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MSEQPVYGAAAEAPKPRVKVRTHHLHKWKAEGHKWAMLTAYDYSTAAVFDEAEIPVLLVGDSAANVVYGY DTTVPVTLDELIPLVRGVVRGAPHALVVADLPFGSYEAGPQQALATATRMLKETGAHAVKLEGGERVADQ IAAVSAAGIPVMAHIGFTPQSVNGLGGFRVQGRGDAAEQTIHDAIAVQEAGAFAVVMEMVPAELATQITG KLTIPTVGIGAGPSCDAQVLVWQDMAGMTNGKTAKFVKRFGAVGDELRRAASDYAREVATGAFPADEHSY
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3602 | panB | - | 100% (280) | 3-methyl-2-oxobutanoate hydroxymethyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2249 | panB | 1e-131 | 82.21% (281) | 3-methyl-2-oxobutanoate hydroxymethyltransferase |
| M. gilvum PYR-GCK | Mflv_2903 | panB | 1e-149 | 92.93% (283) | 3-methyl-2-oxobutanoate hydroxymethyltransferase |
| M. tuberculosis H37Rv | Rv2225 | panB | 1e-131 | 82.21% (281) | 3-methyl-2-oxobutanoate hydroxymethyltransferase |
| M. leprae Br4923 | MLBr_01635 | panB | 1e-120 | 75.52% (286) | 3-methyl-2-oxobutanoate hydroxymethyltransferase |
| M. abscessus ATCC 19977 | MAB_1916c | panB | 1e-127 | 78.77% (292) | 3-methyl-2-oxobutanoate hydroxymethyltransferase |
| M. marinum M | MMAR_3299 | panB | 1e-129 | 78.55% (289) | 3-methyl-2-oxobutanoate hydroxymethyltransferase PanB |
| M. avium 104 | MAV_2239 | panB | 1e-131 | 81.05% (285) | 3-methyl-2-oxobutanoate hydroxymethyltransferase |
| M. smegmatis MC2 155 | MSMEG_4298 | panB | 1e-129 | 79.09% (287) | 3-methyl-2-oxobutanoate hydroxymethyltransferase |
| M. thermoresistible (build 8) | TH_0416 | panB | 1e-132 | 80.21% (288) | Probable 3-methyl-2-oxobutanoate hydroxymethyltransferase |
| M. ulcerans Agy99 | MUL_1330 | panB | 1e-129 | 78.55% (289) | 3-methyl-2-oxobutanoate hydroxymethyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2249|M.bovis_AF2122/97 -------MSEQ--TIYGANTPGGS--GPRTKI---------RTHHLQRWK
Rv2225|M.tuberculosis_H37Rv -------MSEQ--TIYGANTPGGS--GPRTKI---------RTHHLQRWK
Mvan_3602|M.vanbaalenii_PYR-1 -------MSEQ--PVYGAAAEAPK---PRVKV---------RTHHLHKWK
Mflv_2903|M.gilvum_PYR-GCK -------MSEQ--SVYGAGAETAVSSAPRVKV---------RTHHLHKWK
MAB_1916c|M.abscessus_ATCC_199 -------MSES--ALYGAASEKSTEPRTQPDALRAKRSSQTRVHHLQKWK
TH_0416|M.thermoresistible__bu ------MMSEH--SVYGAATDANTPARPRTQQSRTK----VRVHHLQKWK
MSMEG_4298|M.smegmatis_MC2_155 -------MSEQ--PIYGAANTSQSVVDTKPAQR-----TKVRTLTLQKWK
MAV_2239|M.avium_104 -------MSEH--NVYGAAQPAQPAQPAQPRTR-------IRTHHLQKMK
MMAR_3299|M.marinum_M MSEQISEQSEQ--NVYGASSPVPAGESSPSAASAPR--TKVRTHHLQKWK
MUL_1330|M.ulcerans_Agy99 MSEQISEQSEQ--NVYGACPPVPAGESSPSAASAPR--TKVRTHHLQKWK
MLBr_01635|M.leprae_Br4923 -------MSEQNVNVYGADPSTSSIQSIQRTK--------IRTKHLQKMK
