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LTDFGKTLRAVETSIPGLTLWDLPVHGDNRGWFKENWQRAKMVAAGLPDFGPVQNNISFNQAPGTLRGIH AEPWDKFISVGSGRIFGAWVDLRSGPTFGTVFTAEIDPSRAVFVPRGVGNAFQTLEPETVYVYLVNDHYS PGVGYPSLNPGDEALAIEWPIPLDRAEMSEKDRAQPPLSEVTPVPGPKTLVLGADGQLGRALRAAYAEAP HVEFATRAELDLCAPDLDSARRWRDYDTIVNAAAYTAVDAAETSEGRTAAWTVNVTGVAALARVATAHGI TLVHVSSDYVFDGSAASPYREDDPLSPLGVYGQTKAAGDQLVSTVPRHYVVRTSWVVGEGRNFVQTMLSL AAKGVDPAVVDDQFGRLTFTSELARAVRHLTESRAPYGTYNVSGSGTERTWADIARRTFDLAGHDPRRVR GVSTAEYFSAATAPVAPRPARSVLDLGKIEATGFWPADMDETLTDYVRAATLHTQSV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3297 | - | - | 100% (477) | dTDP-4-dehydrorhamnose reductase |
| M. gilvum PYR-GCK | Mflv_4736 | - | 3e-27 | 36.12% (227) | dTDP-4-dehydrorhamnose reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3294c | rmlD | 3e-35 | 37.55% (277) | dTDP-rhamnose modification protein RmlD |
| M. tuberculosis H37Rv | Rv3266c | rmlD | 2e-34 | 37.18% (277) | dTDP-6-deoxy-L-lyxo-4-hexulose reductase RmlD |
| M. leprae Br4923 | MLBr_00751 | rmlD | 3e-35 | 37.76% (286) | putative dTDP-rhamnose modification protein |
| M. abscessus ATCC 19977 | MAB_3613c | - | 1e-30 | 37.45% (267) | dTDP-rhamnose modification protein RmlD |
| M. marinum M | MMAR_1275 | rmlD | 3e-32 | 36.27% (284) | dTDP-6-deoxy-L-lyxo-4-hexulose reductase RmlD |
| M. avium 104 | MAV_4231 | rfbD | 5e-34 | 37.01% (281) | dTDP-4-dehydrorhamnose reductase |
| M. smegmatis MC2 155 | MSMEG_1825 | rfbD | 3e-35 | 36.52% (293) | dTDP-4-dehydrorhamnose reductase |
| M. thermoresistible (build 8) | TH_0781 | rmlD | 1e-34 | 38.04% (276) | dTDP-6-DEOXY-L-LYXO-4-HEXULOSE REDUCTASE RMLD (dTDP-RHAMNOSE |
| M. ulcerans Agy99 | MUL_2612 | rmlD | 2e-32 | 36.62% (284) | dTDP-6-deoxy-L-lyxo-4-hexulose reductase RmlD |
| M. vanbaalenii PYR-1 | Mvan_1727 | - | 6e-31 | 35.51% (276) | dTDP-4-dehydrorhamnose reductase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1275|M.marinum_M --------------------------------------------------
MUL_2612|M.ulcerans_Agy99 --------------------------------------------------
Mb3294c|M.bovis_AF2122/97 --------------------------------------------------
Rv3266c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00751|M.leprae_Br4923 --------------------------------------------------
MAV_4231|M.avium_104 --------------------------------------------------
MSMEG_1825|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1727|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_0781|M.thermoresistible__bu --------------------------------------------------
MAB_3613c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_3297|M.gilvum_PYR-GCK MTDFGKTLRAVETSIPGLTLWDLPVHGDNRGWFKENWQRAKMVAAGLPDF
MMAR_1275|M.marinum_M --------------------------------------------------
MUL_2612|M.ulcerans_Agy99 --------------------------------------------------
Mb3294c|M.bovis_AF2122/97 --------------------------------------------------
Rv3266c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00751|M.leprae_Br4923 --------------------------------------------------
MAV_4231|M.avium_104 --------------------------------------------------
MSMEG_1825|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1727|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_0781|M.thermoresistible__bu --------------------------------------------------
