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VTRARDADACPGALQVHQAADGALVRVRLPGGRLTADQLAALARASNELASATLELTARGNLQLRAITDV MAVADAIANAGLLPSPTHERVRNIVASPLSGRVGGLADLQSWVGELDAAICAEPLLAQLGGRFWFSIDDG RADVSGLGADVGVHVLADGCAVLLDGRDTGVRLAPDDVVPTLTELAVRFTQMRGNFWRVNELIDPSVLVP GAAPGSRFPAVTKAPVGWIPQRDGRVTLGAAVPLGILPARVAEFLAAIEAPIAITPWRSVLVFDLDEAIA DTALRVLAPLGLVFDENSPWLNVSACTGSPGCASSAADVRADAALSVRTEAAASGVHRHFVGCERACGSP LAGEVLVATAQGYRLLRKA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_2288 | - | - | 100% (369) | cobalamin biosynthesis protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2090 | cobG | 1e-149 | 73.57% (367) | cobalamin biosynthesis protein CobG |
| M. gilvum PYR-GCK | Mflv_3106 | - | 1e-131 | 63.96% (369) | precorrin-3B synthase |
| M. tuberculosis H37Rv | Rv2064 | cobG | 1e-149 | 73.57% (367) | cobalamin biosynthesis protein CobG |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2200c | - | 1e-104 | 54.81% (385) | cobalamin biosynthesis protein CobG |
| M. marinum M | MMAR_3044 | - | 0.0 | 99.19% (369) | cobalamin biosynthesis protein |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_3871 | cobG | 1e-134 | 67.03% (370) | precorrin-3B synthase |
| M. thermoresistible (build 8) | TH_0438 | cobG | 1e-129 | 64.27% (375) | Possible cobalamin biosynthesis protein CobG |
| M. vanbaalenii PYR-1 | Mvan_3429 | - | 1e-131 | 64.71% (374) | precorrin-3B synthase |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_2288|M.ulcerans_Agy99 MTRARDADACPGALQVHQAADGALVRVRLPGGRLTADQLAALARASNELA
MMAR_3044|M.marinum_M MTRARDADACPGALQVHQAADGALVRVRLPGGRLTADQLAALARASNELA
Mb2090|M.bovis_AF2122/97 MAGTRDADACPGALRPHQAADGALARIRLPGGMITAAQLATLASVASDFG
Rv2064|M.tuberculosis_H37Rv MAGTRDADACPGALRPHQAADGALARIRLPGGMITAAQLATLASVASDFG
Mflv_3106|M.gilvum_PYR-GCK MVRAREKDACPGALQTHRAADGDLSRIRLPGGAITPPQLEVVAQAAIDLA
Mvan_3429|M.vanbaalenii_PYR-1 MARARDDDACPGALQTHRAADGDLARIRLPGGAITARQLEAVAQAAVNFG
MSMEG_3871|M.smegmatis_MC2_155 MTRTRDQDACPGALTVHQAADGALVRIRLAGGAITAAQLATLADVANDLG
TH_0438|M.thermoresistible__bu VERAREHDACPGALSVHPAADGALARIRLPGGMLTPAQLTALADAARRFG
MAB_2200c|M.abscessus_ATCC_199 MTRSSADDACPGALRLHEAADGALARIRLPGGMLSSAQLAALAEAAGDHG
: : ******* * **** * *:**.** ::. ** .:* .: .
