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M. thermoresistible (build 8) TH_0512 (pcnA)

annotation: PROBABLE POLY(A) POLYMERASE PCNA (POLYNUCLEOTIDE ADENYLYLTRANSFERASE) (NTP POLYMERASE) (RNA ADENYLATING ENZYME) (POLY(A) POLYMERASE)
coordinates: 1093295 - 1094752
length: 486

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_0512pcnA-100% (486)PROBABLE POLY(A) POLYMERASE PCNA (POLYNUCLEOTIDE ADENYLYLTRANSFERASE) (NTP POLYMERASE) (RNA ADENYLATING ENZYME) (POLY(A) POLYMERASE)
M. thermoresistible (build 8)TH_1479glnD1e-0529.28% (222) PROBABLE

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3937cpcnA0.080.71% (482) poly(A) polymerase PCNA (polynucleotide adenylyltransferase)
M. gilvum PYR-GCKMflv_0845-0.077.89% (484) metal dependent phosphohydrolase
M. tuberculosis H37RvRv3907cpcnA0.080.71% (482) poly(A) polymerase
M. leprae Br4923MLBr_02697pcnA0.078.26% (483) pcnA
M. abscessus ATCC 19977MAB_4934c-0.075.42% (480) Poly(A) polymerase PcnA
M. marinum MMMAR_5471pcnA0.079.92% (483) poly(a) polymerase PcnA
M. avium 104MAV_5294-0.081.37% (483) tRNA adenylyltransferase
M. smegmatis MC2 155MSMEG_6926-0.081.74% (482) tRNA adenylyltransferase
M. ulcerans Agy99MUL_5060pcnA0.079.92% (483) poly(a) polymerase PcnA
M. vanbaalenii PYR-1Mvan_6061-0.079.00% (481) metal dependent phosphohydrolase

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_0845|M.gilvum_PYR-GCK          MGSPGPVGSPDVSDPISDAERLATAQVALNRRGDVLRDLGRVFADNGHEL
Mvan_6061|M.vanbaalenii_PYR-1       -----------MPDPTSDSELLAAAQVALNVHGGVLRELGRLFGDHGHQL
MSMEG_6926|M.smegmatis_MC2_155      -----------MPEAAATAELLAGALVALNRRAGVLRELGAVFAAAGHEL
MLBr_02697|M.leprae_Br4923          ---------MNVPEAAQDTDLLTVAAVTLNRHTPVLRDLGSVFAASGHEL
MAV_5294|M.avium_104                -----------MPDAAQDAELLTAAAVALNKHAPMLRELGSAFDAAGHQL
Mb3937c|M.bovis_AF2122/97           -----------MPEAVQEADLLTAAAVALNRHAALLRELGSVFAAAGHEL
Rv3907c|M.tuberculosis_H37Rv        -----------MPEAVQEADLLTAAAVALNRHAALLRELGSVFAAAGHEL
MMAR_5471|M.marinum_M               -----------MPETVQDADLLTAAAVALNRHAAVLGELGSAFADAGHDL
MUL_5060|M.ulcerans_Agy99           -----------MPETVQDADLLTAAAVALNRHAAVLRELGSAFADAGHDL
TH_0512|M.thermoresistible__bu      -----------VPNAVEDAELLAGAAVALNRHAELLRDIGTVFADAGHEL
MAB_4934c|M.abscessus_ATCC_199      -----------MPESIPTAELLATAAVTLNRHKKLLSELGALFDSAGFDL
                                               :.:.   :: *: * *:** :  :* ::*  *   *.:*

