For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. thermoresistible (build 8) TH_0583 ()

annotation: POSSIBLE CONSERVED SECRETED PROTEIN
coordinates: 1244464 - 1245768
length: 435

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_0583-100% (435)POSSIBLE CONSERVED SECRETED PROTEIN
M. thermoresistible (build 8)TH_1053-5e-0741.67% (48) protein of unknown function DUF58, putative
M. thermoresistible (build 8)TH_0627-5e-0731.37% (102) protein of unknown function DUF58, putative

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3188c-1e-14363.27% (422) hypothetical protein Mb3188c
M. gilvum PYR-GCKMflv_0475-1e-13460.00% (415) hypothetical protein Mflv_0475
M. tuberculosis H37RvRv3163c-1e-14363.51% (422) hypothetical protein Rv3163c
M. leprae Br4923MLBr_01809-2e-0927.49% (211) hypothetical protein MLBr_01809
M. abscessus ATCC 19977MAB_1908c-1e-11251.57% (415) hypothetical protein MAB_1908c
M. marinum MMMAR_1400-1e-13758.80% (432) hypothetical protein MMAR_1400
M. avium 104MAV_4050-1e-11859.15% (377) hypothetical protein MAV_4050
M. smegmatis MC2 155MSMEG_3867-1e-13458.92% (426) ATPase family protein associated with various cellular
M. ulcerans Agy99MUL_2476-1e-13659.81% (423) hypothetical protein MUL_2476
M. vanbaalenii PYR-1Mvan_0181-1e-13761.11% (414) hypothetical protein Mvan_0181

CLUSTAL 2.0.9 multiple sequence alignment


Mb3188c|M.bovis_AF2122/97           --------------------------------------------------
Rv3163c|M.tuberculosis_H37Rv        --------------------------------------------------
MMAR_1400|M.marinum_M               --------------------------------------------------
MUL_2476|M.ulcerans_Agy99           --------------------------------------------------
MAV_4050|M.avium_104                --------------------------------------------------
Mflv_0475|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0181|M.vanbaalenii_PYR-1       --------------------------------------------------
TH_0583|M.thermoresistible__bu      --------------------------------------------------
MSMEG_3867|M.smegmatis_MC2_155      MTSQANVDVATAAAARSVLDEIEKAVVGKRDALTLILTTLLARGHVLIED
MAB_1908c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_01809|M.leprae_Br4923          --------------------------------------------------
                                                                                      

Mb3188c|M.bovis_AF2122/97           --------------------------------------------------
Rv3163c|M.tuberculosis_H37Rv        --------------------------------------------------
MMAR_1400|M.marinum_M               --------------------------------------------------
MUL_2476|M.ulcerans_Agy99           --------------------------------------------------
MAV_4050|M.avium_104                --------------------------------------------------
Mflv_0475|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0181|M.vanbaalenii_PYR-1       --------------------------------------------------
TH_0583|M.thermoresistible__bu      --------------------------------------------------
MSMEG_3867|M.smegmatis_MC2_155      LPGLGKTLIARSFAAALGLKFTRVQFTPDLLPADLLGSTVYDMQSGRFEF
MAB_1908c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_01809|M.leprae_Br4923          --------------------------------------------------
                                                                                      

Mb3188c|M.bovis_AF2122/97           --------------------------------------------------
Rv3163c|M.tuberculosis_H37Rv        --------------------------------------------------
MMAR_1400|M.marinum_M               --------------------------------------------------
MUL_2476|M.ulcerans_Agy99           --------------------------------------------------
MAV_4050|M.avium_104                --------------------------------------------------
Mflv_0475|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0181|M.vanbaalenii_PYR-1       --------------------------------------------------
TH_0583|M.thermoresistible__bu      --------------------------------------------------
MSMEG_3867|M.smegmatis_MC2_155      RPGPIFTNLLLADEINRTPPKTQAALLEAMAEGQVSIDGQTHRLPAPFIV
MAB_1908c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_01809|M.leprae_Br4923          --------------------------------------------------
                                                                                      