MAB_3613c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_3297|M.gilvum_PYR-GCK GPVQNNISFNQAPGTLRGIHAEPWDKFISVGSGRIFGAWVDLRSGPTFGT
MMAR_1275|M.marinum_M --------------------------------------------------
MUL_2612|M.ulcerans_Agy99 --------------------------------------------------
Mb3294c|M.bovis_AF2122/97 --------------------------------------------------
Rv3266c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00751|M.leprae_Br4923 --------------------------------------------------
MAV_4231|M.avium_104 --------------------------------------------------
MSMEG_1825|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1727|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_0781|M.thermoresistible__bu --------------------------------------------------
MAB_3613c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_3297|M.gilvum_PYR-GCK VFTAEIDPSRAVFVPRGVGNAFQTLEPETVYVYLVNDHYSPGVGYPSLNP
MMAR_1275|M.marinum_M -------------------------------MVGRSERLVITGAAGQLGG
MUL_2612|M.ulcerans_Agy99 -------------------------------MVGRSERLVIAGAAGQLGG
Mb3294c|M.bovis_AF2122/97 -------------------------------MAGRSERLVITGAGGQLGS
Rv3266c|M.tuberculosis_H37Rv -------------------------------MAGRSERLVITGAGGQLGS
MLBr_00751|M.leprae_Br4923 -------------------------------MSDRSGRLVITGAGGQLGS
MAV_4231|M.avium_104 ---------------------------------------MIAGAGGQLGG
MSMEG_1825|M.smegmatis_MC2_155 ---MDLINGMGTSPGYWRTPREPGNDHRRARLDVMAQRIVITGAGGMVGR
Mvan_1727|M.vanbaalenii_PYR-1 ----------------------------------MTGRIVISGAGGLVGR
TH_0781|M.thermoresistible__bu ------------------------------MTNSSAKRIVIPGAGGMVGT
MAB_3613c|M.abscessus_ATCC_199 -------------------------------------MLVITGAGGQLGT
Mflv_3297|M.gilvum_PYR-GCK GDEALAIEWPIPLDRAEMSEKDRAQPPLSEVTPVPGPKTLVLGADGQLGR
:: ** * :*
MMAR_1275|M.marinum_M VLAAQAVRAGRDVLAKTSSEWDITDAAATEEI----IGTGDVVINCAAYT
MUL_2612|M.ulcerans_Agy99 VLAAQAVRAGRDVLAKTSSEWDITDAAATEEI----IGTGDVVINCAAYT
Mb3294c|M.bovis_AF2122/97 HLTAQAAREGRDMLALTSSQWDITDPAAAERI----IRHGDVVINCAAYT
Rv3266c|M.tuberculosis_H37Rv HLTAQAAREGRDMLALTSSQWDITDPAAAERI----IRHGDVVINCAAYT
MLBr_00751|M.leprae_Br4923 ALAAQATAAGRDVLALTSSQWDITDAAVAERMGRSALKKNDVVVNCAAYT
MAV_4231|M.avium_104 YVSALAADQGRDVVALTSAQWDITDPAAAERI----VRPGDVVINCAAYT
MSMEG_1825|M.smegmatis_MC2_155 VLADQAAAKGHTVLALTSSQCDITDEDAVRRF----VANGDVVINCAAYT
Mvan_1727|M.vanbaalenii_PYR-1 VLAGQARRAGRDVVALTSAQWDITDRAQAERV----IAAGDVVVNCAAFT
TH_0781|M.thermoresistible__bu VLAGQARTQGRDVAAFTSAQWDITDAAAAEHL----IRPGDVVINCAAYT
MAB_3613c|M.abscessus_ATCC_199 HLIARAKLRDLPVRALTSSDWDITRDGTPDGV----VAEGDIVINCAAYT
Mflv_3297|M.gilvum_PYR-GCK ALRAAYAEAP-HVEFATRAELDLCAPDLDSAR---RWRDYDTIVNAAAYT
: : * :: *: * ::*.**:*
MMAR_1275|M.marinum_M DVDSAESDE--ARAYAVNATGPENLAKACARAGAALIHVSTDYVFDGDHA
MUL_2612|M.ulcerans_Agy99 DVDSAESDE--ARAYAVNATGPENLAKACARAGAALIHVSTDYVFDGDHA
Mb3294c|M.bovis_AF2122/97 DVDGAESNE--AVAYAVNATGPQHLARACARVGARLIHVSTDYVFDGDFG
Rv3266c|M.tuberculosis_H37Rv DVDGAESNE--AVAYAVNATGPQHLARACARVGARLIHVSTDYVFDGDFG
MLBr_00751|M.leprae_Br4923 NVDGAESNE--LAAYAVNATGPEYIARACRCAGAALIHVSTDYVFSGDFG
MAV_4231|M.avium_104 DVDGAESDE--AGAFAVNEAGPGHIARACARAGARLLHVSTDYVFGGESP
MSMEG_1825|M.smegmatis_MC2_155 QVDKAEDEP--ERAHAVNAVGPGNLAKACAAVDAGLIHISTDYVFGAVD-
Mvan_1727|M.vanbaalenii_PYR-1 KVDAAEAEP--DRAHAVNAVGAGNVAQACARAGASLIHLSTDYVFSGS--
TH_0781|M.thermoresistible__bu DVDGAESDE--DRAHLVNAVGPGHLARACARVGADLVHISTDYVFSGD--
