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M. thermoresistible (build 8) TH_1222 ()

annotation: PROBABLE ATP-DEPENDENT HELICASE LHR (LARGE HELICASE-RELATED PROTEIN)
coordinates: 2353235 - 2355901
length: 889

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_1222-100% (889)PROBABLE ATP-DEPENDENT HELICASE LHR (LARGE HELICASE-RELATED PROTEIN)

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3324lhr0.075.73% (894) ATP-dependent helicase
M. gilvum PYR-GCKMflv_4810-0.072.83% (898) DEAD/DEAH box helicase domain-containing protein
M. tuberculosis H37RvRv3296lhr0.075.84% (894) ATP-dependent helicase
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_3651-0.065.54% (888) ATP-dependent helicase Lhr
M. marinum MMMAR_1238lhr0.075.50% (906) ATP-dependent helicase Lhr
M. avium 104MAV_4267-0.072.85% (917) DEAD/DEAH box helicase
M. smegmatis MC2 155MSMEG_1757-0.078.23% (891) DEAD/DEAH box helicase
M. ulcerans Agy99-----
M. vanbaalenii PYR-1Mvan_1632-0.074.55% (892) DEAD/DEAH box helicase domain-containing protein

CLUSTAL 2.0.9 multiple sequence alignment


TH_1222|M.thermoresistible__bu      --------------------------------------------------
MSMEG_1757|M.smegmatis_MC2_155      -MTTNGA-----DPLGRFSALTREWFTTAFAAPTPAQADAWSAISEGNNT
Mb3324|M.bovis_AF2122/97            -MRFAQP-----SALSRFSALTRDWFTSTFAAPTAAQASAWAAIADGDNT
Rv3296|M.tuberculosis_H37Rv         -MRFAQP-----SALSRFSALTRDWFTSTFAAPTAAQASAWAAIADGDNT
MMAR_1238|M.marinum_M               -MSTARPEPLGPEPLGRFSAITREWFTNTFAAPTPAQASAWAAIAAGDNT
MAV_4267|M.avium_104                MSTRAEPRP--SDPLGRFSAITREWFTSTFAAPTTAQAQAWSAIADGHNT
Mflv_4810|M.gilvum_PYR-GCK          -------MPAKTDPLSRFSTLTREWFAGTFVEPTPAQAQAWNAISAGENT
Mvan_1632|M.vanbaalenii_PYR-1       ----MEHMPTETDPLARFSALTREWFTGTFVKPTPAQAQAWNAIADGDNT
MAB_3651|M.abscessus_ATCC_1997      --MSSEP-----GPLARFSAPTREWFTESFPTPTRAQSGAWQSIANGDNT
                                                                                      

TH_1222|M.thermoresistible__bu      --------------------------------------------------
MSMEG_1757|M.smegmatis_MC2_155      LVIAPTGSGKTLAAFLWAIDRLADP-------AREPSQGTQVLYVSPLKA
Mb3324|M.bovis_AF2122/97            LVIAPTGSGKTLAAFLWALDSLAGSE-----PMSERPAATRVLYVSPLKA
Rv3296|M.tuberculosis_H37Rv         LVIAPTGSGKTLAAFLWALDSLAGSE-----PMSERPAATRVLYVSPLKA
MMAR_1238|M.marinum_M               LVIAPTGSGKTLAAFLWALDSLAR--------CPDRTAGTRVLYVSPLKA
MAV_4267|M.avium_104                LVIAPTGSGKTLAAFLWALDSLAG--------QAERAPGTRVLYVSPLKA
Mflv_4810|M.gilvum_PYR-GCK          LVIAPTGSGKTLAAFLWAIDGLAR--------EPRAERGTRVLYVSPLKA
Mvan_1632|M.vanbaalenii_PYR-1       LVIAPTGSGKTLAAFLWAIDGLAR--------EPAAQRGTRVLYVSPLKA
MAB_3651|M.abscessus_ATCC_1997      LVIAPTGSGKTLAAFLWAIDTLVQEKEAEAAAESRRLRGSRVLYVSPLKA
                                                                                      

TH_1222|M.thermoresistible__bu      --------------------------------------------------
MSMEG_1757|M.smegmatis_MC2_155      LAVDVERNLRTPLTGITRVAERHGLPAPSITVGVRSGDTPPNQRRAMIAN
Mb3324|M.bovis_AF2122/97            LAVDVERNLRTPLAGLTRLAERQGLPAPQIRVGVRSGDTPPALRRQLVSQ
Rv3296|M.tuberculosis_H37Rv         LAVDVERNLRTPLAGLTRLAERQGLPAPQIRVGVRSGDTPPALRRQLVSQ
MMAR_1238|M.marinum_M               LAVDVERNLRTPLAGLTRLAERRGLPPPQISVGVRSGDTPPAVRRQLITR
MAV_4267|M.avium_104                LAVDVERNLRTPLAGLTRIAERAGLPAPDISVGVRSGDTPPAVRRQLINR
Mflv_4810|M.gilvum_PYR-GCK          LAVDVERNLRTPLTGISRIAERNGEEPPAISVGVRSGDTTPSKRRELITK
Mvan_1632|M.vanbaalenii_PYR-1       LAVDVERNLRTPLTGISRIAERTGQQPPAISVGVRSGDTTPSKRRELITK
MAB_3651|M.abscessus_ATCC_1997      LAVDVERNLRAPLAGIARTAARMGLPEPAITIGVRSGDTPAQRRRTLISS
                                                                                      