Mb3188c|M.bovis_AF2122/97           --------------------------------------------------
Rv3163c|M.tuberculosis_H37Rv        --------------------------------------------------
MMAR_1400|M.marinum_M               --------------------------------------------------
MUL_2476|M.ulcerans_Agy99           --------------------------------------------------
MAV_4050|M.avium_104                --------------------------------------------------
Mflv_0475|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0181|M.vanbaalenii_PYR-1       --------------------------------------------------
TH_0583|M.thermoresistible__bu      --------------------------------------------------
MSMEG_3867|M.smegmatis_MC2_155      LATDNPIEYEGTYPLPEAQLDRFSVRLELKYLSEQDETAMLRRRLDRGSA
MAB_1908c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_01809|M.leprae_Br4923          --------------------------------------------------
                                                                                      

Mb3188c|M.bovis_AF2122/97           --------------------------------------------------
Rv3163c|M.tuberculosis_H37Rv        --------------------------------------------------
MMAR_1400|M.marinum_M               --------------------------------------------------
MUL_2476|M.ulcerans_Agy99           --------------------------------------------------
MAV_4050|M.avium_104                --------------------------------------------------
Mflv_0475|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0181|M.vanbaalenii_PYR-1       --------------------------------------------------
TH_0583|M.thermoresistible__bu      --------------------------------------------------
MSMEG_3867|M.smegmatis_MC2_155      EAGVAEVVDGPRFLAMREAVEQVSVHDDVLRYVVALRGRDAPPPAGCGRR
MAB_1908c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_01809|M.leprae_Br4923          --------------------------------------------------
                                                                                      

Mb3188c|M.bovis_AF2122/97           --------------------------------------------------
Rv3163c|M.tuberculosis_H37Rv        --------------------------------------------------
MMAR_1400|M.marinum_M               --------------------------------------------------
MUL_2476|M.ulcerans_Agy99           --------------------------------------------------
MAV_4050|M.avium_104                --------------------------------------------------
Mflv_0475|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0181|M.vanbaalenii_PYR-1       --------------------------------------------------
TH_0583|M.thermoresistible__bu      --------------------------------------------------
MSMEG_3867|M.smegmatis_MC2_155      QPPRRTRPRATREGQGLAARAGLRHPRGRQDTRGRGDGAPHQPAPGDVGA
MAB_1908c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_01809|M.leprae_Br4923          --------------------------------------------------
                                                                                      

Mb3188c|M.bovis_AF2122/97           ------------------------MIQTCEVELRWRASQLTLAIATCAGV
Rv3163c|M.tuberculosis_H37Rv        ------------------------MIQTCEVELRWRASQLTLAIATCAGV
MMAR_1400|M.marinum_M               ------------------------MIQTRDVELRWRASPLTLAVATCAAV
MUL_2476|M.ulcerans_Agy99           ------------------------MIPTRDVELRWRASPLTLAVATCAGV
MAV_4050|M.avium_104                --------------------------------------------------
Mflv_0475|M.gilvum_PYR-GCK          ---------------------------MVAVELRWRASALTQSIATCVAA
Mvan_0181|M.vanbaalenii_PYR-1       ---------------------------MTAVELRWRPSPLTRSIATCAAA
TH_0583|M.thermoresistible__bu      ---------------VTITPPGPSNMSGIAVEPRWRASPLTLALCSCAAV
MSMEG_3867|M.smegmatis_MC2_155      QHPRCRRHERTAAPAPRAPCGQPAMTVGVHVPLRWGASPLTKSVATAAAG
MAB_1908c|M.abscessus_ATCC_199      -------------------------------MITWRASALISALAACTGA
MLBr_01809|M.leprae_Br4923          --------------------------------------------------
                                                                                      

