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IQTCEVELRWRASQLTLAIATCAGVALAAAVVAGRWQLIAFAAPLLGVLCSISWQRPVPVIQVHGDPDSQ RCFENEHVRVTVWVTTESVDAAVELTVSALAGMQFEALESVSRRTTTVSAVAQRWGRYPIRARVAVVARG GLLMGAGTVDAAEIVVFPLTPPQSTPLPQTELLDRLGAHLTRHVGPGVEYADIRPYVPGDQLRAVNWVVS ARRGRLHVTRRLTDRAADVVVLIDMYRQPAGPATEATERVVRGAAQVVQTALRNGDRAGIVALGGNRPRW LGADIGQRQFYRVLDTVLGAGEGFENTTGTLAPRAAVPAGAVVIAFSTLLDTEFALALIDLRKRGHVVVA VDVLDSCPLQDQLDPLVVRMWALQRSAMYRDMATIGVDVLSWPADHSLQQSMGALPNRRRRGRGRASRAR LP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3163c | - | - | 100% (423) | POSSIBLE CONSERVED SECRETED PROTEIN |
| M. tuberculosis H37Rv | Rv1480 | - | 6e-10 | 26.22% (267) | hypothetical protein Rv1480 |
| M. tuberculosis H37Rv | Rv3693 | - | 7e-06 | 38.60% (57) | hypothetical protein Rv3693 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3188c | - | 0.0 | 99.76% (423) | hypothetical protein Mb3188c |
| M. gilvum PYR-GCK | Mflv_0475 | - | 1e-154 | 66.50% (406) | hypothetical protein Mflv_0475 |
| M. leprae Br4923 | MLBr_01809 | - | 4e-10 | 28.73% (181) | hypothetical protein MLBr_01809 |
| M. abscessus ATCC 19977 | MAB_1908c | - | 1e-118 | 53.06% (409) | hypothetical protein MAB_1908c |
| M. marinum M | MMAR_1400 | - | 0.0 | 79.29% (420) | hypothetical protein MMAR_1400 |
| M. avium 104 | MAV_4050 | - | 1e-163 | 77.17% (368) | hypothetical protein MAV_4050 |
| M. smegmatis MC2 155 | MSMEG_3867 | - | 1e-144 | 63.24% (408) | ATPase family protein associated with various cellular |
| M. thermoresistible (build 8) | TH_0583 | - | 1e-143 | 63.51% (422) | POSSIBLE CONSERVED SECRETED PROTEIN |
| M. ulcerans Agy99 | MUL_2476 | - | 0.0 | 78.57% (420) | hypothetical protein MUL_2476 |
| M. vanbaalenii PYR-1 | Mvan_0181 | - | 1e-154 | 67.73% (406) | hypothetical protein Mvan_0181 |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3163c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3188c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1400|M.marinum_M --------------------------------------------------
MUL_2476|M.ulcerans_Agy99 --------------------------------------------------
MAV_4050|M.avium_104 --------------------------------------------------
Mflv_0475|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0181|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_0583|M.thermoresistible__bu --------------------------------------------------
MSMEG_3867|M.smegmatis_MC2_155 MTSQANVDVATAAAARSVLDEIEKAVVGKRDALTLILTTLLARGHVLIED
MAB_1908c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01809|M.leprae_Br4923 --------------------------------------------------
Rv3163c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3188c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1400|M.marinum_M --------------------------------------------------
MUL_2476|M.ulcerans_Agy99 --------------------------------------------------
MAV_4050|M.avium_104 --------------------------------------------------
Mflv_0475|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0181|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_0583|M.thermoresistible__bu --------------------------------------------------
MSMEG_3867|M.smegmatis_MC2_155 LPGLGKTLIARSFAAALGLKFTRVQFTPDLLPADLLGSTVYDMQSGRFEF
MAB_1908c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01809|M.leprae_Br4923 --------------------------------------------------
Rv3163c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3188c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1400|M.marinum_M --------------------------------------------------
MUL_2476|M.ulcerans_Agy99 --------------------------------------------------
MAV_4050|M.avium_104 --------------------------------------------------
Mflv_0475|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0181|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_0583|M.thermoresistible__bu --------------------------------------------------
MSMEG_3867|M.smegmatis_MC2_155 RPGPIFTNLLLADEINRTPPKTQAALLEAMAEGQVSIDGQTHRLPAPFIV
MAB_1908c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01809|M.leprae_Br4923 --------------------------------------------------
Rv3163c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3188c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1400|M.marinum_M --------------------------------------------------
MUL_2476|M.ulcerans_Agy99 --------------------------------------------------
MAV_4050|M.avium_104 --------------------------------------------------
Mflv_0475|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0181|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_0583|M.thermoresistible__bu --------------------------------------------------
MSMEG_3867|M.smegmatis_MC2_155 LATDNPIEYEGTYPLPEAQLDRFSVRLELKYLSEQDETAMLRRRLDRGSA
MAB_1908c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01809|M.leprae_Br4923 --------------------------------------------------
Rv3163c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3188c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1400|M.marinum_M --------------------------------------------------
MUL_2476|M.ulcerans_Agy99 --------------------------------------------------
MAV_4050|M.avium_104 --------------------------------------------------
Mflv_0475|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0181|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_0583|M.thermoresistible__bu --------------------------------------------------
MSMEG_3867|M.smegmatis_MC2_155 EAGVAEVVDGPRFLAMREAVEQVSVHDDVLRYVVALRGRDAPPPAGCGRR
MAB_1908c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01809|M.leprae_Br4923 --------------------------------------------------
Rv3163c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3188c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1400|M.marinum_M --------------------------------------------------
MUL_2476|M.ulcerans_Agy99 --------------------------------------------------
MAV_4050|M.avium_104 --------------------------------------------------
Mflv_0475|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0181|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_0583|M.thermoresistible__bu --------------------------------------------------
MSMEG_3867|M.smegmatis_MC2_155 QPPRRTRPRATREGQGLAARAGLRHPRGRQDTRGRGDGAPHQPAPGDVGA
MAB_1908c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01809|M.leprae_Br4923 --------------------------------------------------
Rv3163c|M.tuberculosis_H37Rv ------------------------MIQTCEVELRWRASQLTLAIATCAGV
Mb3188c|M.bovis_AF2122/97 ------------------------MIQTCEVELRWRASQLTLAIATCAGV
MMAR_1400|M.marinum_M ------------------------MIQTRDVELRWRASPLTLAVATCAAV
MUL_2476|M.ulcerans_Agy99 ------------------------MIPTRDVELRWRASPLTLAVATCAGV
MAV_4050|M.avium_104 --------------------------------------------------
Mflv_0475|M.gilvum_PYR-GCK ---------------------------MVAVELRWRASALTQSIATCVAA
Mvan_0181|M.vanbaalenii_PYR-1 ---------------------------MTAVELRWRPSPLTRSIATCAAA
TH_0583|M.thermoresistible__bu ---------------VTITPPGPSNMSGIAVEPRWRASPLTLALCSCAAV
MSMEG_3867|M.smegmatis_MC2_155 QHPRCRRHERTAAPAPRAPCGQPAMTVGVHVPLRWGASPLTKSVATAAAG
MAB_1908c|M.abscessus_ATCC_199 -------------------------------MITWRASALISALAACTGA
MLBr_01809|M.leprae_Br4923 --------------------------------------------------
Rv3163c|M.tuberculosis_H37Rv ALAAAVVAGRWQLIAFAAPLLGVLCSISWQRPVPVIQVHGDPDSQRCFEN
Mb3188c|M.bovis_AF2122/97 ALAAAVVAGRWQLIAFAAPLLGVLCSISWQRPVPVIQVHGDPDSQRCFEN
MMAR_1400|M.marinum_M ALAAALIAGRWQLIAFAAPLLGVLCSIYWQRPVPTVHVHAEPDLQRCFED
MUL_2476|M.ulcerans_Agy99 ALAAALIAGRWQLIAFAAPLLGVLCSIYWQRPVPTVHVHAEPDLQRCFED
MAV_4050|M.avium_104 ----------------------MLGTISWQPRVPAVAVHAEPDTQRCFEG
Mflv_0475|M.gilvum_PYR-GCK AITVALVAGRWELVAFAAPLAGALCSIGWQRRLPTVTVTGSPPFQRCFED
Mvan_0181|M.vanbaalenii_PYR-1 AIVAALLAGRWELAAFAAPLLGVLCSIGWQRGKPSVTVQAEPVFQRCFEG
TH_0583|M.thermoresistible__bu TLAAAVIGQRWQLVIFAAPLIGVLASVVRQPPPPRVWLRGHPDPGRCFEG
MSMEG_3867|M.smegmatis_MC2_155 AMLIAVLGFRWQLVIFASPLLGVLCSAYWQRPRVSVEVGAEPATVRCFEN
MAB_1908c|M.abscessus_ATCC_199 ALALAVMTGRWQLVVFAAPFVGALAGASRRPPAARAWVTDEPEPLRCLES
MLBr_01809|M.leprae_Br4923 -MIDPNPAAKPGVFHPPSMQRGQIDDPKLSAALRTLELTVKRKLDGVLHG
: : :..