TH_1222|M.thermoresistible__bu      --------------------------------------------------
MSMEG_1757|M.smegmatis_MC2_155      PPDVLITTPESLFLMLTSAARETLTSVRTVIVDEVHAVAATKRGAHLALS
Mb3324|M.bovis_AF2122/97            PPDVLITTPESLFLMLTSAARQTLTGVQTVIIDEIHAIAATKRGAHLALS
Rv3296|M.tuberculosis_H37Rv         PPDVLITTPESLFLMLTSAARQTLTGVQTVIIDEIHAIAATKRGAHLALS
MMAR_1238|M.marinum_M               PPDVLITTPESLFLMLTSAARETLAGVQTVIVDEIHAIAATKRGAHLALS
MAV_4267|M.avium_104                PPDVLITTPESLFLMLTSAARETLAGVQTVIVDEIHAIAGGKRGAHLALS
Mflv_4810|M.gilvum_PYR-GCK          PPDILITTPESLFLMLTSAARESLSDIETVIVDEVHAVAATKRGAHLAVS
Mvan_1632|M.vanbaalenii_PYR-1       PPDILITTPESLFLMLTSAARETLSQVQTVIVDEVHAVAGTKRGAHLAVS
MAB_3651|M.abscessus_ATCC_1997      PPDILITTPESLYLMLTSAARETLDTVRTVIVDEVHAVAGTKRGAHLALS
                                                                                      

TH_1222|M.thermoresistible__bu      --------------------------------------------------
MSMEG_1757|M.smegmatis_MC2_155      LERLDQLLDTPAQ-----RIGLSATVRPPEEVARFLSGQAP---TTIVCP
Mb3324|M.bovis_AF2122/97            LERLDDLSSRRRA----QRIGLSATVRPPEELARFLSGQSP---TTIVAP
Rv3296|M.tuberculosis_H37Rv         LERLDDLSSRRRA----QRIGLSATVRPPEELARFLSGQSP---TTIVAP
MMAR_1238|M.marinum_M               LERLDQLAPDRRAGPPAQRIGLSATVRPPEELARFLSGSAP---TTIVAP
MAV_4267|M.avium_104                LERLDALREGRPA----QRIGLSATVRPPDELARFLSGAAPGTRTTVVAP
Mflv_4810|M.gilvum_PYR-GCK          LERLDAMLPKPAQ-----RIGLSATVRPPEEVARFLSGASP---TTIVAP
Mvan_1632|M.vanbaalenii_PYR-1       LERLDAMLPKPAQ-----RIGLSATVRPPEEVARFLSGAAP---TTIVAP
MAB_3651|M.abscessus_ATCC_1997      LERLDERLSQPAQ-----RIGLSATVKPAAEVARFLSGRAP---ATVVAP
                                                                                      

TH_1222|M.thermoresistible__bu      --------------------------------------------------
MSMEG_1757|M.smegmatis_MC2_155      PAAKTFDLSVQVPVPDMANLD---------------NNSIWPDVEERIVD
Mb3324|M.bovis_AF2122/97            PAAKTVELSVQVPVPDMANLT---------------DNTIWPDVEARLVD
Rv3296|M.tuberculosis_H37Rv         PAAKTVELSVQVPVPDMANLT---------------DNTIWPDVEARLVD
MMAR_1238|M.marinum_M               HSAKTFDLTVQVPVADMANLA---------------NNTIWPDVESRLVD
MAV_4267|M.avium_104                PSAKTVELSVQVPVPDMANLA---------------NNTIWPDVENRLVD
Mflv_4810|M.gilvum_PYR-GCK          PAAKTFDLTVQVPVPDMAAPN---------------TGSIWPDVEERIVD
Mvan_1632|M.vanbaalenii_PYR-1       PAAKTFDLTVQVPVPDMANLE---------------NNSIWPEVEQRIVD
MAB_3651|M.abscessus_ATCC_1997      ASPKTFDLSVVVPVSDMSAPESFPEPEASPDSTRGGATSLWPHVEQRIVD
                                                                                      

TH_1222|M.thermoresistible__bu      --------------------------------------------------
MSMEG_1757|M.smegmatis_MC2_155      LVEAHNSSIVFANSRRLAERLTSRLNEIHAERSGIELPAGPNPEVGGGAP
Mb3324|M.bovis_AF2122/97            LIESHNSTIVFANSRRLAERLTARLNEIHAARCGIELAPDTNQQVAGGAP
Rv3296|M.tuberculosis_H37Rv         LIESHNSTIVFANSRRLAERLTARLNEIHAARCGIELAPDTNQQVAGGAP
MMAR_1238|M.marinum_M               LIESHNSTIVFANSRRLAERLTARLNEIHAERSGMTLPSEANTQVAGGAP
MAV_4267|M.avium_104                LIEAHGSTIVFANSRRLAERLTARLNEIHAERSGVELSATANPKVAGGAP
Mflv_4810|M.gilvum_PYR-GCK          LIEAHNSSIVFTNSRRLAERLTARINEIHAERTGIELG-AHNPGVAGGAP
Mvan_1632|M.vanbaalenii_PYR-1       LVEAHNSSIVFANSRRLAERLTARLNEIHAERLGVELG-GANPGVAGGAP
MAB_3651|M.abscessus_ATCC_1997      LIEAHRSSIVFANSRRLAERLTARFNEIHAERLGLDLTPMPNPDVPGGPP
                                                                                      

TH_1222|M.thermoresistible__bu      --------------------------------------------------
MSMEG_1757|M.smegmatis_MC2_155      AHLMGSGQANGAPPLLARAHHGSVSKEQRAQVEDDLKSGRLRAVVATSSL
Mb3324|M.bovis_AF2122/97            AHIMGSGQTFGAPPVLARAHHGSISKEQRAVVEEDLKRGQLKAVVATSSL
Rv3296|M.tuberculosis_H37Rv         AHIMGSGQTFGAPPVLARAHHGSISKEQRAVVEEDLKRGQLKAVVATSSL
MMAR_1238|M.marinum_M               AQIMASGQTFGAATLLARAHHGSVSKEQRAQVEEDLKRGALKAVVATSSL
MAV_4267|M.avium_104                AHIMASGQTYGVEPILARAHHGSVSKEQRALVEEDLKRGLLKAVVATSSL
Mflv_4810|M.gilvum_PYR-GCK          AHLMGSGQTYGAEPVLARAHHGSVSKEARADVEDALKSGRLKAVVATSSL
Mvan_1632|M.vanbaalenii_PYR-1       AHLMGSGQTYGAEPLLARAHHGSVSKEARADVEEALKSGRLKAVVATSSL
MAB_3651|M.abscessus_ATCC_1997      AHIMGSGQTYGAAPLLARAHHGSVSKEQRADIEDDLKTGRLKCVVATSSL
                                                                                      