Mflv_0845|M.gilvum_PYR-GCK          YLVGGPVRDALLGRFDPDKNDLDFTTDARPEQMQRFLRGWGDALWDTGIE
Mvan_6061|M.vanbaalenii_PYR-1       YLVGGSVRDALLGRLG---TDLDFTTDARPDQMLPFLRGWGDALWDTGID
MSMEG_6926|M.smegmatis_MC2_155      YLVGGSVRDALLGRLTEN-SDLDFTTDARPEQMQKFLRGWSDALWDTGIE
MLBr_02697|M.leprae_Br4923          YLVGGSVRDALLGRLD--SPDLDFATDAGPEQVQQIMRRWADNLWETGIE
MAV_5294|M.avium_104                YLVGGSVRDALLGRL---SPDLDFTTDARPDQVQQILRRWADNLWDTGIE
Mb3937c|M.bovis_AF2122/97           YLVGGSVRDALLGRL---SPDLDFTTDARPERVQEIVRPWADAVWDTGIE
Rv3907c|M.tuberculosis_H37Rv        YLVGGSVRDALLGRL---SPDLDFTTDARPERVQEIVRPWADAVWDTGIE
MMAR_5471|M.marinum_M               YLVGGSVRDALLGRLK--SPDLDFTTDARPQQVQKIVRSWADAVWDTGIE
MUL_5060|M.ulcerans_Agy99           YLVGGSVRDALLGRLK--SPDLDFTTDARPQQILKIVRPWADAVWDTGIE
TH_0512|M.thermoresistible__bu      YLVGGSVRDALLGRL---GTDLDFTTDARPEQMQKMLRPWAEAMWDTGIE
MAB_4934c|M.abscessus_ATCC_199      YLVGGSVRDAALGKPG---IDLDFTTDARPEQVQNLVTGWAEAIWDTGIA
                                    *****.**** **:      ****:*** *:::  ::  *.: :*:*** 

Mflv_0845|M.gilvum_PYR-GCK          FGTLGVGKGEDRLEITTFRADTYDKVSRNPEVRFGDNLADDLVRRDFTVN
Mvan_6061|M.vanbaalenii_PYR-1       FGTLGVAKGGDRLEITTFRADSYDQVSRHPEVRYGDNLADDLVRRDFTVN
MSMEG_6926|M.smegmatis_MC2_155      FGTIGVGKGDDRLEITTFRADSYDQVSRNPTVEFGDNLGDDLVRRDFTIN
MLBr_02697|M.leprae_Br4923          FGTIGVGKGDYRLEITTFRADRYDQVSRNPEVRFSDRLDDDLVRRDFTVN
MAV_5294|M.avium_104                FGTVGVGKGDRRLEITTFRADTYDQVSRNPQVRFGNRLEDDLVRRDFTTN
Mb3937c|M.bovis_AF2122/97           FGTVGVGKSDHRMEITTFRADSYDRVSRHPEVRFGDCLEGDLVRRDFTTN
Rv3907c|M.tuberculosis_H37Rv        FGTVGVGKSDHRMEITTFRADSYDRVSRHPEVRFGDCLEGDLVRRDFTTN
MMAR_5471|M.marinum_M               FGTIGIAKNDYRLEITTFRADSYDQVSRHPEVRFGERLEDDLVRRDFTVN
MUL_5060|M.ulcerans_Agy99           FGTIGIAKNDYRLEITTFRADSYDQVSRHPEVRFGERLEDDLVRRDFTVN
TH_0512|M.thermoresistible__bu      FGTVGVAKRGLRLEITTFRADSYDQVSRHPEVRFGDRLDDDLVRRDFTVN
MAB_4934c|M.abscessus_ATCC_199      FGTIGVARRGQRVEITTFRSDSYDQQSRNPEVVFGDSLEGDLVRRDFTVN
                                    ***:*:.:   *:******:* **: **:* * :.: * .******** *

Mflv_0845|M.gilvum_PYR-GCK          AMAVRVTADGPT---EFLDPLDGLSALRDGVLDTPAAPEVSFGDDPLRML
Mvan_6061|M.vanbaalenii_PYR-1       AMAVRITPGGPT---EFLDPLDGLAALRDQVLDTPSEPEVSFSDDPLRML
MSMEG_6926|M.smegmatis_MC2_155      AMAVRITADGPG---EFHDPLGGLAAARDKVLDTPSAPEVSFGDDPLRML
MLBr_02697|M.leprae_Br4923          AMAVRIASYGPG---EFFDPLGGLAALRVRVLETPAAPSVSFGDDPLRML
MAV_5294|M.avium_104                AMAVRITPDGPG---EFLDPLGGLAALRQRVLDTPATPEESFGDDPLRML
Mb3937c|M.bovis_AF2122/97           AMAVRVTATGPG---EFLDPLGGLAALRAKVLDTPAAPSGSFGDDPLRML
Rv3907c|M.tuberculosis_H37Rv        AMAVRVTATGPG---EFLDPLGGLAALRAKVLDTPAAPSGSFGDDPLRML
MMAR_5471|M.marinum_M               AMAVRITASGPG---EFLDPLGGLSVLRDKVLDTPAAPSVSFGDDPLRML
MUL_5060|M.ulcerans_Agy99           AMAVRITASGPG---EFLDPLGGLSVLRDKVLDTPAAPSVSFGDDPLRML
TH_0512|M.thermoresistible__bu      AMAVRITPDSPGGFGEFHDPLGGLAHLRARTLDTPAEPEVSFGDDPLRML
MAB_4934c|M.abscessus_ATCC_199      AMAVKIGPDGPG---EFCDPLNGLEALRAGVLDTPSAPEISFGDDPLRML
                                    ****:: . .*    ** ***.**   *  .*:**: *. **.*******