Rv3163c|M.tuberculosis_H37Rv EHVRVTVWVTTESVD----AAVELTVSALAGMQFEALESVSRRTTTVSAV
Mb3188c|M.bovis_AF2122/97 EHVRVTVWVTTESVD----AAVELTVSALAGMQFEALESVSRRTTTVSAV
MMAR_1400|M.marinum_M ERVGVKVWATVDSAAGEGSEAVLVTVRAPAGMQLDIDASSSRQAKSVEVV
MUL_2476|M.ulcerans_Agy99 ERVGVKVWATVDSTAGEGSEAVLVTVRAPAGMQLDIDASTSRQAKSVEVV
MAV_4050|M.avium_104 EPAHVTVWGIEEQGP----CAVRLTVPPVEGMELQFGESGSRRGKTVRAT
Mflv_0475|M.gilvum_PYR-GCK EQVSVGMTAVADDGA-----AVTLDCTAPAPMVLTHRPAG-----ELTVQ
Mvan_0181|M.vanbaalenii_PYR-1 ESVLVTVSAGAEDGS-----AVTLDCSVVTGMELVGPTSLP----TLSVR
TH_0583|M.thermoresistible__bu EEVRVTVTVSADPPG----TALHLRVDDVSGAQVRMLEQRPER-VVAAVS
MSMEG_3867|M.smegmatis_MC2_155 ESAELSVRVSSSAGA-----DARLRVDSVEGLRLEPGDRAGPE-QRVRAN
MAB_1908c|M.abscessus_ATCC_199 ETITVAVSVESTGPA----VVCGLRPALVEGLRIDADRPAAPNQLTMRTS
MLBr_01809|M.leprae_Br4923 DHLGLISGPGSEPGE---------SRVYQPGDDVRRMDWAVTARTTHPHV
: : .
Rv3163c|M.tuberculosis_H37Rv AQRWGRYPIRARVAVVARGGLLMGAG-TVDAAEIVVFPLTPPQSTPLPQT
Mb3188c|M.bovis_AF2122/97 AQRWGRYPIRARVAVVARGGLLMGAG-TVDAAEIVVFPLTPPQSTPLPQT
MMAR_1400|M.marinum_M TQRWGRYPIKARVDVVARGGLLMGDG-TVEAAQVVVFPLTPPQPTAIPQT
MUL_2476|M.ulcerans_Agy99 TQRWGRYPIEARVDVVARGGLLIGDG-TVEAAQVVVFPLTPPQPTAIPQT
MAV_4050|M.avium_104 AQRWGRYHVAARVDVLARGGLLSGTA-LVDAAEVIVFPLTPPQPTPIPRT
Mflv_0475|M.gilvum_PYR-GCK SSRWGRYPVRAGVRVCGRGGLVTGTG-TVDAAEVCVFPLAPAQSTAIPRT
Mvan_0181|M.vanbaalenii_PYR-1 ASRWGRYPLLATVRVGGRGGLLEGTG-TADAAEVCVFPVAPPQSTAIPRT
TH_0583|M.thermoresistible__bu AHRWGRYPVRARVDVPAAGGLLTGTG-AVDVAEIVVFPLAPPESTVLPHG
MSMEG_3867|M.smegmatis_MC2_155 ASRWGRYPLRAHVTVTAPGGLVTGTG-TVEAAELYVFPLAAPHLTPMPRA
MAB_1908c|M.abscessus_ATCC_199 AQRWGRYRVPVEVRSVSASGLWAGTALTLPASELRVYPLADPQDVALPPA
MLBr_01809|M.leprae_Br4923 RQMIADRELETWMVIDMSASLDFGTT----ICEKRDLAVAAAAAITFLNS
. : . : ..* * .: .:: . :
Rv3163c|M.tuberculosis_H37Rv ELLDRLGAHLTRHVGPGVEYADIRPYVPGDQLRAVNWVVSARRGRLHVTR
Mb3188c|M.bovis_AF2122/97 ELLDRLGAHLTRHVGPGVEYADIRPYVPGDQLRAVNWVVSARRGRLHVTR
MMAR_1400|M.marinum_M ELLDRLGAHLTRYIGPGVEYADIRPYVPGDQLRAVNWAVSARRGRLHVTQ
MUL_2476|M.ulcerans_Agy99 ELLDRLGAHLTRYIGPGVEYADIRPYVPGDQLRAVNWAVSARRGRLHVTQ
MAV_4050|M.avium_104 ELLDRLGAHLTRHVGPGVEYADIRPYVPGDQLRAVNWAVSARRRQLHVTQ
Mflv_0475|M.gilvum_PYR-GCK DLLDRLGTHLTRHTGPGVEFADIRPYVPGDQLRIVNWPVSARRGTLHITE