TH_1222|M.thermoresistible__bu      --------------------------------------------------
MSMEG_1757|M.smegmatis_MC2_155      ELGIDMGAVDLVIQVEAPPSVASGLQRVGRAGHQVGEISQGVLFPKHRTD
Mb3324|M.bovis_AF2122/97            ELGIDMGAVDLVIQVQAPPSVASGLQRIGRAGHQVGEISRGVLFPKHRTD
Rv3296|M.tuberculosis_H37Rv         ELGIDMGAVDLVIQVQAPPSVASGLQRIGRAGHQVGEISRGVLFPKHRTD
MMAR_1238|M.marinum_M               ELGIDMGAVDLVIQVEAPPSVASGLQRIGRAGHQVGEVSRGVLFPKHRTD
MAV_4267|M.avium_104                ELGIDMGAVDLVIQVEAPPSVASGLQRIGRAGHQVGEVSRGVLFPKHRTD
Mflv_4810|M.gilvum_PYR-GCK          ELGIDMGAVDLVIQVETPPSVASGLQRVGRAGHQVGEISQGVLFPKHRTD
Mvan_1632|M.vanbaalenii_PYR-1       ELGIDMGAVDLVIQVETPPSVASGLQRIGRAGHQVGEISQGVLFPKHRTD
MAB_3651|M.abscessus_ATCC_1997      ELGIDMGAVDLVVQVEAPPSVASGLQRIGRAGHQVGEVSRGVLFPKHRTD
                                                                                      

TH_1222|M.thermoresistible__bu      --------------------------------------------------
MSMEG_1757|M.smegmatis_MC2_155      LIGCAVTVQRMQTGDIETLRVPANPLDVLAQHTVAVAALEPVDADAWFDA
Mb3324|M.bovis_AF2122/97            LLGCAVSVQRMLAGEIETMRVPANPLDILAQHTVAAAALEPLDADAWFDT
Rv3296|M.tuberculosis_H37Rv         LLGCAVSVQRMLAGEIETMRVPANPLDILAQHTVAAAALEPLDADAWFDT
MMAR_1238|M.marinum_M               LLGCAISVQRMRTGQIETMRVPANPLDILAQHTVAAAALEPLDADQWFDT
MAV_4267|M.avium_104                LIGCAVTVQRMLAGQIETMRVPANPLDILAQQTVAAAALEPLDADRWFDT
Mflv_4810|M.gilvum_PYR-GCK          LIGCAVSVQRMLAGQIETMRVPANPLDVLAQHTVAASALEPINADAWFDT
Mvan_1632|M.vanbaalenii_PYR-1       LIGCAVSVQRMLAGQIETMRVPANPLDVLAQHTVAACALEPINAEAWFDT
MAB_3651|M.abscessus_ATCC_1997      LLGCAVTVRRMLDGDIETLQVPANPLDILAQHTVAACALESMDVEKWFDV
                                                                                      

TH_1222|M.thermoresistible__bu      --------------------------------------------------
MSMEG_1757|M.smegmatis_MC2_155      VRRSAPFATLPRSAFEATLDLLSGKYPSTEFAELRPRLVYDRDTGTLTAR
Mb3324|M.bovis_AF2122/97            VRRAAPFATLPRSLFEATLDLLSGKYPSTEFAELRPRLVYDRDTGTLTAR
Rv3296|M.tuberculosis_H37Rv         VRRAAPFATLPRSLFEATLDLLSGKYPSTEFAELRPRLVYDRDTGTLTAR
MMAR_1238|M.marinum_M               VRRSASFATLPRSVFEATLDLLSGKYPSTEFAELRPRLVYDRGTGTLTAR
MAV_4267|M.avium_104                VRRAAPFATLPRSIYEATLDLLSGKYPSTEFAELRPRLVYDRNTGTLTAR
Mflv_4810|M.gilvum_PYR-GCK          VRRSAPFATLPRSAFEATLDLLSGKYPSTEFAELRPRIVYDRDNGMLTSR
Mvan_1632|M.vanbaalenii_PYR-1       VRRSAPFATLPRSAFEATLDLLSGKYPSTEFAELRPRIVYDRDTGTLTSR
MAB_3651|M.abscessus_ATCC_1997      VRRSAPFTSLPRSAFDAVLDLLSGKYPSTDFAELRPRVVYDRDEGTLTGR
                                                                                      

TH_1222|M.thermoresistible__bu      --------------------------------------------------
MSMEG_1757|M.smegmatis_MC2_155      PGAQRLAVTSGGAIPDRGMFTVYLASETE--KPSRVGELDEEMVYESRPG
Mb3324|M.bovis_AF2122/97            PGAQRLAVTSGGAIPDRGLFAVYLATER----PSRVGELDEEMVYESRPG
Rv3296|M.tuberculosis_H37Rv         PGAQRLAVTSGGAIPDRGLFAVYLATER----PSRVGELDEEMVYESRPG
MMAR_1238|M.marinum_M               PGAQRLAVTSGGAIPDRGLFTVYLASEAE--KPSRVGELDEEMVYESRPG
MAV_4267|M.avium_104                PGAQRLAVTSGGAIPDRGLFTVYLASEAE--KPSRVGELEEEMVYESRPG
Mflv_4810|M.gilvum_PYR-GCK          PGAQRLAVTSGGAIPDRGMFTVFLASSAESEKPSRVGELDEEMVYESRPG
Mvan_1632|M.vanbaalenii_PYR-1       PGAQRLAVTSGGAIPDRGLFTVFLASSADSEKPSRVGELDEEMVYESRPG
MAB_3651|M.abscessus_ATCC_1997      PGAQRLAVTSGGAIPDRGLFTVYMYAGAEGEKPSRVGELDEEMVYESRPG
                                                                                      

