For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. thermoresistible (build 8) TH_1514 (ribD)

annotation: POSSIBLE BIFUNCTIONAL ENZYME RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBD: DIAMINOHYDROXYPHOSPHORIBOSYLAMINOPYRIMIDINE DEAMINASE (RIBOFLAVIN-SPECIFIC DEAMINASE) + 5-AMINO-6-(5-PHOSPHORIBOSYLAMINO)URACIL REDUCTASE (HTP REDUCTASE)
coordinates: 2862347 - 2862643
length: 99

aa seq not available

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. thermoresistible (build 8) TH_1514 ribD - 100% (99) POSSIBLE BIFUNCTIONAL ENZYME RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBD: DIAMINOHYDROXYPHOSPHORIBOSYLAMINOPYRIMIDINE DEAMINASE (RIBOFLAVIN-SPECIFIC DEAMINASE) + 5-AMINO-6-(5-PHOSPHORIBOSYLAMINO)URACIL REDUCTASE (HTP REDUCTASE)
M. thermoresistible (build 8) TH_1007 ribG 5e-07 45.45% (66) PROBABLE BIFUNCTIONAL riboflavin biosynthesis protein RIBG :

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb2690 ribD 1e-26 58.33% (96) hypothetical protein Mb2690
M. gilvum PYR-GCK Mflv_3913 - 1e-25 58.33% (96) hypothetical protein Mflv_3913
M. tuberculosis H37Rv Rv2671 ribD 1e-26 58.33% (96) hypothetical protein Rv2671
M. leprae Br4923 MLBr_01340 - 2e-27 58.33% (96) hypothetical protein MLBr_01340
M. abscessus ATCC 19977 MAB_2976 - 9e-22 56.98% (86) hypothetical protein MAB_2976
M. marinum M MMAR_2045 ribD 3e-25 53.12% (96) bifunctional enzyme riboflavin biosynthesis protein RibD
M. avium 104 MAV_3563 - 5e-28 59.38% (96) hypothetical protein MAV_3563
M. smegmatis MC2 155 MSMEG_2787 - 2e-29 62.89% (97) hypothetical protein MSMEG_2787
M. ulcerans Agy99 MUL_3305 ribD 1e-23 51.04% (96) hypothetical protein MUL_3305
M. vanbaalenii PYR-1 Mvan_2490 - 2e-23 55.21% (96) hypothetical protein Mvan_2490

CLUSTAL 2.0.9 multiple sequence alignment


TH_1514|M.thermoresistible__bu      --------------------------------------------------
MSMEG_2787|M.smegmatis_MC2_155      MSD------------DTAPARFTELTAGGRTVGSGDDELTTRFYAYPDDL
Mflv_3913|M.gilvum_PYR-GCK          MSG------------SGDGTHFTLLGR----TDAVGVPDLAAHYPYPDGL
Mvan_2490|M.vanbaalenii_PYR-1       MSG------------DGDGTQFTLLGR----IEELGAEGVAAHYGYPDGL
Mb2690|M.bovis_AF2122/97            MPD-------SGQLG-AADTPLRLLSS----VHYLTDGELPQLYDYPDD-
Rv2671|M.tuberculosis_H37Rv         MPD-------SGQLG-AADTPLRLLSS----VHYLTDGELPQLYDYPDD-
MLBr_01340|M.leprae_Br4923          MSDFETGPAASTTAGRAAQTPLLMLTS----GRYLDDDELSQLYGYPSER
MAV_3563|M.avium_104                MAL--------------PETPLSLLGS----VREVDDGELPGLYDYPDRH
MMAR_2045|M.marinum_M               MPD--------PTSGRSADAQLTLLGT----DRQLTDEDLPEFYGYPAKL
MUL_3305|M.ulcerans_Agy99           MPD--------PTSGRSADAQLTLLGT----DRQLTDEDLPEFYGYPAKL
MAB_2976|M.abscessus_ATCC_1997      MAD----SDDEQAIRGPAGTQLTQLTT----GAPVDSGELIDLYDFPKN-
                                                                                      