Mflv_0845|M.gilvum_PYR-GCK          RAARFVSQLGFTVAPRVRRALEEMSSQLSRITAERVAAELDKLLLGADPV
Mvan_6061|M.vanbaalenii_PYR-1       RAARFVSQLGFAVAPRVRRALQEMAPQLSRITAERVAAELDKLLLGADPV
MSMEG_6926|M.smegmatis_MC2_155      RAARFVSQLGFSVAPRVLEALIEMAPQLERITAERVAAELDKLLLGADPV
MLBr_02697|M.leprae_Br4923          RAARFVSQLGFTVAPQVHAAIEEMASQLARISAERVSTELDKLLLGNDPA
MAV_5294|M.avium_104                RAARFVSQLGFTVAPRVREAIERMAPQLARISAERVAAELDKLVLGDDPV
Mb3937c|M.bovis_AF2122/97           RAARFVSQLGFAVAPRVRAAIEEMAPQLARISAERVAAELDKLLVGEDPA
Rv3907c|M.tuberculosis_H37Rv        RAARFVSQLGFAVAPRVRAAIEEMAPQLARISAERVAAELDKLLVGEDPA
MMAR_5471|M.marinum_M               RAARFVSQLGFAVAPRVRDAIEEMAPQLARISAERVAAELDKLLLGENPV
MUL_5060|M.ulcerans_Agy99           RAARFVSQLGFAVAPRVRDAIEEMAPQLARISAERVAAELDKLLLGEDPV
TH_0512|M.thermoresistible__bu      RAARFVSQLRFTVAPRVRAAIERMAPQLARISPERVQAELDKLILGDDPV
MAB_4934c|M.abscessus_ATCC_199      RAARFVSQLGFTVAPRVLEALHAMADQLGRITAERVQTELDKLIVGAHPV
                                    ********* *:***:*  *:  *: ** **:.*** :*****::* .*.

Mflv_0845|M.gilvum_PYR-GCK          AGLDLMVDTGLGEVVLPEVGAMRMAIDEHHQHKDVYQHSLTVLRQAMDLE
Mvan_6061|M.vanbaalenii_PYR-1       AGLNLMVETGLGDVVLPEIGAMRMAIDEHHQHKDVYQHSLTVLRQAMDLE
MSMEG_6926|M.smegmatis_MC2_155      AGIDLMVQTGMGAVVLPEVGEMRMAIDEHHQHKDVYWHSLTVLRQAIDLE
MLBr_02697|M.leprae_Br4923          AGIDLLVQTGMGEVVLPEIGDMRMAIDEHHQHKDVYQHSLTVLRQAIALE
MAV_5294|M.avium_104                AGIDLLVHSGMGEVVLPEIGGMQMAIDEHHQHKDVYQHSLTVLRQAIALE
Mb3937c|M.bovis_AF2122/97           AGIDLMVQSGMGAVVLPEIGGMRMAIDEHHQHKDVYQHSLTVLRQAIALE
Rv3907c|M.tuberculosis_H37Rv        AGIDLMVQSGMGAVVLPEIGGMRMAIDEHHQHKDVYQHSLTVLRQAIALE
MMAR_5471|M.marinum_M               AGIDLMVHTGMGEVVLPEIGGMQMAIDEHHQHKDVYQHSLTVLRQAIELE
MUL_5060|M.ulcerans_Agy99           AGIDLMVHTGMGEVVLPEIGGMQMAIDEHHQHKDVYQHSLTVLRQAIELE
TH_0512|M.thermoresistible__bu      AGIDLMVETGMGEVVLPEVGAMRMEIDEHHQHKDVYQHSLQVLRQAIALE
MAB_4934c|M.abscessus_ATCC_199      AGIDLLVDSGLGAVVLPEVGQMQLTIDEHHQHKDVYRHSLTVLEQAVDLE
                                    **::*:*.:*:* *****:* *:: *********** *** **.**: **

Mflv_0845|M.gilvum_PYR-GCK          GADGPDLVLRWAALLHDIGKPATRRHEPDGGVSFHHHEVVGAKMTRKRMR
Mvan_6061|M.vanbaalenii_PYR-1       GPEGPDLVLRWAALLHDIGKPATRRHEPDGGVSFHHHEVVGAKMTRKRLR
MSMEG_6926|M.smegmatis_MC2_155      D-DGPDLVLRWAALLHDIGKPATRKHEPDGGVSFHHHEVVGAKMVRKRMR
MLBr_02697|M.leprae_Br4923          D-NGPDLVLRWAALLHDIGKPATRRHELNGGVSFHHHEVVGAKMVRKRMR
MAV_5294|M.avium_104                D-DGPDLVLRWAALLHDIGKPATRRHEPNGGVSFHHHEVVGAKMVRKRLR
Mb3937c|M.bovis_AF2122/97           D-DGPDLVLRWAALLHDIGKPATRRHEPDGGVSFHHHEVVGAKMVRKRMR
Rv3907c|M.tuberculosis_H37Rv        D-DGPDLVLRWAALLHDIGKPATRRHEPDGGVSFHHHEVVGAKMVRKRMR
MMAR_5471|M.marinum_M               D-DGPDLVLRWAALLHDIGKPTTRRHEANGGVSFHHHEVVGAKMVRKRMR
MUL_5060|M.ulcerans_Agy99           D-EGPDLALRWAALLHDIGKPATRRHEANGGVSFHHHEVVGAKMVRNRMR
TH_0512|M.thermoresistible__bu      D-GEPDLVLRWAALLHDIGKPATRRLESDGRVSFHHHEVVGAKMTRKRMR
MAB_4934c|M.abscessus_ATCC_199      D-EGPDLVLRWAALLHDIGKPATRRHEEGGGVSFHHHEVVGAKMVRKRMR
                                    .   ***.*************:**: * .* *************.*:*:*

Mflv_0845|M.gilvum_PYR-GCK          ELKYSKQMISDVSQLVYLHLRFHGYGDGRWTDSAVRRYVTDAGPLLTRLH
Mvan_6061|M.vanbaalenii_PYR-1       ELKYSKQMISDVSQLVYLHLRFHGYGDGRWTDSAVRRYVTDAGPLLGQLH
MSMEG_6926|M.smegmatis_MC2_155      ALKYSKQMVEDVSQLVYLHLRFHGYGDGKWTDSAVRRYVTDAGPLLSRLH
MLBr_02697|M.leprae_Br4923          ALKYAKQLVDDVSQLVYLHLRFHGYGEGKWTDSAVRRYVTDAGPLLSRLH
MAV_5294|M.avium_104                ALKYSKQMVDDVSQLVYLHLRFHGYGDGKWTDSAVRRYVTDAGPLLPRLH
Mb3937c|M.bovis_AF2122/97           ALKYSKQMIDDISQLVYLHLRFHGYGDGKWTDSAVRRYVTDAGALLPRLH
Rv3907c|M.tuberculosis_H37Rv        ALKYSKQMIDDISQLVYLHLRFHGYGDGKWTDSAVRRYVTDAGALLPRLH
MMAR_5471|M.marinum_M               ALKYSKQMVDDVSQLVYLHLRFHGYGDGKWTDSAVRRYVTDAGPLLARLH
MUL_5060|M.ulcerans_Agy99           ALKYSKQMVDDVSQLVYLHLRFHGYGDGKWTDSAVRRYVTDAGPLLARLH
TH_0512|M.thermoresistible__bu      ALKYSKQMVEDVSQLVYLHLRFHGYGDGKWTDSAVRRYVADAGHLLPKLH
MAB_4934c|M.abscessus_ATCC_199      ALKYSKQMVDDVSQLVYLHLRFHGYGDGKWTDSAVRRYVTDAGPLLPRLH
                                     ***:**::.*:**************:*:**********:*** ** :**

