104 | MAV_4299 | sdhA | - | 100% (584) | succinate dehydrogenase flavoprotein subunit |
M. avium 104 | MAV_4909 | sdhA | 2e-93 | 37.59% (588) | succinate dehydrogenase flavoprotein subunit |
M. avium 104 | MAV_3190 | nadB | 2e-56 | 33.39% (560) | L-aspartate oxidase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3347 | sdhA | 0.0 | 93.56% (590) | succinate dehydrogenase flavoprotein subunit |
M. gilvum PYR-GCK | Mflv_4846 | sdhA | 0.0 | 92.64% (584) | succinate dehydrogenase flavoprotein subunit |
M. tuberculosis H37Rv | Rv3318 | sdhA | 0.0 | 93.56% (590) | succinate dehydrogenase flavoprotein subunit |
M. leprae Br4923 | MLBr_00697 | sdhA | 0.0 | 94.35% (584) | succinate dehydrogenase flavoprotein subunit |
M. abscessus ATCC 19977 | MAB_3675 | sdhA | 0.0 | 90.92% (584) | succinate dehydrogenase flavoprotein subunit |
M. marinum M | MMAR_1201 | sdhA | 0.0 | 95.38% (584) | succinate dehydrogenase (flavoprotein subunit) SdhA |
M. smegmatis MC2 155 | MSMEG_1670 | sdhA | 0.0 | 93.49% (584) | succinate dehydrogenase flavoprotein subunit |
M. thermoresistible (build 8) | TH_2182 | sdhA | 0.0 | 90.92% (584) | PROBABLE SUCCINATE DEHYDROGENASE (FLAVOPROTEIN SUBUNIT) SDHA |
M. ulcerans Agy99 | MUL_1369 | sdhA | 0.0 | 95.21% (584) | succinate dehydrogenase flavoprotein subunit |
M. vanbaalenii PYR-1 | Mvan_1587 | sdhA | 0.0 | 92.81% (584) | succinate dehydrogenase flavoprotein subunit |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_4846|M.gilvum_PYR-GCK ----MIVEHRYDVVIVGAGGAGMRAAVEAGPRVRTAVLTKLYPTRSHTGA Mvan_1587|M.vanbaalenii_PYR-1 ----MIVEHRYDVVIVGAGGAGMRAAVEAGPRARTAVLTKLYPTRSHTGA MSMEG_1670|M.smegmatis_MC2_155 ----MIQEHRYDVVIVGAGGAGMRAAVEAGPRARTAVLTKLYPTRSHTGA MAB_3675|M.abscessus_ATCC_1997 MGSPIIQEHRYDVVIIGAGGAGMRAAVEAGPRARTAVLTKLYPTRSHTGA TH_2182|M.thermoresistible__bu ----MIQEHRYDVVIVGAGGAGMRAAVEAGPRVRTAVLTKVYPTRSHTGA MAV_4299|M.avium_104 ----MIQQHRYDVVIVGAGGAGMRAAVEAGPRVRTAVLTKLYPTRSHTGA MLBr_00697|M.leprae_Br4923 ----MIQQHRYDVVIVGAGGAGMRAAVEAGPRVRTAVLTKLYPTRSHTGA Mb3347|M.bovis_AF2122/97 ----MICQHRYDVVIVGAGGAGMRAAVEAGPRVRTAVLTKLYPTRSHTGA Rv3318|M.tuberculosis_H37Rv ----MICQHRYDVVIVGAGGAGMRAAVEAGPRVRTAVLTKLYPTRSHTGA MMAR_1201|M.marinum_M ----MIQQHRYDVVIVGAGGAGMRAAVEAGPRVRTAVLTKLYPTRSHTGA MUL_1369|M.ulcerans_Agy99 ----MIQQHRYDVVIVGAGGAGMRAAVEAGPRVRTAVLAKLYPTRSHTGA :* :*******:****************.