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M. thermoresistible (build 8) TH_0329 (rmlC)

annotation: dTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE RMLC (dTDP-4-KETO-6-DEOXYGLUCOSE 3,5-EPIMERASE) (dTDP-L-RHAMNOSE SYNTHETASE) (THYMIDINE DIPHOSPHO-4-KETO-RHAMNOSE 3,5-EPIMERASE)
coordinates: 726818 - 727468
length: 217

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_0329rmlC-100% (217)dTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE RMLC (dTDP-4-KETO-6-DEOXYGLUCOSE 3,5-EPIMERASE) (dTDP-L-RHAMNOSE SYNTHETASE) (THYMIDINE DIPHOSPHO-4-KETO-RHAMNOSE 3,5-EPIMERASE)

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3494rmlC3e-7966.16% (198) dTDP-4-dehydrorhamnose 3,5-epimerase RmlC
M. gilvum PYR-GCKMflv_3297-6e-1232.02% (178) dTDP-4-dehydrorhamnose reductase
M. tuberculosis H37RvRv3465rmlC3e-7966.16% (198) dTDP-4-dehydrorhamnose 3,5-epimerase RmlC
M. leprae Br4923MLBr_01965rmlC3e-7865.83% (199) dTDP-4-dehydrorhamnose 3,5-epimerase
M. abscessus ATCC 19977MAB_3780-3e-6760.40% (202) dTDP-4-dehydrorhamnose 3,5-epimerase RmlC
M. marinum MMMAR_1081rmlC2e-8171.21% (198) dTDP-4-dehydrorhamnose 3,5-epimerase, RmlC
M. avium 104MAV_4407rfbC5e-8472.14% (201) dTDP-4-dehydrorhamnose 3,5-epimerase
M. smegmatis MC2 155MSMEG_1510-7e-8171.00% (200) dTDP-4-dehydrorhamnose 3,5-epimerase
M. ulcerans Agy99MUL_0839rmlC3e-8170.71% (198) dTDP-4-dehydrorhamnose 3,5-epimerase, RmlC
M. vanbaalenii PYR-1Mvan_1364-6e-7766.50% (203) dTDP-4-dehydrorhamnose 3,5-epimerase

CLUSTAL 2.0.9 multiple sequence alignment


Mb3494|M.bovis_AF2122/97            ------------MKARELDVPGAWEITPTIHVDSRGLFFEWLTDHGFRAF
Rv3465|M.tuberculosis_H37Rv         ------------MKARELDVPGAWEITPTIHVDSRGLFFEWLTDHGFRAF
MMAR_1081|M.marinum_M               ------------MQARELKVPGAWEITPTIHGDSRGMFFEWLTDSGFTAF
MUL_0839|M.ulcerans_Agy99           ------------MQARELKVPGAWEITPTIHGDSRGMFFEWLTDSGFTAF
MLBr_01965|M.leprae_Br4923          ------------MNVKELDISGAWEITPTIHSDSRGMFFEWLTASRFSAF
MAV_4407|M.avium_104                ------------MSARELKIPGAWEITPTVHGDARGHFFEWLTDKGFRSF
TH_0329|M.thermoresistible__bu      VTVPENVPQNVPENVRALRVPGAWEITPRLHEDARGVFFEWFTDAQFSAF
MSMEG_1510|M.smegmatis_MC2_155      ------------MTARELSIAGAWEITPVLRTDSRGLFFEWFTDAGFTEF
Mvan_1364|M.vanbaalenii_PYR-1       ------------MNVRELTIPGAWEITPVVHTDARGAFFEWFTDAGFTAI
MAB_3780|M.abscessus_ATCC_1997      ------------MKIRELSVPGSFEITPVQHHDSRGVFLELFKGPALAEA
Mflv_3297|M.gilvum_PYR-GCK          -----MTDFGKTLRAVETSIPGLTLWDLPVHGDNRGWFKENWQRAKMVAA
                                                       :.*        : * ** * *      :   

