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aa seq not available
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. thermoresistible (build 8) | TH_1222 | - | 100% (889) | PROBABLE ATP-DEPENDENT HELICASE LHR (LARGE HELICASE-RELATED PROTEIN) |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3324 | lhr | 0.0 | 75.73% (894) | ATP-dependent helicase |
M. gilvum PYR-GCK | Mflv_4810 | - | 0.0 | 72.83% (898) | DEAD/DEAH box helicase domain-containing protein |
M. tuberculosis H37Rv | Rv3296 | lhr | 0.0 | 75.84% (894) | ATP-dependent helicase |
M. leprae Br4923 | - | - | - | - | - |
M. abscessus ATCC 19977 | MAB_3651 | - | 0.0 | 65.54% (888) | ATP-dependent helicase Lhr |
M. marinum M | MMAR_1238 | lhr | 0.0 | 75.50% (906) | ATP-dependent helicase Lhr |
M. avium 104 | MAV_4267 | - | 0.0 | 72.85% (917) | DEAD/DEAH box helicase |
M. smegmatis MC2 155 | MSMEG_1757 | - | 0.0 | 78.23% (891) | DEAD/DEAH box helicase |
M. ulcerans Agy99 | - | - | - | - | - |
M. vanbaalenii PYR-1 | Mvan_1632 | - | 0.0 | 74.55% (892) | DEAD/DEAH box helicase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment TH_1222|M.thermoresistible__bu -------------------------------------------------- MSMEG_1757|M.smegmatis_MC2_155 -MTTNGA-----DPLGRFSALTREWFTTAFAAPTPAQADAWSAISEGNNT Mb3324|M.bovis_AF2122/97 -MRFAQP-----SALSRFSALTRDWFTSTFAAPTAAQASAWAAIADGDNT Rv3296|M.tuberculosis_H37Rv -MRFAQP-----SALSRFSALTRDWFTSTFAAPTAAQASAWAAIADGDNT MMAR_1238|M.marinum_M -MSTARPEPLGPEPLGRFSAITREWFTNTFAAPTPAQASAWAAIAAGDNT MAV_4267|M.avium_104 MSTRAEPRP--SDPLGRFSAITREWFTSTFAAPTTAQAQAWSAIADGHNT Mflv_4810|M.gilvum_PYR-GCK -------MPAKTDPLSRFSTLTREWFAGTFVEPTPAQAQAWNAISAGENT Mvan_1632|M.vanbaalenii_PYR-1 ----MEHMPTETDPLARFSALTREWFTGTFVKPTPAQAQAWNAIADGDNT MAB_3651|M.abscessus_ATCC_1997 --MSSEP-----GPLARFSAPTREWFTESFPTPTRAQSGAWQSIANGDNT TH_1222|M.thermoresistible__bu -------------------------------------------------- MSMEG_1757|M.smegmatis_MC2_155 LVIAPTGSGKTLAAFLWAIDRLADP-------AREPSQGTQVLYVSPLKA Mb3324|M.bovis_AF2122/97 LVIAPTGSGKTLAAFLWALDSLAGSE-----PMSERPAATRVLYVSPLKA Rv3296|M.tuberculosis_H37Rv LVIAPTGSGKTLAAFLWALDSLAGSE-----PMSERPAATRVLYVSPLKA MMAR_1238|M.marinum_M LVIAPTGSGKTLAAFLWALDSLAR--------CPDRTAGTRVLYVSPLKA MAV_4267|M.avium_104 LVIAPTGSGKTLAAFLWALDSLAG--------QAERAPGTRVLYVSPLKA Mflv_4810|M.gilvum_PYR-GCK LVIAPTGSGKTLAAFLWAIDGLAR--------EPRAERGTRVLYVSPLKA Mvan_1632|M.vanbaalenii_PYR-1 LVIAPTGSGKTLAAFLWAIDGLAR--------EPAAQRGTRVLYVSPLKA MAB_3651|M.abscessus_ATCC_1997 LVIAPTGSGKTLAAFLWAIDTLVQEKEAEAAAESRRLRGSRVLYVSPLKA TH_1222|M.thermoresistible__bu -------------------------------------------------- MSMEG_1757|M.smegmatis_MC2_155 LAVDVERNLRTPLTGITRVAERHGLPAPSITVGVRSGDTPPNQRRAMIAN Mb3324|M.bovis_AF2122/97 LAVDVERNLRTPLAGLTRLAERQGLPAPQIRVGVRSGDTPPALRRQLVSQ Rv3296|M.tuberculosis_H37Rv LAVDVERNLRTPLAGLTRLAERQGLPAPQIRVGVRSGDTPPALRRQLVSQ MMAR_1238|M.marinum_M LAVDVERNLRTPLAGLTRLAERRGLPPPQISVGVRSGDTPPAVRRQLITR MAV_4267|M.avium_104 LAVDVERNLRTPLAGLTRIAERAGLPAPDISVGVRSGDTPPAVRRQLINR Mflv_4810|M.gilvum_PYR-GCK LAVDVERNLRTPLTGISRIAERNGEEPPAISVGVRSGDTTPSKRRELITK Mvan_1632|M.vanbaalenii_PYR-1 