*****:*:********* Mflv_4846|M.gilvum_PYR-GCK AQGGMCAALANVEEDNWEWHTFDTVKGGDYLADQDAVEIMAKEAIDAVLD Mvan_1587|M.vanbaalenii_PYR-1 AQGGMCAALANVEEDNWEWHTFDTVKGGDYLADQDAVEIMAKEAIDAVLD MSMEG_1670|M.smegmatis_MC2_155 AQGGMCAALANVEEDNWEWHTFDTVKGGDYLADQDAVEIMCKEAIDAVLD MAB_3675|M.abscessus_ATCC_1997 AQGGMCAALANVEEDNWEWHTFDTVKGGDYLADQDAVEIMCKEAIDAVLD TH_2182|M.thermoresistible__bu AQGGMCAALANVEEDNWEWHAFDTVKGGDYLADQDAVEIMCREAIDAVLD MAV_4299|M.avium_104 AQGGMCAALANVEEDNWEWHTFDTVKGGDYLADQDAVEIMCKEAIDAVLD MLBr_00697|M.leprae_Br4923 AQGGMCAALANVEDDNWEWHAFDTVKGGDYLADQDAVEIMCKEAIDAVLD Mb3347|M.bovis_AF2122/97 AQGGMCAALANVEDDNWEWHTFDTVKGGDYLADQDAVEIMCKEAIDAVLD Rv3318|M.tuberculosis_H37Rv AQGGMCAALANVEDDNWEWHTFDTVKGGDYLADQDAVEIMCKEAIDAVLD MMAR_1201|M.marinum_M AQGGMCAALANVEDDNWEWHTFDTVKGGDYLADQDAVEIMCKEAIDAVLD MUL_1369|M.ulcerans_Agy99 AQGGMCAALANVEDDNWEWHTFDTVKGGDYLADQDAVEIMCKEAIDAVLD *************:******:*******************.:******** Mflv_4846|M.gilvum_PYR-GCK LEKMGMPFNRTPEGRIDQRRFGGHTRDHGKAPVRRACYAADRTGHMILQT Mvan_1587|M.vanbaalenii_PYR-1 LEKMGMPFNRTPEGRIDQRRFGGHTRDHGKAPVRRACYAADRTGHMILQT MSMEG_1670|M.smegmatis_MC2_155 LEKMGMPFNRTPEGRIDQRRFGGHTRDHGKAPVRRACYAADRTGHMILQT MAB_3675|M.abscessus_ATCC_1997 LEKMGMPFNRTPQGRIDQRRFGGHTRDHGKAPVRRACYAADRTGHMILQT TH_2182|M.thermoresistible__bu LEKMGMPFNRTPEGKIDQRRFGGHTRDHGKAPVRRACYAADRTGHMILQT MAV_4299|M.avium_104 LEKMGMPFNRTPEGRIDQRRFGGHTRDHGKAPVRRACYAADRTGHMILQT MLBr_00697|M.leprae_Br4923 LEKMGMPFNRTPEGRIDQRRFGGHTRDHGKAPVRRACYAADRTGHMILQT Mb3347|M.bovis_AF2122/97 LEKMGMPFNRTPEGRIDQRRFGGHTRDHGKAPVRRACYAADRTGHMILQT Rv3318|M.tuberculosis_H37Rv LEKMGMPFNRTPEGRIDQRRFGGHTRDHGKAPVRRACYAADRTGHMILQT MMAR_1201|M.marinum_M LEKMGMPFNRTPEGRIDQRRFGGHTRDHGKAPVRRACYAADRTGHMILQT MUL_1369|M.ulcerans_Agy99 