Mflv_0845|M.gilvum_PYR-GCK          KLVRADCTTRNKRRAARLQANYDDLERRIQDLAAREDLARVRPDIDGNEI
Mvan_6061|M.vanbaalenii_PYR-1       KLVRADCTTRNKRRAARLQASYDDLERRIEELAAKEDLARVRPDIDGNEI
MSMEG_6926|M.smegmatis_MC2_155      KLVRADCTTRNKRRAARLRANYDDLEARIAELAAKEDLQRVRPDLDGNEI
MLBr_02697|M.leprae_Br4923          KLVRADCTTRNQRRAARLQDSYDRLEARIAELAAEEDLARVRPDLDGNQI
MAV_5294|M.avium_104                KLVRADCTTRNKRRAARLQASYDRLEARIAELAAQEDLARVRPDLDGNQI
Mb3937c|M.bovis_AF2122/97           KLVRADCTTRNKRRAARLQASYDRLEERIAELAAQEDLDRVRPDLDGNQI
Rv3907c|M.tuberculosis_H37Rv        KLVRADCTTRNKRRAARLQASYDRLEERIAELAAQEDLDRVRPDLDGNQI
MMAR_5471|M.marinum_M               KLVRADCTTRNKRRAARLQASYDRLEERITELAAQEDLDRVRPDLDGNQI
MUL_5060|M.ulcerans_Agy99           KLVRADCTTRNKRRAARLQSSYDRLEERITELAAQEDLDRVRPDLDGNQI
TH_0512|M.thermoresistible__bu      KLVRADCTTRNRRRAARLQANYDNLERRIAELQAKEDLARVRPDLDGNEI
MAB_4934c|M.abscessus_ATCC_199      KLVRADCTTRNKRRAARLQANYDGLEERIAELAAKEDLARVRPDLDGNQI
                                    ***********:******: .** ** ** :* *.*** *****:***:*

Mflv_0845|M.gilvum_PYR-GCK          MKILGIPPGPQVGQAWNHLKELRLDRGPLDHDEAVEELVRWWNERGGPRV
Mvan_6061|M.vanbaalenii_PYR-1       MRILDIPPGPQVGQAWNHLKELRLDRGPLEYDEAVAELLKWWNEKGRPNV
MSMEG_6926|M.smegmatis_MC2_155      MQILGIPPGPQVGEAWKYLKELRLERGPLSHDEAVDELLKWWNARG----
MLBr_02697|M.leprae_Br4923          MALLDIPAGPQVGEAWRFLKELRLDRGPLTNEEATAELLAWWKTRQSQGL
MAV_5294|M.avium_104                MEILGIPAGPQVGEAWRFLKELRLERGPLDPDEATAELLSWWRSRGNG--
Mb3937c|M.bovis_AF2122/97           MAVLDIPAGPQVGEAWRYLKELRLERGPLSTEEATTELLSWWKSRGNR--
Rv3907c|M.tuberculosis_H37Rv        MAVLDIPAGPQVGEAWRYLKELRLERGPLSTEEATTELLSWWKSRGNR--
MMAR_5471|M.marinum_M               MTLLDIPAGPQVGEAWRYLKELRLERGPLTIEEAKAELLSWWQSRGNP--
MUL_5060|M.ulcerans_Agy99           MTLLDIPAGPQVGEAWRYLKELRLERGPLTIEEAKAELLSWWRSRGNP--
TH_0512|M.thermoresistible__bu      MEILGIGPGPQVGEAWRYLKELRLDRGPLSREEAVDELLKWWEARQNGQK
MAB_4934c|M.abscessus_ATCC_199      MELLGVPAGPIVGQAWQFLKELRLERGPLDHDEAVEALRQWWAGRS----
                                    * :*.: .** **:**..******:****  :**   *  **  :     

Mflv_0845|M.gilvum_PYR-GCK          -
Mvan_6061|M.vanbaalenii_PYR-1       -
MSMEG_6926|M.smegmatis_MC2_155      -
MLBr_02697|M.leprae_Br4923          L
MAV_5294|M.avium_104                -
Mb3937c|M.bovis_AF2122/97           -
Rv3907c|M.tuberculosis_H37Rv        -
MMAR_5471|M.marinum_M               -
MUL_5060|M.ulcerans_Agy99           -
TH_0512|M.thermoresistible__bu      -
MAB_4934c|M.abscessus_ATCC_199      -