TH_1222|M.thermoresistible__bu      --------------------------------------------------
MSMEG_1757|M.smegmatis_MC2_155      DVISLGATSWRITEITHDRVLVIPAPGQPARLPFWRGDSVGRPAELGAAV
Mb3324|M.bovis_AF2122/97            DVISLGATSWRITEITHDRVLVIPAPGQPARLPFWRGDDAGRPAELGAAL
Rv3296|M.tuberculosis_H37Rv         DVISLGATSWRITEITHDRVLVIPAPGQPARLPFWRGDDAGRPAELGAAL
MMAR_1238|M.marinum_M               DVISLGATSWRITEITHDRVLVIPAPGEPARLPFWRGDDVGRPAELGAAL
MAV_4267|M.avium_104                DVISLGATSWRITEITHDRVLVIPAPGQPARLPFWRGDGVGRPAELGAAL
Mflv_4810|M.gilvum_PYR-GCK          DVISLGATSWRITEITHDRVLVIPAPGEPARLPFWRGDGVGRPVELGAAI
Mvan_1632|M.vanbaalenii_PYR-1       DVISLGATSWRITEITHDRVLVIPAPGEPARLPFWRGDGVGRPAELGAAI
MAB_3651|M.abscessus_ATCC_1997      DVISLGATSWRITEITHERVVVVPAFGQPGRLPFWRGDSVGRPAELGIAL
                                                                                      

TH_1222|M.thermoresistible__bu      ---------------------MGFDEFATTNLWQLLDEQRQSTGVVPSDT
MSMEG_1757|M.smegmatis_MC2_155      GAFTGELASLDRKAFDKRCQKMGFAGYATDNLHQLLREQREATGVVPSDT
Mb3324|M.bovis_AF2122/97            GALTGELAALDRTAFGTRCAGLGFDDYATDNLWRLLDDQRTATAVVPTDS
Rv3296|M.tuberculosis_H37Rv         GALTGELAALDRTAFGTRCAGLGFDDYATDNLWRLLDDQRTATAVVPTDS
MMAR_1238|M.marinum_M               GALTGELARLDRAEFDKRCAGLGFDDFATDNLWGLLDDQKTATRVVPTDT
MAV_4267|M.avium_104                GAFTGELAGLSREEFDSRCAALGFDAYAVDNLYGLFDEQRTAAGVVPTDT
Mflv_4810|M.gilvum_PYR-GCK          GAFNGELARLDRPAFESRCRDVGFDDFATDNLWQLISEQREATSSVPSDT
Mvan_1632|M.vanbaalenii_PYR-1       GAFTGELARLDRDAFESRCQEVGFDAFATDNLWQLISEQRDATSAVPSDT
MAB_3651|M.abscessus_ATCC_1997      GQLTGELASARDAEFDKRCAAMGFDDFATGNLRTLLTDQLRSTGAVPTDT
                                                         :**  :*. **  *: :*  ::  **:*:

TH_1222|M.thermoresistible__bu      TLLVERFRDELGDWRVILHSPYGLRVHGPLALAVGRRLAERYGIDEKPTA
MSMEG_1757|M.smegmatis_MC2_155      TFVVERFRDELGDWRVILHSPYGLRVHGPLALAVGRRLRERYGIDEKPTA
Mb3324|M.bovis_AF2122/97            TLLVERFRDELGDWRVILHSPYGLRVHGPLALAVGRRLRDRYGIDEKPTA
Rv3296|M.tuberculosis_H37Rv         TLLVERFRDELGDWRVILHSPYGLRVHGPLALAVGRRLRDRYGIDEKPTA
MMAR_1238|M.marinum_M               TLLVERFRDELGDWRVILHSPYGLRVHGPLALAVGRRLRDRYGLDEKPTA
MAV_4267|M.avium_104                TLLVERFRDELGDWRVILHSPYGLGVNGPLALAVGRRLRERYGIDEKPTA
Mflv_4810|M.gilvum_PYR-GCK          TLVVERFRDELGDWRVILHSPYGLRVHGPLALAVGKRLYERFGIDEKPTA
Mvan_1632|M.vanbaalenii_PYR-1       TLVVERFRDELGDWRVILHSPYGLRVHGPLALAVGKRLYERYGIDEKPTA
MAB_3651|M.abscessus_ATCC_1997      TLIVERFRDELGDWRIVLHCPYGLRVNGPLALAISDRLQQRYGVSESPTA
                                    *::************::**.**** *:******:. ** :*:*:.*.***

TH_1222|M.thermoresistible__bu      SDDGIIVRLPDTGD--------TQPGAELFVFDADEIEPLVTAEVGGSAL
MSMEG_1757|M.smegmatis_MC2_155      SDDGIIVRLPDSGD--------TPPGADLFVFDADEIEPIVTAEVGGSAL
Mb3324|M.bovis_AF2122/97            SDNGIMVRLPDTVS----AGEDSPPGAELFVFDADEIDPIVTTEVAGSAL
Rv3296|M.tuberculosis_H37Rv         SDNGIVVRLPDTVS----AGEDSPPGAELFVFDADEIDPIVTTEVAGSAL
MMAR_1238|M.marinum_M               SDDGIVVRLPDTISD---TGTETPPGAELFLFDADEIDAIVTAEVGASAL
MAV_4267|M.avium_104                SDDGVVVRLPDTVSDFASDGGDTPPGAELFVFDADEIDPIVTAEVGGSAL
Mflv_4810|M.gilvum_PYR-GCK          SDDGIIVRLPDTDD--------TAPGADIFVFDADEIEPLVTTEVSSSAL
Mvan_1632|M.vanbaalenii_PYR-1       SDDGIIVRLPDTDD--------TAPGADIFVFDADEIEPLVTAEVSSSAL
MAB_3651|M.abscessus_ATCC_1997      TDDGIVVRLPDTDD--------SPPGADLFVFDAAEIESIVTREVGGSAL
                                    :*:*::*****: .        : ***::*:*** **:.:** **..***