Mb3494|M.bovis_AF2122/97            AGHSLDVRQVNCSVSSA-GVLRGLHFAQLPPSQAKYVTCVSGSVFDVVVD
Rv3465|M.tuberculosis_H37Rv         AGHSLDVRQVNCSVSSA-GVLRGLHFAQLPPSQAKYVTCVSGSVFDVVVD
MMAR_1081|M.marinum_M               CGHRFDVRQANCSVSSA-GVLRGLHFAELPPSQAKYVTCVSGAVFDVVVD
MUL_0839|M.ulcerans_Agy99           CGHRFDVRQANCSVSSA-GVLRGLHFAELPPSQSKYVTCVSGAVFDVVVD
MLBr_01965|M.leprae_Br4923          TGHRLDVRQANCSVSSA-GVLRGLHFAQVPPSQAKYVTCVTGSVFDVVVD
MAV_4407|M.avium_104                AGHRLDVRQANCSVSAA-GVLRGLHFAQVPPSQAKYVTCVRGSVFDVVVD
TH_0329|M.thermoresistible__bu      AGHRFDLRQANCSVSAK-GVLRGLHFAEVPPSQAKYVTCVTGAVFDVVVD
MSMEG_1510|M.smegmatis_MC2_155      AGHQFDMRQANCSVSAR-GVLRGVHFAQVPPSQAKYVTCVRGAVFDVVVD
Mvan_1364|M.vanbaalenii_PYR-1       TGHRLDLRQANCSVSRA-GVLRGVHFAQLPPSQAKYVSCVRGAVVDVVVD
MAB_3780|M.abscessus_ATCC_1997      IGHPFELQQANCSVSAA-GSLRGIHFADVPPGQAKYVTCLTGSVYDVVVD
Mflv_3297|M.gilvum_PYR-GCK          GLPDFGPVQNNISFNQAPGTLRGIHAEPWD----KFISVGSGRIFGAWVD
                                        :   * * *..   * ***:*         *:::   * : .. **

Mb3494|M.bovis_AF2122/97            IREGSPTFGRWDSVLLDDQDRRTIYVSEGLAHGFLALQDNSTVMYLCSAE
Rv3465|M.tuberculosis_H37Rv         IREGSPTFGRWDSVLLDDQDRRTIYVSEGLAHGFLALQDNSTVMYLCSAE
MMAR_1081|M.marinum_M               IRLGSPTFGQWDSVLLDDR-HRSIYISEGLAHGFLALQDKSTVMYMCSAE
MUL_0839|M.ulcerans_Agy99           IRLGSPTFGQWDSVLLDDR-HRSIYISEGLAHGFLALQDKSTVMYMCSAE
MLBr_01965|M.leprae_Br4923          IRLGSPTFGCWTSITLNDSNRKTIYISESLAHGFLALQDNSTVMYLCSAE
MAV_4407|M.avium_104                IRVGSPTFGQWDSVLLDDAEHRTIYISEGLGHGFLALQDNSTVMYLCSAE
TH_0329|M.thermoresistible__bu      IRVGSPTFGQWDAVLLDGANRKSVYISEGLAHGFLALEDTSTVMYLCSAP
MSMEG_1510|M.smegmatis_MC2_155      IRVGSPTFGQWDAVLLDDKDRRSIYISEGLGHAFLALDDDSTVMYLCSAP
Mvan_1364|M.vanbaalenii_PYR-1       IRVGSPTFGRWDAVVLDDETHRSVYLSEGLGHAFLALHDDSVVTYLCSAG
MAB_3780|M.abscessus_ATCC_1997      IRVGSPTFGAWDAVLLDPRDRRAVYVPEGVGHGFLALEDDSTVVYLCSAG
Mflv_3297|M.gilvum_PYR-GCK          LRSG-PTFGTVFTAEIDPS--RAVFVPRGVGNAFQTLEPETVYVYLVNDH
                                    :* * ****   :  ::    :::::...:.:.* :*.  :.  *: .  

