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M. thermoresistible (build 8) TH_0416 (panB)

annotation: Probable 3-methyl-2-oxobutanoate hydroxymethyltransferase PanB
coordinates: 908801 - 909670
length: 290

aa seq not available

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. thermoresistible (build 8) TH_0416 panB - 100% (290) Probable 3-methyl-2-oxobutanoate hydroxymethyltransferase PanB

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb2249 panB 1e-131 79.86% (288) 3-methyl-2-oxobutanoate hydroxymethyltransferase
M. gilvum PYR-GCK Mflv_2903 panB 1e-134 81.25% (288) 3-methyl-2-oxobutanoate hydroxymethyltransferase
M. tuberculosis H37Rv Rv2225 panB 1e-131 79.86% (288) 3-methyl-2-oxobutanoate hydroxymethyltransferase
M. leprae Br4923 MLBr_01635 panB 1e-123 76.04% (288) 3-methyl-2-oxobutanoate hydroxymethyltransferase
M. abscessus ATCC 19977 MAB_1916c panB 1e-133 80.48% (292) 3-methyl-2-oxobutanoate hydroxymethyltransferase
M. marinum M MMAR_3299 panB 1e-132 80.28% (289) 3-methyl-2-oxobutanoate hydroxymethyltransferase PanB
M. avium 104 MAV_2239 panB 1e-134 81.94% (288) 3-methyl-2-oxobutanoate hydroxymethyltransferase
M. smegmatis MC2 155 MSMEG_4298 panB 1e-130 79.17% (288) 3-methyl-2-oxobutanoate hydroxymethyltransferase
M. ulcerans Agy99 MUL_1330 panB 1e-132 80.28% (289) 3-methyl-2-oxobutanoate hydroxymethyltransferase
M. vanbaalenii PYR-1 Mvan_3602 panB 1e-132 80.21% (288) 3-methyl-2-oxobutanoate hydroxymethyltransferase

CLUSTAL 2.0.9 multiple sequence alignment


Mb2249|M.bovis_AF2122/97            -------MSEQ--TIYGANTPGGS--GPRTKI---------RTHHLQRWK
Rv2225|M.tuberculosis_H37Rv         -------MSEQ--TIYGANTPGGS--GPRTKI---------RTHHLQRWK
TH_0416|M.thermoresistible__bu      ------MMSEH--SVYGAATDANTPARPRTQQSRTK----VRVHHLQKWK
MAB_1916c|M.abscessus_ATCC_199      -------MSES--ALYGAASEKSTEPRTQPDALRAKRSSQTRVHHLQKWK
Mflv_2903|M.gilvum_PYR-GCK          -------MSEQ--SVYGAGAETAVSSAPRVKV---------RTHHLHKWK
Mvan_3602|M.vanbaalenii_PYR-1       -------MSEQ--PVYGAAAEAPK---PRVKV---------RTHHLHKWK
MSMEG_4298|M.smegmatis_MC2_155      -------MSEQ--PIYGAANTSQSVVDTKPAQR-----TKVRTLTLQKWK
MAV_2239|M.avium_104                -------MSEH--NVYGAAQPAQPAQPAQPRTR-------IRTHHLQKMK
MMAR_3299|M.marinum_M               MSEQISEQSEQ--NVYGASSPVPAGESSPSAASAPR--TKVRTHHLQKWK
MUL_1330|M.ulcerans_Agy99           MSEQISEQSEQ--NVYGACPPVPAGESSPSAASAPR--TKVRTHHLQKWK
MLBr_01635|M.leprae_Br4923          -------MSEQNVNVYGADPSTSSIQSIQRTK--------IRTKHLQKMK
                                            **    :***                       *.  *:: *