MUL_2288|M.ulcerans_Agy99 SATLELTARGNLQLRAITDVMAVADAIANAGLLPSPTHERVRNIVASPLS
MMAR_3044|M.marinum_M SATLELTARGNLQLRAITDVMAVADAIANAGLLPSPTHERVRNIVASPLS
Mb2090|M.bovis_AF2122/97 SATLELTARGNVQLRGIRDVAAVADAVAKAGLLPSATHERVRNIVASPLS
Rv2064|M.tuberculosis_H37Rv SATLELTARGNVQLRGIRDVAAVADAVAKAGLLPSATHERVRNIVASPLS
Mflv_3106|M.gilvum_PYR-GCK ASTLELTSRGNLQIRGVRDTAAVADLLAGAGLLPSATHERVRNIVASPLS
Mvan_3429|M.vanbaalenii_PYR-1 TATLELTSRANLQIRGIHDTGAVAALLTDAGLLPSATHERVRNIVASPLS
MSMEG_3871|M.smegmatis_MC2_155 SPAMELTSRGNIQIRGLTDTDAAAAALAGAGLLPSPTHERVRNIVASPLT
TH_0438|M.thermoresistible__bu SEAMELTSRGNIQIRGISDPAAVADAVAAAGLLPSPTHETVRNIVASPLS
MAB_2200c|M.abscessus_ATCC_199 APILELTSRGNVQLRSVRDANAVGALLSEAGLLPSPRHERVRNIVASPLS
: :***:*.*:*:*.: * *.. :: ******. ** *********:
MUL_2288|M.ulcerans_Agy99 GRVGGLADLQSWVGELDAAICAEPLLAQLGGRFWFSIDDGRADVSGLGAD
MMAR_3044|M.marinum_M GRVGGLADVQSWVGELDAAICAEPLLAQLGGRFWFSIDDGRADVSGLGAD
Mb2090|M.bovis_AF2122/97 GRAGGLADVRAWVGELDAAIRAEPRLAELGGRFWFGLDDGRADVSGLGAD
Rv2064|M.tuberculosis_H37Rv GRAGGLADVRAWVGELDAAIRAEPRLAELGGRFWFGLDDGRADVSGLGAD
Mflv_3106|M.gilvum_PYR-GCK GRHGGLCDVRALVADLDAAVQRDPVLAELPGRFLFGFDDGRGDISGLGAD
Mvan_3429|M.vanbaalenii_PYR-1 GRSGGFCDARDLVRSLDHAVQQDPRLARLPGRFLFGIDDGRGDISGLGAD
MSMEG_3871|M.smegmatis_MC2_155 GRSGGVADVGALVSELDAAIQAEPELAGLPGRFLFGLDDGRGDISGLGPD
TH_0438|M.thermoresistible__bu GRCGGATDIRPWVTRLDHAIQSELALAALPGRFLFGIDDGRGDIAALAAD
MAB_2200c|M.abscessus_ATCC_199 GRAGEFPDARPLVSALDRGLTAAATLAELPGRFLFSLDDGRGDMAAMGAD
** * * * ** .: ** * *** *.:****.*::.:..*
MUL_2288|M.ulcerans_Agy99 VGVHVLADGC---AVLLDGRDTGVRLAPD-DVVPTLTELAVRFTQMRGNF
MMAR_3044|M.marinum_M VGVHVLADGC---AVLLDGRDTGVRLAPD-DVVPTLTELAVRFTQIRGNC
Mb2090|M.bovis_AF2122/97 VGVQVFPDGP---RLLLTGRDTGVRVA---DVAETLIEVALRFVKIRETA
Rv2064|M.tuberculosis_H37Rv VGVQVFPDGP---RLLLTGRDTGVRVA---DVAETLIEVALRFVKIRETA
Mflv_3106|M.gilvum_PYR-GCK AGVHALDDSTA--ALLLAGRDTGVRVALS-SAVDELLAVARRFVDGRGKH
Mvan_3429|M.vanbaalenii_PYR-1 AGIHVLDGHTA--ALLLAGRDTGVRLPLG-HVVDELLSVAARFLQVRGTA
MSMEG_3871|M.smegmatis_MC2_155 AGVHMLDAGTG--ALLLGGCDTGVRIDRA-GVVPTLITVARRFAKVHGKA
TH_0438|M.thermoresistible__bu VAVQTLGASGDEAAVLLAGRDSGVRVAAG-DAVEVMVTVARRFTASRGGA
MAB_2200c|M.abscessus_ATCC_199 IGLRHDQKGWR---LLLGGRTTSVCDGDAVDAVERMLTAARKFVEIRGNA
.:: :** * :.* .. : * :* :
MUL_2288|M.ulcerans_Agy99 WRVNELIDPS-VLVPG----AAPGSR-FPAVTKAPVGWIPQRDGR-----
MMAR_3044|M.marinum_M WRVNELIDPS-VLVPG----AAPGSR-FPAVTKAPVGWIPQRDGR-----
Mb2090|M.bovis_AF2122/97 WRVTELADIG-ELQSG----VELGPS-VRPVTKTPVGWIPQDDSR-----
Rv2064|M.tuberculosis_H37Rv WRVTELADIG-ELQSG----VELGPS-VRPVTKTPVGWIPQDDSR-----