LEKMGMPFNRTPEGRIDQRRFGGHTRDHGKAPVRRACYAADRTGHMILQT ************:*:*********************************** Mflv_4846|M.gilvum_PYR-GCK LYQNCVKHDVEFFNEFYALDITMTETPSGPVATGVVAYELATGDIHVFHA Mvan_1587|M.vanbaalenii_PYR-1 LYQNCVKHDVEFFNEFYALDITLTETASGPVATGVVAYELATGDIHIFHA MSMEG_1670|M.smegmatis_MC2_155 LYQNCVKHDVEFFNEFYALDIALTETPAGPVATGVIAYELATGDIHVFHA MAB_3675|M.abscessus_ATCC_1997 LYQNCVKHDVEFFNEFYALDIALTETPNGPVATGVVAYELATGDIHVFHA TH_2182|M.thermoresistible__bu LYQNCVKHDVQFFNEFYALDLAMTETPSGRVATGVIAYELATGDIHVFHA MAV_4299|M.avium_104 LYQNCVRHDVQFFNEFYALDLVLTQTPSGPVASGVVAYELATGDIHVFHA MLBr_00697|M.leprae_Br4923 LYQNCVKHDVEFFNEFYALDLVLTQTPSGPVTTGVVAYELATGDIHVFHT Mb3347|M.bovis_AF2122/97 LYQNCVKHDVEFFNEFYALDLALTQTPSGPVATGVIAYELATGDIHVFHA Rv3318|M.tuberculosis_H37Rv LYQNCVKHDVEFFNEFYALDLALTQTPSGPVATGVIAYELATGDIHVFHA MMAR_1201|M.marinum_M LYQNCVKHDVEFFNEFYALDLALTETPSGPVATGVIAYELATGDIHIFHA MUL_1369|M.ulcerans_Agy99 LYQNCVKHDVEFFNEFYALDLALTETPSGPVATGVIAYELATGDIHIFHA ******:***:*********:.:*:*. * *::**:**********:**: Mflv_4846|M.gilvum_PYR-GCK KAIVFATGGSGRMYKTTSNAHTLTGDGLGIIFRKGLPLEDMEFHQFHPTG Mvan_1587|M.vanbaalenii_PYR-1 KAIVFATGGSGRMYKTTSNAHTLTGDGLGIIFRKGLPLEDMEFHQFHPTG MSMEG_1670|M.smegmatis_MC2_155 KAIVFATGGSGRMYKTTSNAHTLTGDGLGIVFRKGLPLEDMEFHQFHPTG MAB_3675|M.abscessus_ATCC_1997 KAIVFATGGSGRMYKTTSNAHTLTGDGLGIVFRKGLPLEDMEFHQFHPTG TH_2182|M.thermoresistible__bu KAIVFATGGSGRMYKTTSNAHTLTGDGLGIVFRKGLPLEDMEFHQFHPTG MAV_4299|M.avium_104 KAVVLATGGSGRMYKTTSNAHTLTGDGIGIVFRKGLPLEDMEFHQFHPTG MLBr_00697|M.leprae_Br4923 KAVVIATGGSGRMYKTTSNAHTLTGDGIGIVFRKGLPLEDMEFHQFHPTG Mb3347|M.bovis_AF2122/97 KAVVIATGGSGRMYKTTSNAHTLTGDGIGIVFRKGLPLEDMEFHQFHPTG Rv3318|M.tuberculosis_H37Rv KAVVIATGGSGRMYKTTSNAHTLTGDGIGIVFRKGLPLEDMEFHQFHPTG MMAR_1201|M.marinum_M KAIVLATGGSGRMYKTTSNAHTLTGDGIGIVFRKGLPLEDMEFHQFHPTG MUL_1369|M.ulcerans_Agy99 KAIVLATGGSGRMYKTTSNAHTLTGDGIGIVFRKGLPLEDMEFHQFHPTG **:*:**********************:**:******************* Mflv_4846|M.gilvum_PYR-GCK LAGLGILISEAVRGEGGRLLNGDGERFMERYAPTIVDLAPRDIVARSMVL Mvan_1587|M.vanbaalenii_PYR-1 LAGLGILISEAVRGEGGRLLNGEGERFMERYAPTIVDLAPRDIVARSMVL