Mb3494|M.bovis_AF2122/97            YNPQR-EHTICATDPTLAVDWPLVDG----AAPSLSDRDAAAPSFEDVR-
Rv3465|M.tuberculosis_H37Rv         YNPQR-EHTICATDPTLAVDWPLVDG----AAPSLSDRDAAAPSFEDVR-
MMAR_1081|M.marinum_M               YNPQR-EHTICATDPELAIDWPLVDG----APPSLSERDAAAGSLDEVR-
MUL_0839|M.ulcerans_Agy99           YNPQR-EHTICATDPELAIDWPLVDG----APPSLSERDAAAGSLDEVR-
MLBr_01965|M.leprae_Br4923          YNPAR-EHAICATDPDLAIDWPVVDG----VDTHLSKRDATAPNLDDIR-
MAV_4407|M.avium_104                YNPGR-EHTICATDPALGIDWPLVAG----AAPTLSERDAAAPSLEEVR-
TH_0329|M.thermoresistible__bu      YTPDR-EHTVAALDPAIGIEWPTLDAP---AGRVLSERDAAAPTLVEAE-
MSMEG_1510|M.smegmatis_MC2_155      YAPQR-EHTVRPTD--FGIEWPEVP------ELILSDRDAQAPSLAEAQ-
Mvan_1364|M.vanbaalenii_PYR-1       YDPAR-EHTIDPLDPALEIDWNAWPSRAADGELILSDRDRAAPSLEQAR-
MAB_3780|M.abscessus_ATCC_1997      YAPGR-EHGIDPLDPTVGIQWPTRRPDGTELSLLVSEKDGAAPSLLDAR-
Mflv_3297|M.gilvum_PYR-GCK          YSPGVGYPSLNPGDEALAIEWPIPLDR-----AEMSEKDRAQPPLSEVTP
                                    * *      : . *  . ::*             :*.:*     : :   

Mb3494|M.bovis_AF2122/97            --------------------------------------------------
Rv3465|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_1081|M.marinum_M               --------------------------------------------------
MUL_0839|M.ulcerans_Agy99           --------------------------------------------------
MLBr_01965|M.leprae_Br4923          --------------------------------------------------
MAV_4407|M.avium_104                --------------------------------------------------
TH_0329|M.thermoresistible__bu      --------------------------------------------------
MSMEG_1510|M.smegmatis_MC2_155      --------------------------------------------------
Mvan_1364|M.vanbaalenii_PYR-1       --------------------------------------------------
MAB_3780|M.abscessus_ATCC_1997      --------------------------------------------------
Mflv_3297|M.gilvum_PYR-GCK          VPGPKTLVLGADGQLGRALRAAYAEAPHVEFATRAELDLCAPDLDSARRW
                                                                                      

Mb3494|M.bovis_AF2122/97            --------------------ASGLLPRWEQTQRFIGEMRGT---------
Rv3465|M.tuberculosis_H37Rv         --------------------ASGLLPRWEQTQRFIGEMRGT---------
MMAR_1081|M.marinum_M               --------------------ASGVLPTWEETQRFIDGLRGT---------
MUL_0839|M.ulcerans_Agy99           --------------------ASGVLPTWEETQRFIDGLRGT---------
MLBr_01965|M.leprae_Br4923          --------------------ASGLLPTWDETQNFIANLGSK---------
MAV_4407|M.avium_104                --------------------ASGLLPTWAETQAFIEGLPR----------
TH_0329|M.thermoresistible__bu      --------------------AAGLLPSWEETRAFVASLRRHG--------
MSMEG_1510|M.smegmatis_MC2_155      --------------------AAGVLPTWADCQAFVETLRRNLVS------
Mvan_1364|M.vanbaalenii_PYR-1       --------------------TSGLLPTWEQTKKFVDGLRTGR--------
MAB_3780|M.abscessus_ATCC_1997      --------------------DSGLLPDAAEVQAFLDGLSG----------
Mflv_3297|M.gilvum_PYR-GCK          RDYDTIVNAAAYTAVDAAETSEGRTAAWTVNVTGVAALARVATAHGITLV
                                                          *  .        :  :            