TH_1514|M.thermoresistible__bu      --------------------------------------------------
MSMEG_2787|M.smegmatis_MC2_155      RKCRVRANMIVSLDGAATQDGKSGGLGGAGDRAVFNLMRETADVILMGAS
Mflv_3913|M.gilvum_PYR-GCK          DSCWVRANMITSVDGGATSAGKSGGLGGDGDRALFSALRELADVIVVGAQ
Mvan_2490|M.vanbaalenii_PYR-1       QSCWVRANMIASVDGGATSGGKSGGLGGDGDRALFATLRDLADVIVVGAA
Mb2690|M.bovis_AF2122/97            -GTWLRANFISSLDGGATVDGTSGAMAGPGDRFVFNLLRELADVIVVGVG
Rv2671|M.tuberculosis_H37Rv         -GTWLRANFISSLDGGATVDGTSGAMAGPGDRFVFNLLRELADVIVVGVG
MLBr_01340|M.leprae_Br4923          AGVWIRANFITSIDGGATADGRTGAMAGPGDRFVFNMLRELADVIVVGAG
MAV_3563|M.avium_104                AGTWVRANFIASVDGGATADGSSGAMGGPGDRFVFNLLRELADVIVVGAG
MMAR_2045|M.marinum_M               SGTWLRANFITSLDGGATVGGTSGGLAGPGDRAVFVLLRELADVILVGAG
MUL_3305|M.ulcerans_Agy99           SSTWLRANFITSLDGGATVGGTSGGLAGPGDRAVFVLLRELADVILVGAG
MAB_2976|M.abscessus_ATCC_1997      DKIYLRANMISSLDGAATVTGLSGGLGGDGDRAVFAAMRANADVILVGSG
                                                                                      

TH_1514|M.thermoresistible__bu      --------------------------------------------------
MSMEG_2787|M.smegmatis_MC2_155      TVRIENYSGVQLSVPQRQARQRRGQAEVPPIAIVTASADLEPDAKIFTRT
Mflv_3913|M.gilvum_PYR-GCK          TVRSEDYSGVRLSASARLARQQRGQSEVPPIAVLTRSGRLDRDAKLFTRT
Mvan_2490|M.vanbaalenii_PYR-1       TVRVENYSGVQLGAAERLARQRRGQAEVPPVAVLTRSGLLDRDAKLFHLT
Mb2690|M.bovis_AF2122/97            TVRIEGYSGVRMGVVQRQHRQARGQSEVPQLAIVTRSGRLDRDMAVFTRT
Rv2671|M.tuberculosis_H37Rv         TVRIEGYSGVRMGVVQRQHRQARGQSEVPQLAIVTRSGRLDRDMAVFTRT
MLBr_01340|M.leprae_Br4923          TVRIENYSGAHLPVTKRQQRQARGQSEVPQLAIVTNSGRLDRDMAVFTRT
MAV_3563|M.avium_104                TVRIEGYSGAQLGVAQRQQRQARGQSEVPPLGIVTKSGHLNRDMAVFTRT
MMAR_2045|M.marinum_M               TVRIEGYSGAQLGVAERQQRQARGQSEVPQLAIATNSGQLDRDLPVFTRT
MUL_3305|M.ulcerans_Agy99           TVRIEGYSGAQRGVAERQQRQARGQSEVPQLAIATNSGQLDRDLPVFTRT
MAB_2976|M.abscessus_ATCC_1997      TVRAERYHGAHLPVGLRQRRQSRGQDEVPTIAVVTASGAVDPSTPLFNES
                                                                                      

TH_1514|M.thermoresistible__bu      -------------------------VLDASGANPDSVDPAVVLRILSERG
MSMEG_2787|M.smegmatis_MC2_155      EVRPLILTTAHTVSDARRRLGGVAEVLDASGADRTRVDPARALQILAERK
Mflv_3913|M.gilvum_PYR-GCK          DVPPLILTSTRALDDTRRLLGSVAEVLDASGAQPDSVDPAQALTLLAERG
Mvan_2490|M.vanbaalenii_PYR-1       DVPPLILTSSDAVEDTRQRLGAVAEVVDASGPAPDSVDLRTALDLLAERG
Mb2690|M.bovis_AF2122/97            EMAPLVLTTTAVADDTRQRLAGLAEVIACSGDDPGTVDEAVLVSQLAARG
Rv2671|M.tuberculosis_H37Rv         EMAPLVLTTTAVADDTRQRLAGLAEVIACSGDDPGTVDEAVLVSQLAARG
MLBr_01340|M.leprae_Br4923          EIAPLVLTCTETAKKLRTRLADLAYVVSCSGDDPSKVDETVVLATLQTRG
MAV_3563|M.avium_104                EVPPLVLTCAAAADQTRRLLSGLCEVLDCSAGDPERVDEATMLALLGERG
MMAR_2045|M.marinum_M               EVPPLVLTAAAAVYDTRRRLTGLAEVVDCSGKDPHRVDEGLLLARLAGRG
MUL_3305|M.ulcerans_Agy99           EVPPLVLTAAAAVYDTRRRLTGLAEVVGCSGKDPHRVDEGLLLARLAGRG
MAB_2976|M.abscessus_ATCC_1997      EVAPIVVTSASGAPHVASRVPGAQILVSGDG---DTVDLPAALATLHARG
                                                             ::  ..     **    :  *  * 