LAVDVERNLRTPLTGISRIAERTGQQPPAISVGVRSGDTTPSKRRELITK MAB_3651|M.abscessus_ATCC_1997 LAVDVERNLRAPLAGIARTAARMGLPEPAITIGVRSGDTPAQRRRTLISS TH_1222|M.thermoresistible__bu -------------------------------------------------- MSMEG_1757|M.smegmatis_MC2_155 PPDVLITTPESLFLMLTSAARETLTSVRTVIVDEVHAVAATKRGAHLALS Mb3324|M.bovis_AF2122/97 PPDVLITTPESLFLMLTSAARQTLTGVQTVIIDEIHAIAATKRGAHLALS Rv3296|M.tuberculosis_H37Rv PPDVLITTPESLFLMLTSAARQTLTGVQTVIIDEIHAIAATKRGAHLALS MMAR_1238|M.marinum_M PPDVLITTPESLFLMLTSAARETLAGVQTVIVDEIHAIAATKRGAHLALS MAV_4267|M.avium_104 PPDVLITTPESLFLMLTSAARETLAGVQTVIVDEIHAIAGGKRGAHLALS Mflv_4810|M.gilvum_PYR-GCK PPDILITTPESLFLMLTSAARESLSDIETVIVDEVHAVAATKRGAHLAVS Mvan_1632|M.vanbaalenii_PYR-1 PPDILITTPESLFLMLTSAARETLSQVQTVIVDEVHAVAGTKRGAHLAVS MAB_3651|M.abscessus_ATCC_1997 PPDILITTPESLYLMLTSAARETLDTVRTVIVDEVHAVAGTKRGAHLALS TH_1222|M.thermoresistible__bu -------------------------------------------------- MSMEG_1757|M.smegmatis_MC2_155 LERLDQLLDTPAQ-----RIGLSATVRPPEEVARFLSGQAP---TTIVCP Mb3324|M.bovis_AF2122/97 LERLDDLSSRRRA----QRIGLSATVRPPEELARFLSGQSP---TTIVAP Rv3296|M.tuberculosis_H37Rv LERLDDLSSRRRA----QRIGLSATVRPPEELARFLSGQSP---TTIVAP MMAR_1238|M.marinum_M LERLDQLAPDRRAGPPAQRIGLSATVRPPEELARFLSGSAP---TTIVAP MAV_4267|M.avium_104 LERLDALREGRPA----QRIGLSATVRPPDELARFLSGAAPGTRTTVVAP Mflv_4810|M.gilvum_PYR-GCK LERLDAMLPKPAQ-----RIGLSATVRPPEEVARFLSGASP---TTIVAP Mvan_1632|M.vanbaalenii_PYR-1 LERLDAMLPKPAQ-----RIGLSATVRPPEEVARFLSGAAP---TTIVAP MAB_3651|M.abscessus_ATCC_1997 LERLDERLSQPAQ-----RIGLSATVKPAAEVARFLSGRAP---ATVVAP TH_1222|M.thermoresistible__bu -------------------------------------------------- MSMEG_1757|M.smegmatis_MC2_155 PAAKTFDLSVQVPVPDMANLD---------------NNSIWPDVEERIVD Mb3324|M.bovis_AF2122/97 PAAKTVELSVQVPVPDMANLT---------------DNTIWPDVEARLVD Rv3296|M.tuberculosis_H37Rv PAAKTVELSVQVPVPDMANLT---------------DNTIWPDVEARLVD MMAR_1238|M.marinum_M HSAKTFDLTVQVPVADMANLA---------------NNTIWPDVESRLVD MAV_4267|M.avium_104 PSAKTVELSVQVPVPDMANLA---------------NNTIWPDVENRLVD Mflv_4810|M.gilvum_PYR-GCK PAAKTFDLTVQVPVPDMAAPN---------------TGSIWPDVEERIVD Mvan_1632|M.vanbaalenii_PYR-1 PAAKTFDLTVQVPVPDMANLE---------------NNSIWPEVEQRIVD MAB_3651|M.abscessus_ATCC_1997 ASPKTFDLSVVVPVSDMSAPESFPEPEASPDSTRGGATSLWPHVEQRIVD TH_1222|M.thermoresistible__bu -------------------------------------------------- MSMEG_1757|M.smegmatis_MC2_155 LVEAHNSSIVFANSRRLAERLTSRLNEIHAERSGIELPAGPNPEVGGGAP Mb3324|M.bovis_AF2122/97 LIESHNSTIVFANSRRLAERLTARLNEIHAARCGIELAPDTNQQVAGGAP Rv3296|M.tuberculosis_H37Rv LIESHNSTIVFANSRRLAERLTARLNEIHAARCGIELAPDTNQQVAGGAP MMAR_1238|M.marinum_M LIESHNSTIVFANSRRLAERLTARLNEIHAERSGMTLPSEANTQVAGGAP MAV_4267|M.avium_104 LIEAHGSTIVFANSRRLAERLTARLNEIHAERSGVELSATANPKVAGGAP Mflv_4810|M.gilvum_PYR-GCK LIEAHNSSIVFTNSRRLAERLTARINEIHAERTGIELG-AHNPGVAGGAP Mvan_1632|M.vanbaalenii_PYR-1 LVEAHNSSIVFANSRRLAERLTARLNEIHAERLGVELG-GANPGVAGGAP MAB_3651|M.abscessus_ATCC_1997 LIEAHRSSIVFANSRRLAERLTARFNEIHAERLGLDLTPMPNPDVPGGPP TH_1222|M.thermoresistible__bu -------------------------------------------------- MSMEG_1757|M.smegmatis_MC2_155 