Mb2249|M.bovis_AF2122/97            ADGHKWAMLTAYDYSTARIFDEAGIPVLLVGDSAANVVYGYDTTVPISID
Rv2225|M.tuberculosis_H37Rv         ADGHKWAMLTAYDYSTARIFDEAGIPVLLVGDSAANVVYGYDTTVPISID
TH_0416|M.thermoresistible__bu      AEGHKWAMLTAYDYSTARIFDDAQIPVLLVGDSAANVVYGYDTTVPISVD
MAB_1916c|M.abscessus_ATCC_199      AEGHKWSMLTAYDYSTARVFNDAGIPVLLVGDSAANVVYGYDTTVPITID
Mflv_2903|M.gilvum_PYR-GCK          SEGHKWAMLTAYDYSTAAVFDEAQIPVLLVGDSAANVVYGYDTTVPVTLD
Mvan_3602|M.vanbaalenii_PYR-1       AEGHKWAMLTAYDYSTAAVFDEAEIPVLLVGDSAANVVYGYDTTVPVTLD
MSMEG_4298|M.smegmatis_MC2_155      AEGHKWAMLTCYDYSSARVFDDAGIPVLLVGDSAANVVYGYDTTVPISID
MAV_2239|M.avium_104                AEGHKWAMLTAYDYSTARIFDEAGIPVLLVGDSAANVVYGYDTTVPVSID
MMAR_3299|M.marinum_M               AEGHKWAMLTVYDYSTARAFDDAGIPVLLVGDSAANVVYGYDTTVPISID
MUL_1330|M.ulcerans_Agy99           AEGHKWAMLTVYDYSTARAFDDAGIPVLLVGDSAANVVYGYDTTVPISID
MLBr_01635|M.leprae_Br4923          AEGHKWAMLTAYDYSTARVFDEAGIPVLLVGDSAANVVYGYDTTVPVSAD
                                    ::****:*** ****:*  *::* **********************:: *

Mb2249|M.bovis_AF2122/97            ELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAATRFLKDGGAHAV
Rv2225|M.tuberculosis_H37Rv         ELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAATRFLKDGGAHAV
TH_0416|M.thermoresistible__bu      ELIPLVRGVVRGAPHALVVADLPFGSYESGAQQALASATRFMKEAGAHAI
MAB_1916c|M.abscessus_ATCC_199      ELIPLVRGVVRGAPEALVVADLPFGSYEGGAAQALASATRFMKEAGAHAV
Mflv_2903|M.gilvum_PYR-GCK          ELIPLVRGVVRGAPHALVVADLPFGSYEAGAQQALATATRMLKETGAHAV
Mvan_3602|M.vanbaalenii_PYR-1       ELIPLVRGVVRGAPHALVVADLPFGSYEAGPQQALATATRMLKETGAHAV
MSMEG_4298|M.smegmatis_MC2_155      ELIPLARAVVKGAPHALVIGDLPFGSYEDGPSQALATATRFMKEAGVHAV
MAV_2239|M.avium_104                ELIPLVRGVVRGAPHALVVADLPFGSYEAGPAAALAAATRFMKEGGAHAV
MMAR_3299|M.marinum_M               ELIPLVRGVVRGAPHALVVADLPFGSYESGPSAALAAATRFMKEAGAHAV
MUL_1330|M.ulcerans_Agy99           ELIPLVRGVVRGAPHALVVADLPFGSYESGPSAALAAATRFMKEAGAHAV
MLBr_01635|M.leprae_Br4923          ELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAALAVATRFMKEGGAHAV
                                    **:**.*.**:** .***:.******** *.  *** ***::*: *.**:

Mb2249|M.bovis_AF2122/97            KLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAEQ
Rv2225|M.tuberculosis_H37Rv         KLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAEQ
TH_0416|M.thermoresistible__bu      KLEGGERVAEQIATLTAAGIPVVAHIGFTPQSVNTLGGFRVQGRGEAGEQ
MAB_1916c|M.abscessus_ATCC_199      KLEGGERVAEQIATLTAAGIPVVAHIGFTPQSVNGLGGYRVQGRDDAAAQ
Mflv_2903|M.gilvum_PYR-GCK          KLEGGERVAEQIAAVTAAGIPVMAHIGFTPQSVNGLGGFRVQGRGDAAEQ
Mvan_3602|M.vanbaalenii_PYR-1       KLEGGERVADQIAAVSAAGIPVMAHIGFTPQSVNGLGGFRVQGRGDAAEQ
MSMEG_4298|M.smegmatis_MC2_155      KLEGGERVADQIATLSRAGIPVVAHIGFTPQSVNGLGGFRVQGRGDAADQ
MAV_2239|M.avium_104                KLEGGERVAEQIAHLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRGDAAEQ
MMAR_3299|M.marinum_M               KLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAEQ
MUL_1330|M.ulcerans_Agy99           KLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAEQ
MLBr_01635|M.leprae_Br4923          KLEGGQRVAEQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRGGDAEQ
                                    *****:***:*** :: *****:*********** ***:*****.  . *

