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M. thermoresistible (build 8) TH_0591 (mutY)

annotation: PROBABLE ADENINE GLYCOSYLASE MUTY
coordinates: 1259650 - 1260585
length: 312

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_0591mutY-100% (312)PROBABLE ADENINE GLYCOSYLASE MUTY
M. thermoresistible (build 8)TH_2130nth3e-0726.86% (175) PROBABLE ENDONUCLEASE III NTH (DNA-(APURINIC OR APYRIMIDINIC

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3620mutY1e-11772.28% (285) putative adenine glycosylase
M. gilvum PYR-GCKMflv_1438-1e-12877.11% (284) HhH-GPD family protein
M. tuberculosis H37RvRv3589mutY1e-11772.28% (285) adenine glycosylase MutY
M. leprae Br4923MLBr_01920mutY1e-11471.02% (283) putative DNA glycosylase
M. abscessus ATCC 19977MAB_0558c-1e-11772.50% (280) adenine glycosylase MutY
M. marinum MMMAR_5089mutY1e-12476.14% (285) adenine glycosylase MutY
M. avium 104MAV_0563-1e-12375.70% (284) putative A/G-specific adenine glycosylase
M. smegmatis MC2 155MSMEG_6083-1e-13279.79% (282) base excision DNA repair protein, HhH-GPD family protein
M. ulcerans Agy99MUL_4165mutY1e-12576.49% (285) adenine glycosylase MutY
M. vanbaalenii PYR-1Mvan_5346-1e-12877.58% (281) HhH-GPD family protein

CLUSTAL 2.0.9 multiple sequence alignment


Mb3620|M.bovis_AF2122/97            MPHILPEPSVTGPRHISDTNLLAWYQRSHRDLPWREPGVSPWQILVSEFM
Rv3589|M.tuberculosis_H37Rv         MPHILPEPSVTGPRHISDTNLLAWYQRSHRDLPWREPGVSPWQILVSEFM
MMAR_5089|M.marinum_M               ---------MTCPEHIPATNLVAWYERCCRDLPWRAPDVSPWQILVSEFM
MUL_4165|M.ulcerans_Agy99           MPAIVPQPSMTCPEHIPATNLVAWYERCYRDLPWRAPDVSPWQILVSEFM
MAV_0563|M.avium_104                MADIMPQPPAVGSPLISVTDLLEWYRVARRDLPWRAPGVSAWQILVSEFM
MLBr_01920|M.leprae_Br4923          MAHIVPQ------IKISTGGLLDWYRQSCRDLPWRQPGVTAWQILVSEFM
Mflv_1438|M.gilvum_PYR-GCK          --------------MIDPNELIRWYGTAQRDLAWRRPGVSAWQILVSEFM
Mvan_5346|M.vanbaalenii_PYR-1       --------------MIDPDALLDWYEHAQRDLPWRRPGVSAWQILVSEFM
MSMEG_6083|M.smegmatis_MC2_155      -------------MSISPVELLSWYDHARRDLPWRRPGVSAWQILVSEFM
TH_0591|M.thermoresistible__bu      ---------------MRATELLGWYEHARRDLPWRRPGVTPWQILVSEVM
MAB_0558c|M.abscessus_ATCC_199      ---------------------MGWFDVAERDLPWRRPEATPWHILISEVM
                                                         : *:  . ***.** * .:.*:**:**.*

Mb3620|M.bovis_AF2122/97            LQQTPAARVLAIWPDWVRRWPTPSATATASTADVLRAWGKLGYPRRAKRL
Rv3589|M.tuberculosis_H37Rv         LQQTPAARVLAIWPDWVRRWPTPSATATASTADVLRAWGKLGYPRRAKRL
MMAR_5089|M.marinum_M               LQQTPVSRVLSIWPDWVRRWPTASATATATAADVLRAWGKLGYPRRAKRL
MUL_4165|M.ulcerans_Agy99           LQQTPVSRVLSIWPDWVRRWPTASATATATAADVLRAWGKLGYPRRAKRL
MAV_0563|M.avium_104                LQQTPVSRVLPIWPDWVRRWPTPSATAAASAADVLRAWGKLGYPRRAKRL
MLBr_01920|M.leprae_Br4923          LQQTPVARVLSIWPDWVQRWPTPSTTAAASAADVLRAWGKLGYPRRAKRL
Mflv_1438|M.gilvum_PYR-GCK          LQQTPVARVEPIWLDWVSRWPTPSATAAASAADILRAWGKLGYPRRAKRL
Mvan_5346|M.vanbaalenii_PYR-1       LQQTPVARVEPIWLDWIARWPTPSATAAAGPADILRAWGKLGYPRRAKRL
MSMEG_6083|M.smegmatis_MC2_155      LQQTPVSRVEPIWSAWIERWPTASATAAAGPAEVLRAWGKLGYPRRAKRL
TH_0591|M.thermoresistible__bu      LQQTPVARVAPVWTEWVTRWPTPSATAAAGVADVLRAWGRLGYPRRAKRL
MAB_0558c|M.abscessus_ATCC_199      LQQTPVSRVEPVWREWVARWPVPSAMAKTSVAEVLRAWGKLGYPRRAMRL
                                    *****.:** .:*  *: ***..*: * :  *::*****:******* **