Mb3494|M.bovis_AF2122/97            --------------------------------------------------
Rv3465|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_1081|M.marinum_M               --------------------------------------------------
MUL_0839|M.ulcerans_Agy99           --------------------------------------------------
MLBr_01965|M.leprae_Br4923          --------------------------------------------------
MAV_4407|M.avium_104                --------------------------------------------------
TH_0329|M.thermoresistible__bu      --------------------------------------------------
MSMEG_1510|M.smegmatis_MC2_155      --------------------------------------------------
Mvan_1364|M.vanbaalenii_PYR-1       --------------------------------------------------
MAB_3780|M.abscessus_ATCC_1997      --------------------------------------------------
Mflv_3297|M.gilvum_PYR-GCK          HVSSDYVFDGSAASPYREDDPLSPLGVYGQTKAAGDQLVSTVPRHYVVRT
                                                                                      

Mb3494|M.bovis_AF2122/97            --------------------------------------------------
Rv3465|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_1081|M.marinum_M               --------------------------------------------------
MUL_0839|M.ulcerans_Agy99           --------------------------------------------------
MLBr_01965|M.leprae_Br4923          --------------------------------------------------
MAV_4407|M.avium_104                --------------------------------------------------
TH_0329|M.thermoresistible__bu      --------------------------------------------------
MSMEG_1510|M.smegmatis_MC2_155      --------------------------------------------------
Mvan_1364|M.vanbaalenii_PYR-1       --------------------------------------------------
MAB_3780|M.abscessus_ATCC_1997      --------------------------------------------------
Mflv_3297|M.gilvum_PYR-GCK          SWVVGEGRNFVQTMLSLAAKGVDPAVVDDQFGRLTFTSELARAVRHLTES
                                                                                      

Mb3494|M.bovis_AF2122/97            --------------------------------------------------
Rv3465|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_1081|M.marinum_M               --------------------------------------------------
MUL_0839|M.ulcerans_Agy99           --------------------------------------------------
MLBr_01965|M.leprae_Br4923          --------------------------------------------------
MAV_4407|M.avium_104                --------------------------------------------------
TH_0329|M.thermoresistible__bu      --------------------------------------------------
MSMEG_1510|M.smegmatis_MC2_155      --------------------------------------------------
Mvan_1364|M.vanbaalenii_PYR-1       --------------------------------------------------
MAB_3780|M.abscessus_ATCC_1997      --------------------------------------------------
Mflv_3297|M.gilvum_PYR-GCK          RAPYGTYNVSGSGTERTWADIARRTFDLAGHDPRRVRGVSTAEYFSAATA
                                                                                      

Mb3494|M.bovis_AF2122/97            --------------------------------------------
Rv3465|M.tuberculosis_H37Rv         --------------------------------------------
MMAR_1081|M.marinum_M               --------------------------------------------
MUL_0839|M.ulcerans_Agy99           --------------------------------------------
MLBr_01965|M.leprae_Br4923          --------------------------------------------
MAV_4407|M.avium_104                --------------------------------------------
TH_0329|M.thermoresistible__bu      --------------------------------------------
MSMEG_1510|M.smegmatis_MC2_155      --------------------------------------------
Mvan_1364|M.vanbaalenii_PYR-1       --------------------------------------------
MAB_3780|M.abscessus_ATCC_1997      --------------------------------------------
Mflv_3297|M.gilvum_PYR-GCK          PVAPRPARSVLDLGKIEATGFWPADMDETLTDYVRAATLHTQSV