Mb3188c|M.bovis_AF2122/97           ALAAAVVAGRWQLIAFAAPLLGVLCSISWQRPVPVIQVHGDPDSQRCFEN
Rv3163c|M.tuberculosis_H37Rv        ALAAAVVAGRWQLIAFAAPLLGVLCSISWQRPVPVIQVHGDPDSQRCFEN
MMAR_1400|M.marinum_M               ALAAALIAGRWQLIAFAAPLLGVLCSIYWQRPVPTVHVHAEPDLQRCFED
MUL_2476|M.ulcerans_Agy99           ALAAALIAGRWQLIAFAAPLLGVLCSIYWQRPVPTVHVHAEPDLQRCFED
MAV_4050|M.avium_104                ----------------------MLGTISWQPRVPAVAVHAEPDTQRCFEG
Mflv_0475|M.gilvum_PYR-GCK          AITVALVAGRWELVAFAAPLAGALCSIGWQRRLPTVTVTGSPPFQRCFED
Mvan_0181|M.vanbaalenii_PYR-1       AIVAALLAGRWELAAFAAPLLGVLCSIGWQRGKPSVTVQAEPVFQRCFEG
TH_0583|M.thermoresistible__bu      TLAAAVIGQRWQLVIFAAPLIGVLASVVRQPPPPRVWLRGHPDPGRCFEG
MSMEG_3867|M.smegmatis_MC2_155      AMLIAVLGFRWQLVIFASPLLGVLCSAYWQRPRVSVEVGAEPATVRCFEN
MAB_1908c|M.abscessus_ATCC_199      ALALAVMTGRWQLVVFAAPFVGALAGASRRPPAARAWVTDEPEPLRCLES
MLBr_01809|M.leprae_Br4923          -MIDPNPAAKPGVFHPPSMQRGQIDDPKLSAALRTLELTVKRKLDGVLHG
                                                           :             :         :..

Mb3188c|M.bovis_AF2122/97           EHVRVTVWVTTESVD----AAVELTVSALAGMQFEALESVSRRTTTVSAV
Rv3163c|M.tuberculosis_H37Rv        EHVRVTVWVTTESVD----AAVELTVSALAGMQFEALESVSRRTTTVSAV
MMAR_1400|M.marinum_M               ERVGVKVWATVDSAAGEGSEAVLVTVRAPAGMQLDIDASSSRQAKSVEVV
MUL_2476|M.ulcerans_Agy99           ERVGVKVWATVDSTAGEGSEAVLVTVRAPAGMQLDIDASTSRQAKSVEVV
MAV_4050|M.avium_104                EPAHVTVWGIEEQGP----CAVRLTVPPVEGMELQFGESGSRRGKTVRAT
Mflv_0475|M.gilvum_PYR-GCK          EQVSVGMTAVADDGA-----AVTLDCTAPAPMVLTHRPAG-----ELTVQ
Mvan_0181|M.vanbaalenii_PYR-1       ESVLVTVSAGAEDGS-----AVTLDCSVVTGMELVGPTSLP----TLSVR
TH_0583|M.thermoresistible__bu      EEVRVTVTVSADPPG----TALHLRVDDVSGAQVRMLEQRPER-VVAAVS
MSMEG_3867|M.smegmatis_MC2_155      ESAELSVRVSSSAGA-----DARLRVDSVEGLRLEPGDRAGPE-QRVRAN
MAB_1908c|M.abscessus_ATCC_199      ETITVAVSVESTGPA----VVCGLRPALVEGLRIDADRPAAPNQLTMRTS
MLBr_01809|M.leprae_Br4923          DHLGLISGPGSEPGE---------SRVYQPGDDVRRMDWAVTARTTHPHV
                                    :   :                            .                