Mflv_3106|M.gilvum_PYR-GCK WRVGELDDPA-ILLDGRAPTERPGGT-WQARTRPPVGWIEQTDGR-----
Mvan_3429|M.vanbaalenii_PYR-1 WRVDELDDPT-TLLGDRTPTAEPGAT-WPAHSRPPVGWIEQDDGR-----
MSMEG_3871|M.smegmatis_MC2_155 WRVGELDDLA-PLLEGLTATGAGGQR-WAPTVRPPVGWIPQRDGR-----
TH_0438|M.thermoresistible__bu WRIAELDDTS-ALLDGFARRAAPAPA-TPAP-RPPIGWIPQDDGR-----
MAB_2200c|M.abscessus_ATCC_199 WRVAELPEGAGTLARAIDAVFIDGPPDPTPAPRAPVGWIEQLRTGESPGE
**: ** : * . . :.*:*** *
MUL_2288|M.ulcerans_Agy99 -VTLGAAVPLGILPARVAEFLAAIEAPIAITPWRSVLVFDLDEAIADTAL
MMAR_3044|M.marinum_M -VTLGAAVPLGILPARVAEFLAAIEAPIAITPWRSVLVFDLDEAIADTAL
Mb2090|M.bovis_AF2122/97 -VTLGAAVPLGVLPARVAECLAAIEAPLVITPWRSVLICDLDDATADAAL
Rv2064|M.tuberculosis_H37Rv -VTLGAAVPLGVLPARVAECLAAIEAPLVITPWRSVLICDLDDATADAAL
Mflv_3106|M.gilvum_PYR-GCK -IALGAAVPLGVLDAQVARYLAAVEAPLTVTPWRSVLIFDLDEGVADVAL
Mvan_3429|M.vanbaalenii_PYR-1 -IALGAAVPLGVLDAQVARYLAAVEAPLAVTPWRSVLLFDLDEGVADVAL
MSMEG_3871|M.smegmatis_MC2_155 -VALGAGVPLGVLSARDAQFLAAIEAPIVITPWRSVLVFDLDEGVADTAL
TH_0438|M.thermoresistible__bu -VTLAAGVPLGVLTARLAEFLAAIDAPLIVTPWRSVLVCDLDEGVADTAV
MAB_2200c|M.abscessus_ATCC_199 LVTLGAAVPLGQLPARVAALLAAVEKPVIVTPWRSVLLCDLPHGDADAVL
::*.*.**** * *: * ***:: *: :*******: ** .. **..:
MUL_2288|M.ulcerans_Agy99 RVLAPLGLVFDENSPWLNVSACTGSPGCASSAADVRADAALSVRTEAAAS
MMAR_3044|M.marinum_M RVLAPLGLVFDENSPWLNVSACTGSPGCASSAADVRADAALSVRTEAAAS
Mb2090|M.bovis_AF2122/97 RVLAPLGLVFDENSPWLNISACTGSPGCAHSAADVRADAARSLNVESAG-
Rv2064|M.tuberculosis_H37Rv RVLAPLGLVFDENSPWLNISACTGSPGCAHSAADVRADAARSLNVESAG-
Mflv_3106|M.gilvum_PYR-GCK RVLAPLGLIFDEDSAWLSVSACTGSPGCAHSAADVRADAGAAVDPSIAV-
Mvan_3429|M.vanbaalenii_PYR-1 RVLAPLGLVFDENSPWLSVSACTGSPGCERSVADVRADAAAAVDDPVTV-
MSMEG_3871|M.smegmatis_MC2_155 RVLAPMGLVFDENSPWLDVSACTGSPGCAKSLTDVRADAAAAAQEPSAN-
TH_0438|M.thermoresistible__bu RVLAPLGLIFDENSPWLRISSCTGLPGCARSAADVRADAARAATEAAPXG
MAB_2200c|M.abscessus_ATCC_199 RVLAPLGLVFDERSPWLNASSCTGLPGCGRSRTDVHADVRLEVAEEIASG
*****:**:*** *.** *:*** *** * :**:**. .
MUL_2288|M.ulcerans_Agy99 GV---HRHFVGCERACGSPLAGEVLVATAQGYRLLRKA-
MMAR_3044|M.marinum_M GV---HRHFVGCERACGSPLAGEVLVATAQGYRLLRKA-
Mb2090|M.bovis_AF2122/97 -----HRHFVGCERACGSPPAGEVLVATGGGYRRLRP--
Rv2064|M.tuberculosis_H37Rv -----HRHFVGCERACGSPPAGEVLVATGGGYRRLRP--
Mflv_3106|M.gilvum_PYR-GCK -----HRHFVGCDRACGSPADAQVLVATGDGYRSREAHP
Mvan_3429|M.vanbaalenii_PYR-1 -----HRHFVGCERACGSPADGEVLVATGDGYRARKRHP
MSMEG_3871|M.smegmatis_MC2_155 -----HRHFVGCERACGSPPVGDVLVATEDGYRLRIASP
TH_0438|M.thermoresistible__bu QTR-VHRHFVGCERACGTPPGAQVLVATGEGYRLRNPHP
MAB_2200c|M.abscessus_ATCC_199 IHSPVHRHWVGCPRACGSPSTGQVLVATELGYRPLERHP
***:*** ****:* .:***** ***