Mb3620|M.bovis_AF2122/97            HECATVIARDHNDVVPDDIEILVTLPGVGSYTARAVACFAYRQRVPVVDT
Rv3589|M.tuberculosis_H37Rv         HECATVIARDHNDVVPDDIEILVTLPGVGSYTARAVACFAYRQRVPVVDT
MMAR_5089|M.marinum_M               HECAMVVAGDHDDVVPDDVDTLLTLPGVGSYTARAVACFAYRQRVPVVDT
MUL_4165|M.ulcerans_Agy99           HECAMVIAGDHDDVVPDDVDTLLTLPGVGSYTARAVACFAYRQRVPVVDT
MAV_0563|M.avium_104                HECATVIARDHGDVVPRDIDTLLTLPGVGGYTARAVACFAYRRPVPVVDT
MLBr_01920|M.leprae_Br4923          HESATIIAREHDDVVPDDVDVLLTMPGIGSYTARAVACFAYHQPVPVVDT
Mflv_1438|M.gilvum_PYR-GCK          HECATVIATEHGDVVPDDVDTLVTLPGVGTYTARAVACFAYRQRVPVVDT
Mvan_5346|M.vanbaalenii_PYR-1       HECATVIATDHDDTVPDDVETLLTLPGIGTYTARAVACFAYRQRVPVVDT
MSMEG_6083|M.smegmatis_MC2_155      HECAVVIASEYDDVVPRDVDTLLTLPGIGAYTARAVACFAYQASVPVVDT
TH_0591|M.thermoresistible__bu      HECAVIIATRFDDVVPSDVDTLLTLPGVGSYTARAVACFAYRQRVPVVDT
MAB_0558c|M.abscessus_ATCC_199      HECATVLARDYDDQVPGDVETLLTLPGVGAYTARAIACFGYGQRVPVVDT
                                    **.* ::*  ..* ** *:: *:*:**:* *****:***.*   ******

Mb3620|M.bovis_AF2122/97            NVRRVVARAVHGRADAGAPSVPRDHADVLALLPHRETAPEFSVALMELGA
Rv3589|M.tuberculosis_H37Rv         NVRRVVARAVHGRADAGAPSVPRDHADVLALLPHRETAPEFSVALMELGA
MMAR_5089|M.marinum_M               NVRRVVARAVHGRAEAGSPSATRDHAEVSALLPDDELAPRFSVALMELGA
MUL_4165|M.ulcerans_Agy99           NVRRVVARAVHGRAEAGSPSATRDHAEVSALLPDDELAPRFSVALMELGA
MAV_0563|M.avium_104                NVRRVVARAVHGQADAGAPSAGRDHADVAALLPGDGSAPEFSVALMELGA
MLBr_01920|M.leprae_Br4923          NVRRVVARAVHGRADAGPPSATRDHADVSSLLPGKKAAPQFSMALMELGA
Mflv_1438|M.gilvum_PYR-GCK          NVRRVVARAVHGLHDAGPPST-RDLADVAALLPDDDTAPHFSIAVMELGA
Mvan_5346|M.vanbaalenii_PYR-1       NVRRVVARAVHGLADAGSPSS-RDLGDVETLLPADDTAPRFSVALMEFGA
MSMEG_6083|M.smegmatis_MC2_155      NVRRVVTRAVHGAADA--PASTRDLDMVAALLPPDTTAPTFSAALMELGA
TH_0591|M.thermoresistible__bu      NVRRVVTRVVHGVAHA--PPSSRDLDEVAALLPDDDTAPRFSAALMELGA
MAB_0558c|M.abscessus_ATCC_199      NVRRVIARVVHGVADS--APSARDLRDAEALLPTEN-GARFSAALMELGA
                                    *****::*.***  .:  ..  **   . :***    .. ** *:**:**

Mb3620|M.bovis_AF2122/97            TVCTARTPRCGLCPLDWCAWRHAGYPPSDGPPRRGQAYTGTDRQVRGRLL
Rv3589|M.tuberculosis_H37Rv         TVCTARTPRCGLCPLDWCAWRHAGYPPSDGPPRRGQAYTGTDRQVRGRLL
MMAR_5089|M.marinum_M               TVCTARAPRCGQCPLAECAWRRAGYPPATGPARRVQTYAGTDRQVRGRLL
MUL_4165|M.ulcerans_Agy99           TVCTARAPRCGQCPLAECAWRRAGYPPATGPARRVQTYAGTDRQVRGRLL
MAV_0563|M.avium_104                TVCTARAPRCGLCPLRRCAWREAGHPPPTGPARRVQTYAGTDRQVRGRLM
MLBr_01920|M.leprae_Br4923          IVCTARSPRCGLCPLNECAWRHAGYPPAQGPARRAQQYAGTDRQVRGLLL
Mflv_1438|M.gilvum_PYR-GCK          TVCTARAPRCGVCPLTHCAWRSRGFPAGTGPARRVQRYAGTDRQVRGRLL
Mvan_5346|M.vanbaalenii_PYR-1       TVCTARAPRCGVCPLQRCGWRARGFPAGTGPARRAQKYAGTDRQARGRLL
MSMEG_6083|M.smegmatis_MC2_155      TVCTARSPRCGICPLSHCRWRSAGFPAGT-VARRVQRYAGTDRQVRGKLL
TH_0591|M.thermoresistible__bu      TVCTARSPRCGDCPLSRCRWRERKYPPAT-APRRVQRYAGTDRQVRGLLL
MAB_0558c|M.abscessus_ATCC_199      LVCTARTPQCPMCPLSSCAWHEAGQPPLDAPARPVQKYAGTDRQVRGRLL
                                     *****:*:*  ***  * *:    *.    .*  * *:*****.** *:

Mb3620|M.bovis_AF2122/97            DVLRAAEFPVTRAELDVAWLTDTAQRDRALESLLADALVTRTVDGRFALP
Rv3589|M.tuberculosis_H37Rv         DVLRAAEFPVTRAELDVAWLTDTAQRDRALESLLADALVTRTVDGRFALP
MMAR_5089|M.marinum_M               DVLRDNNGPVTRAQLDVAWLTDTAQRDRALYSLLADGLVTQTADGLFALA
MUL_4165|M.ulcerans_Agy99           DVLRDNNGPVTRAQLDVAWLTDTAQRDRALYSLLADGLVTQTADGLFALA
MAV_0563|M.avium_104                DVLRGNDSPVTRAELDVAWLTDTAQRDRALYSLLADGLVTQTADGRFALA
MLBr_01920|M.leprae_Br4923          DVLRAKDSPVTGTELNVTWLTNSIQLDRALDSLLADGLVTRTTDGRFALT
Mflv_1438|M.gilvum_PYR-GCK          DVLRDNASPVTRAELDVAWTTDPAQRDRALDSLLVDGLVEQTADGRFALA
Mvan_5346|M.vanbaalenii_PYR-1       DVLRGSDSPVTRAELDVAWTTDTAQRDRALDSLLVDGLVEQTADGRFALC
MSMEG_6083|M.smegmatis_MC2_155      DVLRDSTTPVTRAQLDVVWLSDPAQRDRALDSLLVDGLVEQTADGRFALA
TH_0591|M.thermoresistible__bu      DVLRNSSAPVERAALDMVWLTDTAQRDRALHSLLADGLVEQTPDGRFALA
MAB_0558c|M.abscessus_ATCC_199      DVLRGSSIPVTRAQLDVAWLSDITQRDRALDSLLVDGLVEQTADGRFALA
                                    ****    **  : *::.* ::  * **** ***.*.** :* ** *** 

Mb3620|M.bovis_AF2122/97            GEGF-------------------------
Rv3589|M.tuberculosis_H37Rv         GEGF-------------------------
MMAR_5089|M.marinum_M               GEA--------------------------
MUL_4165|M.ulcerans_Agy99           GEE--------------------------
MAV_0563|M.avium_104                GEE--------------------------
MLBr_01920|M.leprae_Br4923          GEG--------------------------
Mflv_1438|M.gilvum_PYR-GCK          GEGDQT-----------------------
Mvan_5346|M.vanbaalenii_PYR-1       GEAGS------------------------
MSMEG_6083|M.smegmatis_MC2_155      GEGETGRPA--------------------
TH_0591|M.thermoresistible__bu      GEGEPDQSVTSAPDSVDPDVVEPQANRRR
MAB_0558c|M.abscessus_ATCC_199      GEGG-------------------------
                                    **