Mb3188c|M.bovis_AF2122/97           AQRWGRYPIRARVAVVARGGLLMGAG-TVDAAEIVVFPLTPPQSTPLPQT
Rv3163c|M.tuberculosis_H37Rv        AQRWGRYPIRARVAVVARGGLLMGAG-TVDAAEIVVFPLTPPQSTPLPQT
MMAR_1400|M.marinum_M               TQRWGRYPIKARVDVVARGGLLMGDG-TVEAAQVVVFPLTPPQPTAIPQT
MUL_2476|M.ulcerans_Agy99           TQRWGRYPIEARVDVVARGGLLIGDG-TVEAAQVVVFPLTPPQPTAIPQT
MAV_4050|M.avium_104                AQRWGRYHVAARVDVLARGGLLSGTA-LVDAAEVIVFPLTPPQPTPIPRT
Mflv_0475|M.gilvum_PYR-GCK          SSRWGRYPVRAGVRVCGRGGLVTGTG-TVDAAEVCVFPLAPAQSTAIPRT
Mvan_0181|M.vanbaalenii_PYR-1       ASRWGRYPLLATVRVGGRGGLLEGTG-TADAAEVCVFPVAPPQSTAIPRT
TH_0583|M.thermoresistible__bu      AHRWGRYPVRARVDVPAAGGLLTGTG-AVDVAEIVVFPLAPPESTVLPHG
MSMEG_3867|M.smegmatis_MC2_155      ASRWGRYPLRAHVTVTAPGGLVTGTG-TVEAAELYVFPLAAPHLTPMPRA
MAB_1908c|M.abscessus_ATCC_199      AQRWGRYRVPVEVRSVSASGLWAGTALTLPASELRVYPLADPQDVALPPA
MLBr_01809|M.leprae_Br4923          RQMIADRELETWMVIDMSASLDFGTT----ICEKRDLAVAAAAAITFLNS
                                        .   : . :     ..*  *       .:    .:: .    :   

Mb3188c|M.bovis_AF2122/97           ELLDRLGAHLTRHVGPGVEYADIRPYVPGDQLRAVNWVVSARRGRLHVTR
Rv3163c|M.tuberculosis_H37Rv        ELLDRLGAHLTRHVGPGVEYADIRPYVPGDQLRAVNWVVSARRGRLHVTR
MMAR_1400|M.marinum_M               ELLDRLGAHLTRYIGPGVEYADIRPYVPGDQLRAVNWAVSARRGRLHVTQ
MUL_2476|M.ulcerans_Agy99           ELLDRLGAHLTRYIGPGVEYADIRPYVPGDQLRAVNWAVSARRGRLHVTQ
MAV_4050|M.avium_104                ELLDRLGAHLTRHVGPGVEYADIRPYVPGDQLRAVNWAVSARRRQLHVTQ
Mflv_0475|M.gilvum_PYR-GCK          DLLDRLGTHLTRHTGPGVEFADIRPYVPGDQLRIVNWPVSARRGTLHITE
Mvan_0181|M.vanbaalenii_PYR-1       DLLDRLGTHLTRHVGPGVEFADIRPYVPGDQLRTVNWPVSARRGALHVTE
TH_0583|M.thermoresistible__bu      EMRDRLGTHLTANSGSGVEYADIRPYVPGDQLRTVNWPVSARRGRLHVTQ
MSMEG_3867|M.smegmatis_MC2_155      ELPDRLGTHLTRHTGPGVEYADVRPYVPGDHLRTVNWPVSARRGRLHVTE
MAB_1908c|M.abscessus_ATCC_199      DLPDRIGTRLTRHHGPGVEYADIREYVPGDSLRTVNWRVSAQRGRLHVTD
MLBr_01809|M.leprae_Br4923          GGGNRLGALICN--------------------GARMTRVPARSGRQHEQT
                                       :*:*: :                            *.*:    *   

