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M. thermoresistible (build 8) TH_0438 (cobG)

annotation: Possible cobalamin biosynthesis protein CobG
coordinates: 962705 - 963841
length: 379

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_0438cobG-100% (379)Possible cobalamin biosynthesis protein CobG

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2090cobG1e-12863.03% (376) cobalamin biosynthesis protein CobG
M. gilvum PYR-GCKMflv_3106-1e-13063.85% (379) precorrin-3B synthase
M. tuberculosis H37RvRv2064cobG1e-12863.03% (376) cobalamin biosynthesis protein CobG
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_2200c-1e-10956.12% (392) cobalamin biosynthesis protein CobG
M. marinum MMMAR_3044-1e-12964.27% (375) cobalamin biosynthesis protein
M. avium 104-----
M. smegmatis MC2 155MSMEG_3871cobG1e-13263.93% (377) precorrin-3B synthase
M. ulcerans Agy99MUL_2288-1e-12964.27% (375) cobalamin biosynthesis protein
M. vanbaalenii PYR-1Mvan_3429-1e-13063.40% (377) precorrin-3B synthase

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_3106|M.gilvum_PYR-GCK          MVRAREKDACPGALQTHRAADGDLSRIRLPGGAITPPQLEVVAQAAIDLA
Mvan_3429|M.vanbaalenii_PYR-1       MARARDDDACPGALQTHRAADGDLARIRLPGGAITARQLEAVAQAAVNFG
MSMEG_3871|M.smegmatis_MC2_155      MTRTRDQDACPGALTVHQAADGALVRIRLAGGAITAAQLATLADVANDLG
Mb2090|M.bovis_AF2122/97            MAGTRDADACPGALRPHQAADGALARIRLPGGMITAAQLATLASVASDFG
Rv2064|M.tuberculosis_H37Rv         MAGTRDADACPGALRPHQAADGALARIRLPGGMITAAQLATLASVASDFG
MMAR_3044|M.marinum_M               MTRARDADACPGALQVHQAADGALVRVRLPGGRLTADQLAALARASNELA
MUL_2288|M.ulcerans_Agy99           MTRARDADACPGALQVHQAADGALVRVRLPGGRLTADQLAALARASNELA
TH_0438|M.thermoresistible__bu      VERAREHDACPGALSVHPAADGALARIRLPGGMLTPAQLTALADAARRFG
MAB_2200c|M.abscessus_ATCC_199      MTRSSADDACPGALRLHEAADGALARIRLPGGMLSSAQLAALAEAAGDHG
                                    :  :   *******  * **** * *:**.** ::. ** .:* .:   .

Mflv_3106|M.gilvum_PYR-GCK          ASTLELTSRGNLQIRGVRDTAAVADLLAGAGLLPSATHERVRNIVASPLS
Mvan_3429|M.vanbaalenii_PYR-1       TATLELTSRANLQIRGIHDTGAVAALLTDAGLLPSATHERVRNIVASPLS
MSMEG_3871|M.smegmatis_MC2_155      SPAMELTSRGNIQIRGLTDTDAAAAALAGAGLLPSPTHERVRNIVASPLT
Mb2090|M.bovis_AF2122/97            SATLELTARGNVQLRGIRDVAAVADAVAKAGLLPSATHERVRNIVASPLS
Rv2064|M.tuberculosis_H37Rv         SATLELTARGNVQLRGIRDVAAVADAVAKAGLLPSATHERVRNIVASPLS
MMAR_3044|M.marinum_M               SATLELTARGNLQLRAITDVMAVADAIANAGLLPSPTHERVRNIVASPLS
MUL_2288|M.ulcerans_Agy99           SATLELTARGNLQLRAITDVMAVADAIANAGLLPSPTHERVRNIVASPLS
TH_0438|M.thermoresistible__bu      SEAMELTSRGNIQIRGISDPAAVADAVAAAGLLPSPTHETVRNIVASPLS
MAB_2200c|M.abscessus_ATCC_199      APILELTSRGNVQLRSVRDANAVGALLSEAGLLPSPRHERVRNIVASPLS
                                    :  :***:*.*:*:*.: *  *..  :: ******. ** *********:

Mflv_3106|M.gilvum_PYR-GCK          GRHGGLCDVRALVADLDAAVQRDPVLAELPGRFLFGFDDGRGDISGLGAD
Mvan_3429|M.vanbaalenii_PYR-1       GRSGGFCDARDLVRSLDHAVQQDPRLARLPGRFLFGIDDGRGDISGLGAD
MSMEG_3871|M.smegmatis_MC2_155      GRSGGVADVGALVSELDAAIQAEPELAGLPGRFLFGLDDGRGDISGLGPD
Mb2090|M.bovis_AF2122/97            GRAGGLADVRAWVGELDAAIRAEPRLAELGGRFWFGLDDGRADVSGLGAD
Rv2064|M.tuberculosis_H37Rv         GRAGGLADVRAWVGELDAAIRAEPRLAELGGRFWFGLDDGRADVSGLGAD
MMAR_3044|M.marinum_M               GRVGGLADVQSWVGELDAAICAEPLLAQLGGRFWFSIDDGRADVSGLGAD
MUL_2288|M.ulcerans_Agy99           GRVGGLADLQSWVGELDAAICAEPLLAQLGGRFWFSIDDGRADVSGLGAD
TH_0438|M.thermoresistible__bu      GRCGGATDIRPWVTRLDHAIQSELALAALPGRFLFGIDDGRGDIAALAAD
MAB_2200c|M.abscessus_ATCC_199      GRAGEFPDARPLVSALDRGLTAAATLAELPGRFLFSLDDGRGDMAAMGAD
                                    ** *   *    *  ** .:     ** * *** *.:****.*::.:..*

Mflv_3106|M.gilvum_PYR-GCK          AGVHALDDSTA--ALLLAGRDTGVRVALS-SAVDELLAVARRFVDGRGKH
Mvan_3429|M.vanbaalenii_PYR-1       AGIHVLDGHTA--ALLLAGRDTGVRLPLG-HVVDELLSVAARFLQVRGTA
MSMEG_3871|M.smegmatis_MC2_155      AGVHMLDAGTG--ALLLGGCDTGVRIDRA-GVVPTLITVARRFAKVHGKA
Mb2090|M.bovis_AF2122/97            VGVQVFPDGP---RLLLTGRDTGVRVA---DVAETLIEVALRFVKIRETA
Rv2064|M.tuberculosis_H37Rv         VGVQVFPDGP---RLLLTGRDTGVRVA---DVAETLIEVALRFVKIRETA
MMAR_3044|M.marinum_M               VGVHVLADGC---AVLLDGRDTGVRLAPD-DVVPTLTELAVRFTQIRGNC
MUL_2288|M.ulcerans_Agy99           VGVHVLADGC---AVLLDGRDTGVRLAPD-DVVPTLTELAVRFTQMRGNF
TH_0438|M.thermoresistible__bu      VAVQTLGASGDEAAVLLAGRDSGVRVAAG-DAVEVMVTVARRFTASRGGA
MAB_2200c|M.abscessus_ATCC_199      IGLRHDQKGWR---LLLGGRTTSVCDGDAVDAVERMLTAARKFVEIRGNA
                                     .::          :** *  :.*       ..  :   * :*   :   

Mflv_3106|M.gilvum_PYR-GCK          WRVGELDDPA-ILLDGRAPTERPGGT-WQARTRPPVGWIEQTDGR-----
Mvan_3429|M.vanbaalenii_PYR-1       WRVDELDDPT-TLLGDRTPTAEPGAT-WPAHSRPPVGWIEQDDGR-----
MSMEG_3871|M.smegmatis_MC2_155      WRVGELDDLA-PLLEGLTATGAGGQR-WAPTVRPPVGWIPQRDGR-----
Mb2090|M.bovis_AF2122/97            WRVTELADIG-ELQSG----VELGPS-VRPVTKTPVGWIPQDDSR-----
Rv2064|M.tuberculosis_H37Rv         WRVTELADIG-ELQSG----VELGPS-VRPVTKTPVGWIPQDDSR-----
MMAR_3044|M.marinum_M               WRVNELIDPS-VLVPG----AAPGSR-FPAVTKAPVGWIPQRDGR-----
MUL_2288|M.ulcerans_Agy99           WRVNELIDPS-VLVPG----AAPGSR-FPAVTKAPVGWIPQRDGR-----
TH_0438|M.thermoresistible__bu      WRIAELDDTS-ALLDGFARRAAPAPA-TPAP-RPPIGWIPQDDGR-----
MAB_2200c|M.abscessus_ATCC_199      WRVAELPEGAGTLARAIDAVFIDGPPDPTPAPRAPVGWIEQLRTGESPGE
                                    **: ** :    *          .     .  :.*:*** *         