MAB_3613c|M.abscessus_ATCC_199 AVDAAEEDE--SRAYAVNAEGAERVARACRDVGARLIHISTDYVFDGEFG
Mflv_3297|M.gilvum_PYR-GCK AVDAAETSEGRTAAWTVNVTGVAALARVATAHGITLVHVSSDYVFDGS--
** ** . * ** * :*:.. . *:*:*:****..
MMAR_1275|M.marinum_M DLPDGAQPQPYEPGDKTAPQGVYARSKFAGERAVLAALPD---AVVVRSA
MUL_2612|M.ulcerans_Agy99 DLPDGAQPQPYEPGDKTAPQGVYARSKFAGERAVLAALPD---AVVVRSA
Mb3294c|M.bovis_AF2122/97 ----GAEPRPYEPTDETAPQGVYARSKLAGEQAVLAAFPE---AAVVRTA
Rv3266c|M.tuberculosis_H37Rv ----GAEPRPYEPTDETAPQGVYARSKLAGEQAVLAAFPE---AAVVRTA
MLBr_00751|M.leprae_Br4923 SGANRVAPRPYEPTDETGPLGVYGRSKLAGEQAVLAAMPE---ATVVRTA
MAV_4231|M.avium_104 AG-APDRPRPYEPGDPVAPQGVYARSKVAGERAVLAALPDPAQGVVVRTA
MSMEG_1825|M.smegmatis_MC2_155 ------RDTPYEVDDETGPVNIYGRTKLAGEQAVLAAKPD---AYVVRTA
Mvan_1727|M.vanbaalenii_PYR-1 ------RRRPYEIDDETGPLSVYGRTKLAGEQAVLAALPD---AYVVRTA
TH_0781|M.thermoresistible__bu ------RREPFEIDDDTTPMNVYGRTKLAGEQAVLSALPS---ARVVRTS
MAB_3613c|M.abscessus_ATCC_199 ----DAGPRPYRPGDATAPQGVYARTKVAGELAVHGVLPS---AQVVRTA
Mflv_3297|M.gilvum_PYR-GCK ------AASPYREDDPLSPLGVYGQTKAAGDQLVSTVPRH----YVVRTS
*:. * * .:*.::* **: * . ***::
MMAR_1275|M.marinum_M WVYTGG-TGSDFVAIMRRLAAGEGPVDVVDDQTGSPTYVADLAAALLEVA
MUL_2612|M.ulcerans_Agy99 WVYTGG-TGSDFVAIMRRLAAGEGPVDVVDDQTGSPTYVADLAAALLEVA
Mb3294c|M.bovis_AF2122/97 WVYTGG-TGKDFVAVMRRLAAGHGRVDVVDDQTGSPTYVADLAEALLALA
Rv3266c|M.tuberculosis_H37Rv WVYTGG-TGKDFVAVMRRLAAGHGRVDVVDDQTGSPTYVADLAEALLALA
MLBr_00751|M.leprae_Br4923 WVYTGG-TGKDFVAVMRRLAAGDGPVYVVDDQIGSPTYVVDLAAALLQVA
MAV_4231|M.avium_104 WVYTGG-TGKDFVAVMRRLAAGEGPVQVVDDQIGSPTYVGDLAAALLQIV
MSMEG_1825|M.smegmatis_MC2_155 WVYRGG-DGSDFVATMRRLAAGDGAIDVVADQVGSPTYTGDLVGALLQIV
Mvan_1727|M.vanbaalenii_PYR-1 WIYEGG-AGTDFAAVMRRAAQGDGTVEVVADQIGSPTYVGDLCRALLQIA
TH_0781|M.thermoresistible__bu WVYRGDVDGKDFVAVMRRLAAGPDPVNVVADQVGSPTYAADLAAALLQVA
MAB_3613c|M.abscessus_ATCC_199 WVYTGV--NGDFVGVMRRLAAGEGPVRVVTDQTGSPTYAVDLAEALLDLA
Mflv_3297|M.gilvum_PYR-GCK WVVGEG---RNFVQTMLSLAAKGVDPAVVDDQFGRLTFTSELARAVRHLT
*: :*. * * ** ** * *:. :* *: :.