** :*** *. *:: *
Mb2249|M.bovis_AF2122/97 ADGHKWAMLTAYDYSTARIFDEAGIPVLLVGDSAANVVYGYDTTVPISID
Rv2225|M.tuberculosis_H37Rv ADGHKWAMLTAYDYSTARIFDEAGIPVLLVGDSAANVVYGYDTTVPISID
Mvan_3602|M.vanbaalenii_PYR-1 AEGHKWAMLTAYDYSTAAVFDEAEIPVLLVGDSAANVVYGYDTTVPVTLD
Mflv_2903|M.gilvum_PYR-GCK SEGHKWAMLTAYDYSTAAVFDEAQIPVLLVGDSAANVVYGYDTTVPVTLD
MAB_1916c|M.abscessus_ATCC_199 AEGHKWSMLTAYDYSTARVFNDAGIPVLLVGDSAANVVYGYDTTVPITID
TH_0416|M.thermoresistible__bu AEGHKWAMLTAYDYSTARIFDDAQIPVLLVGDSAANVVYGYDTTVPISVD
MSMEG_4298|M.smegmatis_MC2_155 AEGHKWAMLTCYDYSSARVFDDAGIPVLLVGDSAANVVYGYDTTVPISID
MAV_2239|M.avium_104 AEGHKWAMLTAYDYSTARIFDEAGIPVLLVGDSAANVVYGYDTTVPVSID
MMAR_3299|M.marinum_M AEGHKWAMLTVYDYSTARAFDDAGIPVLLVGDSAANVVYGYDTTVPISID
MUL_1330|M.ulcerans_Agy99 AEGHKWAMLTVYDYSTARAFDDAGIPVLLVGDSAANVVYGYDTTVPISID
MLBr_01635|M.leprae_Br4923 AEGHKWAMLTAYDYSTARVFDEAGIPVLLVGDSAANVVYGYDTTVPVSAD
::****:*** ****:* *::* **********************:: *
Mb2249|M.bovis_AF2122/97 ELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAATRFLKDGGAHAV
Rv2225|M.tuberculosis_H37Rv ELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAATRFLKDGGAHAV
Mvan_3602|M.vanbaalenii_PYR-1 ELIPLVRGVVRGAPHALVVADLPFGSYEAGPQQALATATRMLKETGAHAV
Mflv_2903|M.gilvum_PYR-GCK ELIPLVRGVVRGAPHALVVADLPFGSYEAGAQQALATATRMLKETGAHAV
MAB_1916c|M.abscessus_ATCC_199 ELIPLVRGVVRGAPEALVVADLPFGSYEGGAAQALASATRFMKEAGAHAV
TH_0416|M.thermoresistible__bu ELIPLVRGVVRGAPHALVVADLPFGSYESGAQQALASATRFMKEAGAHAI
MSMEG_4298|M.smegmatis_MC2_155 ELIPLARAVVKGAPHALVIGDLPFGSYEDGPSQALATATRFMKEAGVHAV
MAV_2239|M.avium_104 ELIPLVRGVVRGAPHALVVADLPFGSYEAGPAAALAAATRFMKEGGAHAV
MMAR_3299|M.marinum_M ELIPLVRGVVRGAPHALVVADLPFGSYESGPSAALAAATRFMKEAGAHAV
MUL_1330|M.ulcerans_Agy99 ELIPLVRGVVRGAPHALVVADLPFGSYESGPSAALAAATRFMKEAGAHAV
MLBr_01635|M.leprae_Br4923 ELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAALAVATRFMKEGGAHAV
**:**.*.**:** .***:.******** *. *** ***::*: *.**:
Mb2249|M.bovis_AF2122/97 KLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAEQ
Rv2225|M.tuberculosis_H37Rv KLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAEQ
Mvan_3602|M.vanbaalenii_PYR-1 KLEGGERVADQIAAVSAAGIPVMAHIGFTPQSVNGLGGFRVQGRGDAAEQ
Mflv_2903|M.gilvum_PYR-GCK KLEGGERVAEQIAAVTAAGIPVMAHIGFTPQSVNGLGGFRVQGRGDAAEQ
MAB_1916c|M.abscessus_ATCC_199 KLEGGERVAEQIATLTAAGIPVVAHIGFTPQSVNGLGGYRVQGRDDAAAQ
TH_0416|M.thermoresistible__bu KLEGGERVAEQIATLTAAGIPVVAHIGFTPQSVNTLGGFRVQGRGEAGEQ
MSMEG_4298|M.smegmatis_MC2_155 KLEGGERVADQIATLSRAGIPVVAHIGFTPQSVNGLGGFRVQGRGDAADQ
MAV_2239|M.avium_104 KLEGGERVAEQIAHLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRGDAAEQ
MMAR_3299|M.marinum_M KLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAEQ
MUL_1330|M.ulcerans_Agy99 KLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAEQ
MLBr_01635|M.leprae_Br4923 KLEGGQRVAEQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRGGDAEQ
*****:***:*** :: *****:*********** ***:*****. . *
Mb2249|M.bovis_AF2122/97 TIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQV
Rv2225|M.tuberculosis_H37Rv TIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQV
Mvan_3602|M.vanbaalenii_PYR-1 TIHDAIAVQEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPSCDAQV
Mflv_2903|M.gilvum_PYR-GCK TIHDAIAVQEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDAQV
MAB_1916c|M.abscessus_ATCC_199 LIHDAIAVQEAGAIAVVMEMVPAELATQITGKLTIPTVGIGAGRECDAQV
TH_0416|M.thermoresistible__bu TIHDALAVQEAGAVAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDAQV
MSMEG_4298|M.smegmatis_MC2_155 TIRDAIAVAEAGAVAVVLEMVPAELATQITGKLTIPTVGIGAGPNCDAQV
MAV_2239|M.avium_104 TIADAIAVAEAGAFSVVMEMVPAGLATQITGKLTIPTIGIGAGPNCDGQV
MMAR_3299|M.marinum_M TIADAIAVAEAGAFSVVMEMVPAELATQITGKLTIPTIGIGAGPSCDGQV
MUL_1330|M.ulcerans_Agy99 TIADAIAVAEAGAFSVVMEMVPAELATQITGKLTIPTIGIGAGPSCDGQV
MLBr_01635|M.leprae_Br4923 TVADAVAVAEAGAFSVVMEMVPTELATQITGKLTIPTIGIGAGLNCDAQV
: **:** ****.:**:****: *************:***** .**.**
Mb2249|M.bovis_AF2122/97 LVWQDMAGFSGAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHS
Rv2225|M.tuberculosis_H37Rv LVWQDMAGFSGAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHS
Mvan_3602|M.vanbaalenii_PYR-1 LVWQDMAGMTNGKTAKFVKRFGAVGDELRRAASDYAREVATGAFPADEHS
Mflv_2903|M.gilvum_PYR-GCK LVWQDMAGMTNGRTAKFVKRFGAVGDELRRAATEYAQEVATGVFPAEEHS
MAB_1916c|M.abscessus_ATCC_199 LVWQDMAGMTSGKTAKFVKQFGQVGAELRKAAEQYADEVARGVFPAPEHS
TH_0416|M.thermoresistible__bu LVWQDMAGMTAGKTARFVKRFGEVGAELGRAAAQFAEEVAAGTFPAEQHC
MSMEG_4298|M.smegmatis_MC2_155 LVWQDMAGLTSGKTAKFVRRFGDVGGELHRAATQFADDVAAGVFPAEEHS
MAV_2239|M.avium_104 LVWQDMAGMSSGKSARFVKRFADIGGELRRAATQYAHEVAAGVFPADEHC
MMAR_3299|M.marinum_M LVWQDMAGLSSGKAPRFVKRYADVGGELRRAAVQYAQDVAGGVFPAEEHC
MUL_1330|M.ulcerans_Agy99 LVWQDMAGLSSGKAPRFVKRYADVGGELRRAAVQYAQDVAGGVFPAEEHC
MLBr_01635|M.leprae_Br4923 LVWQDMAGLSSGKVARFVKQYADIAGELRRAAMQYAEEVASAVFPAEEHC
********:: .: .:**:::. :. ** :** ::* :** ..*** :*.
Mb2249|M.bovis_AF2122/97 F
Rv2225|M.tuberculosis_H37Rv F
Mvan_3602|M.vanbaalenii_PYR-1 Y
Mflv_2903|M.gilvum_PYR-GCK Y
MAB_1916c|M.abscessus_ATCC_199 Y
TH_0416|M.thermoresistible__bu F
MSMEG_4298|M.smegmatis_MC2_155 Y
MAV_2239|M.avium_104 F
MMAR_3299|M.marinum_M F
MUL_1330|M.ulcerans_Agy99 F
MLBr_01635|M.leprae_Br4923 F
: