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MKARELDVPGAWEITPTIHVDSRGLFFEWLTDHGFRAFAGHSLDVRQVNCSVSSAGVLRGLHFAQLPPSQ AKYVTCVSGSVFDVVVDIREGSPTFGRWDSVLLDDQDRRTIYVSEGLAHGFLALQDNSTVMYLCSAEYNP QREHTICATDPTLAVDWPLVDGAAPSLSDRDAAAPSFEDVRASGLLPRWEQTQRFIGEMRGT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3465 | rmlC | - | 100% (202) | dTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE RMLC (dTDP-4-KETO-6-DEOXYGLUCOSE 3,5-EPIMERASE) (dTDP-L-RHAMNOSE SYNTHETASE) (THYMIDINE DIPHOSPHO-4-KETO-RHAMNOSE 3,5-EPIMERASE) |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3494 | rmlC | 1e-118 | 100.00% (202) | dTDP-4-dehydrorhamnose 3,5-epimerase RmlC |
| M. gilvum PYR-GCK | Mflv_3297 | - | 2e-12 | 29.73% (185) | dTDP-4-dehydrorhamnose reductase |
| M. leprae Br4923 | MLBr_01965 | rmlC | 6e-90 | 75.38% (199) | dTDP-4-dehydrorhamnose 3,5-epimerase |
| M. abscessus ATCC 19977 | MAB_3780 | - | 2e-63 | 57.56% (205) | dTDP-4-dehydrorhamnose 3,5-epimerase RmlC |
| M. marinum M | MMAR_1081 | rmlC | 1e-97 | 82.67% (202) | dTDP-4-dehydrorhamnose 3,5-epimerase, RmlC |
| M. avium 104 | MAV_4407 | rfbC | 7e-96 | 82.14% (196) | dTDP-4-dehydrorhamnose 3,5-epimerase |
| M. smegmatis MC2 155 | MSMEG_1510 | - | 2e-75 | 66.67% (198) | dTDP-4-dehydrorhamnose 3,5-epimerase |
| M. thermoresistible (build 8) | TH_0329 | rmlC | 3e-79 | 66.16% (198) | dTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE RMLC |
| M. ulcerans Agy99 | MUL_0839 | rmlC | 2e-97 | 82.18% (202) | dTDP-4-dehydrorhamnose 3,5-epimerase, RmlC |
| M. vanbaalenii PYR-1 | Mvan_1364 | - | 2e-76 | 64.71% (204) | dTDP-4-dehydrorhamnose 3,5-epimerase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3465|M.tuberculosis_H37Rv ------------MKARELDVPGAWEITPTIHVDSRGLFFEWLTDHGFRAF
Mb3494|M.bovis_AF2122/97 ------------MKARELDVPGAWEITPTIHVDSRGLFFEWLTDHGFRAF
MMAR_1081|M.marinum_M ------------MQARELKVPGAWEITPTIHGDSRGMFFEWLTDSGFTAF
MUL_0839|M.ulcerans_Agy99 ------------MQARELKVPGAWEITPTIHGDSRGMFFEWLTDSGFTAF
MLBr_01965|M.leprae_Br4923 ------------MNVKELDISGAWEITPTIHSDSRGMFFEWLTASRFSAF
MAV_4407|M.avium_104 ------------MSARELKIPGAWEITPTVHGDARGHFFEWLTDKGFRSF
TH_0329|M.thermoresistible__bu VTVPENVPQNVPENVRALRVPGAWEITPRLHEDARGVFFEWFTDAQFSAF
MSMEG_1510|M.smegmatis_MC2_155 ------------MTARELSIAGAWEITPVLRTDSRGLFFEWFTDAGFTEF
Mvan_1364|M.vanbaalenii_PYR-1 ------------MNVRELTIPGAWEITPVVHTDARGAFFEWFTDAGFTAI
MAB_3780|M.abscessus_ATCC_1997 ------------MKIRELSVPGSFEITPVQHHDSRGVFLELFKGPALAEA
Mflv_3297|M.gilvum_PYR-GCK -----MTDFGKTLRAVETSIPGLTLWDLPVHGDNRGWFKENWQRAKMVAA
:.* : * ** * * :
Rv3465|M.tuberculosis_H37Rv AGHSLDVRQVNCSVSSA-GVLRGLHFAQLPPSQAKYVTCVSGSVFDVVVD
Mb3494|M.bovis_AF2122/97 AGHSLDVRQVNCSVSSA-GVLRGLHFAQLPPSQAKYVTCVSGSVFDVVVD
MMAR_1081|M.marinum_M CGHRFDVRQANCSVSSA-GVLRGLHFAELPPSQAKYVTCVSGAVFDVVVD
MUL_0839|M.ulcerans_Agy99 CGHRFDVRQANCSVSSA-GVLRGLHFAELPPSQSKYVTCVSGAVFDVVVD
MLBr_01965|M.leprae_Br4923 TGHRLDVRQANCSVSSA-GVLRGLHFAQVPPSQAKYVTCVTGSVFDVVVD
MAV_4407|M.avium_104 AGHRLDVRQANCSVSAA-GVLRGLHFAQVPPSQAKYVTCVRGSVFDVVVD
TH_0329|M.thermoresistible__bu AGHRFDLRQANCSVSAK-GVLRGLHFAEVPPSQAKYVTCVTGAVFDVVVD
MSMEG_1510|M.smegmatis_MC2_155 AGHQFDMRQANCSVSAR-GVLRGVHFAQVPPSQAKYVTCVRGAVFDVVVD
Mvan_1364|M.vanbaalenii_PYR-1 TGHRLDLRQANCSVSRA-GVLRGVHFAQLPPSQAKYVSCVRGAVVDVVVD
MAB_3780|M.abscessus_ATCC_1997 IGHPFELQQANCSVSAA-GSLRGIHFADVPPGQAKYVTCLTGSVYDVVVD
Mflv_3297|M.gilvum_PYR-GCK GLPDFGPVQNNISFNQAPGTLRGIHAEPWD----KFISVGSGRIFGAWVD
: * * *.. * ***:* *::: * : .. **
Rv3465|M.tuberculosis_H37Rv IREGSPTFGRWDSVLLDDQDRRTIYVSEGLAHGFLALQDNSTVMYLCSAE
Mb3494|M.bovis_AF2122/97 IREGSPTFGRWDSVLLDDQDRRTIYVSEGLAHGFLALQDNSTVMYLCSAE
MMAR_1081|M.marinum_M IRLGSPTFGQWDSVLLDDR-HRSIYISEGLAHGFLALQDKSTVMYMCSAE
MUL_0839|M.ulcerans_Agy99 IRLGSPTFGQWDSVLLDDR-HRSIYISEGLAHGFLALQDKSTVMYMCSAE
MLBr_01965|M.leprae_Br4923 IRLGSPTFGCWTSITLNDSNRKTIYISESLAHGFLALQDNSTVMYLCSAE
MAV_4407|M.avium_104 IRVGSPTFGQWDSVLLDDAEHRTIYISEGLGHGFLALQDNSTVMYLCSAE
TH_0329|M.thermoresistible__bu IRVGSPTFGQWDAVLLDGANRKSVYISEGLAHGFLALEDTSTVMYLCSAP
MSMEG_1510|M.smegmatis_MC2_155 IRVGSPTFGQWDAVLLDDKDRRSIYISEGLGHAFLALDDDSTVMYLCSAP
Mvan_1364|M.vanbaalenii_PYR-1 IRVGSPTFGRWDAVVLDDETHRSVYLSEGLGHAFLALHDDSVVTYLCSAG
MAB_3780|M.abscessus_ATCC_1997 IRVGSPTFGAWDAVLLDPRDRRAVYVPEGVGHGFLALEDDSTVVYLCSAG
Mflv_3297|M.gilvum_PYR-GCK LRSG-PTFGTVFTAEIDPS--RAVFVPRGVGNAFQTLEPETVYVYLVNDH
:* * **** : :: :::::...:.:.* :*. :. *: .
Rv3465|M.tuberculosis_H37Rv YNPQR-EHTICATDPTLAVDWPLVDG----AAPSLSDRDAAAPSFEDVR-
Mb3494|M.bovis_AF2122/97 YNPQR-EHTICATDPTLAVDWPLVDG----AAPSLSDRDAAAPSFEDVR-
MMAR_1081|M.marinum_M YNPQR-EHTICATDPELAIDWPLVDG----APPSLSERDAAAGSLDEVR-
MUL_0839|M.ulcerans_Agy99 YNPQR-EHTICATDPELAIDWPLVDG----APPSLSERDAAAGSLDEVR-
MLBr_01965|M.leprae_Br4923 YNPAR-EHAICATDPDLAIDWPVVDG----VDTHLSKRDATAPNLDDIR-
MAV_4407|M.avium_104 YNPGR-EHTICATDPALGIDWPLVAG----AAPTLSERDAAAPSLEEVR-
TH_0329|M.thermoresistible__bu YTPDR-EHTVAALDPAIGIEWPTLDAP---AGRVLSERDAAAPTLVEAE-
MSMEG_1510|M.smegmatis_MC2_155 YAPQR-EHTVRPTD--FGIEWPEVP------ELILSDRDAQAPSLAEAQ-
Mvan_1364|M.vanbaalenii_PYR-1 YDPAR-EHTIDPLDPALEIDWNAWPSRAADGELILSDRDRAAPSLEQAR-
MAB_3780|M.abscessus_ATCC_1997 YAPGR-EHGIDPLDPTVGIQWPTRRPDGTELSLLVSEKDGAAPSLLDAR-
Mflv_3297|M.gilvum_PYR-GCK YSPGVGYPSLNPGDEALAIEWPIPLDR-----AEMSEKDRAQPPLSEVTP
* * : . * . ::* :*.:* : :
Rv3465|M.tuberculosis_H37Rv --------------------------------------------------
Mb3494|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1081|M.marinum_M --------------------------------------------------
MUL_0839|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01965|M.leprae_Br4923 --------------------------------------------------
MAV_4407|M.avium_104 --------------------------------------------------
TH_0329|M.thermoresistible__bu --------------------------------------------------
MSMEG_1510|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1364|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3780|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_3297|M.gilvum_PYR-GCK VPGPKTLVLGADGQLGRALRAAYAEAPHVEFATRAELDLCAPDLDSARRW
Rv3465|M.tuberculosis_H37Rv --------------------ASGLLPRWEQTQRFIGEMRGT---------
Mb3494|M.bovis_AF2122/97 --------------------ASGLLPRWEQTQRFIGEMRGT---------
MMAR_1081|M.marinum_M --------------------ASGVLPTWEETQRFIDGLRGT---------
MUL_0839|M.ulcerans_Agy99 --------------------ASGVLPTWEETQRFIDGLRGT---------
MLBr_01965|M.leprae_Br4923 --------------------ASGLLPTWDETQNFIANLGSK---------
MAV_4407|M.avium_104 --------------------ASGLLPTWAETQAFIEGLPR----------
TH_0329|M.thermoresistible__bu --------------------AAGLLPSWEETRAFVASLRRHG--------
MSMEG_1510|M.smegmatis_MC2_155 --------------------AAGVLPTWADCQAFVETLRRNLVS------
Mvan_1364|M.vanbaalenii_PYR-1 --------------------TSGLLPTWEQTKKFVDGLRTGR--------
MAB_3780|M.abscessus_ATCC_1997 --------------------DSGLLPDAAEVQAFLDGLSG----------
Mflv_3297|M.gilvum_PYR-GCK RDYDTIVNAAAYTAVDAAETSEGRTAAWTVNVTGVAALARVATAHGITLV
* . : :
Rv3465|M.tuberculosis_H37Rv --------------------------------------------------
Mb3494|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1081|M.marinum_M --------------------------------------------------
MUL_0839|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01965|M.leprae_Br4923 --------------------------------------------------
MAV_4407|M.avium_104 --------------------------------------------------
TH_0329|M.thermoresistible__bu --------------------------------------------------
MSMEG_1510|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1364|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3780|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_3297|M.gilvum_PYR-GCK HVSSDYVFDGSAASPYREDDPLSPLGVYGQTKAAGDQLVSTVPRHYVVRT
Rv3465|M.tuberculosis_H37Rv --------------------------------------------------
Mb3494|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1081|M.marinum_M --------------------------------------------------
MUL_0839|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01965|M.leprae_Br4923 --------------------------------------------------
MAV_4407|M.avium_104 --------------------------------------------------
TH_0329|M.thermoresistible__bu --------------------------------------------------
MSMEG_1510|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1364|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3780|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_3297|M.gilvum_PYR-GCK SWVVGEGRNFVQTMLSLAAKGVDPAVVDDQFGRLTFTSELARAVRHLTES
Rv3465|M.tuberculosis_H37Rv --------------------------------------------------
Mb3494|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1081|M.marinum_M --------------------------------------------------
MUL_0839|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01965|M.leprae_Br4923 --------------------------------------------------
MAV_4407|M.avium_104 --------------------------------------------------
TH_0329|M.thermoresistible__bu --------------------------------------------------
MSMEG_1510|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1364|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3780|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_3297|M.gilvum_PYR-GCK RAPYGTYNVSGSGTERTWADIARRTFDLAGHDPRRVRGVSTAEYFSAATA
Rv3465|M.tuberculosis_H37Rv --------------------------------------------
Mb3494|M.bovis_AF2122/97 --------------------------------------------
MMAR_1081|M.marinum_M --------------------------------------------
MUL_0839|M.ulcerans_Agy99 --------------------------------------------
MLBr_01965|M.leprae_Br4923 --------------------------------------------
MAV_4407|M.avium_104 --------------------------------------------
TH_0329|M.thermoresistible__bu --------------------------------------------
MSMEG_1510|M.smegmatis_MC2_155 --------------------------------------------
Mvan_1364|M.vanbaalenii_PYR-1 --------------------------------------------
MAB_3780|M.abscessus_ATCC_1997 --------------------------------------------
Mflv_3297|M.gilvum_PYR-GCK PVAPRPARSVLDLGKIEATGFWPADMDETLTDYVRAATLHTQSV