AHLMGSGQANGAPPLLARAHHGSVSKEQRAQVEDDLKSGRLRAVVATSSL Mb3324|M.bovis_AF2122/97 AHIMGSGQTFGAPPVLARAHHGSISKEQRAVVEEDLKRGQLKAVVATSSL Rv3296|M.tuberculosis_H37Rv AHIMGSGQTFGAPPVLARAHHGSISKEQRAVVEEDLKRGQLKAVVATSSL MMAR_1238|M.marinum_M AQIMASGQTFGAATLLARAHHGSVSKEQRAQVEEDLKRGALKAVVATSSL MAV_4267|M.avium_104 AHIMASGQTYGVEPILARAHHGSVSKEQRALVEEDLKRGLLKAVVATSSL Mflv_4810|M.gilvum_PYR-GCK AHLMGSGQTYGAEPVLARAHHGSVSKEARADVEDALKSGRLKAVVATSSL Mvan_1632|M.vanbaalenii_PYR-1 AHLMGSGQTYGAEPLLARAHHGSVSKEARADVEEALKSGRLKAVVATSSL MAB_3651|M.abscessus_ATCC_1997 AHIMGSGQTYGAAPLLARAHHGSVSKEQRADIEDDLKTGRLKCVVATSSL TH_1222|M.thermoresistible__bu -------------------------------------------------- MSMEG_1757|M.smegmatis_MC2_155 ELGIDMGAVDLVIQVEAPPSVASGLQRVGRAGHQVGEISQGVLFPKHRTD Mb3324|M.bovis_AF2122/97 ELGIDMGAVDLVIQVQAPPSVASGLQRIGRAGHQVGEISRGVLFPKHRTD Rv3296|M.tuberculosis_H37Rv ELGIDMGAVDLVIQVQAPPSVASGLQRIGRAGHQVGEISRGVLFPKHRTD MMAR_1238|M.marinum_M ELGIDMGAVDLVIQVEAPPSVASGLQRIGRAGHQVGEVSRGVLFPKHRTD MAV_4267|M.avium_104 ELGIDMGAVDLVIQVEAPPSVASGLQRIGRAGHQVGEVSRGVLFPKHRTD Mflv_4810|M.gilvum_PYR-GCK ELGIDMGAVDLVIQVETPPSVASGLQRVGRAGHQVGEISQGVLFPKHRTD Mvan_1632|M.vanbaalenii_PYR-1 ELGIDMGAVDLVIQVETPPSVASGLQRIGRAGHQVGEISQGVLFPKHRTD MAB_3651|M.abscessus_ATCC_1997 ELGIDMGAVDLVVQVEAPPSVASGLQRIGRAGHQVGEVSRGVLFPKHRTD TH_1222|M.thermoresistible__bu -------------------------------------------------- MSMEG_1757|M.smegmatis_MC2_155 LIGCAVTVQRMQTGDIETLRVPANPLDVLAQHTVAVAALEPVDADAWFDA Mb3324|M.bovis_AF2122/97 LLGCAVSVQRMLAGEIETMRVPANPLDILAQHTVAAAALEPLDADAWFDT Rv3296|M.tuberculosis_H37Rv LLGCAVSVQRMLAGEIETMRVPANPLDILAQHTVAAAALEPLDADAWFDT MMAR_1238|M.marinum_M LLGCAISVQRMRTGQIETMRVPANPLDILAQHTVAAAALEPLDADQWFDT MAV_4267|M.avium_104 LIGCAVTVQRMLAGQIETMRVPANPLDILAQQTVAAAALEPLDADRWFDT Mflv_4810|M.gilvum_PYR-GCK LIGCAVSVQRMLAGQIETMRVPANPLDVLAQHTVAASALEPINADAWFDT Mvan_1632|M.vanbaalenii_PYR-1 LIGCAVSVQRMLAGQIETMRVPANPLDVLAQHTVAACALEPINAEAWFDT MAB_3651|M.abscessus_ATCC_1997 LLGCAVTVRRMLDGDIETLQVPANPLDILAQHTVAACALESMDVEKWFDV TH_1222|M.thermoresistible__bu -------------------------------------------------- MSMEG_1757|M.smegmatis_MC2_155 VRRSAPFATLPRSAFEATLDLLSGKYPSTEFAELRPRLVYDRDTGTLTAR Mb3324|M.bovis_AF2122/97 VRRAAPFATLPRSLFEATLDLLSGKYPSTEFAELRPRLVYDRDTGTLTAR Rv3296|M.tuberculosis_H37Rv VRRAAPFATLPRSLFEATLDLLSGKYPSTEFAELRPRLVYDRDTGTLTAR MMAR_1238|M.marinum_M VRRSASFATLPRSVFEATLDLLSGKYPSTEFAELRPRLVYDRGTGTLTAR MAV_4267|M.avium_104 VRRAAPFATLPRSIYEATLDLLSGKYPSTEFAELRPRLVYDRNTGTLTAR Mflv_4810|M.gilvum_PYR-GCK VRRSAPFATLPRSAFEATLDLLSGKYPSTEFAELRPRIVYDRDNGMLTSR Mvan_1632|M.vanbaalenii_PYR-1 VRRSAPFATLPRSAFEATLDLLSGKYPSTEFAELRPRIVYDRDTGTLTSR MAB_3651|M.abscessus_ATCC_1997 VRRSAPFTSLPRSAFDAVLDLLSGKYPSTDFAELRPRVVYDRDEGTLTGR TH_1222|M.thermoresistible__bu -------------------------------------------------- MSMEG_1757|M.smegmatis_MC2_155 PGAQRLAVTSGGAIPDRGMFTVYLASETE--KPSRVGELDEEMVYESRPG Mb3324|M.bovis_AF2122/97 PGAQRLAVTSGGAIPDRGLFAVYLATER----PSRVGELDEEMVYESRPG Rv3296|M.tuberculosis_H37Rv PGAQRLAVTSGGAIPDRGLFAVYLATER----PSRVGELDEEMVYESRPG MMAR_1238|M.marinum_M PGAQRLAVTSGGAIPDRGLFTVYLASEAE--KPSRVGELDEEMVYESRPG MAV_4267|M.avium_104 PGAQRLAVTSGGAIPDRGLFTVYLASEAE--KPSRVGELEEEMVYESRPG Mflv_4810|M.gilvum_PYR-GCK PGAQRLAVTSGGAIPDRGMFTVFLASSAESEKPSRVGELDEEMVYESRPG Mvan_1632|M.vanbaalenii_PYR-1 PGAQRLAVTSGGAIPDRGLFTVFLASSADSEKPSRVGELDEEMVYESRPG MAB_3651|M.abscessus_ATCC_1997 PGAQRLAVTSGGAIPDRGLFTVYMYAGAEGEKPSRVGELDEEMVYESRPG TH_1222|M.thermoresistible__bu -------------------------------------------------- MSMEG_1757|M.smegmatis_MC2_155 DVISLGATSWRITEITHDRVLVIPAPGQPARLPFWRGDSVGRPAELGAAV Mb3324|M.bovis_AF2122/97 DVISLGATSWRITEITHDRVLVIPAPGQPARLPFWRGDDAGRPAELGAAL Rv3296|M.tuberculosis_H37Rv DVISLGATSWRITEITHDRVLVIPAPGQPARLPFWRGDDAGRPAELGAAL MMAR_1238|M.marinum_M DVISLGATSWRITEITHDRVLVIPAPGEPARLPFWRGDDVGRPAELGAAL MAV_4267|M.avium_104 DVISLGATSWRITEITHDRVLVIPAPGQPARLPFWRGDGVGRPAELGAAL Mflv_4810|M.gilvum_PYR-GCK DVISLGATSWRITEITHDRVLVIPAPGEPARLPFWRGDGVGRPVELGAAI Mvan_1632|M.vanbaalenii_PYR-1 DVISLGATSWRITEITHDRVLVIPAPGEPARLPFWRGDGVGRPAELGAAI MAB_3651|M.abscessus_ATCC_1997 DVISLGATSWRITEITHERVVVVPAFGQPGRLPFWRGDSVGRPAELGIAL TH_1222|M.thermoresistible__bu ---------------------MGFDEFATTNLWQLLDEQRQSTGVVPSDT MSMEG_1757|M.smegmatis_MC2_155 GAFTGELASLDRKAFDKRCQKMGFAGYATDNLHQLLREQREATGVVPSDT Mb3324|M.bovis_AF2122/97 GALTGELAALDRTAFGTRCAGLGFDDYATDNLWRLLDDQRTATAVVPTDS Rv3296|M.tuberculosis_H37Rv GALTGELAALDRTAFGTRCAGLGFDDYATDNLWRLLDDQRTATAVVPTDS MMAR_1238|M.marinum_M GALTGELARLDRAEFDKRCAGLGFDDFATDNLWGLLDDQKTATRVVPTDT MAV_4267|M.avium_104 GAFTGELAGLSREEFDSRCAALGFDAYAVDNLYGLFDEQRTAAGVVPTDT Mflv_4810|M.gilvum_PYR-GCK GAFNGELARLDRPAFESRCRDVGFDDFATDNLWQLISEQREATSSVPSDT Mvan_1632|M.vanbaalenii_PYR-1 GAFTGELARLDRDAFESRCQEVGFDAFATDNLWQLISEQRDATSAVPSDT MAB_3651|M.abscessus_ATCC_1997 GQLTGELASARDAEFDKRCAAMGFDDFATGNLRTLLTDQLRSTGAVPTDT :** :*. ** *: :* :: **:*: TH_1222|M.thermoresistible__bu TLLVERFRDELGDWRVILHSPYGLRVHGPLALAVGRRLAERYGIDEKPTA MSMEG_1757|M.smegmatis_MC2_155 TFVVERFRDELGDWRVILHSPYGLRVHGPLALAVGRRLRERYGIDEKPTA Mb3324|M.bovis_AF2122/97 TLLVERFRDELGDWRVILHSPYGLRVHGPLALAVGRRLRDRYGIDEKPTA Rv3296|M.tuberculosis_H37Rv TLLVERFRDELGDWRVILHSPYGLRVHGPLALAVGRRLRDRYGIDEKPTA MMAR_1238|M.marinum_M TLLVERFRDELGDWRVILHSPYGLRVHGPLALAVGRRLRDRYGLDEKPTA MAV_4267|M.avium_104 TLLVERFRDELGDWRVILHSPYGLGVNGPLALAVGRRLRERYGIDEKPTA Mflv_4810|M.gilvum_PYR-GCK TLVVERFRDELGDWRVILHSPYGLRVHGPLALAVGKRLYERFGIDEKPTA Mvan_1632|M.vanbaalenii_PYR-1 TLVVERFRDELGDWRVILHSPYGLRVHGPLALAVGKRLYERYGIDEKPTA MAB_3651|M.abscessus_ATCC_1997 TLIVERFRDELGDWRIVLHCPYGLRVNGPLALAISDRLQQRYGVSESPTA *::************::**.**** *:******:. ** :*:*:.*.*** TH_1222|M.thermoresistible__bu SDDGIIVRLPDTGD--------TQPGAELFVFDADEIEPLVTAEVGGSAL MSMEG_1757|M.smegmatis_MC2_155 SDDGIIVRLPDSGD--------TPPGADLFVFDADEIEPIVTAEVGGSAL Mb3324|M.bovis_AF2122/97 SDNGIMVRLPDTVS----AGEDSPPGAELFVFDADEIDPIVTTEVAGSAL Rv3296|M.tuberculosis_H37Rv SDNGIVVRLPDTVS----AGEDSPPGAELFVFDADEIDPIVTTEVAGSAL MMAR_1238|M.marinum_M SDDGIVVRLPDTISD---TGTETPPGAELFLFDADEIDAIVTAEVGASAL MAV_4267|M.avium_104 SDDGVVVRLPDTVSDFASDGGDTPPGAELFVFDADEIDPIVTAEVGGSAL Mflv_4810|M.gilvum_PYR-GCK SDDGIIVRLPDTDD--------TAPGADIFVFDADEIEPLVTTEVSSSAL Mvan_1632|M.vanbaalenii_PYR-1 SDDGIIVRLPDTDD--------TAPGADIFVFDADEIEPLVTAEVSSSAL MAB_3651|M.abscessus_ATCC_1997 TDDGIVVRLPDTDD--------SPPGADLFVFDAAEIESIVTREVGGSAL :*:*::*****: . : ***::*:*** **:.:** **..