MMAR_1275|M.marinum_M DAGVRGRLLHAANGG-AVSRFGLARAVFEECGTDPQRVRPVSTAQFPRPA
MUL_2612|M.ulcerans_Agy99 DAGVRGRLLHAANGG-AVSRFGLARAVFEECGTDPQRVRPVSTAQFPRPV
Mb3294c|M.bovis_AF2122/97 DAGVRGRVLHAANEG-VVSRFGQARAVFEECGADPQRVRPVSSAQFPRPA
Rv3266c|M.tuberculosis_H37Rv DAGVRGRVLHAANEG-VVSRFGQARAVFEECGADPQRVRPVSSAQFPRPA
MLBr_00751|M.leprae_Br4923 DGSVHGSVLHAANEG-EVSRFGQARAVFEECGADPLQVQPVSTAQNPRSA
MAV_4231|M.avium_104 DDRVPGPVLHAANEG-AVSRFEQARAVFEECGADPARVRPVGTEHFPRPA
MSMEG_1825|M.smegmatis_MC2_155 DGGVEPGILHAANAG-VASRFDQARATFEAVGADPERVRPCGSDRHPRPA
Mvan_1727|M.vanbaalenii_PYR-1 DGGVRGPVLHAANLG-AVSRFDQAQAVFAELGADPSRVRPVGSDRHPRPA
TH_0781|M.thermoresistible__bu DGAVDIPVLHAANAG-AASRFEQARAVFELVGADPDRVRPVTSDQVPRPA
MAB_3613c|M.abscessus_ATCC_199 ASDVREPFLHAAGSG-HVNRFEWAKAVFELVGADASRLQPCLSVDFPRPA
Mflv_3297|M.gilvum_PYR-GCK ESRAPYGTYNVSGSGTERTWADIARRTFDLAGHDPRRVRGVSTAEYFSAA
. :.:. * . *: .* * *. ::: : ..
MMAR_1275|M.marinum_M VRPGYSALGGRQWAAAGLTPLRPWRSALVAALAAASDRALAGRPVPSTSD
MUL_2612|M.ulcerans_Agy99 VRPGYSALGGRQWAAAGLTPLRPWRSALVAALAAASDRALAGRPVPSTSD
Mb3294c|M.bovis_AF2122/97 PRPSYSALSSRQWALAGLTPLRHWRSALATALAAPANSTSIDRRLPSTRD
Rv3266c|M.tuberculosis_H37Rv PRSSYSALSSRQWALAGLTPLRHWRSALATALAAPANSTSIDRRLPSTRD
MLBr_00751|M.leprae_Br4923 ARPAYSALSGRQSVAAGLTPLRPWRSALVEALAVSR-SLPVDRPLPSTRD
MAV_4231|M.avium_104 PRPTYSALGSRESAAAGLRPLRPWRPALVAALTNAGSPAAADRPLPSTRD
MSMEG_1825|M.smegmatis_MC2_155 PRPSYTVLSSQRSAQAGLTPLRDWREALQDAVAAVVGATTDG-PLPSTP-
Mvan_1727|M.vanbaalenii_PYR-1 PRPAYSALSPVKSAEAGLTPLRPWRDALAEALATVAG-------------
TH_0781|M.thermoresistible__bu PRPAYTVLSGRRSAEAGLTPLRPWREALASALAS-AGEPAGY-PLRRE--
MAB_3613c|M.abscessus_ATCC_199 PRPAYTALDGDHWADAGLPRLRPWRDALAEALATN---------------
Mflv_3297|M.gilvum_PYR-GCK TAPVAPRPARSVLDLGKIEATGFWPADMDETLTDYVRAATLHTQSV----
. . . : * : :::