TH_1222|M.thermoresistible__bu      FASRFRECAARALLLPRRHPGKRSPLWHQRQRAAQLLDVARKYPDFPIVL
MSMEG_1757|M.smegmatis_MC2_155      FASRFRECAARALLLPRRHPGKRSPLWHQRQRAAQLLDIARKYPDFPIVL
Mb3324|M.bovis_AF2122/97            FASRFRESAARALLLPRRHPGRRSPLWQQRQRAARLLEVARKYPDFPIVL
Rv3296|M.tuberculosis_H37Rv         FASRFRESAARALLLPRRHPGRRSPLWQQRQRAARLLEVARKYPDFPIVL
MMAR_1238|M.marinum_M               FASRFRESAARALLLPRRHPGRRSPLWHQRQRAAQLLDVARKYPDFPMVL
MAV_4267|M.avium_104                FASRFRECAARALLLPRRHPGRRSPLWQQRQRAAQLLEVARKYPDFPVVL
Mflv_4810|M.gilvum_PYR-GCK          FASRFRECAARALLLPRRHPGKRSPLWHQRQRAAQLLDVARNYPDFPIVL
Mvan_1632|M.vanbaalenii_PYR-1       FASRFRECAARALLLPRRHPGKRSPLWHQRQRAAQLLDVAKGYPDFPIVL
MAB_3651|M.abscessus_ATCC_1997      FAARFRECAARALLLPRRTPGRRSPLWQQRQRAAQLLDVARKHSDFPMVL
                                    **:****.********** **:*****:******:**::*: :.***:**

TH_1222|M.thermoresistible__bu      ETVRECLQDVYDVPTLTELMRGIAQRRLRLIEVETAAPSPFAASLLFGYV
MSMEG_1757|M.smegmatis_MC2_155      EAVRECLQDVYDVPALIELMHKIAQRRLRIVEVETATPSPFAASLLFGYV
Mb3324|M.bovis_AF2122/97            ETVRECLQNVYDVPILVELMARIAQRRVRVAEAETAKPSPFAASLLFGYV
Rv3296|M.tuberculosis_H37Rv         ETVRECLQDVYDVPILVELMARIAQRRVRVAEAETAKPSPFAASLLFGYV
MMAR_1238|M.marinum_M               ETVRECLQDVYDVPTLTTLMTDIAQRRVRVAETETTKPSPFAASLLFGYV
MAV_4267|M.avium_104                ETVRECLQDVYDVPALVALMAGIAQRRVRVLEVETQRPSPFAASLLFGYV
Mflv_4810|M.gilvum_PYR-GCK          EAVRECLQDVYDVPALTALMDRIAQRRVRILEVETPTPSPFAASLLFGYV
Mvan_1632|M.vanbaalenii_PYR-1       EAVRECLQDVYDVPTLTALMGRIAQRRVRLLEVETPTPSPFAASLLFGYV
MAB_3651|M.abscessus_ATCC_1997      EALRECLQDVYDISTLVRLMSGIEQRRIRIVEVQTDTPSPFAAAQLFSYI
                                    *::*****:***:. *  **  * ***:*: *.:*  ******: **.*:

TH_1222|M.thermoresistible__bu      GAFIYEGDSPLAERRAAALSLDPTLLAELLGRVELRELLDPDVVATTGRQ
MSMEG_1757|M.smegmatis_MC2_155      GAFMYEGDSPLAERRAAALALDTVLLSELLGRVELRELLDPAVVASTSAQ
Mb3324|M.bovis_AF2122/97            GAFMYEGDTPLAERRAAALALDGTLLAELLGRVELRELLDPDVIAATSRQ
Rv3296|M.tuberculosis_H37Rv         GAFMYEGDTPLAERRAAALALDGTLLAELLGRVELRELLDPDVIAATSRQ
MMAR_1238|M.marinum_M               GAFMYEGDVPLAERRAAALSLDSTLLAELLGRVELRELLDPEVIAATGRQ
MAV_4267|M.avium_104                GAFMYEGDSPLAERRAAALSLDSTLLAELLGRVELRELLDPEVVAATARA
Mflv_4810|M.gilvum_PYR-GCK          GAFMYEGDSPLAERRAAALALDPTLLAELLGRVELRELLDPDVIATTTRQ
Mvan_1632|M.vanbaalenii_PYR-1       GAFMYEGDSPLAERRAAALSLDPTLLAELLGRVELRELLDADVVTTTARQ
MAB_3651|M.abscessus_ATCC_1997      GGFMYDEDRPLAERRAAALSLDTNLLAELMGRVELRELLDPAVIDATERQ
                                    *.*:*: * **********:**  **:**:**********. *: :*   

TH_1222|M.thermoresistible__bu      LQHLTADRAVRDVEGVADLLRMLGPLTAEEIAAR---STSADVGGWLDEL
MSMEG_1757|M.smegmatis_MC2_155      LQHLTPERAARDAEGVADLLRLLGPLTEADIAQR---CTADNIGAWLDGL
Mb3324|M.bovis_AF2122/97            LQHLAADRVARDAEGVADLLRLLGPLTEDEIAAR---AGAPEVSGWLDGL
Rv3296|M.tuberculosis_H37Rv         LQHLAADRVARDAEGVADLLRLLGPLTEDEIAAR---AGAPEVSGWLDGL
MMAR_1238|M.marinum_M               LQHLCADRAARDAEGVADLLRLLGPLTEDEVAARSDTTGGTDIGGWLEGL
MAV_4267|M.avium_104                LQHLAPERAARDAEAVADLLRLLGPLTEDEVVARAGGADAVEVRGWLEGL
Mflv_4810|M.gilvum_PYR-GCK          LQHLTPERAARDAEGVADLLRLLGPLTVDEIAER---CVQPDIGGWLEGL
Mvan_1632|M.vanbaalenii_PYR-1       LQHLTPERLARDAEGVADLLRLLGPLTTEEIAAR---CVVSEVGGWLEGL
MAB_3651|M.abscessus_ATCC_1997      LQHLAEERKARDAEALADLFRLLGPLTAEEIAQR----CAGPGAAWLDEL
                                    ****  :* .**.*.:***:*:*****  ::. *          .**: *