Mvan_0181|M.vanbaalenii_PYR-1 DLLDRLGTHLTRHVGPGVEFADIRPYVPGDQLRTVNWPVSARRGALHVTE
TH_0583|M.thermoresistible__bu EMRDRLGTHLTANSGSGVEYADIRPYVPGDQLRTVNWPVSARRGRLHVTQ
MSMEG_3867|M.smegmatis_MC2_155 ELPDRLGTHLTRHTGPGVEYADVRPYVPGDHLRTVNWPVSARRGRLHVTE
MAB_1908c|M.abscessus_ATCC_199 DLPDRIGTRLTRHHGPGVEYADIREYVPGDSLRTVNWRVSAQRGRLHVTD
MLBr_01809|M.leprae_Br4923 GGGNRLGALICN--------------------GARMTRVPARSGRQHEQT
:*:*: : *.*: *
Rv3163c|M.tuberculosis_H37Rv RLTDRAADVVVLIDMYRQPAGPATEATERVVRGAAQVVQTALRNGDRAGI
Mb3188c|M.bovis_AF2122/97 RLTDRAADVVVLIDMYRQPAGPATEATERVVRGAAQVVQTALRNGDRAGI
MMAR_1400|M.marinum_M RLTDRAADVIVLIDTYRQPPGPASEATERVARGAAQVVQTALRNGDRAGI
MUL_2476|M.ulcerans_Agy99 RLTDRAADVIVLIDTYRQPPGPASEATERVARGAAQVVQTALRNGDRAGI
MAV_4050|M.avium_104 RLTDRAADVVVLIDGYRQPAGPATQATERIVRGAAQVVQTALRHGDRAGI
Mflv_0475|M.gilvum_PYR-GCK RLTDRAADVVVLVDTYPQPPGPATAATERTARGAAQVVQSALRYGDRAGL
Mvan_0181|M.vanbaalenii_PYR-1 RLTDRAADVVALVDTYPQPPGPATAATERIARGAAQVVQSALRYGDRAGL
TH_0583|M.thermoresistible__bu RLSERAADVVVLVDAYPQPPGPATEVTERIARGAVQVVQSALRGGDRAGI
MSMEG_3867|M.smegmatis_MC2_155 RLTDRGGDVVVLIDTHDQAPGPATQATERTARGAAQVVQSALRSGDRAGI
MAB_1908c|M.abscessus_ATCC_199 RLTDRAADVVVLIDTYPQPSGPATTATERSARGAAQLVQSVLQRGDRAGV
MLBr_01809|M.leprae_Br4923 LLR-------TIATTPKAPVG---------VRGDLTVAIDALRRPERR--
* .: . * .** :. .*: :*
Rv3163c|M.tuberculosis_H37Rv VALGGNRPRWLGADIGQRQFYRVLDTVLGAGEGFENTT--------GTLA
Mb3188c|M.bovis_AF2122/97 VALGGNRPRWLGADIGQRQFYRVLDTVLGAGEGFENTT--------GTLA
MMAR_1400|M.marinum_M IALGGNRPRWMGADIGQRQFYRVLDTVLGSGDRFEKTT--------GTLA
MUL_2476|M.ulcerans_Agy99 IALGGNRPRWMGADIGQRQFYRVLDTVLGSGDRFEKTT--------GTLA
MAV_4050|M.avium_104 VALGGNRPRWLGADIGQRQFYRVLDTVLAAGGGFEHTT--------GTLA
Mflv_0475|M.gilvum_PYR-GCK VALGGRSTRWLGADIGRRQFYRILDTVLGADDTFEKAT--------GTLA
Mvan_0181|M.vanbaalenii_PYR-1 VALGSRNVRWLGADIGQRQFYRVLDTMLGASDTFQNAT--------GTLA
TH_0583|M.thermoresistible__bu ATLGGRGPRWLGVDLGRRQFYRVVDTMLGAAPGSGPTTPTGPGSGRGTLV
MSMEG_3867|M.smegmatis_MC2_155 VALGGRQPRWLGLDIGRRQFYRVLDAILGAGGGFETTT--------GTLA
MAB_1908c|M.abscessus_ATCC_199 VVLG-SSARWLAPNIGRHQFYRLLDATLDAGEWHSHSA--------SALA
MLBr_01809|M.leprae_Br4923 -----------------RGMAVIISDFLGPINWMRPLR---------AIA
: : ::. * . ::.
Rv3163c|M.tuberculosis_H37Rv PRAAVPAGAVVIAFSTLLDTEFALALIDLRKRGHVVVAVDVLDSCPLQDQ
Mb3188c|M.bovis_AF2122/97 PRAAVPAGAVVIAFSTLLDTEFALALIELRKRGHVVVAVDVLDSCPLQDQ
MMAR_1400|M.marinum_M PRAAVPAGAIVIAFSTLLDTEFALALIDLRKRGHVVVAVDVLDSAPFEGE
MUL_2476|M.ulcerans_Agy99 PRAAVPTGAIVIAFSTLLDTEFALALIDLRKRGHVVVAVDVLDGAPFEGE
MAV_4050|M.avium_104 PRAAVPAGAIVIAFSTLLDTEFALALIDLRRRGHVVLAVDILEGSPSEDE
Mflv_0475|M.gilvum_PYR-GCK PRAAVPTGAIVVAFSTMLDTEFALALIDLRKRGHPVVVVDVLEGSPVEGE
Mvan_0181|M.vanbaalenii_PYR-1 PRPAVPTRAIVIAFSTMLDTEFALALIDLRKRGHPVVAIDVLDGSPLEGD
TH_0583|M.thermoresistible__bu PRPAVPPEAIVVAFSTLLDTDFALALIDLARRGHPVVAVDVLDREPFDG-
MSMEG_3867|M.smegmatis_MC2_155 PRAAVPPGAIVVAFSTMLNTEFAFALIELAKHGHAVVAVDILEGAPFDNP
MAB_1908c|M.abscessus_ATCC_199 PRAAVPPNAIVVAFSTLLNADFGLALTDLRRRGHPVVVVDVLDRLPFREE
MLBr_01809|M.leprae_Br4923 ARHEVLGIEVLDPRDVALPDIGEVVLQDAETG----VTREFTIDAALRDD
.* * :: . .. * ..* : :. :. .
Rv3163c|M.tuberculosis_H37Rv --LDPLVVRMWALQRSAMYRDMATIGVDVLSWPADHSLQQSMGALPNRRR
Mb3188c|M.bovis_AF2122/97 --LDPLVVRMWALQRSAMYRDMATIGVDVLSWPADHSLQQSMGALPNRRR
MMAR_1400|M.marinum_M --QDPLVVRMWALQRAGMYRDMATVGVDVLDWPGNRALEQSMGALPDRRR
MUL_2476|M.ulcerans_Agy99 --QDPLVVRMWALQRAGMYRDMATVGVDVLDWPGNRALEQSMGALPDRRR
MAV_4050|M.avium_104 --QDPLVDRMWALQRSAMYRDMATVGVDIVWWPGDRGLEQSMGVLPDRRR
Mflv_0475|M.gilvum_PYR-GCK --HDPLVHRMWAMQRSFMYRDMATVGVDIVAWPGDATLDQAMALVPARRR
Mvan_0181|M.vanbaalenii_PYR-1 --HDPLVHRMWSMQRSFMYRDMATVGVDVVGWPAAVTLDQAMALVPVHRA
TH_0583|M.thermoresistible__bu --VDPLVGRMWSLQRSFMYRDMRTIGVDVVAWGAGQALDQVLHVVADHRR
MSMEG_3867|M.smegmatis_MC2_155 DGLDPLIPRLWALQRSAMYRDMSTIGIDVVHWRGDIPLQDVMRLIPDRHR
MAB_1908c|M.abscessus_ATCC_199 --PDPIVARWWRLERSRMYRNIAVTGVDVVGWSHDSGLNHAMHLMPRRPR
MLBr_01809|M.leprae_Br4923 ------FARAAAAHCADVSRSLRNCGAPLMSLRTDRDWIADIVRFVESRR
. * . : : *.: * :: : .
Rv3163c|M.tuberculosis_H37Rv RGRGRASRARLP
Mb3188c|M.bovis_AF2122/97 RGRGRASRARLP
MMAR_1400|M.marinum_M RIRGRLRGSV--
MUL_2476|M.ulcerans_Agy99 RIRGRLRGSV--
MAV_4050|M.avium_104 RVRGRLRG----
Mflv_0475|M.gilvum_PYR-GCK RL----------
Mvan_0181|M.vanbaalenii_PYR-1 RR----------
TH_0583|M.thermoresistible__bu RTLRRVSR----
MSMEG_3867|M.smegmatis_MC2_155 RRTR--------
MAB_1908c|M.abscessus_ATCC_199 RGRRR-------
MLBr_01809|M.leprae_Br4923 RGALAGRQ----
*