MSMEG_1670|M.smegmatis_MC2_155 LAGLGILISEAVRGEGGRLLNGEGERFMERYAPTIVDLAPRDIVARSMVL MAB_3675|M.abscessus_ATCC_1997 LAGLGILISEAVRGEGGRLLNADGERFMERYAPTIVDLAPRDIVARSMVL TH_2182|M.thermoresistible__bu LAGLGILISEAVRGEGGRLLNGEGERFMERYAPTIVDLAPRDIVARSMVL MAV_4299|M.avium_104 LAGLGILISEAVRGEGGRLLNGEGERFMERYAPTIVDLAPRDIVARSMVL MLBr_00697|M.leprae_Br4923 LAGLGILISEAVRGEGGRLLNGENERFMEHYAPTIVDLAPRDIVARSMVL Mb3347|M.bovis_AF2122/97 LAGLGILISEAVRGEGGRLLNGEGERFMERYAPTIVDLAPRDIVARSMVL Rv3318|M.tuberculosis_H37Rv LAGLGILISEAVRGEGGRLLNGEGERFMERYAPTIVDLAPRDIVARSMVL MMAR_1201|M.marinum_M LAGLGILISEAVRGEGGRLLNGEGERFMERYAPTIVDLAPRDIVARSMVL MUL_1369|M.ulcerans_Agy99 LAGLGILISEAVRGEGGRLLNGEGERFMERYAPTIVDLAPRDIVARSMVL *********************.:.*****:******************** Mflv_4846|M.gilvum_PYR-GCK EVLEGRGAGPNKDYVYIDVRHLGEDVLEAKLPDITEFARTYLGVDPVKEL Mvan_1587|M.vanbaalenii_PYR-1 EVLEGRGAGPNKDYVYIDVRHLGEDVLEAKLPDITEFARTYLGVDPVKEL MSMEG_1670|M.smegmatis_MC2_155 EVLEGRGAGPNKDYVYIDVRHLGEDVLEAKLPDITEFARTYLGVDPVKEL MAB_3675|M.abscessus_ATCC_1997 EVLEGRGAGPNKDYVYIDVRHLGADVLEAKLPDITEFARTYLGVDPVTEL TH_2182|M.thermoresistible__bu EVLEGRGAGPNKDYVYIDVRHLGEDVLEAKLPDITEFARTYLGVDPVTEL MAV_4299|M.avium_104 EVLEGRGAGPHKDYVYIDVRHLGEDVLESKLPDITEFARTYLGVDPVHEL MLBr_00697|M.leprae_Br4923 EVLEGRGAGPHKDYVYIDVRHLGEEVLESKLPDITEFSRTYLGVDPVHEL Mb3347|M.bovis_AF2122/97 EVLEGRGAGPLKDYVYIDVRHLGEEVLEAKLPDITEFARTYLGVDPVTEL Rv3318|M.tuberculosis_H37Rv EVLEGRGAGPLKDYVYIDVRHLGEEVLEAKLPDITEFARTYLGVDPVTEL MMAR_1201|M.marinum_M EVLEGRGAGPHKDYVYIDVRHLGEDVLEAKLPDITEFARTYLGVDPVHEL MUL_1369|M.ulcerans_Agy99 EVLEGRGAGPHKDYVYIDVRHLGEDVLEAKLPDITEFARTYLGVDPVHEL ********** ************ :***:********:********* ** Mflv_4846|M.gilvum_PYR-GCK VPVYPTCHYVMGGIPTTVNGQVLSDNTTVVPGLYAAGECACVSVHGANRL Mvan_1587|M.vanbaalenii_PYR-1 VPVYPTCHYVMGGIPTTVNGQVLADNTTIIPGLYAAGECACVSVHGANRL MSMEG_1670|M.smegmatis_MC2_155 VPVYPTCHYVMGGIPTTVNGQVLRDNTNVIPGLYAAGECACVSVHGANRL MAB_3675|M.abscessus_ATCC_1997 VPVYPTCHYVMGGIPTNIHGQVLRDNDNVVPGLYAAGECACVSVHGANRL TH_2182|M.thermoresistible__bu