TH_1222|M.thermoresistible__bu      AAARRALRVSYAGRQWWVAVEDIGLLRDAVGVAVPVGVPTTFTGAVADPL
MSMEG_1757|M.smegmatis_MC2_155      HAAKRALPVTYAGQTWWAAVEDIGLLRDGIGVPVPVGVPAAFTESASDPL
Mb3324|M.bovis_AF2122/97            RAAKRALVVSFAGRSWWVAVEDMGRLRDGVGAAVPVGLPASFTEAVADPL
Rv3296|M.tuberculosis_H37Rv         RAAKRALVVSFAGRSWWVAVEDMGRLRDGVGAAVPVGLPASFTEAVADPL
MMAR_1238|M.marinum_M               RAARRALEVSYAGRSWWVAVEDIGRLRDGVGAAVPVGLPAAFTEAVADPL
MAV_4267|M.avium_104                RAARRAVPVSFAGRSWWVAIEDIGRLRDGLGIAVPLGVPAAFTEEVADPL
Mflv_4810|M.gilvum_PYR-GCK          LTSKRVVTLSFAGQTWWAAIEDIGRLRDGVGVAVPVGVPIAFLEPIVDPL
Mvan_1632|M.vanbaalenii_PYR-1       LGAKRAVQVSFAGQSWWAAVEDIGRLRDGVGVAVPVGVPMAFLEQVVDPL
MAB_3651|M.abscessus_ATCC_1997      VSARRVVGTSYGQRSWWAAVEDVARLRDALGVPVPPGVPAAFTDAATDPL
                                      ::*.:  ::. : **.*:**:. ***.:* .** *:* :*     ***

TH_1222|M.thermoresistible__bu      GELLGRYARTRGPFTTAQAAARFGLGLRVAGDVLHRMAA----DGRLVRG
MSMEG_1757|M.smegmatis_MC2_155      GDLIGRYARTRGPFTTEQTAARFGLGVRVASDVLSRMAV----DGRLIRG
Mb3324|M.bovis_AF2122/97            GELLGRYARTHTPFTTAAAAARFGLGLRVTADVLGRLAS----DGRLVRG
Rv3296|M.tuberculosis_H37Rv         GELLGRYARTHTPFTTAAAAARFGLGLRVTADVLGRLAS----DGRLVRG
MMAR_1238|M.marinum_M               AELLGRYARTHPPFTTAEAAGRFGLGLRVTADVLGRLAS----DGRLVRG
MAV_4267|M.avium_104                GELLGRYARTHTPFSTAEAAARFGLGLRVTADVLGRLADPSTSQGRLVRG
Mflv_4810|M.gilvum_PYR-GCK          SELLSRYARTRGPFTTMEAATRFGLGVRVAADVLGRLTA----DGKLVRG
Mvan_1632|M.vanbaalenii_PYR-1       GELLSRYARTRGPFTTAEAAARFGLGLRVAADVLGRLAV----DGKLVRG
MAB_3651|M.abscessus_ATCC_1997      AELLSRYARTHGPFTTGEAAQRFGLGVRVAADTLSAMAA----RGQLVRG
                                    .:*:.*****: **:*  :* *****:**:.*.*  ::      *:*:**

TH_1222|M.thermoresistible__bu      EFTTD------AVDTTEQWCDAEVLRILRRRSLAALRAQVEPVSTAAFGR
MSMEG_1757|M.smegmatis_MC2_155      EFAAD------LSG--EQWCDAQVLKILRRRSLAALRAQVEPVSTDAYAR
Mb3324|M.bovis_AF2122/97            EFVAA----AEGSAGGEQWCDAEVLRILRRRSLAALRAQAEPVSTAAYGR
Rv3296|M.tuberculosis_H37Rv         EFVAA----AKGSAGGEQWCDAEVLRILRRRSLAALRAQAEPVSTAAYGR
MMAR_1238|M.marinum_M               DFVATG---VFGGAGSEQWCDAEVLRILRRRSLAALRAQVEPVSTAAYGR
MAV_4267|M.avium_104                DFVAARPSEPGGVLGAEQWCDADVLRILRRRSLAALRAQVEPVSTAAYGR
Mflv_4810|M.gilvum_PYR-GCK          EFTDLP-----TESGVEQWCDAEVLRILRRRSLAALRAQIEPVSTGAFGR
Mvan_1632|M.vanbaalenii_PYR-1       EFTDAP-----TDSG-GQWCDAEVLRILRRRSLAALRAQIEPVSTAAFGR
MAB_3651|M.abscessus_ATCC_1997      EFTSD-------ATDSEQWCDAEVLRILRRRSLAALRAQVEPVSTSAFAR
                                    :*.              *****:**:************* ***** *:.*

TH_1222|M.thermoresistible__bu      FLPAWQQVGTAN-------SGIDGLAAVIEQLAGVPMPASAVESLILPQR
MSMEG_1757|M.smegmatis_MC2_155      FLPSWQHVGSTNT------TGIDGLATVIEQLAGVPIPASAVESLVFPQR
Mb3324|M.bovis_AF2122/97            FLPAWQHVSAGNS-------GIDGLAAVIDQLAGVRIPASAIEPLVLAPR
Rv3296|M.tuberculosis_H37Rv         FLPAWQHVSAGNS-------GIDGLAAVIDQLAGVRIPASAIEPLVLAPR
MMAR_1238|M.marinum_M               FLPEWHQVGGADSS----HGGIDRLASVIDQLAGVRIPASALEPLVLAPR
MAV_4267|M.avium_104                FLPAWHRVGAAESSRAPGHSGLDGLMSVIEQLAGVRLPASALEPLVLAPR
Mflv_4810|M.gilvum_PYR-GCK          FLPAWQMVGADSAS------GVDGLASVIDQLAGVPVPASAVEPLILGQR
Mvan_1632|M.vanbaalenii_PYR-1       FLPAWQMLGGDAVS------GVDGLAAVIDQLAGVPMPASAVEPLIFGQR
MAB_3651|M.abscessus_ATCC_1997      FLPDWQYLDSNLR-------GIDGVATVIEQLAGVPIPASAWEPLILARR
                                    *** *: :.           *:* : :**:***** :**** *.*::  *