*** TH_1222|M.thermoresistible__bu FASRFRECAARALLLPRRHPGKRSPLWHQRQRAAQLLDVARKYPDFPIVL MSMEG_1757|M.smegmatis_MC2_155 FASRFRECAARALLLPRRHPGKRSPLWHQRQRAAQLLDIARKYPDFPIVL Mb3324|M.bovis_AF2122/97 FASRFRESAARALLLPRRHPGRRSPLWQQRQRAARLLEVARKYPDFPIVL Rv3296|M.tuberculosis_H37Rv FASRFRESAARALLLPRRHPGRRSPLWQQRQRAARLLEVARKYPDFPIVL MMAR_1238|M.marinum_M FASRFRESAARALLLPRRHPGRRSPLWHQRQRAAQLLDVARKYPDFPMVL MAV_4267|M.avium_104 FASRFRECAARALLLPRRHPGRRSPLWQQRQRAAQLLEVARKYPDFPVVL Mflv_4810|M.gilvum_PYR-GCK FASRFRECAARALLLPRRHPGKRSPLWHQRQRAAQLLDVARNYPDFPIVL Mvan_1632|M.vanbaalenii_PYR-1 FASRFRECAARALLLPRRHPGKRSPLWHQRQRAAQLLDVAKGYPDFPIVL MAB_3651|M.abscessus_ATCC_1997 FAARFRECAARALLLPRRTPGRRSPLWQQRQRAAQLLDVARKHSDFPMVL **:****.********** **:*****:******:**::*: :.***:** TH_1222|M.thermoresistible__bu ETVRECLQDVYDVPTLTELMRGIAQRRLRLIEVETAAPSPFAASLLFGYV MSMEG_1757|M.smegmatis_MC2_155 EAVRECLQDVYDVPALIELMHKIAQRRLRIVEVETATPSPFAASLLFGYV Mb3324|M.bovis_AF2122/97 ETVRECLQNVYDVPILVELMARIAQRRVRVAEAETAKPSPFAASLLFGYV Rv3296|M.tuberculosis_H37Rv ETVRECLQDVYDVPILVELMARIAQRRVRVAEAETAKPSPFAASLLFGYV MMAR_1238|M.marinum_M ETVRECLQDVYDVPTLTTLMTDIAQRRVRVAETETTKPSPFAASLLFGYV MAV_4267|M.avium_104 ETVRECLQDVYDVPALVALMAGIAQRRVRVLEVETQRPSPFAASLLFGYV Mflv_4810|M.gilvum_PYR-GCK EAVRECLQDVYDVPALTALMDRIAQRRVRILEVETPTPSPFAASLLFGYV Mvan_1632|M.vanbaalenii_PYR-1 EAVRECLQDVYDVPTLTALMGRIAQRRVRLLEVETPTPSPFAASLLFGYV MAB_3651|M.abscessus_ATCC_1997 EALRECLQDVYDISTLVRLMSGIEQRRIRIVEVQTDTPSPFAAAQLFSYI *::*****:***:. * ** * ***:*: *.:* ******: **.*: TH_1222|M.thermoresistible__bu GAFIYEGDSPLAERRAAALSLDPTLLAELLGRVELRELLDPDVVATTGRQ MSMEG_1757|M.smegmatis_MC2_155 GAFMYEGDSPLAERRAAALALDTVLLSELLGRVELRELLDPAVVASTSAQ Mb3324|M.bovis_AF2122/97 GAFMYEGDTPLAERRAAALALDGTLLAELLGRVELRELLDPDVIAATSRQ Rv3296|M.tuberculosis_H37Rv GAFMYEGDTPLAERRAAALALDGTLLAELLGRVELRELLDPDVIAATSRQ MMAR_1238|M.marinum_M GAFMYEGDVPLAERRAAALSLDSTLLAELLGRVELRELLDPEVIAATGRQ MAV_4267|M.avium_104 GAFMYEGDSPLAERRAAALSLDSTLLAELLGRVELRELLDPEVVAATARA Mflv_4810|M.gilvum_PYR-GCK GAFMYEGDSPLAERRAAALALDPTLLAELLGRVELRELLDPDVIATTTRQ Mvan_1632|M.vanbaalenii_PYR-1 GAFMYEGDSPLAERRAAALSLDPTLLAELLGRVELRELLDADVVTTTARQ MAB_3651|M.abscessus_ATCC_1997 GGFMYDEDRPLAERRAAALSLDTNLLAELMGRVELRELLDPAVIDATERQ *.*:*: * **********:** **:**:**********. *: :* TH_1222|M.thermoresistible__bu LQHLTADRAVRDVEGVADLLRMLGPLTAEEIAAR---STSADVGGWLDEL MSMEG_1757|M.smegmatis_MC2_155 LQHLTPERAARDAEGVADLLRLLGPLTEADIAQR---CTADNIGAWLDGL Mb3324|M.bovis_AF2122/97 LQHLAADRVARDAEGVADLLRLLGPLTEDEIAAR---AGAPEVSGWLDGL Rv3296|M.tuberculosis_H37Rv LQHLAADRVARDAEGVADLLRLLGPLTEDEIAAR---AGAPEVSGWLDGL MMAR_1238|M.marinum_M LQHLCADRAARDAEGVADLLRLLGPLTEDEVAARSDTTGGTDIGGWLEGL MAV_4267|M.avium_104 LQHLAPERAARDAEAVADLLRLLGPLTEDEVVARAGGADAVEVRGWLEGL Mflv_4810|M.gilvum_PYR-GCK LQHLTPERAARDAEGVADLLRLLGPLTVDEIAER---CVQPDIGGWLEGL Mvan_1632|M.vanbaalenii_PYR-1 LQHLTPERLARDAEGVADLLRLLGPLTTEEIAAR---CVVSEVGGWLEGL MAB_3651|M.abscessus_ATCC_1997 LQHLAEERKARDAEALADLFRLLGPLTAEEIAQR----CAGPGAAWLDEL **** :* .**.*.:***:*:***** ::. * .**: * TH_1222|M.thermoresistible__bu AAARRALRVSYAGRQWWVAVEDIGLLRDAVGVAVPVGVPTTFTGAVADPL MSMEG_1757|M.smegmatis_MC2_155 HAAKRALPVTYAGQTWWAAVEDIGLLRDGIGVPVPVGVPAAFTESASDPL Mb3324|M.bovis_AF2122/97 RAAKRALVVSFAGRSWWVAVEDMGRLRDGVGAAVPVGLPASFTEAVADPL Rv3296|M.tuberculosis_H37Rv RAAKRALVVSFAGRSWWVAVEDMGRLRDGVGAAVPVGLPASFTEAVADPL MMAR_1238|M.marinum_M RAARRALEVSYAGRSWWVAVEDIGRLRDGVGAAVPVGLPAAFTEAVADPL MAV_4267|M.avium_104 RAARRAVPVSFAGRSWWVAIEDIGRLRDGLGIAVPLGVPAAFTEEVADPL Mflv_4810|M.gilvum_PYR-GCK LTSKRVVTLSFAGQTWWAAIEDIGRLRDGVGVAVPVGVPIAFLEPIVDPL Mvan_1632|M.vanbaalenii_PYR-1 LGAKRAVQVSFAGQSWWAAVEDIGRLRDGVGVAVPVGVPMAFLEQVVDPL MAB_3651|M.abscessus_ATCC_1997 VSARRVVGTSYGQRSWWAAVEDVARLRDALGVPVPPGVPAAFTDAATDPL ::*.: ::. : **.*:**:. ***.:* .** *:* :* *** TH_1222|M.thermoresistible__bu GELLGRYARTRGPFTTAQAAARFGLGLRVAGDVLHRMAA----DGRLVRG MSMEG_1757|M.smegmatis_MC2_155 GDLIGRYARTRGPFTTEQTAARFGLGVRVASDVLSRMAV----DGRLIRG Mb3324|M.bovis_AF2122/97 GELLGRYARTHTPFTTAAAAARFGLGLRVTADVLGRLAS----DGRLVRG Rv3296|M.tuberculosis_H37Rv GELLGRYARTHTPFTTAAAAARFGLGLRVTADVLGRLAS----DGRLVRG MMAR_1238|M.marinum_M AELLGRYARTHPPFTTAEAAGRFGLGLRVTADVLGRLAS----DGRLVRG MAV_4267|M.avium_104 GELLGRYARTHTPFSTAEAAARFGLGLRVTADVLGRLADPSTSQGRLVRG Mflv_4810|M.gilvum_PYR-GCK SELLSRYARTRGPFTTMEAATRFGLGVRVAADVLGRLTA----DGKLVRG Mvan_1632|M.vanbaalenii_PYR-1 GELLSRYARTRGPFTTAEAAARFGLGLRVAADVLGRLAV----DGKLVRG MAB_3651|M.abscessus_ATCC_1997 AELLSRYARTHGPFTTGEAAQRFGLGVRVAADTLSAMAA----RGQLVRG .:*:.*****: **:* :* *****:**:.*.* :: *:*:** TH_1222|M.thermoresistible__bu EFTTD------AVDTTEQWCDAEVLRILRRRSLAALRAQVEPVSTAAFGR MSMEG_1757|M.smegmatis_MC2_155 EFAAD------LSG--EQWCDAQVLKILRRRSLAALRAQVEPVSTDAYAR Mb3324|M.bovis_AF2122/97 EFVAA----AEGSAGGEQWCDAEVLRILRRRSLAALRAQAEPVSTAAYGR Rv3296|M.tuberculosis_H37Rv EFVAA----AKGSAGGEQWCDAEVLRILRRRSLAALRAQAEPVSTAAYGR MMAR_1238|M.marinum_M DFVATG---VFGGAGSEQWCDAEVLRILRRRSLAALRAQVEPVSTAAYGR MAV_4267|M.avium_104 DFVAARPSEPGGVLGAEQWCDADVLRILRRRSLAALRAQVEPVSTAAYGR Mflv_4810|M.gilvum_PYR-GCK EFTDLP-----TESGVEQWCDAEVLRILRRRSLAALRAQIEPVSTGAFGR Mvan_1632|M.vanbaalenii_PYR-1 EFTDAP-----TDSG-GQWCDAEVLRILRRRSLAALRAQIEPVSTAAFGR MAB_3651|M.abscessus_ATCC_1997 EFTSD-------ATDSEQWCDAEVLRILRRRSLAALRAQVEPVSTSAFAR :*. *****:**:************* ***** *:.* TH_1222|M.thermoresistible__bu FLPAWQQVGTAN-------SGIDGLAAVIEQLAGVPMPASAVESLILPQR MSMEG_1757|M.smegmatis_MC2_155 FLPSWQHVGSTNT------TGIDGLATVIEQLAGVPIPASAVESLVFPQR Mb3324|M.bovis_AF2122/97 FLPAWQHVSAGNS-------GIDGLAAVIDQLAGVRIPASAIEPLVLAPR Rv3296|M.tuberculosis_H37Rv FLPAWQHVSAGNS-------GIDGLAAVIDQLAGVRIPASAIEPLVLAPR MMAR_1238|M.marinum_M FLPEWHQVGGADSS----HGGIDRLASVIDQLAGVRIPASALEPLVLAPR MAV_4267|M.avium_104 FLPAWHRVGAAESSRAPGHSGLDGLMSVIEQLAGVRLPASALEPLVLAPR Mflv_4810|M.gilvum_PYR-GCK FLPAWQMVGADSAS------GVDGLASVIDQLAGVPVPASAVEPLILGQR Mvan_1632|M.vanbaalenii_PYR-1 FLPAWQMLGGDAVS------GVDGLAAVIDQLAGVPMPASAVEPLIFGQR MAB_3651|M.abscessus_ATCC_1997 FLPDWQYLDSNLR-------GIDGVATVIEQLAGVPIPASAWEPLILARR *** *: :. *:* : :**:***** :**** *.*:: * TH_1222|M.thermoresistible__bu VRDYQPAMLDELLASGEVIWSGAGAIGGGATGADGWIAFHLGDSAPLTLA MSMEG_1757|M.smegmatis_MC2_155 VRDYQPAMLDELLASGEVMWSGAGQIGN----GDGWVAFHLADTAPLTLT Mb3324|M.bovis_AF2122/97 IRDYSPAMLDELLASGDVTWSGAGSISG----SDGWIALHPADSAPMTLA Rv3296|M.tuberculosis_H37Rv IRDYSPAMLDELLASGDVTWSGAGSISG----SDGWIALHPADSAPMTLA MMAR_1238|M.marinum_M VRDYSPAMLDELLATGEVTWAGAGSISG----SDGWVTLHLADSAPLTLA MAV_4267|M.avium_104 VRDYSPALLDELLATGEVTWSGAGSISG----SDGWIALHPSESAPLTLQ Mflv_4810|M.gilvum_PYR-GCK VRDYQPGMLDELLASGEVLWSGAGSLSA----ADGWVSFHPADTAPLSLA Mvan_1632|M.vanbaalenii_PYR-1 VRDYQPGMLDELLASGEVLWSGVGSLST----ADGWVAFHLAETAPLSLA MAB_3651|M.abscessus_ATCC_1997 IRDYSPQMLDELLASGEAVWSGQGSISA----QDGWIALHPSGVAPATLA :***.* :******:*:. *:* * :. ***:::* . ** :* TH_1222|M.thermoresistible__bu EPAEIEFTDVHRAILDTLGGGGGYFFRQLAGG--AGTDTTAVRTALWELV MSMEG_1757|M.smegmatis_MC2_155 HGAEIEFTDTHRVILETLGHGGAYFFRQLTDGTVEGTAGQELKQALWELI Mb3324|M.bovis_AF2122/97 EPAEIDFTDAHRAILASLGTGGAYFFRQLTHD---GLTEAELKAALWELI Rv3296|M.tuberculosis_H37Rv EPAEIDFTDAHRAILASLGTGGAYFFRQLTHD---GLTEAELKAALWELI MMAR_1238|M.marinum_M APAEIEFGEAHRAILDTLAGGGAYFFRQLIGD---IPDEAAIKAALWELI MAV_4267|M.avium_104 GPADIELGEAHRAILDVLAGGGGYFFRQLATD---GVSDAELKAALWELV Mflv_4810|M.gilvum_PYR-GCK PPGDLDLTDVHHQILAALAGGGAYFFRQLSLD---GVSSESLKEALWQLI Mvan_1632|M.vanbaalenii_PYR-1 PYGDLGLTDIHHAVLAALAGGGAYFFRQLTVD---GVGTESLKEALWQLI MAB_3651|M.abscessus_ATCC_1997 AAETVILDDAHRAILNCLTAGGGYFFRQFGSD--------ATRAALWDLV : : : *: :* * **.*****: . : ***:*: TH_1222|M.thermoresistible__bu WAGWVTGDTFAPVRAMLSGAGR-TGRRGGAPAHQQSRRPPRLSRYSVVAA MSMEG_1757|M.smegmatis_MC2_155 WAGWVTGDTFAPVRAVLSGP-----RRSGAPAHRQRQRPPRLSRYSVAHA Mb3324|M.bovis_AF2122/97 WAGRVTGDTFAPVRAVLGGAG---TRKRAAPAHG-GHRPPRLSRYRLTHA Rv3296|M.tuberculosis_H37Rv WAGRVTGDTFAPVRAVLGGAG---TRKRAAPAHG-GHRPPRLSRYRLTHA MMAR_1238|M.marinum_M WAGRVCGDTFAPVRALLGGGGP-GSRKRSAPAHR-GHRPPRLSRYSVAHA MAV_4267|M.avium_104 WAGWITGDTFAPVRALLGGGG---TRRRSAPAHR-AQRPPRLSRYSVAHP Mflv_4810|M.gilvum_PYR-GCK WAGYVGGDTFAPVRALLAGTKGPGSRRTAAPSHR-HRRPPRLSRYSLSTS Mvan_1632|M.vanbaalenii_PYR-1 WAGYVGGDTFAPVRALLAGARGSGPRKSATPSHR-HRRAPRLSRYSLSTS MAB_3651|M.abscessus_ATCC_1997 WAGQVTGDTFAPVRALLGTST------TSRTAHR-NRRAPRLRAYTPITT *** : *********:*. . .:* :*.*** * . TH_1222|M.thermoresistible__bu QT---RAADPTVAGRWSALPAPETDATVRAHFQAELLLHRYGVLTKGSVV MSMEG_1757|M.smegmatis_MC2_155 QT---RGTDPTVSGRWSALPAAEPDSTVRAHFQAELLLGRHGVLTKGAVG Mb3324|M.bovis_AF2122/97 QA---RNADPTVAGRWSALPLPEPDSTLRAHYQAELLLNRHGVLTKDAVA Rv3296|M.tuberculosis_H37Rv QA---RNADPTVAGRWSALPLPEPDSTLRAHYQAELLLNRHGVLTKDAVA MMAR_1238|M.marinum_M QP---RSVDPTVAGRWSLLPPPEPDSTVRAHYQAELLLNRHGVLTKGAVA MAV_4267|M.avium_104 QA---RPADTTVAGRWSVLPPPEPDSTVRAHFQAELLLGRHGVLTRGAVA Mflv_4810|M.gilvum_PYR-GCK SLSAHRDSDPTVAGRWSALPTAEVDTTVRAHYQADQLLARHGVLTKGAVA Mvan_1632|M.vanbaalenii_PYR-1 SLSAHRDSDPTVAGRWSALPVAEVDTTVRAHYQADQLLARHGVLTKGAVA MAB_3651|M.abscessus_ATCC_1997 AA----PVDPAVAGRWSMLPERLTGGTERSHIQAELLLGRYGVVTKGSVV *.:*:**** ** . * *:* **: ** *:**:*:.:* TH_1222|M.thermoresistible__bu AEA----VPGGFGTLYKVLTAFEEAGRCQRGYFVESLGGAQFAVASTVDR MSMEG_1757|M.smegmatis_MC2_155 AEG----VPGGFATLYKVLSTFEDAGRCQRGYFVESLGGAQFAVASTVDR Mb3324|M.bovis_AF2122/97 AEG----VAGGFATLYKVLSAFEDAGRCQRGYFIESLGGAQFAVASTVDR Rv3296|M.tuberculosis_H37Rv AEG----VAGGFATLYKVLSAFEDAGRCQRGYFIESLGGAQFAVASTVDR MMAR_1238|M.marinum_M SEG----VPGGFATLYKVLSAFEDAGRCQRGYFVESLGGAQFAVAATVDR MAV_4267|M.avium_104 AEG----VAGGFATLYKVLSTFEDAGRCQRGYFIESLGGAQFAVASTVDR Mflv_4810|M.gilvum_PYR-GCK SENFRGNIPGGFASMYKVLTTMEDAGRCQRGYFVESLGGAQFATASTVDR Mvan_1632|M.vanbaalenii_PYR-1 GEN----IPGGFASMYKVLTTMEEAGRCQRGYFVESLGGAQFATASTVDR MAB_3651|M.abscessus_ATCC_1997 AES----VAGGFAWLYKVLSTFEDNGRCRRGYFVESLGGAQFASPATVDR .* :.***. :****:::*: ***:****:********* .:**** TH_1222|M.thermoresistible__bu LRSYLDS----VDPQRPGYHAVVLAAADPANPYGAALPWPAGGAGDPDVG MSMEG_1757|M.smegmatis_MC2_155 LRSYLDN----VDPERPEYHAVVLAATDPANPYGAALGWPTD-----SEA Mb3324|M.bovis_AF2122/97 LRSYLDG----VDPEQPDYHAVVLAAADPANPYGAALPWPASSADGT--- Rv3296|M.tuberculosis_H37Rv LRSYLDG----VDPEQPDYHAVVLAAADPANPYGAALPWPASSADGT--- MMAR_1238|M.marinum_M LRSYLDDPSAFTDSRRPQYQAVLLAAADPANPYGAALPWPTSDDDGSNVG MAV_4267|M.avium_104 LRGFADG----VDPQRPEYRAIVLAAADPANPYGAALPWPASSADGA--- Mflv_4810|M.gilvum_PYR-GCK LRSHADS----IDDQQQKLRAVTLAATDPANPYGAALPWPSRGTDG-DTA Mvan_1632|M.vanbaalenii_PYR-1 LRSHADS----IDDQQHTLRAVALAATDPANPYGAALPWPSRGGE--DSA MAB_3651|M.abscessus_ATCC_1997 LREYLDP----VDDARKPYRATVLAATDPANPYGAALVWPRATSES---G ** . * * : :* ***:********** ** TH_1222|M.thermoresistible__bu HRPGRKAGALVVLVDGALRWFIERGGRSLLTFGDHADAEAHAAAAAALAG MSMEG_1757|M.smegmatis_MC2_155 HRPGRKAGALVALVDGRLVWFLERGGRSLLSFG--ADADAQRAAAGALTD Mb3324|M.bovis_AF2122/97 ARPGRKAGALVVLVDGELAWFLERGGRSLLTFTD--DPEANHAAAIGLAD Rv3296|M.tuberculosis_H37Rv ARPGRKAGALVVLVDGELAWFLERGGRSLLTFTD--DPEANHAAAIGLAD MMAR_1238|M.marinum_M ARPGRKAGALVVLVDGALAWFLERGGRTLLTFTD--DPEANAAAAIALAD MAV_4267|M.avium_104 -RPGRKAGALVVLVDGELAWFLERGGRSLLTFTD--DPAAQHAAAAALAG Mflv_4810|M.gilvum_PYR-GCK HRPGRKAGALVVLIDGELTWFVERGGRSLLSFTD--DAETANAAAAALAE Mvan_1632|M.vanbaalenii_PYR-1 HRPGRKAGALVVLVDGALAWFVERGGRSLLSFTA--DAETCHAAAASLAE MAB_3651|M.abscessus_ATCC_1997 HRPGRKAGALAVLVDGDLALYIERGGKSLLSFVI--DPTVLHAAALGTME *********..*:** * ::****::**:* *. . *** . TH_1222|M.thermoresistible__bu LVTAGRVPSLLVERINGVPVLEPGAD-AARQAVVDALTGAGFSRTPRGLR MSMEG_1757|M.smegmatis_MC2_155 LVSAGRIPSLLVERINGVAVLDPDVD-AERAVVQDALLGAGLSRTPRGLR Mb3324|M.bovis_AF2122/97 LVTAGRVASILVERADGMPVLQPG---GRASAALTALLAAGFVRTPRGLR Rv3296|M.tuberculosis_H37Rv LVTAGRVASILVERADGMPVLQPG---GRASAALTALLAAGFVRTPRGLR MMAR_1238|M.marinum_M LVATRRVGSLLVERINGVPVLQAGA--GQASLAVTALADAGFLRTPRGLR MAV_4267|M.avium_104 LVSARRVAAILVERIDGVPALAPRGDGAAGNDALTALADAGFARTPRGMR Mflv_4810|M.gilvum_PYR-GCK LVTRHRVPALLVERIDGVPVLESR-----ESVMVEALILAGFSRTPRGLR Mvan_1632|M.vanbaalenii_PYR-1 LVSRQRVPGLLVERIDGAPVLEAR-----DSAVAEALVQAGFARTPRGLR MAB_3651|M.abscessus_ATCC_1997 LVRDGGLDGLVIERIDGRSVFDIG-----DSAVVAALMEAGFARTPRGLR ** : .:::** :* ..: ** **: *****:* TH_1222|M.thermoresistible__bu LR- MSMEG_1757|M.smegmatis_MC2_155 LR- Mb3324|M.bovis_AF2122/97 RR- Rv3296|M.tuberculosis_H37Rv RR- MMAR_1238|M.marinum_M LR- MAV_4267|M.avium_104 LR- Mflv_4810|M.gilvum_PYR-GCK LR- Mvan_1632|M.vanbaalenii_PYR-1 LR- MAB_3651|M.abscessus_ATCC_1997 IRR *