VPVYPTCHYLMGGIPTTVHGQVLADNTTIVPGLYAAGECACVSVHGANRL MAV_4299|M.avium_104 VPVYPTCHYVMGGIPTTVTGQVLRDNTSTVPGLYAAGECACVSVHGANRL MLBr_00697|M.leprae_Br4923 VPVYPTCHYVMGGIPTTVTGQVLRDNTSTVPGLYAAGECACVSVHGANRL Mb3347|M.bovis_AF2122/97 VPVYPTCHYLMGGIPTTVTGQVLRDNTSVVPGLYAAGECACVSVHGANRL Rv3318|M.tuberculosis_H37Rv VPVYPTCHYLMGGIPTTVTGQVLRDNTSVVPGLYAAGECACVSVHGANRL MMAR_1201|M.marinum_M VPVYPTCHYVMGGIPTTVTGQVLRDNTHVVPGLFAAGECACVSVHGANRL MUL_1369|M.ulcerans_Agy99 VPVYPTCHYVMGGIPTTVTGQVLRDNTHVVPGLFAAGECACVSVHGANRL *********:******.: **** ** :***:**************** Mflv_4846|M.gilvum_PYR-GCK GTNSLLDINVFGRRAGIAAANYALGHDFVELPESPAEMVVGWVGDILSEH Mvan_1587|M.vanbaalenii_PYR-1 GTNSLLDINVFGRRAGIAAANYALGHDFVDLPENPAEMVVGWVGDILSEH MSMEG_1670|M.smegmatis_MC2_155 GTNSLLDINVFGRRAGIAAAEYAQNHNFVDMPENPAEMVVGWVGDILSEH MAB_3675|M.abscessus_ATCC_1997 GTNSLLDINVFGRRAGIAAAEYAEAHDFIDLPENPATMVTEWVADVLSEH TH_2182|M.thermoresistible__bu GTNSLLDINVFGRRAGLAAADYAQNHDFVPLPDNPAGMVTEWIAHILSEH MAV_4299|M.avium_104 GTNSLLDINVFGRRAGIAAANYARGHDFVDMPPDPAAMVVRWVADILSEH MLBr_00697|M.leprae_Br4923 GTNSLLDINVFGRRSGIAAASYASANDFVDMPPNPAEMVISWVANILSEH Mb3347|M.bovis_AF2122/97 GTNSLLDINVFGRRAGIAAASYAQGHDFVDMPPNPEAMVVGWVSDILSEH Rv3318|M.tuberculosis_H37Rv GTNSLLDINVFGRRAGIAAASYAQGHDFVDMPPNPEAMVVGWVSDILSEH MMAR_1201|M.marinum_M GTNSLLDINVFGRRAGIAAARYARGHDFVDMPAEPASMVVSWVADILSEH MUL_1369|M.ulcerans_Agy99 GTNSLLDINVFGRRAGIAAARYARGHDFVDMPAEPASMVVSWVADILSEH **************:*:*** ** ::*: :* .* ** *:..:**** Mflv_4846|M.gilvum_PYR-GCK GNERVADIRGALQQSMDNNAAVFRTEETLKQALTDIHALKERYSRITVQD Mvan_1587|M.vanbaalenii_PYR-1 GNERVADIRGALQQSMDNNAAVFRTEETLKQALTDIHALKERYSRITVQD MSMEG_1670|M.smegmatis_MC2_155 GNERVADIRGALQQSMDNNAAVFRTEETLKQALTDIHALKERYSRITVHD MAB_3675|M.abscessus_ATCC_1997 GDERVADIRTELQQSMDNNAAVFRTEDTLKQALNDIHALKERYSRITVHD TH_2182|M.thermoresistible__bu GHERVADIRGALQQTMDNNAAVFRTEETLKTALSDIHRLKERYSRITVQD MAV_4299|M.avium_104 GNERVADIRGTLQQSMDNNAAVFRTEETLKQALTDIHACKERYSRIRIHD MLBr_00697|M.leprae_Br4923 GNERVADIRGALQQTMDNNAAVFRTEETLKQALTDIHSLKERYSRITVHD Mb3347|M.bovis_AF2122/97 GNERVADIRGALQQSMDNNAAVFRTEETLKQALTDIHALKERYSRITVHD Rv3318|M.tuberculosis_H37Rv GNERVADIRGALQQSMDNNAAVFRTEETLKQALTDIHALKERYSRITVHD MMAR_1201|M.marinum_M GTERVADIRGALQQTMDNNAAVFRTEETLKQALTDIHALKERYSRITVHD MUL_1369|M.ulcerans_Agy99 GNEPVADIRGALQQTMDNNAAVFRTEETLKQALTDIHALKERYSRITVHD * * ***** ***:***********:*** **.