TH_1222|M.thermoresistible__bu      VRDYQPAMLDELLASGEVIWSGAGAIGGGATGADGWIAFHLGDSAPLTLA
MSMEG_1757|M.smegmatis_MC2_155      VRDYQPAMLDELLASGEVMWSGAGQIGN----GDGWVAFHLADTAPLTLT
Mb3324|M.bovis_AF2122/97            IRDYSPAMLDELLASGDVTWSGAGSISG----SDGWIALHPADSAPMTLA
Rv3296|M.tuberculosis_H37Rv         IRDYSPAMLDELLASGDVTWSGAGSISG----SDGWIALHPADSAPMTLA
MMAR_1238|M.marinum_M               VRDYSPAMLDELLATGEVTWAGAGSISG----SDGWVTLHLADSAPLTLA
MAV_4267|M.avium_104                VRDYSPALLDELLATGEVTWSGAGSISG----SDGWIALHPSESAPLTLQ
Mflv_4810|M.gilvum_PYR-GCK          VRDYQPGMLDELLASGEVLWSGAGSLSA----ADGWVSFHPADTAPLSLA
Mvan_1632|M.vanbaalenii_PYR-1       VRDYQPGMLDELLASGEVLWSGVGSLST----ADGWVAFHLAETAPLSLA
MAB_3651|M.abscessus_ATCC_1997      IRDYSPQMLDELLASGEAVWSGQGSISA----QDGWIALHPSGVAPATLA
                                    :***.* :******:*:. *:* * :.      ***:::* .  ** :* 

TH_1222|M.thermoresistible__bu      EPAEIEFTDVHRAILDTLGGGGGYFFRQLAGG--AGTDTTAVRTALWELV
MSMEG_1757|M.smegmatis_MC2_155      HGAEIEFTDTHRVILETLGHGGAYFFRQLTDGTVEGTAGQELKQALWELI
Mb3324|M.bovis_AF2122/97            EPAEIDFTDAHRAILASLGTGGAYFFRQLTHD---GLTEAELKAALWELI
Rv3296|M.tuberculosis_H37Rv         EPAEIDFTDAHRAILASLGTGGAYFFRQLTHD---GLTEAELKAALWELI
MMAR_1238|M.marinum_M               APAEIEFGEAHRAILDTLAGGGAYFFRQLIGD---IPDEAAIKAALWELI
MAV_4267|M.avium_104                GPADIELGEAHRAILDVLAGGGGYFFRQLATD---GVSDAELKAALWELV
Mflv_4810|M.gilvum_PYR-GCK          PPGDLDLTDVHHQILAALAGGGAYFFRQLSLD---GVSSESLKEALWQLI
Mvan_1632|M.vanbaalenii_PYR-1       PYGDLGLTDIHHAVLAALAGGGAYFFRQLTVD---GVGTESLKEALWQLI
MAB_3651|M.abscessus_ATCC_1997      AAETVILDDAHRAILNCLTAGGGYFFRQFGSD--------ATRAALWDLV
                                        : : : *: :*  *  **.*****:  .          : ***:*:

TH_1222|M.thermoresistible__bu      WAGWVTGDTFAPVRAMLSGAGR-TGRRGGAPAHQQSRRPPRLSRYSVVAA
MSMEG_1757|M.smegmatis_MC2_155      WAGWVTGDTFAPVRAVLSGP-----RRSGAPAHRQRQRPPRLSRYSVAHA
Mb3324|M.bovis_AF2122/97            WAGRVTGDTFAPVRAVLGGAG---TRKRAAPAHG-GHRPPRLSRYRLTHA
Rv3296|M.tuberculosis_H37Rv         WAGRVTGDTFAPVRAVLGGAG---TRKRAAPAHG-GHRPPRLSRYRLTHA
MMAR_1238|M.marinum_M               WAGRVCGDTFAPVRALLGGGGP-GSRKRSAPAHR-GHRPPRLSRYSVAHA
MAV_4267|M.avium_104                WAGWITGDTFAPVRALLGGGG---TRRRSAPAHR-AQRPPRLSRYSVAHP
Mflv_4810|M.gilvum_PYR-GCK          WAGYVGGDTFAPVRALLAGTKGPGSRRTAAPSHR-HRRPPRLSRYSLSTS
Mvan_1632|M.vanbaalenii_PYR-1       WAGYVGGDTFAPVRALLAGARGSGPRKSATPSHR-HRRAPRLSRYSLSTS
MAB_3651|M.abscessus_ATCC_1997      WAGQVTGDTFAPVRALLGTST------TSRTAHR-NRRAPRLRAYTPITT
                                    *** : *********:*.          . .:*   :*.***  *    .

TH_1222|M.thermoresistible__bu      QT---RAADPTVAGRWSALPAPETDATVRAHFQAELLLHRYGVLTKGSVV
MSMEG_1757|M.smegmatis_MC2_155      QT---RGTDPTVSGRWSALPAAEPDSTVRAHFQAELLLGRHGVLTKGAVG
Mb3324|M.bovis_AF2122/97            QA---RNADPTVAGRWSALPLPEPDSTLRAHYQAELLLNRHGVLTKDAVA
Rv3296|M.tuberculosis_H37Rv         QA---RNADPTVAGRWSALPLPEPDSTLRAHYQAELLLNRHGVLTKDAVA
MMAR_1238|M.marinum_M               QP---RSVDPTVAGRWSLLPPPEPDSTVRAHYQAELLLNRHGVLTKGAVA
MAV_4267|M.avium_104                QA---RPADTTVAGRWSVLPPPEPDSTVRAHFQAELLLGRHGVLTRGAVA
Mflv_4810|M.gilvum_PYR-GCK          SLSAHRDSDPTVAGRWSALPTAEVDTTVRAHYQADQLLARHGVLTKGAVA
Mvan_1632|M.vanbaalenii_PYR-1       SLSAHRDSDPTVAGRWSALPVAEVDTTVRAHYQADQLLARHGVLTKGAVA
MAB_3651|M.abscessus_ATCC_1997      AA----PVDPAVAGRWSMLPERLTGGTERSHIQAELLLGRYGVVTKGSVV
                                            *.:*:**** **    . * *:* **: ** *:**:*:.:* 

