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M. thermoresistible (build 8) TH_0687 ()

annotation: CONSERVED HYPOTHETICAL PROTEIN
coordinates: 1474801 - 1475817
length: 339

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_0687-100% (339)CONSERVED HYPOTHETICAL PROTEIN
M. thermoresistible (build 8)TH_2648-4e-2932.39% (284) PUTATIVE putative phosphotransferase enzyme family protein,
M. thermoresistible (build 8)TH_4149-2e-1327.90% (276) PUTATIVE aminoglycoside phosphotransferase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3193-1e-14471.98% (339) hypothetical protein Mb3193
M. gilvum PYR-GCKMflv_4497-1e-14270.59% (340) aminoglycoside phosphotransferase
M. tuberculosis H37RvRv3168-1e-14471.68% (339) hypothetical protein Rv3168
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_4482-2e-6840.72% (334) putative phosphotransferase
M. marinum MMMAR_1393-1e-14872.57% (339) hypothetical protein MMAR_1393
M. avium 104MAV_4058-1e-14571.98% (339) phosphotransferase enzyme family protein
M. smegmatis MC2 155MSMEG_2042-1e-14573.67% (338) phosphotransferase enzyme family protein
M. ulcerans Agy99MUL_2483-1e-14671.98% (339) hypothetical protein MUL_2483
M. vanbaalenii PYR-1Mvan_1869-1e-14773.53% (340) aminoglycoside phosphotransferase

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_4497|M.gilvum_PYR-GCK          MTSEPA-VDNVDRLQRSSRDLSDVPAALSRWLSTKLPGVTPDAPVDITVE
Mvan_1869|M.vanbaalenii_PYR-1       MTSEPA-VDNVDRLQRSSRDMSNVPAALSQWLSTLIPDITP----EITVE
TH_0687|M.thermoresistible__bu      ----------------------------------------------VQVH
Mb3193|M.bovis_AF2122/97            MANEPA-IGAIDRLQRSSRDVTTLPAVISRWLSSVLPGGAAP---EVTVE
Rv3168|M.tuberculosis_H37Rv         MANEPA-IGAIDRLQRSSRDVTTLPAVISRWLSSVLPGGAAP---EVTVE
MAV_4058|M.avium_104                MATEPA-VDNVDRLQRSSRDVTTVPAVMSRWLSTVLPEGAEP---EVTVE
MMAR_1393|M.marinum_M               MANETP-VEDVAHLQRSSRDMTTLPAVMARWLAGVLPGNAAP---EVTVE
MUL_2483|M.ulcerans_Agy99           MANETP-VEDVAHLQRSSRDMTTLPAVMARWLAGVLPGNAAP---EVTVE
MSMEG_2042|M.smegmatis_MC2_155      MANEPA-VEDVSHLQLSSRDVSTVPVALADWLSTVLPAGAEP---RVTVE
MAB_4482|M.abscessus_ATCC_1997      MTEQTATHEDVARPAESQRDPETLRGALTDWISGQLPADAAL---SVDHA
                                                                                  :   

Mflv_4497|M.gilvum_PYR-GCK          DGIDANGMSSETILLRGRWS--DGG---DPVEHRWVARVAPTDADIPVFE
Mvan_1869|M.vanbaalenii_PYR-1       SGIDANGMSSETILLRGRWL--QAG---DPVEQRWVARVAPAEADIPVFE
TH_0687|M.thermoresistible__bu      SGIDANGMSSETIVLSVDWRRRDGGRAEQRAPERYVARVAPAATDVPVFD
Mb3193|M.bovis_AF2122/97            SGVDSTGMSSETIILTARRQ--QDG---RSIQQKLVARVAPAAEDVPVFP
Rv3168|M.tuberculosis_H37Rv         SGVDSTGMSSETIILTARWQ--QDG---RSIQQKLVARVAPAAEDVPVFP
MAV_4058|M.avium_104                SGVDSTGMSSETIILTARWR--QDE---RPTEQKLVARVAPTAEDVQVFP
MMAR_1393|M.marinum_M               SGVDSTGMSSETIILTARWH--EDH---RPVQQKLVARVAPAAGDVPVFP
MUL_2483|M.ulcerans_Agy99           SGVDSTGMSSETIILTARWH--EDH---RPVQQKLVARVAPAAGDVPVFP
MSMEG_2042|M.smegmatis_MC2_155      DGVDSNGMSSETLLLTAEWT--EDG---APVQQRLVARVAPAPGDVPVFS
MAB_4482|M.abscessus_ATCC_1997      ELPSANGMSSETILADAQWT--ENG---QRTAHRLVIRTAPQPDSSPVFP
                                    .  .:.******::        :         .: * *.**   .  ** 

Mflv_4497|M.gilvum_PYR-GCK          HYRLDHQHEVMRLVAESTDVAVPAVRWLEDTGDVLGRPFFLMDRVDGVVP
Mvan_1869|M.vanbaalenii_PYR-1       HYRLDHQHEVMRLVAELTDVAVPPVRWLERRGDVLGRPFFLMDRVEGIVP
TH_0687|M.thermoresistible__bu      SYRLDHQFEVMRLVSELTDVPVPRVRWLEPTGSVLGTPFFLMDHVEGVVP
Mb3193|M.bovis_AF2122/97            TYRLDHQFEVIRLVGELTDVPVPRVRWIETTGDVLGTPFFLMDYVEGVVP
Rv3168|M.tuberculosis_H37Rv         TYRLDHQFEVIRLVGELTDVPVPRVRWIETTGDVLGTPFFLMDYVEGVVP
MAV_4058|M.avium_104                TYRLDHQFEVIRKVGELTDVPVPRVRWLENTGEVLGTPFFVMDYVDGLVP
MMAR_1393|M.marinum_M               SYRLDHQFEVIKLVGELSDVPVPRVRWMEPTGEVLGTPFFLMDYVEGVVP
MUL_2483|M.ulcerans_Agy99           SYRLDHRFEVIKLVGELSDVPVPRVRWMVPTGEVLGTPFFLMDYVEGVVP
MSMEG_2042|M.smegmatis_MC2_155      SYRLDHQFELMRQIGELTDVPVPRVRWLESTGSVLGTPFFLMDRVDGIVP
MAB_4482|M.abscessus_ATCC_1997      SYDMRRQFDVMDTLGRHSSAVVPPVRWYCDDTAVLGGEFFVMDRVDGDVP
                                     * : ::.:::  :.. :.. ** ***      ***  **:** *:* **

Mflv_4497|M.gilvum_PYR-GCK          PDVMPYTFGDNWLYDASPEQQRALQDRTVEVLAALHSIPDAQRTFGFLQE
Mvan_1869|M.vanbaalenii_PYR-1       PDVMPYTFGDNWLFDATAEQQRQLQDRTVEVLAKLHSIPNAQQVFGFLQD
TH_0687|M.thermoresistible__bu      PDVMPYTFGDNWFYDAPAERQRELQDRTVEVLAKLHSIPQPEQTFGFLS-
Mb3193|M.bovis_AF2122/97            PDVMPYTFGDNWFADAPAERQRQLQDATVAALATLHSIPNAQNTFSFLTQ
Rv3168|M.tuberculosis_H37Rv         PDVMPYTFGDNWFADAPAERQRQLQDATVAALATLHSIPNAQNTFSFLTQ
MAV_4058|M.avium_104                PDVMPYTFGGNWFADAPAERQRELQDATVGVLAKLHSIPNAANTFGFLTE
MMAR_1393|M.marinum_M               PDVMPYTFGNNWFADAPAERQRELQDATVGLLAMLHSIPKPQDTFGFLSD
MUL_2483|M.ulcerans_Agy99           PDVMPYTFGNNWFADAPAERQRELQDATVGLLAMLHSIPKPQDTFGFLSD
MSMEG_2042|M.smegmatis_MC2_155      PDVMPYTFGGNWFADAPADRRRLLQDGTVAVLAKLHSIPDALNRFGFLLD
MAB_4482|M.abscessus_ATCC_1997      PDRMPYTFG-SWVTEASEADRRKMQRLTVDQLARIHAAP--VERFAFLND
                                    ** ****** .*. :*.   :* :*  **  ** :*: *     *.**  

Mflv_4497|M.gilvum_PYR-GCK          IDPPGETALHRHFGWLTRWYAFSSADLGSSPLVERAISWLEEHFPHDVAA
Mvan_1869|M.vanbaalenii_PYR-1       VDPPGPTALHRHFGWLKNWYEFSVPDIGRSPLVERALAWLEDRFPEDVAA
TH_0687|M.thermoresistible__bu      -GDAGRTALEQNLNRLKSWYDFAVPDIGRSPLVERALAWLDDHLPTDVAA
Mb3193|M.bovis_AF2122/97            -GRTSDTTLHRHFNWVRSWYDFAVEGIGRSPLLERTFEWLQSHWPDDAAA
Rv3168|M.tuberculosis_H37Rv         -GRTSDTTLHRHFNWVRSWYDFAVEGIGRSPLLERTFEWLQSHWPDDAAA
MAV_4058|M.avium_104                -GQTGDTALRRHFNWVRSWYDFAVPDIGRSPLLERTFDWLEAHWPAAADA
MMAR_1393|M.marinum_M               -GPSGDTALRRHFDWVRSWYDFAVPGIGNSALIERTFQWLQEHWPSEVAA
MUL_2483|M.ulcerans_Agy99           -GPSGDTALRRHFDWVRSWYDFAVPGIGNSALIERTFQWLQEHWPSEVAA
MSMEG_2042|M.smegmatis_MC2_155      VDPPGDTPLRRHFAWLKDWYEFAVTDIGRSPLVEHALAWLEDNFPSDVAA
MAB_4482|M.abscessus_ATCC_1997      -AREGETGLDAHVRRTHEFYEWVRGDGPTIPLIDRGFEWLRENWPEESLS
                                        . * *  :.     :* :   .    .*::: : **  . *    :

Mflv_4497|M.gilvum_PYR-GCK          SEP----VLVWGDSRIGNVIYRDFRPVAVLDWEMATIGPREFDLAWISFA
Mvan_1869|M.vanbaalenii_PYR-1       AEP----VLVWGDSRIGNVIYQDFSPVAVLDWEMATVGPREFDVAWISFA
TH_0687|M.thermoresistible__bu      GDP----VLAWGDARIGNVLYSDFRPVAVLDWEMATLGPRELDVAWMIFA
Mb3193|M.bovis_AF2122/97            REP----VLLWGDARVGNVLYRDFQPVAVLDWEMVALGPRELDVAWMIFA
Rv3168|M.tuberculosis_H37Rv         REP----VLLWGDARVGNVLYRDFQPVAVLDWEMVALGPRELDVAWMIFA
MAV_4058|M.avium_104                AEP----VLLWGDARVGNVLYRDFVPVAVLDWEMVTLGPRELDVAWMIFA
MMAR_1393|M.marinum_M               REP----VLLWGDARVGNVLYRDFRPVAVLDWEMVTLGPRELDVAWMIFA
MUL_2483|M.ulcerans_Agy99           REP----VLLWGDARVGNVLYRDFRPVAVLDWEMVTLGPRELDVAWMIFA
MSMEG_2042|M.smegmatis_MC2_155      GEP----VLAWGDSRIGNVLYEDFEPVAVLDWEMATVGPRELDVSWIIFA
MAB_4482|M.abscessus_ATCC_1997      GVGRPIDVVSWGDSRPGNVIYRDFEPVALLDWEMASVGPRELDLGWIIFL
                                           *: ***:* ***:* ** ***:*****.::****:*:.*: * 

Mflv_4497|M.gilvum_PYR-GCK          HMVFQELTKLAGLPGMPDFLREDDVRDTYRKLTGVEVGDLHWFHVYSAVV
Mvan_1869|M.vanbaalenii_PYR-1       HMVFQELTKLAGLPGMPDFLREDDVRETYRELTGVEIGDLHWFHVYSAVV
TH_0687|M.thermoresistible__bu      HMVFQELTGLAGLPGMPDFMREDDVRARYRELTALDLGDLHWFYVYSGVI
Mb3193|M.bovis_AF2122/97            HRVFQELAGLATLPGLPEVMREDDVRATYQALTGVELGDLHWFYVYSGVM
Rv3168|M.tuberculosis_H37Rv         HRVFQELAGLATLPGLPEVMREDDVRATYQALTGVELGDLHWFYVYSGVM
MAV_4058|M.avium_104                HMVFQELAGLATLPGLPGVMREDDVRATYERLTGVEIGDLHWFYVYSGVM
MMAR_1393|M.marinum_M               HMVFEELAGLATLPGLPTVMREDDVRRTYQRLTGTQLGDLHWFYVYSGVM
MUL_2483|M.ulcerans_Agy99           HMVFEELAGLATLPGLPTVMREDDVRRTYQRLTGTQLGDLHWFYVYSGVM
MSMEG_2042|M.smegmatis_MC2_155      HMVFQELAGLAGLPGLPDVLREDDVRATYTRLTGAQLGDLRWFYIYSGVI
MAB_4482|M.abscessus_ATCC_1997      HRFFQDLAEVATLPGLPDFCKREDIAAEYAALTGHHAADLDFYTAYAALQ
                                    * .*::*: :* ***:* . :.:*:   *  **. . .** ::  *:.: 

Mflv_4497|M.gilvum_PYR-GCK          WCCVFMRTGTRRVHFGEIERPDDIESLFYHASLLKRLIGEAD------
Mvan_1869|M.vanbaalenii_PYR-1       WCCVFMRTGARRVHFGEIERPADIETLFYHASLLKRLIGETD------
TH_0687|M.thermoresistible__bu      WCCVFMRTGARRVHFGEIERPDDVESLFYHASLLRRLIGD--------
Mb3193|M.bovis_AF2122/97            WACVFMRTGARRVHFGEIEKPDDVESLFYHAGLMKHLLGEEH------
Rv3168|M.tuberculosis_H37Rv         WACVFMRTGARRVHFGEIEKPDDVESLFYHAGLMKHLLGEEH------
MAV_4058|M.avium_104                WACVFMRTGARRVHFGETEKPDDVESLFYHAGLMKRLIGEE-------
MMAR_1393|M.marinum_M               WACVFMRTGARRVHFGEVEKPDDVESLFYHAGLMKRLIGDER------
MUL_2483|M.ulcerans_Agy99           WACVFMRTGARRVHFGEVEKPDDVESLFYHAGLMKRLIGDER------
MSMEG_2042|M.smegmatis_MC2_155      WCCVFMRTGARRVRFGEIEKPEDVESLFYHASLLRRLIEEA-------
MAB_4482|M.abscessus_ATCC_1997      HAVIMARIQMRAMAFGQAQMPDDPDDLILHRATLEKMLNGTYWAGVKA
                                     . :: *   * : **: : * * : *: * . :.:::