Mb2249|M.bovis_AF2122/97            TIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQV
Rv2225|M.tuberculosis_H37Rv         TIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQV
TH_0416|M.thermoresistible__bu      TIHDALAVQEAGAVAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDAQV
MAB_1916c|M.abscessus_ATCC_199      LIHDAIAVQEAGAIAVVMEMVPAELATQITGKLTIPTVGIGAGRECDAQV
Mflv_2903|M.gilvum_PYR-GCK          TIHDAIAVQEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDAQV
Mvan_3602|M.vanbaalenii_PYR-1       TIHDAIAVQEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPSCDAQV
MSMEG_4298|M.smegmatis_MC2_155      TIRDAIAVAEAGAVAVVLEMVPAELATQITGKLTIPTVGIGAGPNCDAQV
MAV_2239|M.avium_104                TIADAIAVAEAGAFSVVMEMVPAGLATQITGKLTIPTIGIGAGPNCDGQV
MMAR_3299|M.marinum_M               TIADAIAVAEAGAFSVVMEMVPAELATQITGKLTIPTIGIGAGPSCDGQV
MUL_1330|M.ulcerans_Agy99           TIADAIAVAEAGAFSVVMEMVPAELATQITGKLTIPTIGIGAGPSCDGQV
MLBr_01635|M.leprae_Br4923          TVADAVAVAEAGAFSVVMEMVPTELATQITGKLTIPTIGIGAGLNCDAQV
                                     : **:** ****.:**:****: *************:***** .**.**

Mb2249|M.bovis_AF2122/97            LVWQDMAGFSGAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHS
Rv2225|M.tuberculosis_H37Rv         LVWQDMAGFSGAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHS
TH_0416|M.thermoresistible__bu      LVWQDMAGMTAGKTARFVKRFGEVGAELGRAAAQFAEEVAAGTFPAEQHC
MAB_1916c|M.abscessus_ATCC_199      LVWQDMAGMTSGKTAKFVKQFGQVGAELRKAAEQYADEVARGVFPAPEHS
Mflv_2903|M.gilvum_PYR-GCK          LVWQDMAGMTNGRTAKFVKRFGAVGDELRRAATEYAQEVATGVFPAEEHS
Mvan_3602|M.vanbaalenii_PYR-1       LVWQDMAGMTNGKTAKFVKRFGAVGDELRRAASDYAREVATGAFPADEHS
MSMEG_4298|M.smegmatis_MC2_155      LVWQDMAGLTSGKTAKFVRRFGDVGGELHRAATQFADDVAAGVFPAEEHS
MAV_2239|M.avium_104                LVWQDMAGMSSGKSARFVKRFADIGGELRRAATQYAHEVAAGVFPADEHC
MMAR_3299|M.marinum_M               LVWQDMAGLSSGKAPRFVKRYADVGGELRRAAVQYAQDVAGGVFPAEEHC
MUL_1330|M.ulcerans_Agy99           LVWQDMAGLSSGKAPRFVKRYADVGGELRRAAVQYAQDVAGGVFPAEEHC
MLBr_01635|M.leprae_Br4923          LVWQDMAGLSSGKVARFVKQYADIAGELRRAAMQYAEEVASAVFPAEEHC
                                    ********:: .: .:**:::. :. ** :** ::* :** ..*** :*.

Mb2249|M.bovis_AF2122/97            F
Rv2225|M.tuberculosis_H37Rv         F
TH_0416|M.thermoresistible__bu      F
MAB_1916c|M.abscessus_ATCC_199      Y
Mflv_2903|M.gilvum_PYR-GCK          Y
Mvan_3602|M.vanbaalenii_PYR-1       Y
MSMEG_4298|M.smegmatis_MC2_155      Y
MAV_2239|M.avium_104                F
MMAR_3299|M.marinum_M               F
MUL_1330|M.ulcerans_Agy99           F
MLBr_01635|M.leprae_Br4923          F
                                    :

species	id	gene	e-value	identity (len)	annotation
M. thermoresistible (build 8)	TH_0416	panB	-	100% (290)	Probable 3-methyl-2-oxobutanoate hydroxymethyltransferase PanB