Mb3188c|M.bovis_AF2122/97           RLTDRAADVVVLIDMYRQPAGPATEATERVVRGAAQVVQTALRNGDRAGI
Rv3163c|M.tuberculosis_H37Rv        RLTDRAADVVVLIDMYRQPAGPATEATERVVRGAAQVVQTALRNGDRAGI
MMAR_1400|M.marinum_M               RLTDRAADVIVLIDTYRQPPGPASEATERVARGAAQVVQTALRNGDRAGI
MUL_2476|M.ulcerans_Agy99           RLTDRAADVIVLIDTYRQPPGPASEATERVARGAAQVVQTALRNGDRAGI
MAV_4050|M.avium_104                RLTDRAADVVVLIDGYRQPAGPATQATERIVRGAAQVVQTALRHGDRAGI
Mflv_0475|M.gilvum_PYR-GCK          RLTDRAADVVVLVDTYPQPPGPATAATERTARGAAQVVQSALRYGDRAGL
Mvan_0181|M.vanbaalenii_PYR-1       RLTDRAADVVALVDTYPQPPGPATAATERIARGAAQVVQSALRYGDRAGL
TH_0583|M.thermoresistible__bu      RLSERAADVVVLVDAYPQPPGPATEVTERIARGAVQVVQSALRGGDRAGI
MSMEG_3867|M.smegmatis_MC2_155      RLTDRGGDVVVLIDTHDQAPGPATQATERTARGAAQVVQSALRSGDRAGI
MAB_1908c|M.abscessus_ATCC_199      RLTDRAADVVVLIDTYPQPSGPATTATERSARGAAQLVQSVLQRGDRAGV
MLBr_01809|M.leprae_Br4923          LLR-------TIATTPKAPVG---------VRGDLTVAIDALRRPERR--
                                     *        .:      . *         .**   :.  .*:  :*   

Mb3188c|M.bovis_AF2122/97           VALGGNRPRWLGADIGQRQFYRVLDTVLGAGEGFENTT--------GTLA
Rv3163c|M.tuberculosis_H37Rv        VALGGNRPRWLGADIGQRQFYRVLDTVLGAGEGFENTT--------GTLA
MMAR_1400|M.marinum_M               IALGGNRPRWMGADIGQRQFYRVLDTVLGSGDRFEKTT--------GTLA
MUL_2476|M.ulcerans_Agy99           IALGGNRPRWMGADIGQRQFYRVLDTVLGSGDRFEKTT--------GTLA
MAV_4050|M.avium_104                VALGGNRPRWLGADIGQRQFYRVLDTVLAAGGGFEHTT--------GTLA
Mflv_0475|M.gilvum_PYR-GCK          VALGGRSTRWLGADIGRRQFYRILDTVLGADDTFEKAT--------GTLA
Mvan_0181|M.vanbaalenii_PYR-1       VALGSRNVRWLGADIGQRQFYRVLDTMLGASDTFQNAT--------GTLA
TH_0583|M.thermoresistible__bu      ATLGGRGPRWLGVDLGRRQFYRVVDTMLGAAPGSGPTTPTGPGSGRGTLV
MSMEG_3867|M.smegmatis_MC2_155      VALGGRQPRWLGLDIGRRQFYRVLDAILGAGGGFETTT--------GTLA
MAB_1908c|M.abscessus_ATCC_199      VVLG-SSARWLAPNIGRHQFYRLLDATLDAGEWHSHSA--------SALA
MLBr_01809|M.leprae_Br4923          -----------------RGMAVIISDFLGPINWMRPLR---------AIA
                                                     : :  ::.  * .                 ::.

Mb3188c|M.bovis_AF2122/97           PRAAVPAGAVVIAFSTLLDTEFALALIELRKRGHVVVAVDVLDSCPLQDQ
Rv3163c|M.tuberculosis_H37Rv        PRAAVPAGAVVIAFSTLLDTEFALALIDLRKRGHVVVAVDVLDSCPLQDQ
MMAR_1400|M.marinum_M               PRAAVPAGAIVIAFSTLLDTEFALALIDLRKRGHVVVAVDVLDSAPFEGE
MUL_2476|M.ulcerans_Agy99           PRAAVPTGAIVIAFSTLLDTEFALALIDLRKRGHVVVAVDVLDGAPFEGE
MAV_4050|M.avium_104                PRAAVPAGAIVIAFSTLLDTEFALALIDLRRRGHVVLAVDILEGSPSEDE
Mflv_0475|M.gilvum_PYR-GCK          PRAAVPTGAIVVAFSTMLDTEFALALIDLRKRGHPVVVVDVLEGSPVEGE
Mvan_0181|M.vanbaalenii_PYR-1       PRPAVPTRAIVIAFSTMLDTEFALALIDLRKRGHPVVAIDVLDGSPLEGD
TH_0583|M.thermoresistible__bu      PRPAVPPEAIVVAFSTLLDTDFALALIDLARRGHPVVAVDVLDREPFDG-
MSMEG_3867|M.smegmatis_MC2_155      PRAAVPPGAIVVAFSTMLNTEFAFALIELAKHGHAVVAVDILEGAPFDNP
MAB_1908c|M.abscessus_ATCC_199      PRAAVPPNAIVVAFSTLLNADFGLALTDLRRRGHPVVVVDVLDRLPFREE
MLBr_01809|M.leprae_Br4923          ARHEVLGIEVLDPRDVALPDIGEVVLQDAETG----VTREFTIDAALRDD
                                    .*  *    :: . .. *     ..* :        :. :.    .    

Mb3188c|M.bovis_AF2122/97           --LDPLVVRMWALQRSAMYRDMATIGVDVLSWPADHSLQQSMGALPNRRR
Rv3163c|M.tuberculosis_H37Rv        --LDPLVVRMWALQRSAMYRDMATIGVDVLSWPADHSLQQSMGALPNRRR
MMAR_1400|M.marinum_M               --QDPLVVRMWALQRAGMYRDMATVGVDVLDWPGNRALEQSMGALPDRRR
MUL_2476|M.ulcerans_Agy99           --QDPLVVRMWALQRAGMYRDMATVGVDVLDWPGNRALEQSMGALPDRRR
MAV_4050|M.avium_104                --QDPLVDRMWALQRSAMYRDMATVGVDIVWWPGDRGLEQSMGVLPDRRR
Mflv_0475|M.gilvum_PYR-GCK          --HDPLVHRMWAMQRSFMYRDMATVGVDIVAWPGDATLDQAMALVPARRR
Mvan_0181|M.vanbaalenii_PYR-1       --HDPLVHRMWSMQRSFMYRDMATVGVDVVGWPAAVTLDQAMALVPVHRA
TH_0583|M.thermoresistible__bu      --VDPLVGRMWSLQRSFMYRDMRTIGVDVVAWGAGQALDQVLHVVADHRR
MSMEG_3867|M.smegmatis_MC2_155      DGLDPLIPRLWALQRSAMYRDMSTIGIDVVHWRGDIPLQDVMRLIPDRHR
MAB_1908c|M.abscessus_ATCC_199      --PDPIVARWWRLERSRMYRNIAVTGVDVVGWSHDSGLNHAMHLMPRRPR
MLBr_01809|M.leprae_Br4923          ------FARAAAAHCADVSRSLRNCGAPLMSLRTDRDWIADIVRFVESRR
                                          . *    . : : *.:   *  ::           :  .     

Mb3188c|M.bovis_AF2122/97           RGRGRASRARLP
Rv3163c|M.tuberculosis_H37Rv        RGRGRASRARLP
MMAR_1400|M.marinum_M               RIRGRLRGSV--
MUL_2476|M.ulcerans_Agy99           RIRGRLRGSV--
MAV_4050|M.avium_104                RVRGRLRG----
Mflv_0475|M.gilvum_PYR-GCK          RL----------
Mvan_0181|M.vanbaalenii_PYR-1       RR----------
TH_0583|M.thermoresistible__bu      RTLRRVSR----
MSMEG_3867|M.smegmatis_MC2_155      RRTR--------
MAB_1908c|M.abscessus_ATCC_199      RGRRR-------
MLBr_01809|M.leprae_Br4923          RGALAGRQ----
                                    *