TH_1222|M.thermoresistible__bu      AEA----VPGGFGTLYKVLTAFEEAGRCQRGYFVESLGGAQFAVASTVDR
MSMEG_1757|M.smegmatis_MC2_155      AEG----VPGGFATLYKVLSTFEDAGRCQRGYFVESLGGAQFAVASTVDR
Mb3324|M.bovis_AF2122/97            AEG----VAGGFATLYKVLSAFEDAGRCQRGYFIESLGGAQFAVASTVDR
Rv3296|M.tuberculosis_H37Rv         AEG----VAGGFATLYKVLSAFEDAGRCQRGYFIESLGGAQFAVASTVDR
MMAR_1238|M.marinum_M               SEG----VPGGFATLYKVLSAFEDAGRCQRGYFVESLGGAQFAVAATVDR
MAV_4267|M.avium_104                AEG----VAGGFATLYKVLSTFEDAGRCQRGYFIESLGGAQFAVASTVDR
Mflv_4810|M.gilvum_PYR-GCK          SENFRGNIPGGFASMYKVLTTMEDAGRCQRGYFVESLGGAQFATASTVDR
Mvan_1632|M.vanbaalenii_PYR-1       GEN----IPGGFASMYKVLTTMEEAGRCQRGYFVESLGGAQFATASTVDR
MAB_3651|M.abscessus_ATCC_1997      AES----VAGGFAWLYKVLSTFEDNGRCRRGYFVESLGGAQFASPATVDR
                                    .*     :.***. :****:::*: ***:****:********* .:****

TH_1222|M.thermoresistible__bu      LRSYLDS----VDPQRPGYHAVVLAAADPANPYGAALPWPAGGAGDPDVG
MSMEG_1757|M.smegmatis_MC2_155      LRSYLDN----VDPERPEYHAVVLAATDPANPYGAALGWPTD-----SEA
Mb3324|M.bovis_AF2122/97            LRSYLDG----VDPEQPDYHAVVLAAADPANPYGAALPWPASSADGT---
Rv3296|M.tuberculosis_H37Rv         LRSYLDG----VDPEQPDYHAVVLAAADPANPYGAALPWPASSADGT---
MMAR_1238|M.marinum_M               LRSYLDDPSAFTDSRRPQYQAVLLAAADPANPYGAALPWPTSDDDGSNVG
MAV_4267|M.avium_104                LRGFADG----VDPQRPEYRAIVLAAADPANPYGAALPWPASSADGA---
Mflv_4810|M.gilvum_PYR-GCK          LRSHADS----IDDQQQKLRAVTLAATDPANPYGAALPWPSRGTDG-DTA
Mvan_1632|M.vanbaalenii_PYR-1       LRSHADS----IDDQQHTLRAVALAATDPANPYGAALPWPSRGGE--DSA
MAB_3651|M.abscessus_ATCC_1997      LREYLDP----VDDARKPYRATVLAATDPANPYGAALVWPRATSES---G
                                    ** . *      *  :   :*  ***:********** **          

TH_1222|M.thermoresistible__bu      HRPGRKAGALVVLVDGALRWFIERGGRSLLTFGDHADAEAHAAAAAALAG
MSMEG_1757|M.smegmatis_MC2_155      HRPGRKAGALVALVDGRLVWFLERGGRSLLSFG--ADADAQRAAAGALTD
Mb3324|M.bovis_AF2122/97            ARPGRKAGALVVLVDGELAWFLERGGRSLLTFTD--DPEANHAAAIGLAD
Rv3296|M.tuberculosis_H37Rv         ARPGRKAGALVVLVDGELAWFLERGGRSLLTFTD--DPEANHAAAIGLAD
MMAR_1238|M.marinum_M               ARPGRKAGALVVLVDGALAWFLERGGRTLLTFTD--DPEANAAAAIALAD
MAV_4267|M.avium_104                -RPGRKAGALVVLVDGELAWFLERGGRSLLTFTD--DPAAQHAAAAALAG
Mflv_4810|M.gilvum_PYR-GCK          HRPGRKAGALVVLIDGELTWFVERGGRSLLSFTD--DAETANAAAAALAE
Mvan_1632|M.vanbaalenii_PYR-1       HRPGRKAGALVVLVDGALAWFVERGGRSLLSFTA--DAETCHAAAASLAE
MAB_3651|M.abscessus_ATCC_1997      HRPGRKAGALAVLVDGDLALYIERGGKSLLSFVI--DPTVLHAAALGTME
                                     *********..*:** *  ::****::**:*    *. .  *** .   

TH_1222|M.thermoresistible__bu      LVTAGRVPSLLVERINGVPVLEPGAD-AARQAVVDALTGAGFSRTPRGLR
MSMEG_1757|M.smegmatis_MC2_155      LVSAGRIPSLLVERINGVAVLDPDVD-AERAVVQDALLGAGLSRTPRGLR
Mb3324|M.bovis_AF2122/97            LVTAGRVASILVERADGMPVLQPG---GRASAALTALLAAGFVRTPRGLR
Rv3296|M.tuberculosis_H37Rv         LVTAGRVASILVERADGMPVLQPG---GRASAALTALLAAGFVRTPRGLR
MMAR_1238|M.marinum_M               LVATRRVGSLLVERINGVPVLQAGA--GQASLAVTALADAGFLRTPRGLR
MAV_4267|M.avium_104                LVSARRVAAILVERIDGVPALAPRGDGAAGNDALTALADAGFARTPRGMR
Mflv_4810|M.gilvum_PYR-GCK          LVTRHRVPALLVERIDGVPVLESR-----ESVMVEALILAGFSRTPRGLR
Mvan_1632|M.vanbaalenii_PYR-1       LVSRQRVPGLLVERIDGAPVLEAR-----DSAVAEALVQAGFARTPRGLR
MAB_3651|M.abscessus_ATCC_1997      LVRDGGLDGLVIERIDGRSVFDIG-----DSAVVAALMEAGFARTPRGLR
                                    **    : .:::** :* ..:              **  **: *****:*

TH_1222|M.thermoresistible__bu      LR-
MSMEG_1757|M.smegmatis_MC2_155      LR-
Mb3324|M.bovis_AF2122/97            RR-
Rv3296|M.tuberculosis_H37Rv         RR-
MMAR_1238|M.marinum_M               LR-
MAV_4267|M.avium_104                LR-
Mflv_4810|M.gilvum_PYR-GCK          LR-
Mvan_1632|M.vanbaalenii_PYR-1       LR-
MAB_3651|M.abscessus_ATCC_1997      IRR
                                     *