*** ******* ::* Mflv_4846|M.gilvum_PYR-GCK KGKRYNSDLLEAIELGFLLELAEVTVVGALNRKESRGGHAREDYPNRDDT Mvan_1587|M.vanbaalenii_PYR-1 KGKRYNSDLLEAIELGFLLELAEVTVVGALNRKESRGGHAREDYPNRDDT MSMEG_1670|M.smegmatis_MC2_155 KGKRYNSDLLEAIELGFLLELAEVTVVGALNRKESRGGHAREDYPNRDDT MAB_3675|M.abscessus_ATCC_1997 KGKRYNSDLLEAIELGFLLELAEVTVVGALNRKESRGGHAREDYPNRDDT TH_2182|M.thermoresistible__bu KGKRYNSDLLEAIELGFLLELAEVTVVGALNRKETRGGHAREDYPNRDDT MAV_4299|M.avium_104 KGKRFNSDLLEAIELGFLLELAEVTVVGALNRKESRGGHAREDYPNRDDV MLBr_00697|M.leprae_Br4923 KGKSFNSDLLEAIELGFLLELAEVTVVGALNRKESRGGHAREDYPHRDDT Mb3347|M.bovis_AF2122/97 KGKRFNTDLLEAIELGFLLELAEVTVVGALNRKESRGGHAREDYPNRDDV Rv3318|M.tuberculosis_H37Rv KGKRFNTDLLEAIELGFLLELAEVTVVGALNRKESRGGHAREDYPNRDDV MMAR_1201|M.marinum_M KGKRFNSDLLEAIELGFLLELAEVTVVGALNRKESRGGHAREDYPNRDDV MUL_1369|M.ulcerans_Agy99 KGKRFNSDLLEAIELGFLLELAEVTVVGALNRKESRGGHAREDYPNRDDV *** :*:***************************:**********:***. Mflv_4846|M.gilvum_PYR-GCK NYMRHTMAY------KEGSDLLSDIRLDYKPVVMTRYEPMERKY Mvan_1587|M.vanbaalenii_PYR-1 NYMRHTMAY------KEGTDLLSDIRLDYKPVVQTRYEPMERKY MSMEG_1670|M.smegmatis_MC2_155 NYMRHTMAY------KQGTDLLSDIRLDYKPVVQTRYEPMERKY MAB_3675|M.abscessus_ATCC_1997 NYMRHTMAY------KQGAELLSDIRLDYKPVVQTRYEPMERKY TH_2182|M.thermoresistible__bu NYMRHTMAY------KQGTELLSDIRLDYKPVVQTRYEPMERKY MAV_4299|M.avium_104 NYMRHTMAY------KQGTDLLSDIALDFKPVVQTRYEPKERKY MLBr_00697|M.leprae_Br4923 NYMRHTMAY------KQGTDLLSDIALDFKPVVQTRYEPQERKY Mb3347|M.bovis_AF2122/97 NYMRHTMAYKEIGADKEGPELRSDVRLDFKPVVQTRYEPKERKY Rv3318|M.tuberculosis_H37Rv NYMRHTMAYKEIGADKEGPELRSDVRLDFKPVVQTRYEPKERKY MMAR_1201|M.marinum_M NYMRHTMAY------KEGTDLLSDIRLDFKPVVQTRYEPKERKY MUL_1369|M.ulcerans_Agy99 NYMRHTMAY------KEGTDLLSDIRLDFKPVVQTRYEPKERKY ********* *:*.:* **: **:**** ***** ****