TH_1514|M.thermoresistible__bu      LWRVLAEGGPTLLSQMLAAGLLDELCLTVAPVLVGGTGPRIVDGPHRVHQ
MSMEG_2787|M.smegmatis_MC2_155      LFRVLTEGGPSLLGLLIEHDLLDELCLTIAPVLVGGGAPRIAAGIGQART
Mflv_3913|M.gilvum_PYR-GCK          LRRVLTEGGPGILGMFTDDDLVDELCVTVAPLLLGGGPGRIVTGDGEVRS
Mvan_2490|M.vanbaalenii_PYR-1       LVRVLTEGGPGILGMFTEQDLLDELCLTVAPLLLGGGSARIVTGLGEVRS
Mb2690|M.bovis_AF2122/97            LRRILTEGGPTLLGTFVERDVLDELCLTIAPYVVGGLARRIVTGPGQVLT
Rv2671|M.tuberculosis_H37Rv         LRRILTEGGPTLLGTFVERDVLDELCLTIAPYVVGGLARRIVTGPGQVLT
MLBr_01340|M.leprae_Br4923          LRRVLTEGGPMLLGSFIQHGMLDELCLTIAPLIVGGRARRIATGPEQLLT
MAV_3563|M.avium_104                MRRILTEGGPTLLNSLLERQLLDELCLTIAPYLVGGHARRIATGPGQLLT
MMAR_2045|M.marinum_M               MRRILTEGGPTLFGSLIEQDLLDELCLTIAPVVVGGLPRRIASGPGQLQT
MUL_3305|M.ulcerans_Agy99           MRCILTEGGPTLFGSLIEQDLLDELCLTIAPVVVGGLPRRIASGPGQLQT
MAB_2976|M.abscessus_ATCC_1997      LSRVLCEGGPALLGTLLSAHLVDELCLTIAPTTIGGAGLRITSGPAEVLT
                                    :  :* **** ::. :    ::****:*:**  :**   **. *  .   

TH_1514|M.thermoresistible__bu      RMRRTHVLADDDGYLYTRYVKGD-------
MSMEG_2787|M.smegmatis_MC2_155      RMRVSHLLTDDEGYLYTRYVRG--------
Mflv_3913|M.gilvum_PYR-GCK          GMVLGHALTDGDGYLYLRYLRDR-------
Mvan_2490|M.vanbaalenii_PYR-1       DLALLHALTDDRGFLYLRYVRDRLARDAER
Mb2690|M.bovis_AF2122/97            RMRCAHVLTDDSGYLYTRYVKT--------
Rv2671|M.tuberculosis_H37Rv         RMRCAHVLTDDSGYLYTRYVKT--------
MLBr_01340|M.leprae_Br4923          RMRCAHVLTDDAGYLYTRYVKA--------
MAV_3563|M.avium_104                RMRCAHVLTDDAGYLYTRYVRC--------
MMAR_2045|M.marinum_M               RMHCAHVITDDAGYLYTRYVRA--------
MUL_3305|M.ulcerans_Agy99           RMHCAHVITDDAGYLYTRYVRA--------
MAB_2976|M.abscessus_ATCC_1997      GWRRVLLLADADGYLFTRYVPA--------
                                           ::*  *:*: **:

species	id	gene	e-value	identity (len)	annotation
M. thermoresistible (build 8)	TH_1514	ribD	-	100% (99)	POSSIBLE BIFUNCTIONAL ENZYME RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBD: DIAMINOHYDROXYPHOSPHORIBOSYLAMINOPYRIMIDINE DEAMINASE (RIBOFLAVIN-SPECIFIC DEAMINASE) + 5-AMINO-6-(5-PHOSPHORIBOSYLAMINO)URACIL REDUCTASE (HTP REDUCTASE)
M. thermoresistible (build 8)	TH_1007	ribG	5e-07	45.45% (66)	PROBABLE BIFUNCTIONAL riboflavin biosynthesis protein RIBG :