Mflv_3106|M.gilvum_PYR-GCK          -IALGAAVPLGVLDAQVARYLAAVEAPLTVTPWRSVLIFDLDEGVADVAL
Mvan_3429|M.vanbaalenii_PYR-1       -IALGAAVPLGVLDAQVARYLAAVEAPLAVTPWRSVLLFDLDEGVADVAL
MSMEG_3871|M.smegmatis_MC2_155      -VALGAGVPLGVLSARDAQFLAAIEAPIVITPWRSVLVFDLDEGVADTAL
Mb2090|M.bovis_AF2122/97            -VTLGAAVPLGVLPARVAECLAAIEAPLVITPWRSVLICDLDDATADAAL
Rv2064|M.tuberculosis_H37Rv         -VTLGAAVPLGVLPARVAECLAAIEAPLVITPWRSVLICDLDDATADAAL
MMAR_3044|M.marinum_M               -VTLGAAVPLGILPARVAEFLAAIEAPIAITPWRSVLVFDLDEAIADTAL
MUL_2288|M.ulcerans_Agy99           -VTLGAAVPLGILPARVAEFLAAIEAPIAITPWRSVLVFDLDEAIADTAL
TH_0438|M.thermoresistible__bu      -VTLAAGVPLGVLTARLAEFLAAIDAPLIVTPWRSVLVCDLDEGVADTAV
MAB_2200c|M.abscessus_ATCC_199      LVTLGAAVPLGQLPARVAALLAAVEKPVIVTPWRSVLLCDLPHGDADAVL
                                     ::*.*.**** * *: *  ***:: *: :*******: ** .. **..:

Mflv_3106|M.gilvum_PYR-GCK          RVLAPLGLIFDEDSAWLSVSACTGSPGCAHSAADVRADAGAAVDPSIAV-
Mvan_3429|M.vanbaalenii_PYR-1       RVLAPLGLVFDENSPWLSVSACTGSPGCERSVADVRADAAAAVDDPVTV-
MSMEG_3871|M.smegmatis_MC2_155      RVLAPMGLVFDENSPWLDVSACTGSPGCAKSLTDVRADAAAAAQEPSAN-
Mb2090|M.bovis_AF2122/97            RVLAPLGLVFDENSPWLNISACTGSPGCAHSAADVRADAARSLNVESAG-
Rv2064|M.tuberculosis_H37Rv         RVLAPLGLVFDENSPWLNISACTGSPGCAHSAADVRADAARSLNVESAG-
MMAR_3044|M.marinum_M               RVLAPLGLVFDENSPWLNVSACTGSPGCASSAADVRADAALSVRTEAAAS
MUL_2288|M.ulcerans_Agy99           RVLAPLGLVFDENSPWLNVSACTGSPGCASSAADVRADAALSVRTEAAAS
TH_0438|M.thermoresistible__bu      RVLAPLGLIFDENSPWLRISSCTGLPGCARSAADVRADAARAATEAAPXG
MAB_2200c|M.abscessus_ATCC_199      RVLAPLGLVFDERSPWLNASSCTGLPGCGRSRTDVHADVRLEVAEEIASG
                                    *****:**:*** *.**  *:*** ***  * :**:**.        .  

Mflv_3106|M.gilvum_PYR-GCK          -----HRHFVGCDRACGSPADAQVLVATGDGYRSREAHP
Mvan_3429|M.vanbaalenii_PYR-1       -----HRHFVGCERACGSPADGEVLVATGDGYRARKRHP
MSMEG_3871|M.smegmatis_MC2_155      -----HRHFVGCERACGSPPVGDVLVATEDGYRLRIASP
Mb2090|M.bovis_AF2122/97            -----HRHFVGCERACGSPPAGEVLVATGGGYRRLRP--
Rv2064|M.tuberculosis_H37Rv         -----HRHFVGCERACGSPPAGEVLVATGGGYRRLRP--
MMAR_3044|M.marinum_M               GV---HRHFVGCERACGSPLAGEVLVATAQGYRLLRKA-
MUL_2288|M.ulcerans_Agy99           GV---HRHFVGCERACGSPLAGEVLVATAQGYRLLRKA-
TH_0438|M.thermoresistible__bu      QTR-VHRHFVGCERACGTPPGAQVLVATGEGYRLRNPHP
MAB_2200c|M.abscessus_ATCC_199      IHSPVHRHWVGCPRACGSPSTGQVLVATELGYRPLERHP
                                         ***:*** ****:*  .:*****  ***